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Next Generation Sequencing in Oncological Diagnostics: Hype or Hope?

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Journal of Biosciences and Medicines 2024年第2期12卷 244-256页

作者： rana Hallak Manfred Kuepper Amer Al Chikh Youssef Department of Biochemistry Faculty of Pharmacy Al Rasheed University Ghabareb Syria rana Hallak Clinical Laboratory Damascus Kafar Sousseh Syria Department of Biochemistry Faculty of Pharmacy Arab International University Ghabareb Syria Doctors Cancer Care Center Damascus Damascus Syria

The understanding of how genetic and epigenetic factors influence tumorigenesis, progression and invasion, is vastly growing since new technologies allow the analysis of the functional genome namely the exome, the transcriptome and the epigenome, besides enabling genome-wide assessment of genetic variations. With the advent of new drugs that are indicated tissue agnostic, depending on certain mutations, there is a growing demand for fast and cost-effective genetic diagnosis. The method in focus that already became an indispensable tool in viral diagnosis is next-generation sequencing (NGS). This approach allows sequencing of literally every DNA molecule in the sample and can either be used to assess numerous genetic markers of one patient at a time, or to assess fewer markers of many patients in parallel, which reduces costs. We submitted 23 samples of different tumor entities to four diagnostic companies with different analysis profiles. The results as disclosed and discussed in this report indicate that so far, the main application of NGS is rather in cancer research than in diagnosis, as none of the reports had a real impact on the therapeutic scheme. We are perfectly aware that such a small cohort cannot be generalized, but considering the costs vs. benefits, NGS should be engaged upon a very stringent evaluation only. However, in cases where obtaining a tissue biopsy is impossible or unfavorable, analysis of liquid biopsy by NGS provides a vital alternative.

关键词： Oncology Next Generation Sequencing Tumor Diagnosis Personalized Medicine

Enhancing cotton resilience to challenging climates through genetic modifications

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Journal of Cotton Research 2024年第2期7卷 196-206页

作者： AHMED Ali Ijaz KHAN Azeem Iqbal NEGM Mohamed A.M. IQBAL Rida AZHAR Muhammad Tehseen KHAN Sultan Habibullah rana Iqrar Ahmad Department of Plant Breeding and Genetics University of AgricultureFaisalabadFaisalabad 38000Pakistan Cotton Research Institute-Giza GizaEgypt Centre for Advanced Studies in Agriculture and Food Security University of AgricultureFaisalabadFaisalabad 38000Pakistan Centre of Agricultural Biochemistry and Biotechnology University of AgricultureFaisalabadFaisalabad 38000Pakistan School of Agriculture Sciences Zhengzhou UniversityZhengzhou 450000China

Cotton is one of the most important fiber crops that plays a vital role in the textile *** production has been unstable over the years due to climate change induced biotic stresses such as insects,diseases,and weeds,as well as abiotic stresses including drought,salinity,heat,and *** breeding methods have been used to breed climate resilient cotton,but it requires a considerable amount of time to enhance crop tolerance to insect pests and changing climatic conditions.A promising strategy for improving tolerance against these stresses is genetic *** review article discusses the role of genetic engineering in cotton *** essential concepts and techniques include genome editing via clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR-Cas9),overexpression of target genes,downregulation using RNA interference(RNAi),and virus-induced gene silencing(VIGS).Notably,the Agrobacterium-mediated transformation has made significant contributions to using these techniques for obtaining stable transgenic plants.

关键词： Cotton Genome editing Drought Salinity Heat

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Assessment of the Characteristics of the Municipal Solid Waste Compost in Lebanon

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Journal of Geoscience and Environment Protection 2024年第5期12卷 17-39页

作者： rana Sawaya Jalal Halwani Nada Nehme Hiba Alawiye Walaa Diab Water & Environment Science Lab Lebanese University Tripoli Lebanon Faculty of Sciences Lebanese University Hadath Lebanon Faculty of Agriculture Engineering and Veterinary Sciences Lebanese University Dekwaneh Lebanon

Waste management is crucial due to the fast increase of human population, causing an increase in solid waste generation which if not properly managed causes environmental problems. Around 57% of the wastes generated from homes are made up of green material (fruits, vegetables…). Thus, reusing and recycling green wastes through composting is one way of reducing the waste load to landfills. Composting is the transformation of raw organic materials into organic soil amendments that provide nutrients to crops and enhance the tilth, fertility, and productivity of soils. Aerobic windrow composting system at Sukomi Greensite facility located at Karantina is performed, where materials biodegrade under controlled conditions to produce compost. However, assessment of the quality of the compost is fundamental in order to determine its usages. Thus, regular testing of physical, chemical and biological parameters was performed for adequate monitoring purposes. The basic objective of this study was to determine the characteristics of the Lebanese municipal solid waste compost on a yearly basis and compare these characteristics amongst the years. Hence, each parameter was tested and compared to the BNQ international Canadian standards for proper classification of the compost and adequate identification of its usages. The preliminary data obtained were statistically diagnosed through principal component analysis by Spadv55 software. All the data reflected the normal content value of the studied parameters with minor differences between the years except for year 2007 which demonstrated higher levels of Potassium, Phosphate, Lead and Cadmium. The characteristics of the compost enabled it to be used as a soil amendment on all types of agricultural and landscape commodities at the adequate dosages and proper timing. This data will additionally reflect the efficiency of the solid waste management practices adopted via highlighting the importance of the implementation of the integrated s

关键词： Composting Organic Material Lebanon Contamination Solid Waste Management

Genetics of biochemical attributes regulating morpho-physiology of upland cotton under high temperature conditions

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Journal of Cotton Research 2024年第1期7卷 29-44页

作者： MAJEED Sajid CHAUDHARY Muhammad Tanees MUBARIK Muhammad Salman rana Iqrar Ahmad SHABAN Muhammad TAN Daniel KY JIA Yinhua DU Xiongming HINZE Lori AZHAR Muhammad Tehseen Federal Seed Certification and Registration Department Ministry of National Food Security and ResearchIslamabad 44090Pakistan Horticultural Research Institute National Agricultural Research CentreIslamabad 44000Pakistan Department of Biotechnology University of NarowalNarowal 51600Pakistan Centre of Agricultural Biochemistry and Biotechnology University of AgricultureFaisalabad 38400Pakistan Department of Plant Breeding and Genetics University of Agriculture FaisalabadSub-Campus BurewalaVehariPakistan Faculty of Science School of Life and Environ-mental SciencesPlant Breeding InstituteSydney Institute of AgricultureThe University of SydneySydneyNSW 2006Australia State Key Laboratory of Cotton Biology Institute of Cotton Research of Chinese Academy of Agri-cultural ScienceAnyang 455000China Agricultural Research Service USDASouthern Plains Agricultural Research CentreCollege StationTX 77845USA Department of Plant Breeding and Genetics University of AgricultureFaisal-abad 38400Pakistan School of Agriculture Sciences Zhengzhou UniversityZhengzhou 450000China.

Background Cotton is a strategically important fibre crop for global textile *** profoundly impacts several countries’industrial and agricultural *** cotton production is continuously threatened by the unpre-dictable changes in climate,specifically high *** heat-tolerant,high-yielding cotton cultivars with wide adaptability to be grown in the regions with rising temperatures is one of the primary objectives of modern cotton breeding ***,the main objective of the current study is to figure out the effective breed-ing approach to imparting heat tolerance as well as the judicious utilization of commercially significant and stress-tolerant attributes in cotton ***,the two most notable heat-susceptible(FH-115 and NIAB Kiran)and tolerant(IUB-13 and GH-Mubarak)cotton cultivars were spotted to develop filial and backcross populations to accom-plish the preceding study *** heat tolerant cultivars were screened on the basis of various morphological(seed cotton yield per plant,ginning turnout percentage),physiological(pollen viability,cell membrane thermostabil-ity)and biochemical(peroxidase activity,proline content,hydrogen peroxide content)*** The results clearly exhibited that heat stress consequently had a detrimental impact on every studied plant trait,as revealed by the ability of crossing and their backcross populations to tolerate high ***,when considering overall yield,biochemical,and physiological traits,the IUB-13×FH-115 cross went over particularly well at both normal and high temperature ***,overall seed cotton yield per plant exhibited a posi-tive correlation with both pollen viability and antioxidant levels(POD activity and proline content).Conclusions Selection from segregation population and criteria involving pollen viability and antioxidant levels concluded to be an effective strategy for the screening of heat-tolerant cotton g

关键词： Accessions Biochemical Breeding Cotton Generation mean analysis Heat stress

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Insights into Manipulation: Unveiling Tampered Images Using Modified ELA, Deep Learning, and Explainable AI

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Journal of Computer and Communications 2024年第6期12卷 135-151页

作者： Md. Mehedi Hasan Md. Masud rana Abu Sayed Md. Mostafizur Rahaman Department of Information and Communication Technology Bangladesh University of Professionals Dhaka Bangladesh Department of Computer Science and Engineering Jahangirnagar University Dhaka Bangladesh

Digital image forgery (DIF) is a prevalent issue in the modern age, where malicious actors manipulate images for various purposes, including deception and misinformation. Detecting such forgeries is a critical task for maintaining the integrity of digital content. This thesis explores the use of Modified Error Level Analysis (ELA) in combination with a Convolutional Neural Network (CNN), as well as, Feedforward Neural Network (FNN) model to detect digital image forgeries. Additionally, incorporation of Explainable Artificial Intelligence (XAI) to this research provided insights into the process of decision-making by the models. The study trains and tests the models on the CASIA2 dataset, emphasizing both authentic and forged images. The CNN model is trained and evaluated, and Explainable AI (SHapley Additive exPlanation— SHAP) is incorporated to explain the model’s predictions. Similarly, the FNN model is trained and evaluated, and XAI (SHAP) is incorporated to explain the model’s predictions. The results obtained from the analysis reveals that the proposed approach using CNN model is most effective in detecting image forgeries and provides valuable explanations for decision interpretability.

关键词： IFD DIF ELA CNN FNN XAI SHAP CASIA2.0

基于网络药理学和分子对接探讨木犀草素抗急性肺损伤的分子机制

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中国药理学通报 2024年第8期40卷 1583-1591页

作者：汪雪峰潘信芝曹宁孙可一 rana Dhar 汤慧芳浙江中医药大学附属第二医院药剂科浙江杭州310005 浙江中医药大学药学院浙江杭州310053 浙江大学医学院浙江杭州310058

目的通过网络药理学及分子对接技术探讨木犀草素抗急性肺损伤的作用机制,并进行实验验证。方法利用PubChem和SwissTargetPrediction数据库预测木犀草素作用的相关靶点;通过GeneCards数据库收集急性肺损伤相关靶点;以Venny 2.1绘制韦恩图... 详细信息

目的通过网络药理学及分子对接技术探讨木犀草素抗急性肺损伤的作用机制,并进行实验验证。方法利用PubChem和SwissTargetPrediction数据库预测木犀草素作用的相关靶点;通过GeneCards数据库收集急性肺损伤相关靶点;以Venny 2.1绘制韦恩图,并得到药物与疾病的共同靶点;应用String在线平台建立蛋白互作网络(PPI),通过Cytoscape 3.8.2软件筛选出核心靶点;利用DAVID数据库将共同靶点进行GO功能富集分析和KEGG通路富集分析,将其结果可视化;最后,通过Auto Dock软件进行分子对接,并运用Pymol对分子结果进行可视化。构建小鼠急性肺损伤模型,采用苏木精伊红(HE)染色检测组织病理学,蛋白免疫印迹(Western blot)检测肺组织中相关蛋白。结果经筛选得到85个共同靶点,其中,核心靶点有AKT1、EGFR、SRC、MMP9、ESR1、PTGS2等。GO富集分析获得生物过程265条,主要包括信号转导、蛋白磷酸化、凋亡过程的负调控等过程;细胞组成48条,主要包括质膜、细胞溶质、细胞质等;分子功能107条,主要包括ATP结合、蛋白丝氨酸/苏氨酸/酪氨酸激酶活性、蛋白激酶活性等。KEGG通路富集分析共获得92条信号通路,主要作用于PI3K-AKT信号通路、ErbB信号通路、VEGF信号通路等。分子对接结果显示木犀草素与核心靶点AKT1、EGFR、SRC、MMP9、ESR1、PTGS2、MMP2、GSK3B、KDR、PARP1均具有良好的对接活性,其中ERS1、GSK3B、MMP2结合能低于-5.0 kal·mol^(-1),与木犀草素之间的亲和力更强。肺组织病理学结果显示,木犀草素在LPS诱导的小鼠急性肺损伤模型中,能够抑制炎症浸润,有较强的抗炎作用。Western blot实验显示,木犀草素可能通过抑制AKT的磷酸化缓解炎症反应。结论木犀草素可通过多靶点、多途径机制发挥抗急性肺损伤的作用,其中可能与抑制AKT的磷酸化密切相关。

关键词：网络药理学分子对接木犀草素急性肺损伤急性呼吸窘迫综合征作用机制

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High Na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo Hong Harpalsinh H.rana Jeong Hee Park Jun Su Kim Sang Joon Lee Gun Jang Tae Hoon Kang Kang Ho Shin Sang Ha Baek Wooseok Yang Kwang Ho Kim Ju-Hyuk Lee Ho Seok Park School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Clean Energy Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea COSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the Na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate Na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-N,N′-methylene-bisacrylamide film immersed in NaClO_(4) solution(ex-DDA-Dex+NaClO_(4))for flexible sodium-ion hybrid capacitors(f-NIHC).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum ClO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦C and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-NIHCs with the ex-DDA-Dex+NaClO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

Evaluation of Information Technology Implementation for Business Goal Improvement under Process Functionality in Economic Development

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Journal of Data Analysis and Information Processing 2024年第2期12卷 304-317页

作者： Sk Ayub Al Wahid Nur Mohammad Rakibul Islam Md. Habibullah Faisal Md. Sohel rana International American University Los Angeles California USA

Improving organizational performance can be achieved through business process redesign (BPR). When it comes to modern work practices, organizations must often redesign their processes to keep up. This is where enterprise software comes in, offering a common data infrastructure that enables different parts of the organization to access all necessary financial data. The architecture of network accounting business process is divided into three layers. The core layer lies in the enterprise LAN that it can integrate six business processes information into one unity of financial information and non-financial information, including purchasing, inventory, production, sales, finance and customer service, and it can generate flexibly a variety of accounting statements to meet fully the information users’ demands by providing more complete and more valuable related information. The second layer lies in Intranet among enterprises based on the core layer that it can support the link of business processes and the inter-sharing of information among node enterprises of SCM and other external enterprises. The third layer lies in Internet based on the second layer that it can fit society, enterprise and individual together, the specific lays the solid foundation of business collaboration, remote management, online management and centralized management. The operating mechanisms of the network accounting business processes are as follows. When the business event occurs, the probe can get the event information in real-time and the result is stored in the database. Meanwhile, the drive controller can control the business events in real-time by gaining control criteria and standards from database. In case the standard is exceeded, the event is not allowed to occur. Enterprise’ business staff or external personnel can output automatically the required results through report tools if they had the reading authority. Supported the information system and optimizing processes, the managers can

关键词： ISMS OKC EA EAF EAP

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小狮子学吼叫

中学生英语 2024年第21期 28-31页

作者： Indu rana 肖雅琪

从前，丛林里住着一只狮子爸爸和它的儿子。狮子爸爸非常爱它。但它也非常担心，小狮子还没有学会吼叫。一天，狮子爸爸决定请一位老师来教它的儿子如何吼叫。它请到了豺狼杰克做它儿子的家庭教师。第二天早上，杰克来到了狮子的洞穴。...

从前，丛林里住着一只狮子爸爸和它的儿子。狮子爸爸非常爱它。但它也非常担心，小狮子还没有学会吼叫。一天，狮子爸爸决定请一位老师来教它的儿子如何吼叫。它请到了豺狼杰克做它儿子的家庭教师。第二天早上，杰克来到了狮子的洞穴。小狮子从未见过如此有趣的老师。

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