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Clinical trials in otology:Examining trends and framework for prioritization

Journal of Otology 2021年第2期16卷 95-98页

作者： Jake Altshuler Rohan Viswanathan Divya B.Dasani Katherine Webb Tam Ramsey Varun Patel randall ruffner Jason Mouzakes David Foyt Division of Otolaryngology-Head and Neck Surgery Albany Medical Center50 New Scotland AvenueAlbanyNY12208United States

Objective:To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the *** ***:Data was collected from *** and included all clinical trials that focused on otology from 2008 to *** measures include status of trials,funding sources,details regarding otologic conditions studied,and trends in clinical ***:There were 992 otology clinical trials from 2008 to 2018.457(46.1%)were completed and 94(9.5%)were *** remained the highest(76.5%)contributor to otology clinical *** otologic conditions studied,from most common to least common,include hearing loss(40.6%),vestibulopathy(18.8%),tinnitus(18.8%),and otitis media(15.1%).The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018(p<0.001).The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period(p<0.001),while those focusing on tinnitus and otitis media did not(p=0.09 and p=0.20,respectively).The majority of clinical trials on each of these four conditions focused on treatment ***:Our study describes trends in otology clinical trials registered on *** from 2008 through *** total number of clinical trials over this time period increased significantly,driven by trials investigating hearing loss and ***,most clinical trials were industrysponsored and focused on treatment *** study provides an outline of otology clinical trials registered in a US web-based database,which may be of use for the development of future clinical trials.

关键词： Otology Clinical trials Otology trend

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