检索结果-南通市图书馆

In Vitro Antioxidant and Radio Protective Activities of Lycopene from Tomato Extract against Radiation—Induced DNA Aberration

引用

Journal of Biosciences and Medicines 2024年第2期12卷 202-213页

作者： Safaiatul Islam Abu Hena Mostofa Kamal Md. Ziaur Rahman Protul Kumar Roy A.Y.K. Md. Masud rana Molecular Radiobiology and Biodosimetry Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Savar Bangladesh

Background: The accumulation of free radicals is linked to a number of diseases. Free radicals can be scavenged by antioxidants and reduce their harmful effects. It is therefore essential to look for naturally occurring antioxidants that come from plants, as synthetic antioxidants are toxic, carcinogenic and problematic for the environment. Lycopene is one of the carotenoids, a pigment that dissolves in fat and has antioxidant properties. Materials and Methods: The antioxidant and free radical scavenging activity were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The impact of lycopene on bacteria (E. coli) susceptibility to γ-radiation was examined by radio sensitivity assay. The study also examined the induction of strand breaks in plasmid pUC19 DNA and how lycopene extract protected the DNA from γ-radiation in vitro. Results: At varying concentrations, lycopene demonstrated its ability to scavenge free radicals such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). IC50 for lycopene was determined at 112 μg/mL which was almost partial to IC50 of standard antioxidant L-ascorbic acid. The D10 value 180 Gy of E. coli was found to be >2-fold higher in the extract-containing lycopene sample than in the extract-free controls. The lycopene extracts inhibited the radiation-induced deterioration of the plasmid pUC19 DNA. At an IC50 concentration, lycopene provided the highest level of protection. Conclusion: Lycopene functions as an efficient free radical scavenger and possible natural antioxidant source. For cancer patients and others who frequently expose themselves to radiation, lycopene may be a useful plant-based pharmaceutical product for treating a variety of diseases caused by free radicals.

关键词： Radio Protective Antioxidants Free Radical DNA Damage pUC19 Plasmid Gamma Irradiation DPPH

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence

引用

World Journal of Cardiovascular Diseases 2024年第3期14卷 140-156页

作者： Dilip Kumar Amit Malviya Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee Soumya Patra Arindam Pande rana Rathor Roy Debopriyo Mondal Ashesh Halder Sumit Shanker Medica Superspecialty Hospital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results.

关键词： Bifurcation Stenting Coronary Bifurcation Lesions Percutaneous

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolving strategies: Enhancements in managing eosinophilic esophagitis in pediatric patients

引用

World Journal of Clinical Pediatrics 2024年第1期13卷 14-22页

作者： Ahmed Elghoudi Doaa Zourob Eman Al Atrash Fatima Alshamsi Manal Alkatheeri Hassib Narchi rana Bitar Department of Pediatric Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Division of Pediatric Gastroenterology Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Pediatric Residency Program Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences United Arab Emirates UniversityAlainAbu DhabiUnited Arab Emirates

Eosinophilic esophagitis is a newly recognized disease first described about 50 years *** definition,diagnosis,and management have evolved with new published consensus guidelines and newly approved treatment available to pediatricians,enabling a better understanding of this disease and more targeted treatment for *** describe the definition,presentation,and diagnosis of eosinophilic esophagitis including management,challenges,and future directions in *** definition,diagnosis,and management of eosinophilic esophagitis have evolved over the last 50 *** guidelines and newly approved biologic treatment have enabled pediatricians to better understand this disease and allow for more targeted treatment for *** describe the definition,presentation,diagnosis,management,and treatment in addition to the challenges and future directions of eosinophilic esophagitis management in children.

关键词： Eosinophilic esophagitis Esophagitis Gastroesophageal reflux disease Food allergy Dysphagia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Focus on current and emerging treatment options for glioma:A comprehensive review

引用

World Journal of Clinical Oncology 2024年第4期15卷 482-495页

作者： Brandon Lucke-Wold Burhanuddin Sohail Rangwala Muhammad Ashir Shafique Mohammad Arham Siddiq Muhammad Saqlain Mustafa Fnu Danish rana Muhammad Umer Nasrullah Noor Zainab Abdul Haseeb Department of Neurosurgery University of FloridaGainesvilleFL 32608United States Department of Neurosurgery Jinnah Sindh Medical UniversityKarachi 75510Pakistan Department of Neurosurgery Army Medical CollegeRawalpindi 46000Pakistan

This comprehensive review delves into the current updates and challenges associated with the management of low-grade gliomas(LGG),the predominant primary tumors in the central nervous *** a general incidence rate of 5.81 per 100000,gliomas pose a significant global concern,necessitating advancements in treatment techniques to reduce mortality and *** review places a particular focus on immunotherapies,discussing promising agents such as Zotiraciclib and ***,a CDK9 inhibitor,has demonstrated efficacy in glioblastoma treatment in preclinical and clinical studies,showing its potential as a therapeutic ***,a viral immunotherapy,induces inflammation in glioblastoma and displays positive outcomes in both adult and pediatric *** of immunotherapy extends to Pembrolizumab,Nivolumab,and Entrectinib,revealing the challenges and variabilities in patient *** promising preclinical data,the monoclonal antibody Depatuxizumab has proven ineffective in glioblastoma treatment,emphasizing the critical need to understand resistance *** review also covers the success of radiation therapy in pediatric LGG,with evolving techniques,such as proton therapy,showing potential improvements in patient quality of *** treatment is discussed in the context of achieving a balance between preserving the patient’s quality of life and attaining gross total resection,with the extent of surgical resection significantly influencing the survival *** addition to advancements in cancer vaccine development,this review highlights the evolving landscape of LGG treatment,emphasizing a shift toward personalized and targeted *** research is essential for refining strategies and enhancing outcomes in the management of LGG.

关键词： Low-grade gliomas Monoclonal antibody Lerapolturev Glioblastoma CDK9 inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于BSG深度学习模型的中医药智能问答系统研究:以方剂和中药为例

引用

Digital Chinese Medicine 2024年第1期7卷 47-55页

作者：李冉任高晏峻峰邹北骥刘青萍湖南中医药大学信息科学与工程学院湖南长沙410208 中南大学计算机学院湖南长沙410083

目的基于深度学习的方法,利用知识图谱构建中医药知识库,探寻联合模型在中医药智能问答系统的应用。方法以《方剂学》和《中药学》规划教材为基础建立知识图谱,作为智能问答系统的知识来源,本研究提出一种BERT+Slot-Gated(BSG)深度学习... 详细信息

目的基于深度学习的方法,利用知识图谱构建中医药知识库,探寻联合模型在中医药智能问答系统的应用。方法以《方剂学》和《中药学》规划教材为基础建立知识图谱,作为智能问答系统的知识来源,本研究提出一种BERT+Slot-Gated(BSG)深度学习模型,获取用户自然问题中包含的中医药实体和问句意图,通过实体和意图在知识图谱检索答案返回给用户,运用Flask框架和BSG模型研发中医药智能问答系统。结果构建了包含3149个实体和6891个关系三元组的中医药知识图谱,通过问题语料测试,本系统在回答中医药20类问题的实体识别F1值为0.9969,意图识别准确率为99.75%,表明本系统具有较高的实用性和可行性,并通过微信公众号平台实现了用户与系统交互。结论本文所提出的BSG模型通过提高向量维度在实验中取得了较好的结果,表明联合模型方法的有效性,可为实现中医药智能问答系统提供新的研究思路。

关键词：中医药深度学习知识图谱智能问答系统 BERT+Slot-Gated模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

引用

International Journal of Mental Health Promotion 2024年第5期26卷 351-359页

作者： Abdullah A.Alharbi Ahmad Y.Alqassim Mohammed A.Muaddi Najat H.Aldubayyan rana I.Abuhadi Futon A.Akoor Sarah J.Mobarki Imtenan A.Oberi Ghaidaa H.Alharbi Yara Ajeebi Adnan M.Alkhayat Hafiz Malhan Mohammed Bakkar Anwar M.Makeen Family and Community Medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal Medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia Hematology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in the Jazan *** study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this *** study involved 391 adult participants,all patients in the hematology center of Prince Mohammed bin Nasser Hospital(PMNH).Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9(PHQ-9)–between March–May *** questionnaire covered socio-demographic information and variables related to the participant’s SCA history,such as pain levels,frequency of pain,hospitalization duration,and frequency of blood *** variables underwent Chi-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among the SCA *** significantly linked with heightened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of hospital *** educational level of at least a bachelor’s degree was also a significant *** study reveals a high prevalence of depression among SCA patients in the Jazan *** underscores the need for policymakers to educate both physicians and patients about the importance of mental health in SCA *** study also highlights the need for more research into the specific causes and effects of depressive symptoms in SCA patients to inform the creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public health policy Jazan region Saudi Arabia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heat transfer optimization and rheological features of Buongiorno nanofluid in a convectively heated inclined annulus with nonlinear thermal radiation

引用

Propulsion and Power Research 2023年第4期12卷 539-555页

作者： Puneet rana School of Mathematical Sciences College of ScienceMathematics and TechnologyWenzhou Kean UniversityWenzhou 325060China

The theoretical analysis of the mixed convective Buongiorno nanofluid flow in an inclined annular microchannel with convectively heated walls subjected to the effects of nonlinear thermal radiation,exponential heat source(EHS),thermal dependent heat source(THS)is carried *** description of the Buongiorno nanofluid is implemented to analyze the Brownian diffusion and thermo-migration *** general boundary conditions for the velocity,thermal,and nanoparticle volume fraction(NVF)are *** solutions for fully developed governing equations are obtained using bvp5c solver and verified with *** optimization of heat transport rates is made by using the Box-Behnken designbased response surface *** is found that the Lorentz force and the inclination angle of the annulus significantly affect the rheological characteristics of the *** increase thermal energy in the system through Brownian diffusion and thermophoresis,resulting in increased temperature *** heat sources would serve as an important tool for modulating the thermal field in microchannel,as they are directly *** low-level values of the thermal Biot number,the exponential heat source,and the thermal radiation parameter,it is possible to attain the maximum Nusselt number on both walls of the annulus.

关键词： Buongiorno model Convective boundary conditions Exponential spacerelated heat source Nanofluid Annulus Response surface methodology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Formation control of quad-rotor UAV via PIO

引用

Science China(Technological Sciences) 2022年第2期65卷 432-439页

作者： BAI TingTing WANG DaoBo MASOOD rana Javed College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China Department of Electrical Engineering Usman Institute of TechnologyKarachi 75850Pakistan

In this article, the formation control of quad-rotor unmanned aerial vehicle(UAV) via pigeon inspired optimization(PIO) is designed. The nonlinear mathematical model of the quad-rotor UAV is used by applying algebraic graph theory and matrix analysis. A high order consistent formation control algorithm with fixed control topology is designed by using a position deviation matrix to describe its formation. To control the attitude of quad-rotor UAVs, it is difficult to obtain a set of optimal solutions, and hence a PIO based algorithm with variable weight hybridization is proposed. The algorithm is mainly composed of two parts. First, according to the distance between the particles in the iterative process, the inertia weight is dynamically changed,and the coefficient is adjusted to control the degree of influence on its inertia weight. Second, the overall scenario is designed by using MATLAB based simulations which show that the formation control of the quad-rotor UAV is achieved with the help of PIO.

关键词： pigeon inspired optimization formation control unmanned aerial vehicle and quad-rotor UAV

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A hierarchical multi-purpose roller shade controller to enhance indoor comfort and energy efficiency

引用

Building Simulation 2023年第7期16卷 1239-1256页

作者： Amir Tabadkani Morteza Haddadi rana Abdollahi Rizi Emad Tabadkani Stantec Inc. Level 3/52 Merivale St.BrisbaneQLDAustralia Department of Energy Engineering Sharif University of TechnologyTehranIran Wellington School of Architecture Victoria University of WellingtonNew Zealand Department of Architecture Built environment and Construction engineeringPolitecnico di MilanoItaly

Building envelope is the sole interface with outdoors that can lie in the level of integrating control strategies to enhance occupant's comfort and building performance. However, in the literature, there is still a lack of multi-purpose control strategies which can balance diverse and antagonistic aspects of occupant comfort while keeping the building energy consumption under control. Therefore, this research proposed an integrated simulation-based workflow using EnergyPlus and Python-based package, OpyPlus, to adjust a roller shade for single occupied office space in a hot and arid climate. The developed system aims to improve both occupant's visual and thermal comfort considering daylight level, potential glare at occupant's field of view, view to outdoor satisfaction, and Fanger PMV method, and then, managing the HVAC system in favor of enhancing building energy efficiency. Furthermore, the controller's performance was compared to multiple fixed controls and another multi-agent control scenario from visual and thermal comfort and energy performance perspectives. The developed control system could perform effectively to provide a glare-free view and higher thermally comfortable indoor environment by 99% for the occupant across the year, while improving the heating and cooling loads. The research provides novel insights and potential future integrations for facade designers and building operators.

关键词： occupant's comfort building energy efficiency functional programming EnergyPlus Opyplus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets

引用

Genes & Diseases 2023年第3期10卷 948-959页

作者： Abhi Dutta Moumita Das Ankita Ghosh Santanu rana Raja Peary Mohan College Integrated Biological Research Facility(RIBRF) Raja Peary Mohan CollegeUttarparaHooghlyWest Bengal 712258India

Pathological cardiac damage during heart failure is associated with cell death and damage associated molecular patterns (DAMPs) release which triggers a viscous cycle of sterile inflammation to mediate maladaptive cardiac tissue remodelling during the progression to heart failure. DAMPs like cytokines, chemokines, and nuclear or mitochondrial genomic fragments are released in the pathological myocardium. Interestingly, circulating or cytosolic DNA fragments can play a role in the disease by interaction with nucleic acid sensors expressed in cardiomyocyte and non-myocyte neighbouring cells. The circulating cell free DNA (cfDNA) fragments have been clinically reported as markers for various diseases including cardiovascular pathophysiology. Such cfDNA within the DAMP pool can mediate intra- and inter-cellular signalling cascade to upregulate transcriptional expression of inflammatory mediators and trigger oxidative stress within cells. The cellular role of such genomic equivalents varying with chronic or acute stress might be correlated with the cell death forms encountered in myocardium during disease progression. Thus, cfDNA can be phenotypically correlated as a critical player towards upregulation of pathological processes like interstitial fibrosis, cardiomyocyte contractile dysfunction and cell death. Herein, we review the association of cfDNA with heart failure and analyse their potential usage as novel and effective therapeutic targets towards augmentation of cardiac function.

关键词： Apoptosis Circulating DNA Fibrosis Heart failure Inflammation Nucleic acid receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：