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World Journal of Diabetes 2023年第11期14卷 1710-1716页

作者： Priscille Huret Philippe Lopes randa dardari Alfred Penfornis Claire Thomas Dured dardari LBEPS University EvryIRBAUniversitéParis SaclayEvry 91000France Diabetology Al FourkanAleppo 90000Syria Diabetology Centre Hospitalier Sud FrancilienCorbeil Essonne 91100France

BACKGROUND The correction and control of chronic hyperglycemia are the management goals of patients living with *** hyperglycemia is the main factor inducing diabetes-related ***,in certain situations,the rapid and intense correction of chronic hyperglycemia can paradoxically favor the onset of microvascular *** SUMMARY In this case report,we describe the case of a 25-year-old woman living with type 1 diabetes since the age of 9 *** diabetes was chronic and unstable but without *** an unplanned pregnancy,her diabetes was intensely managed with the rapid correction of her ***,over the following 2 years,she developed numerous degenerative microvascular complications:Charcot neuroarthropathy with multiple joint involvement,severe proliferative diabetic retinopathy,gastroparesis,bladder voiding disorders,and end-stage renal failure requiring *** In the literature to date,the occurrence of multiple microvascular complications following the rapid correction of chronic hyperglycemia has been rarely described in the same individual.

关键词： Unstable diabetes Chronic hyperglycemia Microvascular complication Type 1 diabetes Case report

The impact of foot reflexology on fatigue and sleep quality in school-aged children undergoing hemodialysis

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Journal of Integrative Nursing 2024年第2期6卷 76-82页

作者： Amal Hashem MOHAMED Mostafa SHABAN Huda Hamdy MOHAMMED randa Mohamed ABOBAKER Salman Hamdan ALSAQRI Rania Abd-Elnaby Mohammed ALLAM Faculty of Nursing Minia UniversityMinyaEgypt College of Nursing Jouf UniversitySakakaSaudi Arabia Faculty of Nursing Cairo UniversityGizaEgypt Northern College of Nursing ARARSaudi Arabia College of Nursing University of HailHailSaudi Arabia

Objective:This study aimed to evaluate the effects of foot reflexology on fatigue and sleep quality in school-aged children receiving ***:A quasi-experimental pretest-posttest design was *** children of ages 6-12 undergoing in-center hemodialysis were *** Pittsburgh Sleep Quality Index(PSQI)and Inventory of Fatigue Symptom(IFS)scales were administered at *** then received 30 min of foot reflexology massage before hemodialysis sessions 3 days per week for 12 *** administration of the sleep and fatigue scales occurred after the intervention ***:Reflexology massage led to significant improvements in sleep quality components,including duration(0%-30%normal sleepers),efficiency(0%-50%>85%),latency(50%-0%>60 min),disturbances,and daytime *** mean PSQI score decreased from 18.2 to 9.7(P<0.05).Fatigue severity substantially decreased,with the mean IFS score improving from 105.7 to 64.1(P<0.05).Conclusion:Foot reflexology is an effective nursing intervention for reducing fatigue and improving sleep quality in children on hemodialysis,warranting integration into routine care.

关键词： Fatigue hemodialysis massage pediatric reflexology sleep

Interstitial cells of Cajal, the Maestro in health and disease

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World Journal of Gastroenterology 2010年第26期16卷 3239-3248页

作者： randa M Mostafa Yasser M Moustafa Hosam Hamdy Department of Basic Medical Sciences College of Medicine Sharjah University Sharjah 27272 United Arab Emirates Department of Pharmacology and Toxicology College of Pharmacy Suez Canal University Ismaelia 24421 Egypt Department of Surgery Vice Chancellor of Medical and Health sciences Colleges Sharjah University Sharjah 27272 United Arab Emirates

Interstitial cells of Cajal (ICC) are important players in the symphony of gut motility. They have a very signif icant physiological role orchestrating the normal peristaltic activity of the digestive system. They are the pacemaker cells in gastrointestinal (GI) muscles. Absence, reduction in number or altered integrity of the ICC network may have a dramatic effect on GI system motility. More understanding of ICC physiology will foster advances in physiology of gut motility which will help in a future breakthrough in the pharmacological interventions to restore normal motor function of GI tract. This mini review describes what is known about the physiologic function and role of ICCs in GI system motility and in a variety of GI system motility disorders.

关键词： Interstitial cells of Cajal Gastrointestinal motility Peristalsis

Chemical composition, antiproliferative, antioxidant and antibacterial activities of essential oils from aromatic plants growing in Sudan

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 741-748页

作者： Sakina Yagi randa Babiker Tzvetomira Tzanova Herve Schohn Department of Botany Faculty of Science University of Khartoum Department of Botany Faculty of Science University of Kordofan Universite de Lorraine-UMR CNRS 7565-Structure et Reactivite des Systemes Moleculaires Complexes-Campus Bridoux-rue du General Delestraint57070 Metz Cedex

Objective: To explore the potential of essential oil, as therapeutic molecule source, from olibanum of Boswellia papyrifera(Burseraceae), leafy stems of Cymbopogon schoenanthus(Poaceae) and Croton zambesicus(Euphorbiaceae) and rhizome of Cyperus rotundus(Cyperaceae) found in Sudan. Respective essential oil was evaluated for antiproliferative, antibacterial and antioxidant activity. Methods: Essential oils were extracted by hydrodistillation and then analysed by gas chromatography coupled to mass spectrometry(GCMS). Anti-proliferative activity was determined against human cell lines(MCF7 and MDAMB231, HT29 and HCT116) by the thiazolyl blue tetrazolium bromide(MTT) procedure. Antioxidant activity was evaluated by diphenyl 2 pycril hydrazil(DPPH) assay. Antibacterial activity was determined against two Gram-positive and two Gram-negative bacteria by microdilution method. Results: The essential oil from olibanum of Boswellia papyriferacontained mainly alcohol and ester derivatives(46.82%) while monoterpenes(69.84%) dominated in Corton zambesicus oil. Sesquiterpenes were the most highly represented classes of terpene derivatives in Cyperus schoenanthus(71.59%) and Cyperus rotundus(44.26%). Oil of Cymbopogon schoenanthus revealed the best anti-proliferative activity against HCT116 cell line with IC50 value at(19.1 ± 2.0) μg/m L. Oil of Croton zambesicus showed the best antioxidant activity [EC50(4.20 ± 0.19) mg/m L]. All oils showed good antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus with minimum inhibitory concentration(MIC) value ranged from 16 to 250 μg/m L. Conclusions: The results suggest that the essential oils of these plants could be used as a source of natural anti-proliferative, antioxidant and antibacterial agents.

关键词： Boswellia papyrifera Croton zambesicus Cymbopogon schoenanthus Cyperus rotundus GC/MS profile anti-proliferative activity

Care4U: Integrated healthcare systems based on blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 2-13页

作者： randa Kamal Ezz El-Din Hemdan Nawal El-Fishway Department of Computer Science and Engineering Faculty of Electronic EngineeringMenoufia UniversityEgypt

During the COVID-19 crisis, the need to stay at home has increased dramatically. In addition, the number of sickpeople, especially elderly persons, has increased exponentially. In such a scenario, home monitoring of patientscan ensure remote healthcare at home using advanced technologies such as the Internet of Medical Things (IoMT).The IoMT can monitor and transmit sensitive health data;however, it may be vulnerable to various attacks. In thispaper, an efficient healthcare security system is proposed for IoMT applications. In the proposed system, themedical sensors can transmit sensed encrypted health data via a mobile application to the doctor for ***, three consortium blockchains are constructed for load balancing of transactions and reducing transactionlatency. They store the credentials of system entities, doctors' prescriptions and recommendations according to thedata transmitted via mobile applications, and the medical treatment process. Besides, cancelable biometrics areused for providing authentication and increasing the security of the proposed medical system. The investigationalresults show that the proposed system outperforms existing work where the proposed model consumed lessprocessing time by values of 18%, 22%, and 40%, and less energy for processing a 200 KB file by values of 9%,13%, and 17%. Finally, the proposed model consumed less memory usage by values of 7%, 7%, and 18.75%. Fromthese results, it is clear that the proposed system gives a very reliable and secure performance for efficientlysecuring medical applications.

关键词： Healthcare Blockchain Cyber security Internet of things Internet of Medical Things Cancelable biometrics

Rome Ⅲ:The functional gastrointestinal disorders, third edition, 2006

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World Journal of Gastroenterology 2008年第13期14卷 2124-2125页

作者： randa Mostafa Department of Basic Medical Sciences Collegeof Medicine Sharjah University Sharjah United Arab Emirates

Functional gastrointestinal disorders （FGIDs） represent a common and important class of disorders within gastroenterology. Rome Ⅰ, the first edition was published in 1994, with symptom-based diagnostic criteria for FGIDs. These criteria began to change the diagnostic approach to F-GIDs, and no longer considered ＂diagnoses of exclusion＂ but rather ＂diagnoses of inclusion＂. Rome Ⅱ, the second edition published in 2000, resulted from the continual process of analyzing new scientific and clinical evidence in the study of F-GIDs. Rome Ⅱ, diagnostic criteria for irritable bowel syndrome （IBS）, was extended with a focus on the frequency of symptoms occurring twelve weeks （not necessarily consecutive weeks） within twelve months. ROlE Ⅲ, the third edition, conservative one, was published in September 2006, with changes made only where there is good evidence to do so. Some of the differences between Rome Ⅱ and Rome Ⅲ criteria are highlighted in this issue.

关键词： Rome Ⅲ Functional gastrointestinal disorders Diagnosis Classification

Rectal prolapse: Diagnosis and clinical management

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World Journal of Gastroenterology 2010年第17期16卷 2193-2194页

作者： randa Mohamed Mostafa Department of Basic Medical Sciences College of MedicineSharjah University

The exact cause of rectal prolapse is not well addressed,but it is often associated with long standing constipation,advanced age,chronic obstructive pulmonary disease and some neurological *** prolapse is usually only a symptom,which needs a focus on discovery of the underlying pathology or *** different clinical presentations are often combined and called rectal *** prolapse can be divided into full thickness rectal prolapse where the entire rectum protrudes beyond the anus,mucosal prolapse where only the rectal mucosa (not the entire wall) prolapses,and internal intussuception wherein the rectum collapses but does not exit the *** constipation and straining may contribute to the development of rectal prolapse,simply correcting these problems may not improve the prolapse once it has *** are many different approaches to surgical correction of rectal prolapse.

关键词： Rectal Prolapse Procidentia Complete prolapse

Statistical Analysis with Dingo Optimizer Enabled Routing for Wireless Sensor Networks

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Computers, Materials & Continua 2022年第11期73卷 2865-2878页

作者： Abdulaziz S.Alghamdi randa Alharbi Suliman A.Alsuhibany Sayed Abdel-Khalek Department of Mathematics College of Science&ArtsKing Abdulaziz UniversityRabigh21911Saudi Arabia Department Statistics College of ScienceUniversity of TabukTabukSaudi Arabia Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Mathematics and Statistics College of ScienceTaif UniversityTaif21944Saudi Arabia Mathematics Department Faculty of ScienceSohag UniversitySohag82524Egypt

Security is a vital parameter to conserve energy in wireless sensor networks(WSN).Trust management in the WSN is a crucial process as trust is utilized when collaboration is important for accomplishing trustworthy data *** the available routing techniques do not involve security in the design of routing *** study develops a novel statistical analysis with dingo optimizer enabled reliable routing scheme(SADO-RRS)for *** proposed SADO-RRS technique aims to detect the existence of attacks and optimal routes in *** addition,the presented SADORRS technique derives a new statistics based linear discriminant analysis(LDA)for attack detection,Moreover,a trust based dingo optimizer(TBDO)algorithm is applied for optimal route selection in the WSN and accomplishes secure data transmission in ***,the TBDO algorithm involves the derivation of the fitness function involving different input variables of *** demonstrating the enhanced outcomes of the SADO-RRS technique,a wide range of simulations was carried out and the outcomes demonstrated the enhanced outcomes of the SADO-RRS technique.

关键词： Statistical analysis reliability routing wireless sensor networks linear discriminant analysis dingo optimizer security

The role of veterinarians in the One Health approach to antimicrobial resistance perspectives in Jordan

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Animal Diseases 2022年第1期2卷 61-70页

作者： randa Bazzi Akram Alaboudi Gabor Racz Faculty of Public Health University of DebrecenDebrecenHungary Department of Pathology and Public Health Faculty of Veterinary Medicine and SurgeryJordan University of Science and Technology(Retired)Ar-RamthaJordan Department of Public Health and Epidemiology Faculty of MedicineUniversity of DebrecenDebrecenHungary.

This study aims to evaluate the role of Jordanian veterinarians in terms of their knowledge,attitudes and common practices in combating antimicrobial resistance(AMR)and summarize the registered veterinary drugs between *** study data were collected using a standardized questionnaire that focused on the knowledge,attitudes,and practices of Jordanian *** findings were analyzed descriptively;84%of the participants agreed with the statement on the definition of *** majority(95.65%)of participants agreed that AMR is a challenge for the veterinary sector in Jordan and that it should be prioritized over other zoonotic *** 69%of the participants believed that the misuse and overuse of antimicrobials by unqualified,fraudulent,or unauthorized practitioners is the primary reason for the rise of cases associated with AMR and the challenges that accompany *** most common practice among the respondents in this study was to recommend clients(e.g.,farmers and owners)to practice good animal husbandry(80.00%).The study also revealed that there was a significant difference(p=O.015)between attendance at AMR training sessions and the professional sector(private,public,and academic)of the *** study underscores the importance of implementing a continuous education program on AMR so as to enhance the all-round knowledge of veterinarians and improve their advisory *** addition,laws should be enacted to ensure that veterinarians prescribe the correct antimicrobials and to improve surveillance systems for monitoring the use of antimicrobials in veterinary medicine.

关键词： Antimicrobial resistance Veterinarian Knowledge Practices Attitudes Jordan

Design framework for robotic surgery wards at hospitals:Computational implementation

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Frontiers of Architectural Research 2020年第3期9卷 514-540页

作者： randa M.A.Mahmoud Amr M.A.Youssef Department of Architectural Ensineering Assiut UniversityAssiut 71518Egypt

Robotic surgery is one of the most recent technologies in healthcare building *** to the design complexity of Robotic surgery wards,computational implementations are being developed to either measure the effect of inserting advanced technologies as Electronic medical recorders and tele surgery,or evaluate design alternatives on healthcare *** paper presents a design framework that responds to the need for coordinating design phases for Robotic Surgery Wards(RSWs)*** proposed design framework for RSWs can generate functional RSW alternatives and more than one solution for each *** framework has been structured based on the main architectural considerations of RSWs which are geom etric and topological,the economic considerations,specific developed pools for shape and corridor patterns,and the theory of,fShape Grammars"has been utilized to compute the framework to generate a vast number of design ***,a computational implementation has been established to assist designers in early design *** validation for the applications of the developed framework and implementation has been conducted by using reference examples of *** main finding in this paper is providing healthcare building designers with a computational implementation that generates RSW alternative computationally based on specific shape and cost levels.

关键词： Robotic surgery ward design Architectural and economic design consideration Design framework Computational implementation Shape grammar