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Chemical composition, antiproliferative, antioxidant and antibacterial activities of essential oils from aromatic plants growing in Sudan

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 741-748页

作者： Sakina Yagi randa babiker Tzvetomira Tzanova Herve Schohn Department of Botany Faculty of Science University of Khartoum Department of Botany Faculty of Science University of Kordofan Universite de Lorraine-UMR CNRS 7565-Structure et Reactivite des Systemes Moleculaires Complexes-Campus Bridoux-rue du General Delestraint57070 Metz Cedex

Objective: To explore the potential of essential oil, as therapeutic molecule source, from olibanum of Boswellia papyrifera(Burseraceae), leafy stems of Cymbopogon schoenanthus(Poaceae) and Croton zambesicus(Euphorbiaceae) and rhizome of Cyperus rotundus(Cyperaceae) found in Sudan. Respective essential oil was evaluated for antiproliferative, antibacterial and antioxidant activity. Methods: Essential oils were extracted by hydrodistillation and then analysed by gas chromatography coupled to mass spectrometry(GCMS). Anti-proliferative activity was determined against human cell lines(MCF7 and MDAMB231, HT29 and HCT116) by the thiazolyl blue tetrazolium bromide(MTT) procedure. Antioxidant activity was evaluated by diphenyl 2 pycril hydrazil(DPPH) assay. Antibacterial activity was determined against two Gram-positive and two Gram-negative bacteria by microdilution method. Results: The essential oil from olibanum of Boswellia papyriferacontained mainly alcohol and ester derivatives(46.82%) while monoterpenes(69.84%) dominated in Corton zambesicus oil. Sesquiterpenes were the most highly represented classes of terpene derivatives in Cyperus schoenanthus(71.59%) and Cyperus rotundus(44.26%). Oil of Cymbopogon schoenanthus revealed the best anti-proliferative activity against HCT116 cell line with IC50 value at(19.1 ± 2.0) μg/m L. Oil of Croton zambesicus showed the best antioxidant activity [EC50(4.20 ± 0.19) mg/m L]. All oils showed good antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus with minimum inhibitory concentration(MIC) value ranged from 16 to 250 μg/m L. Conclusions: The results suggest that the essential oils of these plants could be used as a source of natural anti-proliferative, antioxidant and antibacterial agents.

关键词： Boswellia papyrifera Croton zambesicus Cymbopogon schoenanthus Cyperus rotundus GC/MS profile anti-proliferative activity

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The impact of foot reflexology on fatigue and sleep quality in school-aged children undergoing hemodialysis

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Journal of Integrative Nursing 2024年第2期6卷 76-82页

作者： Amal Hashem MOHAMED Mostafa SHABAN Huda Hamdy MOHAMMED randa Mohamed ABOBAKER Salman Hamdan ALSAQRI Rania Abd-Elnaby Mohammed ALLAM Faculty of Nursing Minia UniversityMinyaEgypt College of Nursing Jouf UniversitySakakaSaudi Arabia Faculty of Nursing Cairo UniversityGizaEgypt Northern College of Nursing ARARSaudi Arabia College of Nursing University of HailHailSaudi Arabia

Objective:This study aimed to evaluate the effects of foot reflexology on fatigue and sleep quality in school-aged children receiving ***:A quasi-experimental pretest-posttest design was *** children of ages 6-12 undergoing in-center hemodialysis were *** Pittsburgh Sleep Quality Index(PSQI)and Inventory of Fatigue Symptom(IFS)scales were administered at *** then received 30 min of foot reflexology massage before hemodialysis sessions 3 days per week for 12 *** administration of the sleep and fatigue scales occurred after the intervention ***:Reflexology massage led to significant improvements in sleep quality components,including duration(0%-30%normal sleepers),efficiency(0%-50%>85%),latency(50%-0%>60 min),disturbances,and daytime *** mean PSQI score decreased from 18.2 to 9.7(P<0.05).Fatigue severity substantially decreased,with the mean IFS score improving from 105.7 to 64.1(P<0.05).Conclusion:Foot reflexology is an effective nursing intervention for reducing fatigue and improving sleep quality in children on hemodialysis,warranting integration into routine care.

关键词： Fatigue hemodialysis massage pediatric reflexology sleep

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Mental Health Consequences among Sudanese Due to the Armed Conflicts and Civil Unrest of 2023: One Year Later

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Journal of Biosciences and Medicines 2024年第4期12卷 21-37页

作者： Sahar Moawia Balla Elnour Nahla Yousif Osman Mohammed Saeed Awadia babiker Mohammed Osman Abeer Alawad Hassan Eman Mohamed Nour Hamad Alneel Mustafa Rowa Abdelmonem Sidig Hamato Malaz Mohamed Khair Alsafi Mohamed Amna Alnaim Mohamed Ahmed Osman Awab Abdelbagi Mustafa Ahmed Jalal Abdelrasool Hassan Eltaib Department of Family Medicine Health Gates Riyadh Saudi Arabia Family Medicine Department Ultracare Home Health Care Riyadh Saudi Arabia Psychiatic Department Erada Hospital and Mental Health Alkharj Saudi Arabia Family Medicine Department Ahmed Gasim Diabetic Center Portsudan Sudan QCHP Qatar Qatar Primary Care Najran Health Cluster Najran Saudi Arabia Emergency Department Best Care Hospital Khartoum Sudan Family Medicine Department Mouwasat Hospital Khobar Saudi Arabia

Aim: To investigate depression, anxiety, PTSD, and insomnia levels among Sudanese citizens after a year has passed since the start of Armed Forces conflict in Sudan. Methods: An online survey was distributed. It is composed of five parts, covering the following areas: 1) sociodemographic data;2) depression assessment;3) generalized anxiety disorder assessment;4) post-traumatic stress disorder assessment;and 5) insomnia assessment. Statistical Package for Social Sciences version 27 was used for data analysis;frequency and percentage were used to describe the qualitative variables. Spearman’s correlation analysis and Chi-square test were used for correlation and association analysis;a P-value equal to or less than 0.05 was considered statistically significant. Results: The study included 283 participants, primarily female (76.0%), with a mean age of 35.26 ± 6.96 years. The majority of participants were married (50.5%) and had a university level of education (50.2%). At the start of the war, 70.3% of participants were inside the war zones, and at the time of data collection, 73.5% were outside Sudan. The length of stay in the war zone ranged from 1 to 300 days, with a mean of 48.59 ± 70.284 days. Additionally, 63.3% of participants stated that they did not receive any form of mental health intervention, and the remaining did not provide an answer. There was a high prevalence of moderate-severe depression (50.5%), moderate anxiety (35.3%), PTSD (56.5%), and sub-threshold insomnia (53.4%) among the participants. Correlation analyses revealed associations between demographic factors such as sex, age, marital status, and education and mental health issues. Notably, female participants showed a higher prevalence of PTSD (53.0%) compared to male participants (67.6%). Conclusions: There is a substantial impact of war-related trauma on mental health, revealing a high prevalence of moderate-severe depression, moderate anxiety, PTSD, and sub-threshold insomnia among the particip

关键词： Sudan War Conflict Mental Health

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Loading and releasing behavior of carboxymethyl cellulose and chitosan complex beads

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Progress in Natural Science:Materials International 2022年第6期32卷 715-723页

作者： Ali A.Altam Liping Zhu Dafaalla babiker Hajo Yagoub Shuguang Yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials Donghua University

The complex beads of carboxymethyl cellulose（CMC） and chitosan（CHI） that are fabricated by interfacial complexation have a core-shell structure composed of a thin skin layer and a 3D entangled internal structure,which endows the beads with adsorption possibilities toward anionic and cationic molecules via electrostatic ***,the loading and releasing behavior of such a system is essential and fundamental for their application yet has not been studied *** this work,the influences of beads physical state,adsorbent dosage,agitation speed,solution pH and temperature on the loading behavior were *** CMC@CHI beads demonstrated different loading efficiency to three typical dyes of methylene blue（MB）,acid blue-113（AB）,and methyl orange（MO） with different charge *** adsorption rate followed an order of MB>AB>MO,giving 97.4%,73.3% and 20.2%,*** releasing of three dyes from CMC@CHI beads also exhibited different rates,and MB release was found to be prolonged compared to AB and *** loading mechanism of dyes was further investigated via X-ray photoelectron *** CMC@CHI beads may have possible applications in mixed dye removal as well as encapsulating systems of drugs or sensitive chemicals with different charges.

关键词： Polysaccharide Encapsulation Loading mechanism Dye removal Interfacial complexation

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Care4U: Integrated healthcare systems based on blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 2-13页

作者： randa Kamal Ezz El-Din Hemdan Nawal El-Fishway Department of Computer Science and Engineering Faculty of Electronic EngineeringMenoufia UniversityEgypt

During the COVID-19 crisis, the need to stay at home has increased dramatically. In addition, the number of sickpeople, especially elderly persons, has increased exponentially. In such a scenario, home monitoring of patientscan ensure remote healthcare at home using advanced technologies such as the Internet of Medical Things (IoMT).The IoMT can monitor and transmit sensitive health data;however, it may be vulnerable to various attacks. In thispaper, an efficient healthcare security system is proposed for IoMT applications. In the proposed system, themedical sensors can transmit sensed encrypted health data via a mobile application to the doctor for ***, three consortium blockchains are constructed for load balancing of transactions and reducing transactionlatency. They store the credentials of system entities, doctors' prescriptions and recommendations according to thedata transmitted via mobile applications, and the medical treatment process. Besides, cancelable biometrics areused for providing authentication and increasing the security of the proposed medical system. The investigationalresults show that the proposed system outperforms existing work where the proposed model consumed lessprocessing time by values of 18%, 22%, and 40%, and less energy for processing a 200 KB file by values of 9%,13%, and 17%. Finally, the proposed model consumed less memory usage by values of 7%, 7%, and 18.75%. Fromthese results, it is clear that the proposed system gives a very reliable and secure performance for efficientlysecuring medical applications.

关键词： Healthcare Blockchain Cyber security Internet of things Internet of Medical Things Cancelable biometrics

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Statistical Analysis with Dingo Optimizer Enabled Routing for Wireless Sensor Networks

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Computers, Materials & Continua 2022年第11期73卷 2865-2878页

作者： Abdulaziz S.Alghamdi randa Alharbi Suliman A.Alsuhibany Sayed Abdel-Khalek Department of Mathematics College of Science&ArtsKing Abdulaziz UniversityRabigh21911Saudi Arabia Department Statistics College of ScienceUniversity of TabukTabukSaudi Arabia Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Mathematics and Statistics College of ScienceTaif UniversityTaif21944Saudi Arabia Mathematics Department Faculty of ScienceSohag UniversitySohag82524Egypt

Security is a vital parameter to conserve energy in wireless sensor networks(WSN).Trust management in the WSN is a crucial process as trust is utilized when collaboration is important for accomplishing trustworthy data *** the available routing techniques do not involve security in the design of routing *** study develops a novel statistical analysis with dingo optimizer enabled reliable routing scheme(SADO-RRS)for *** proposed SADO-RRS technique aims to detect the existence of attacks and optimal routes in *** addition,the presented SADORRS technique derives a new statistics based linear discriminant analysis(LDA)for attack detection,Moreover,a trust based dingo optimizer(TBDO)algorithm is applied for optimal route selection in the WSN and accomplishes secure data transmission in ***,the TBDO algorithm involves the derivation of the fitness function involving different input variables of *** demonstrating the enhanced outcomes of the SADO-RRS technique,a wide range of simulations was carried out and the outcomes demonstrated the enhanced outcomes of the SADO-RRS technique.

关键词： Statistical analysis reliability routing wireless sensor networks linear discriminant analysis dingo optimizer security

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The role of veterinarians in the One Health approach to antimicrobial resistance perspectives in Jordan

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Animal Diseases 2022年第1期2卷 61-70页

作者： randa Bazzi Akram Alaboudi Gabor Racz Faculty of Public Health University of DebrecenDebrecenHungary Department of Pathology and Public Health Faculty of Veterinary Medicine and SurgeryJordan University of Science and Technology(Retired)Ar-RamthaJordan Department of Public Health and Epidemiology Faculty of MedicineUniversity of DebrecenDebrecenHungary.

This study aims to evaluate the role of Jordanian veterinarians in terms of their knowledge,attitudes and common practices in combating antimicrobial resistance(AMR)and summarize the registered veterinary drugs between *** study data were collected using a standardized questionnaire that focused on the knowledge,attitudes,and practices of Jordanian *** findings were analyzed descriptively;84%of the participants agreed with the statement on the definition of *** majority(95.65%)of participants agreed that AMR is a challenge for the veterinary sector in Jordan and that it should be prioritized over other zoonotic *** 69%of the participants believed that the misuse and overuse of antimicrobials by unqualified,fraudulent,or unauthorized practitioners is the primary reason for the rise of cases associated with AMR and the challenges that accompany *** most common practice among the respondents in this study was to recommend clients(e.g.,farmers and owners)to practice good animal husbandry(80.00%).The study also revealed that there was a significant difference(p=O.015)between attendance at AMR training sessions and the professional sector(private,public,and academic)of the *** study underscores the importance of implementing a continuous education program on AMR so as to enhance the all-round knowledge of veterinarians and improve their advisory *** addition,laws should be enacted to ensure that veterinarians prescribe the correct antimicrobials and to improve surveillance systems for monitoring the use of antimicrobials in veterinary medicine.

关键词： Antimicrobial resistance Veterinarian Knowledge Practices Attitudes Jordan

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Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

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World Journal of Gastroenterology 2022年第2期28卷 242-262页

作者： Abeer babiker Idris Alaa B Idris Manal A Gumaa Mohammed babiker Idris Amanda Elgoraish Mohamed Mansour Dalia Allam Bashir MO Arbab Nazar Beirag El-Amin M Ibrahim Mohamed A Hassan Department of Agricultural Science and Technology Institute of Natural and Applied SciencesErciyes UniversityKayseri 38039Turkey Department of Medical Microbiology Faculty of Medical Laboratory SciencesUniversity of KhartoumKhartoum 11111Sudan Department of Neurosurgery Ribat University HospitalKhartoum 11111Sudan BioMérieux Clinical and Application Advisor Al-Jeel Medical Co.Riyadh 11422Saudi Arabia Department of Epidemiology Tropical Medicine Research InstituteKhartoum 11111Sudan Department of Gastroenterology Ibn Sina Specialized HospitalKhartoum 11111Sudan Department of Gastroenterology Modern Medical CentreKhartoum 11111Sudan Biosciences College of HealthMedicine and Life SciencesBrunel UniversityLondon UB83PHUxbridgeUnited Kingdom Department of Translation Bioinformatics Detavax BiotechKayseri 38350Turkey

BACKGROUND Helicobacter pylori(***)is a ubiquitous bacterium that affects nearly half of the world’s population with a high morbidity and mortality *** within the tumor necrosis factor-alpha(TNF-A)promoter region are considered a possible genetic basis for this *** To functionally characterize the genetic variations in the TNF-A 5’-region(-584 to+107)of Sudanese patients infected with *** using in silico *** An observational study was carried out in major public and private hospitals in Khartoum state.A total of 122 gastric biopsies were taken from patients who had been referred for *** DNA was *** of the TNF-A-1030 polymorphism was performed using PCR with confronting two-pair primer to investigate its association with the susceptibility to *** infection in the Sudanese ***,Sanger sequencing was applied to detect single nucleotide polymorphisms in the 5’-region(-584 to+107)of TNF-A in ***-infected *** analyses were used to predict whether these mutations would alter transcription factor binding sites or composite regulatory elements in this region.A comparative profiling analysis was conducted in 11 species using the ECR browser and multiple-sequence local alignment and visualization search engine to investigate the possible ***,a multivariate logistic regression model was constructed to estimate odds ratios and their 95%confidence intervals for the association between TNF-A-1030,sociodemographic characteristics and *** *** were statistically significant if PA,-76)was located at the in silico-predicted promoter region(-146 to+10),and it was predicted to alter transcription factor b

关键词： 5’-region Promoter TNF-A Helicobacter pylori In silico analysis Sudan

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Dynamic Response and Deformation Behavior of Kadui-2 Landslide Influenced by Reservoir Impoundment and Rainfall,Baoxing,China

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Journal of Earth Science 2023年第3期34卷 911-923页

作者： Muhammad Kamran Xiewen Hu Muhammad Awais Hussain Muhammad Sanaullah randa Ali Kun He Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China Department of Civil Engineering Technology National Skills UniversityIslamabadPakistan Institute of Geology Unversity of the PunjabLahore 54590Pakistan

This study focuses on the deformation characteristics of Kadui-2 Landslide by the influence of reservoir filling-drawdown and precipitation.A three-year monitoring project was implemented in order to observe the short/long-term *** slide mass experienced consistent deformation with a maximum cumulative displacement of 331.34 *** on the recorded data of reservoir water level and precipitation during this period,a two-dimensional(2-D)finite element model using Geostudio software was set up for deformation simulation under different conditions to understand the real influence of these triggering factors on *** numerical simulation results are in consistent with monitoring field *** numerical simulation and field monitoring results exhibit that the maximum deformation occurred at the foreside of slumping *** slip surface shows significant creep characteristics decreasing as long-term shear strength reducing *** water level fluctuation is the primary triggering factor to reactivate the landslide mass and has a negative correlation with deformation *** rate increases with the reservoir drawdown and decreases with impoundment *** with reservoir filling-drawdown operation,rainfall has no significant effect on the slide motion of landslide due to limited penetration from the ground surface.

关键词： landslide reservoir water level fluctuation rainfall finite element method cumulative displacement deformation characteristics

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Developing phoneme-based lip-reading sentences system for silent speech recognition

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CAAI Transactions on Intelligence Technology 2023年第1期8卷 129-138页

作者： randa El-Bialy Daqing Chen Souheil Fenghour Walid Hussein Perry Xiao Omar HKaram Bo Li School of Engineering London South Bank UniversityLondonUK Faculty of Informatics and Computer Science British University in EgyptCairoEgypt School of Electronics and Informatics Northwestern Polytechnical UniversityXi'anChina

Lip-reading is a process of interpreting speech by visually analysing lip *** research in this area has shifted from simple word recognition to lip-reading sentences in the *** paper attempts to use phonemes as a classification schema for lip-reading sentences to explore an alternative schema and to enhance system *** classification schemas have been investigated,including characterbased and visemes-based *** visual front-end model of the system consists of a Spatial-Temporal(3D)convolution followed by a 2D *** utilise multi-headed attention for phoneme recognition *** the language model,a Recurrent Neural Network is *** performance of the proposed system has been testified with the BBC Lip Reading Sentences 2(LRS2)benchmark *** with the state-of-the-art approaches in lip-reading sentences,the proposed system has demonstrated an improved performance by a 10%lower word error rate on average under varying illumination ratios.

关键词： deep learning deep neural networks lip-reading phoneme-based lip-reading spatial-temporal convolution,transformers

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