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The biomechanical role of periodontal ligament in bonded and replanted vertically fractured teeth under cyclic biting forces

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International Journal of Oral Science 2015年第2期7卷 125-130页

作者： Ya-Nan Zhu Wei-Dong Yang Paul v Abbott Nicolas martin Wen-Jia Wei Jing-Jing Li Zhi Chen Wen-Mei Wang Department of Endodontics Institute and Hospital of StomatologyNanjing University Medical School Department of Endodontics School of DentistryThe University of Western Australia Department of Adult Dental Care School of Clinical DentistryThe University of Sheffield Department of Prothodontics Institute and Hospital of StomatologyNanjing University Medical School Department of Oral Medicine Institute and Hospital of StomatologyNanjing University Medical School Department of Endodontics The School and Hospital of StomatologyWuhan University

After teeth are replanted,there are two possible healing responses：periodontal ligament healing or ankylosis with subsequent replacement *** purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing ***-two human premolars were vertically fractured and the fragments were bonded together with Super-Bond C＆*** were then randomly distributed into four groups（BP,CP,CA,BA）.The BP and CP groups were used to investigate the periodontal ligament healing mode whilst the BA and CA groups simulated *** teeth had root canal treatment *** crowns were constructed for the CP and CA *** BP and BA groups only had composite resin restorations in the access *** specimens were subjected to a 260 N load at 4 Hz until failure of the bond or until 2 x 106 cycles had been reached if no fracture *** were detected by stereomicroscope imaging and also assessed via dye penetration ***,interfaces of the resin luting agent were examined by scanning electron *** results confirmed that the fatigue resistance was higher in the groups with simulated periodontal ligament *** reattachment showed important biomechanical role in bonded and replanted vertically fractured teeth.

关键词： fractured vertically teeth periodontal ligament bonding bonded resin subsequent restoration

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The spike protein of SARS-Cov-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency

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Cellular & Molecular Immunology 2021年第12期18卷 2673-2675页

作者： Prerna Arora Cheila Rocha Amy Kempf Inga Nehlmeier Luise Graichen martin S.Winkler martin Lier Sebastian Schulz Hans-martin Jäck Anne Cossmann Metodi v.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany Division of Molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany

The COvID-19 pandemic,caused by SARS-Cov-2,continues to rage in many countries,straining health systems and *** protect against severe disease and death and are considered central to ending the ***-19 vaccines(and SARS-Cov-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the ***,the emergence of SARS-Cov-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1].

关键词： antibodies vaccine death

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Kinetic Rates of the Fischer Tropsch Synthesis on a Co/Nb_2O_5 Catalyst

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Journal of Natural Gas Chemistry 2006年第4期15卷 307-312页

作者： víctor R.Ahón Paulo L.C.Lage Carlos D.D.de Souza Fabiana M.Mendes martin Schmal Federal University of Rio de Janeiro Programa de Engenharia Química COPPE/UFRJ C.P.6850221941-972Rio de JaneiroRJBrazil

The kinetics of the Fischer-Tropsch reaction over a Co/Nb2O5 catalyst in a fixed bed reactor was investigated experimentally. Experiments were carried out under isothermal and isobaric conditions （T=543 K, P=2.1 MPa） and under different conditions of several H2/CO feed molar ratio （0.49-4.79）, space velocities （0.2-3.8 h^-1）, mass of catalyst （0.3-1.5 g）, and CO conversion （10%-29%）. Synthesis gas conversion was measured and data were reduced to estimate the kinetic parameters for different Langmuir-Hinshelwood rate expressions. Differential and integral reactor models were used for the nonlinear regression of kinetics parameters. One of the rate equations could well explain the data. The hydrocarbon product distributions that were experimentally determined exhibited an unusual behavior, and a possible explanation was discussed.

关键词： Fischer-Tropsch natural gas kinetics selectivity

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Experimental confirmation of the linear relation between plasma current and external vertical magnetic field in EXL-50 spherical torus energetic electron plasmas

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Plasma Science and Technology 2024年第8期26卷 32-36页

作者：董力立王明远刘文军石跃江董家齐郭栋孙恬恬顾翔宋显明袁保山彭元凯 the ENN Team Hebei Key Laboratory of Compact Fusion Langfang 065001People’s Republic of China School of Mathematics and Physics Anqing Normal UniversityAnqing 246133People’s Republic of China ENN Science and Technology Development Co.Ltd. Langfang 065001People’s Republic of China

A three-fluid equilibrium plasma with bulk plasma and energetic electrons has been observed on the Xuanlong-50(EXL-50) spherical torus, where the energetic electrons play a crucial role in sustaining the plasma current and pressure. In this study, the equilibrium of a multi-fluid plasma was investigated by analyzing the relationship between the external vertical magnetic field(B_(v)),plasma current(I_(p)), the poloidal ratio(β_(p)) and the Shafranov formula. Remarkably, our research demonstrates some validity of the Shafranov formula in the presence of multi-fluid plasma in EXL-50 spherical torus. This finding holds significant importance for future reactors as it allows for differentiation between alpha particles and background plasma. The study of multi-fluid plasma provides a significant reference value for the equilibrium reconstruction of burning plasma involving alpha particles.

关键词： plasma equilibrium Shafranov formula multi-fluid plasma

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A system for underground road condition monitoring

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International Journal of Mining Science and Technology 2020年第3期30卷 405-411页

作者： Max Astrand Erik Jakobsson martin Lindfors John Svensson KTH Royal Institute of Technology SE-10044 StockholmSweden ABB Corporate Research SE-72226 VästeråsSweden Epiroc SE-70191ÖrebroSweden Linköping University SE-58183 LinköpingSweden Boliden Mines SE-93632 BolidenSweden

Poor road conditions in underground mine tunnels can lead to decreased production efficiency and increased wear on production vehicles. A prototype system for road condition monitoring is presented in this paper to counteract this. The system consists of three components i.e. localization, road monitoring, and scheduling. The localization of vehicles is performed using a Rao-Blackwellized extended particle filter, combining vehicle mounted sensors with signal strengths of Wi Fi access points. Two methods for road monitoring are described: a Kalman filter used together with a model of the vehicle suspension system, and a relative condition measure based on the power spectral density. Lastly, a method for taking automatic action on an ill-conditioned road segment is proposed in the form of a rescheduling *** scheduling algorithm is based on the large neighborhood search and is used to integrate road service activities in the short-term production schedule while minimizing introduced production *** system is demonstrated on experimental data collected in a Swedish underground mine.

关键词： Localization Road condition monitoring Scheduling Underground mining

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Evolving landscape and novel treatments in, metastatic castrate-resistant prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 342-349页

作者： Paul J Toren martin E Gleave Department of Urologic Sciences Faculty of Medicine University of British Columbia Vancouver BC V5Z 1M9 Canada

Treatment options for castrate-resistant prostate cancer （CRPC） have advanced in recent years and significantly improved the Outlook for patients with this aggressive and lethal disease. Further understanding of the biology＇of CRPC has led to several new targeted therapies and continues to emphasize the importance of androgen receptor （AR） directed therapy. The treatment landscape is rapidly changing and further biologically rationale, biomarker-based ongoing clinical trials are needed. We review the recent results of major clinical trials in CRPC. New and investigational agents now in clinical evaluation are reviewed including inhibitors of angiogenesis, microtubules, chaperones, AR and intracellular kinases, as well as immunotherapy, radiopharmaceuticals and bone-targeted agents. The recent improvement in prognosis for CRPC brings continued optimism for further improvements. Thoughtful planning of clinical trials and further understanding of the mechanisms of resistance to therapies will allow for continued progress in patient care.

关键词： prostate cancer treatment resistance androgen receptor antagonists molecular targets

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An Event Horizon Imager(EHI) Mission Concept Utilizing Medium Earth Orbit Sub-mm Interferometry

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空间科学学报 2021年第2期41卷 211-233页

作者： KUDRIASHOv v.martin-NEIRA M ROELOFS F FALCKE H BRINKERINK C BARYSHEv A HOGERHEIJDE M YOUNG A POURSHAGHAGHI H KLEIN-WOLT M MOSCIBRODZKA M DAvELAAR J BARAT I DUESMANN B vALENTA v PERDIGUES ARMENGOL J M DE WILDE D martin IGLESIAS P ALAGHA N vAN DER vORST M Department of Astrophysics/IMAPP Radboud University NijmegenP.O.Box 90106500 GL Nijmegenthe Netherlands ESTEC/ESA Keplerlaan 12201 A2 Noordurigkthe Netherlands Mar Planck Institute for Radio Astrorny Auf dem Higel 69D-53121 Bon(Endenich)Germany University of Groningen Landleven 129747 AD Groningenthe Netherlands Leiden Observatory Leiden UniversityPO Box 95132300 RALeidenthe Netherlands Anton Pannekoek Institute for Astronomy University of AmsterdamScience Park 9041098 XHAmsterdamthe Netherlands Center for Computational Astrophysics Flatiron Institute162 Fifth AvenueNew YorkNY 10010USA

Submillimeter interferometry has the potential to image supermassive black holes on event horizon scales,providing tests of the theory of general relativity and increasing our understanding of black hole accretion *** Event Horizon Telescope(EHT) performs these observations from the ground,and its main imaging targets are Sagittarius A~* in the Galactic Center and the black hole at the center of the M87 ***,the EHT is fundamentally limited in its performance by atmospheric effects and sparse terrestrial(u,v)-coverage(Fourier sampling of the image).The scientific interest in quantitative studies of the horizon size and shape of these black holes has motivated studies into using space interferometry which is free of these *** resolution considerations and interstellar scattering effects push the desired observing frequency to bands above 500 *** paper presents the requirements for meeting these science goals,describes the concept of interferometry from Polar or Equatorial Medium Earth Orbits(PECMEO) which we dub the Event Horizon Imager(EHI),and utilizes suitable space technology *** this concept,two or three satellites orbit at slightly different orbital radii,resulting in a dense and uniform spiral-shaped(u,v)-coverage over *** local oscillator signals are shared via an inter-satellite link,and the data streams are correlated on-board before final processing on the ***-satellite metrology and satellite positioning are extensively employed to facilitate the knowledge of the instrument position vector,and its time *** European space heritage usable for both the front ends and the antenna technology of such an instrument is *** and future sensors for the required inter-satellite metrology are *** performance estimates and simulation results are given.

关键词： Instrumentation Space vLBI Radio Telescopes

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Ultrasmall CoS nanoparticles embedded in heteroatom-doped carbon for sodium-ion batteries and mechanism explorations via synchrotron X-ray techniques

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Journal of Energy Chemistry 2023年第4期79卷 373-381页

作者： Congcong Liu Qiongqiong Lu Mikhail v.Gorbunov Ahmad Omar Ignacio G.Gonzalez martinez Panpan Zhao martin Hantusch Antonius Dimas Chandra Permana Huanyu He Nikolai Gaponik Daria Mikhailova Leibniz Institute for Solid State and Materials Research(IFW)Dresden e.v. Helmholtzstraße 2001069 DresdenGermany Inorganic Chemistry II Technische Universität DresdenBergstraße 6601069 DresdenGermany Physical Chemistry Technische Universität DresdenZellescher Weg 1901069 DresdenGermany

Transition metal sulfides have been regarded as promising anode materials for sodium-ion batteries(SIB).However,they face the challenges of poor electronic conductivity and large volume change,which result in capacity fade and low rate *** this work,a composite containing ultrasmall CoS(~7 nm)nanoparticles embedded in heteroatom(N,S,and O)-doped carbon was synthesized by an efficient one-step sulfidation process using a Co(Salen)*** ultrasmall CoS nanoparticles are beneficial for mechanical stability and shortening Na-ions diffusion ***,the N,S,and O-doped defect-rich carbon provides a robust and highly conductive framework enriched with active sites for sodium storage as well as mitigates volume expansion and polysulfide *** anode for SIB,CoS@HDC exhibits a high initial capacity of 906 mA h g^(-1)at 100 mA g^(-1)and a stable long-term cycling life with over 1000 cycles at 500 mA g^(-1),showing a reversible capacity of 330 mA h g^(-1).Meanwhile,the CoS@HDC anode is proven to maintain its structural integrity and compositional reversibility during ***,Na-ion full batteries based on the CoS@HDC anode and Na_(3)v_(2)(PO_(4))_(3)cathode demonstrate a stable cycling behavior with a reversible specific capacity of~200 m A h g^(-1)at least for 100 ***,advanced synchrotron operando X-ray diffraction,ex-situ X-ray absorption spectroscopy,and comprehensive electrochemical tests reveal the structural transformation and the Co coordination chemistry evolution of the CoS@HDC during cycling,providing fundamental insights into the sodium storage mechanism.

关键词： Sodium-ion batteries Cobalt sulfide nanoparticles Heteroatom-doped porous carbon matrix Synchrotron X-ray techniques Reaction mechanisms

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Livestock detection in aerial images using a fully convolutional network

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Computational visual Media 2019年第2期5卷 221-228页

作者： Liang Han Pin Tao Ralph R.martin Department of Computer Technology and Application Qinghai UniversityXiningChina Department of Computer Science and Technology Tsinghua UniversityBeijingChina School of Computer Science and Informatics Cardiff UniversityCardiffWalesUK

In order to accurately count the number of animals grazing on grassland, we present a livestock detection algorithm using modified versions of U-net and Google Inception-v4 net. This method works well to detect dense and touching instances. We also introduce a dataset for livestock detection in aerial images, consisting of 89 aerial images collected by quadcopter. Each image has resolution of about 3000 ×4000 pixels, and contains livestock with varying shapes,scales, and *** evaluate our method by comparison against Faster RCNN and Yolo-v3 algorithms using our aerial livestock dataset. The average precision of our method is better than Yolo-v3 and is comparable to Faster RCNN.

关键词： livestock detection segmentation classification

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NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients

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World Journal of Gastroenterology 2010年第41期16卷 5233-5240页

作者： Nora Meggyesi Lajos S Kiss Magdalena Koszarska martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar martin Lenicek Libor vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos Department of Molecular Diagnostics Hun-garian National Blood Transfusion Service H-1113 BudapestHungary 1st Depart-ment of Medicine Semmelweis University H-1083 BudapestHungary IBD Clinicaland Research Centre ISCARE IVF and 1st Medical FacultyCharles University 170 04 Prague Czech Republic 1st Department of Medicine Csolnoky F.County Hospital H8200 Veszprem Hungary 1st Department of Medicine University ofSzeged H6720 Szeged Hungary Department of Biochemistry andLaboratory Diagnostics 1st Medical Faculty Charles Univer-sity 170 04 Prague Czech Republic 2nd Department of Medicine University of Debrecen H4032 Debrecen Hungary 2nd Department of Medicine Semmelweis University H1085 Budapest Hungary

AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations.

关键词： Crohn’s disease Ulcerative colitis NKX2-3 Immunity-related GTPase family M ECM1 Genotype Phenotype Pharmacogenetics

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