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Suicide transport blockade of motor neuron survival generates a focal graded injury and functional deficit

Neural Regeneration Research 2021年第7期16卷 1281-1287页

作者： Allison S.Liang Joanna E.Pagano Christopher A.Chrzan randall D.McKinnon Department of Neurosurgery Rutgers-Robert Wood Johnson Medical SchoolPiscatawayNJUSA Member The Cancer Institute of New JerseyNew BrunswickNJUSA

We describe a pre-clinical spinal cord motor neuron injury model that is minimal invasive, reproducible, focal and easily applied to small *** axonal transport of a pro-apoptotic phosphatidylinosotol 3'-kinase inhibitor, wortmannin, via the sciatic nerve results in loss of ipsilateral lumbar motor neurons proportional to the level of drug *** neuron loss was detected by choline acetyltransferase(ChAT) immunostaining and with a transgenic thy1-eGFP *** short half-life of wortmannin generates minimal wound spread, and wortmannin does not affect axon transport, as determined by co-injection of a pseudorabies virus *** quantitative transcript analysis, we found that ChAT transcripts significantly decreased at 14 days post-delivery of 1 μg wortmannin, relative to sham controls, and remained low after 90 *** effects were observed with 200 ng and 100 ng *** also generated a transient and significant increase in astrocyte Gfap transcripts after 14 days with a return to control levels at 90 *** mice had hind limb spasticity and a forced motor function defect that was quantified using a water exit *** rapidly exit a shallow water tray, and wortmannin treated animals were up to 12-fold slower, a phenotype that persisted for at least 3 *** the focal delivery of wortmannin to motor neurons generates a reproducible and scalable injury that can facilitate quantitative studies on neural regeneration and *** efficacy of sciatic nerve suicide transport can also explain neurotoxin-mediated selective loss of motor neurons in diseases such as amyotrophic lateral *** procedures were performed at Rutgers under established Institutional Animal Care and Use protocols(eIACUC_TR201800022, approved on March 20, 2018).

关键词： amyotrophic lateral sclerosis injury motor function motor neuron PI3'kinase sciatic nerve suicide transport wortmannin

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INTEGRATION OF THE MODELS OF ANNAGNPS AND REMM TO ASSESS RIPARIAN BUFFER SYSTEM FOR SEDIMENT REDUCTION

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International Journal of Sediment Research 2007年第1期22卷 60-69页

作者： Ronald BINGNER randall WILLIAMS Richard LOWRANCE David BOSCH Joe SHERIDAN Ph.D Agricultural Engineer USDA-Agricultural Research Science -National Sedimentation Laboratory P.O. Box 1157 Oxford MS 38655 USA Agricultural Engineer USDA-Agricultural Research Science -National Sedimentation Laboratory 2316 RAINWATER RD TIFTON GA 31793 Ph.D Ecologist USDA-Agricultural Research Service-Southeast Watershed Research Laboratory P.O. Box 748 2379 Rainwater Road Tifton Georgia 31793 USA Ph.D Research Hydraulic Engineer USDA-Agricultural Research Service-Southeast Watershed Research Laboratory P.O. Box 748 2316 RAINWATER RD Tifton Georgia 31793 Ph.D Research Hydraulic Engineer USDA-Agricultural Research Service-Southeast Watershed Research Laboratory P.O. Box 748 2316 RAINWATER RD Tifton Georgia 31793

The United States Department of Agriculture (USDA) Annualized Agricultural Non-Point Source Pollution model (AnnAGNPS) is used to help evaluate a watershed response to agricultural management practices to control water quality. However, AnnAGNPS version 3.5 does not contain features to estimate the effect of a riparian buffer (RB) system on water quality. The Riparian Ecosystem Management Model (REMM) is used to simulate the impact of riparian buffer systems on water quality. However, frequently the lack of measured upland loadings that are required by REMM simulation limits the application of REMM. To address this data gap, a study was conducted to integrate AnnAGNPS with REMM for RB system simulation. AnnAGNPS was used to simulate water and sediment loadings from an upland field into a three-zone RB system at the Gibbs Farm located in the Georgia coastal plain. These AnnAGNPS outputs were used as the inputs to REMM. REMM was used to simulate water and sediment movement along the riparian buffers. The AnnAGNPS simulated amount of annual runoff at the edge of the field was close to observed amounts (Nash-Sutcliffe efficiency of 0.92). It is believed that a substantial portion of sand was removed from the runoff one meter into the grass buffer where the samplers were located; therefore, sand was excluded from the AnnAGNPS simulation for comparison with observed sediment. Excluding sand, the AnnAGNPS predicted amount of annual sediment matches the observed amount fairly well (Nash-Sutcliffe efficiency of 0.46). In addition, based on evaluating the percent reduction of sediment at each zonal interface, the AnnAGNPS/REMM model well simulated the function of the RB system to reduce sediment.

关键词： AnnAGNPS REMM Watershed modeling Riparian buffer systems Runoff Sediment simulation

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Understanding fluorine-free electrolytes via small-angle X-ray scattering

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Journal of Energy Chemistry 2022年第7期31卷 340-346,I0009页

作者： Kun Qian Zhou Yu Yuzi Liu David J.Gosztola randall E.Winans Lei Cheng Tao Li Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Materials Science Division and Joint Center for Energy Storage Research Argonne National LaboratoryLemontIL 60439USA Center for Nanoscale Materials Argonne National LaboratoryLemontIL 60439USA X-ray Science Division and Joint Center for Energy Storage Research Argonne National LaboratoryLemontIL 60439USA

Fluorine-free electrolytes have attracted great attention because of its low-cost and environmental friendliness. However, so far, little is known about the solution structures of these electrolytes. Here,we compare the solvation phenomenon of sodium tetraphenylborate(NaBPh_(4)) salt dissolved in organic solvents of propylene carbonate(PC), 1,2-dimethoxyethane(DME), acetonitrile(ACN) and tetrahydrofuran(THF). Small-angle X-ray scattering(SAXS) reveals a unique two-peak structural feature in this saltconcentrated PC electrolyte, while solutions using other solvents only have one scattering *** dynamics(MD) simulations further reveal that there are anion-based clusters in addition to the short-range charge ordering in the concentrated NaBPh4/PC electrolyte. Raman spectroscopy confirms the existence of considerable contact ion pairs(CIPs). This work emphasizes the importance of global and local structural analysis, which will provide valuable clues for understanding the structureperformance relationship of electrolytes.

关键词： Fluorine-free electrolytes Sodium-ion batteries Small-angle X-ray scattering Solvation structures Sodium tetraphenylborate

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The Effect of Signal Propagation Delay on the Measured Vibration in Planetary Gearboxes

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Journal of Dynamics, Monitoring and Diagnostics 2022年第1期1卷 9-18页

作者： Marc Hilbert Wade A.Smith Robert B.randall LIACS Leiden UniversityRapenburg 702311 EZLeidenThe Netherlands School of Mechanical and Manufacturing Engineering University of New South WalesUNSWSydneyNSW2052Australia

Modulation of the gear mesh vibration is a major field of research for the condition monitoring of planetary *** modulation creates sidebands around the gearmesh frequency in the vibration spectrum,and the distribution of these sidebands has been researched in numerous *** publications on the subject assume that the effect of the time varying signal propagation delay between the main vibration source–the gear mesh point(s)–and the(usually fixed)transducer can be *** paper investigates the validity of this *** do so,a planetary gearbox with a transducer mounted on the(fixed)ring gear is studied,and the effect of the propagation delay is modelled as a phase modulation of the gear mesh *** expressions are then derived for the distribution and strength of the modulation sidebands,and these expressions are applied to quantify the effect of the propagation delay on five industrial *** results show that the amplitude of the sidebands is negligible and would not interfere with condition assessment based on analysis of the modulation of the gear mesh frequency,and thus the propagation delay can be neglected for practical purposes.

关键词： gear diagnostics phase modulation planetary gearbox propagation delay

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Cyclooxygenase-2 and the inflammogenesis of breast cancer

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World Journal of Clinical Oncology 2014年第4期5卷 677-692页

作者： randall E Harris Bruce C Casto Zachary M Harris The Ohio State University Comprehensive Cancer Center The Ohio State University College of Medicine Columbus OH 43210-1351 United States College of Medicine and College of Public Health Center of Molecular Epidemiology and Environmental Health The Ohio State University Medical Center Columbus OH 43210-1351 United States

Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the "inflammogenesis of breast cancer".

关键词： Breast Cancer Cyclooxygenase-2 Nonsteroidal anti-inflammatory drugs Inflammogenesis Estrogen Aromatase

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Practice Wisdom Knowledge Versus Empirical Science Knowledge:Guiding Historical Social Work Direct Practice

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Sociology Study 2018年第7期8卷 305-312页

作者： randall Basham University of Texas at Arlington USA

For social workers who are interested in research associated with validating methodology for the amelioration of human problems,or the mastery of intervention models,used in direct practice;definitive consensus,on guidelines,remains *** has been written in recent years about the necessity of the profession to be guided by either empirical research,which has validated specific interventions,or by the theory,heuristic rules,and the decision‐making schema of experienced *** debate is not simply limited to clinical practice issues,or factions defending or refuting,a particular theoretical *** one hand,social research has in recent years,invalidated some long held practice models,and has modified our understanding of core social ***,social research is an often difficult and arduous pursuit,which may require some time to make thorough evaluation,as compared to the immediacy of emerging social *** transmission of scholarly research findings takes time and considerable effort to disseminate and gain understanding and acceptance within the practice community even when well *** the other hand,practitioners serve as the wellspring of observations,which are often translated into models or theory,and frequently become the subject matter of empirical ***,few in the practice community are encouraged or committed,to systematically review research findings so as to modify practice approaches,which have not been well validated by recent research findings.

关键词： Social work practice wisdom empirical science evidence based practice

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A Case Review of Selected Popular Computing Games： Therapeutic and Affective Aspects of Gaming and Comparisons to Children＇s Literature

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通讯和计算机（中英文版） 2016年第6期13卷 271-280页

作者： randall Basham School of Social Work the University of Texas at Arlington U.S.A.

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Spontaneous pneumothorax in a single lung transplant recipient-a blessing in disguise: A case report

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World Journal of Clinical Cases 2020年第14期8卷 3031-3038页

作者： Himanshu Deshwal Subha Ghosh Kathleen Hogan Olufemi Akindipe Charles randall Lane Atul C Mehta Division of Pulmonary Critical Care and Sleep MedicineNew York University Grossman School of MedicineNew YorkNY 10016United States Imaging Institute Section of Thoracic ImagingCleveland ClinicClevelandOH 44195United States Respiratory Institute Cleveland ClinicClevelandOH 44195United States

BACKGROUND End-stage chronic obstructive pulmonary disease(COPD)is one of the common lung diseases referred for lung *** to the international society of heart and lung transplantation,30%of all lung transplantations are carried out for COPD *** compared to bilateral lung transplant,singlelung transplant(SLT)has similar short-term and medium-term results for *** patients with severe upper lobe predominant emphysema,lung volume reduction surgery is an excellent alternative which results in improvement in functional status and long-term *** 2018,endobronchial valves were approved by the Food and Drug Administration for severe upper lobe predominant emphysema as they demonstrated improvement in lung function,exercise capacity,and quality of ***,the role of endobronchial valves in native lung emphysema in SLT patients has not been *** SUMMARY We describe an unusual case of severe emphysema who underwent a successful SLT 15 years ago and had gradual worsening of lung function suggestive of chronic lung allograft ***,her lung function improved significantly after a spontaneous pneumothorax of the native lung resulting in auto-deflation of large *** This case highlights the clinical significance of native lung hyperinflation in single lung transplant recipient and how spontaneous decompression due to pneumothorax led to clinical improvement in our patient.

关键词： Native lung hyperinflation Single lung transplant Pneumothorax Bronchoscopic lung volume reduction Endobronchial valve Case report

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粉末注射成形与液相烧结科学基础的建立

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粉末冶金技术 2008年第2期26卷 145-151,152页

作者： randall M. German 韩凤麟(译) CAVS Chair Professor in Mechanical Engineering Director Center for Advanced Vehicular Systems Mississipi State University P. O. Box 5405 Mississippi State MS 39762-5405 USA 不详

就固-液-孔隙系统的流变学特性而言,粉末注射成形与液相烧结具有同样特点。粉末注射成形起始于1930年代,而金属粉末的液相烧结大体上也可溯源于同一时代。这2种工艺都对粘度和固体含量与温度的关系高度敏感,但都有所不同。因此,提出了... 详细信息

就固-液-孔隙系统的流变学特性而言,粉末注射成形与液相烧结具有同样特点。粉末注射成形起始于1930年代,而金属粉末的液相烧结大体上也可溯源于同一时代。这2种工艺都对粘度和固体含量与温度的关系高度敏感,但都有所不同。因此,提出了一个包括应变速率、颗粒大小、固体含量等因素及颗粒结合程度的模型。在液相烧结中,固体在液体中的溶解度通过颗粒结合影响与时间相关的粘度。同样,在粉末注射成形中,长聚合物的缠结影响与时间相关的粘度。粉末注射成形与液相烧结二者的相似之处,在于都能够将流变学特性模型用于计算机模拟。

关键词：粉末注射成形液相烧结流变学模型粘度粘性流动烧结

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Lots of Physicists Are Nervous about the Speed of Light

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考试（高考英语） 2011年第11期 26-28页

作者： Eric randall 不详

[1]Physicists spent their weekends walking back media hype over an experiment that at first glance seems to disprove Einstein’s famed theory of *** preached dispassionate skepticism,but behind all that careful cynicism,there seemed a lot of hand-wringing.编者注:hype:Hype is the use of a lot of publicity and advertising to make people interested

关键词：高中英语教学教学方法阅读教学

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