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Enhancing ferromagnetic coupling in CrXY(X=O,S,Se;Y=Cl,Br,I)monolayers by turning the covalent character of Cr-X bonds

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npj Computational Materials 2023年第1期9卷 1781-1786页

作者： Hao-ran zhu Bin Shao Xu Zuo College of Electronic Information and Optical Engineering Nankai UniversityTianjinChina Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Nankai UniversityTianjinChina Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Nankai UniversityTianjinChina Engineering Research Center of Thin Film Optoelectronics Technology Ministry of EducationNankai UniversityTianjinChina

On the basis of first-principles calculations,we investigate the electronic and magnetic properties of 1T phase chromium sulfide halide CrXY(X=O,S,Se;Y=Cl,Br,I)monolayers in CrCl_(2) structure with the P3m1 space *** for the CrOI monolayer,all CrXY monolayers are stable and ferromagnetic *** results show that the ferromagnetic coupling is dominated by the kinetic exchange between the empty e_(g)-orbital of Cr atoms and the p-orbital of anions under the three-fold rotational *** this context,the coupling strength allows for being greatly enhanced by turning the nature of Cr–X bonds,i.e.,increasing the covalent contribution of the bonds by minimizing the energy difference of the coupled *** we illustrate for the example of CrOY,the Curie temperature(T_(c))is nearly tripled by substituting O by S/Se ion,eventually reaching the highest Tc in CrSeI monolayer(334 K).The high stabilities and Curie temperature manifest these monolayer ferromagnetic materials feasible for synthesis and applicable to 2D spintronic devices.

关键词： ferromagnetic bonds coupling

Splicing factor proline and glutamine-rich is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in hepatocellular carcinoma

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Medical Data Mining 2024年第2期7卷 45-59页

作者： Chao-ran zhu Shi-Chen zhu Clinical and Basic Medical Sciences College Shandong First Medical UniversityJinan 250021China Department of Surgery Jinan Changqing District Traditional Chinese Medicine HospitalJinan 250021China

Background:Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related deaths *** factor proline and glutamine-rich(SFPQ)is a multifunctional protein that controls various biological *** a potential therapeutic target and a promising prognostic indicator,the potential effects and processes of SFPQ in HCC require further ***:The RNA sequencing data were obtained from the Gene Expression Omnibus,International Cancer Genome Consortium,and The Cancer Genome Atlas databases to analyze SFPQ expression and differentially expressed genes(DEGs).We utilized the LinkedOmics database to identify co-expressed genes.A Venn diagram was constructed to determine the overlapping genes between the DEGs and the co-expressed *** enrichment analysis was performed on the overlapping genes and ***,our study involved functional enrichment analysis,a protein-protein interaction network analysis,and an analysis of immune cell *** cBioPortal and Tumor Immune Single-cell Hub were utilized to investigate the genetic alterations of SFPQ and the single-cell transcriptome visualization of the tumor microenvironment.A ceRNA network was established with the assistance of the ENCORI ***,we elucidated the clinical significance of SFPQ in HCC by employing Kaplan-Meier survival analysis,univariate and multivariate Cox regression,and prognostic nomogram ***:The expression of SFPQ in HCC tissues was significantly elevated compared to normal *** results indicated that increased expression of SFPQ was associated with pathways related to *** ceRNA network,including SFPQ,hsa-miR-101-3p,AC023043.4,AC124798.1,AC145207.5,and GSEC,was constructed with the assistance of *** SFPQ expression was related to a poor prognosis in HCC and its *** and multivariate Cox regression analysis showed that elevated SFPQ expression is an independent predictive ***

关键词： biomarker splicing factor proline and glutamine-rich prognosis immune infiltration hepatic cell carcinoma

Single boron atom anchored on graphitic carbon nitride nanosheet(B/g-C_(2)N)as a photocatalyst for nitrogen fixation:A first-principles study

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Chinese Physics B 2021年第8期30卷 287-294页

作者： Hao-ran zhu Jia-Liang Chen Shi-Hao Wei Department of Microelectronic Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China College of Electronic Information and Optical Engineering Nankai UniversityTianjin 300350China

It is essential to explore high efficient catalysts for nitrogen reduction in ammonia *** on the first-principles calculation,we find that B/g-C_(2)N can serve as high performance photocatalyst in N_(2)fixation,where single boron atom is anchored on the g-C_(2)N to form B/g-C_(2)*** the introduction of B atom to g-C_(2)N,the energy gap reduces from 2.45 eV to 1.21 eV and shows strong absorption in the visible light *** addition,N_(2)can be efficiently reduced on B/g-C_(2)N through the enzymatic mechanism with low onset potential of 0.07 V and rate-determining barrier of 0.50 ***"acceptance-donation"interaction between B/g-C_(2)N and N_(2)plays a key role to active N_(2),and the BN_(2)moiety of B/g-C_(2)N acts as active and transportation *** activity originates from the strong interaction between 1π1π*orbitals of N_(2)and molecular orbitals of B/g-C_(2)N,the ionization of 1πorbital and the filling of 1π*orbital can increase the N≡N bond length greatly,making the activation of N_(2).Overall,this work demonstrates that B/g-C_(2)N is a promising photocatalyst for N_(2)fixation.

关键词： first-principles calculation N_(2)reduction catalysts electronic structure reaction mechanisms reaction paths

Single-doped charged gold cluster with highly selective catalytic activity for the reduction of SO2 by CO: First-principles study

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Chinese Physics B 2019年第11期28卷 140-149页

作者： Yan-Ling Hu Hao-ran zhu Shi-Hao Wei Department of Microelectronic Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China

It is important for environmental protection to search for catalysts with excellent performance and cost-effective to reduce SO2 by CO. In this work, using first-principles calculation, we have studied the catalytic performance of Au5Mn（M = Ni, Pd, Pt, Cu, Ag, Au; n = 1, 0,-1） clusters, and showed that, by giving a negative charge to the Au5M（M = Cu,Ag, Au, Pd） clusters, we could improve the selectivity of SO2 and avoid effectively catalyst CO poisoning *** the same time, the catalytic reaction rate for the reduction of SO2 by CO with Au5M-（M = Cu, Ag, Au, Pd） clusters is greatly improved when the Au5M clusters are charged. These advantages can be well explained by the charge transfer between the clusters and adsorbed molecules, which means that we can effectively control the performance of the *** equilibrium structures of Au5Mn（M = Ni, Pd, Pt, Cu, Ag, Au; n = 1, 0,-1） clusters without or with adsorbed SO2 or CO molecule are also discussed, and the most stable geometrical structures of Aun5 M-ML（ML = SO2, CO, SO, and COS）can be explained very well by the match of orbitals symmetry and density of electron cloud through their frontier molecular orbitals. Considering the catalyst cost（Cu is much cheaper than Ag and Au）, selectivity of SO2, and effectively avoiding the catalyst CO poisoning, we propose that Au5Cu-is an ideal catalyst for getting rid of SO2 and CO simultaneously.

关键词： bimetallic clusters catalyst first-principles electronic structure

Deep learning-based method for detecting anomalies in electromagnetic environment situation

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Defence Technology（防务技术） 2023年第8期26卷 231-241页

作者： Wei-lin Hu Lun-wen Wang Chuang Peng ran-gang zhu Meng-bo Zhang College of Electronic Engineering National University of Defense TechnologyHefei230001China

The anomaly detection of electromagnetic environment situation(EMES) has essential reference value for electromagnetic equipment behavior cognition and battlefield threat *** this paper,we proposed a deep learning-based method for detecting anomalies in EMES to address the problem of relatively low efficiency of electromagnetic environment situation anomaly detection(EMES-AD).Firstly,the convolutional kernel extracts the static features of different regions of the ***,the dynamic features of the region are obtained by using a recurrent neural network(LSTM).Thirdly,the Spatio-temporal features of the region are recovered by using a de-convolutional network and then fused to predict the *** structural similarity algorithm(SSIM) is used to determine whether it is *** developed the detection framework,de-signed the network parameters,simulated the data sets containing different anomalous types of EMES,and carried out the detection *** experimental results show that the proposed method is effective.

关键词： Electromagnetic environment situation(EMES) Anomaly detection(AD) Regional features integration LSTM CNN

Cascading adaptation of rural livelihood to changing environment:Conceptual framework and experiment from the Koshi River basin

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Advances in Climate Change Research 2020年第2期11卷 141-157页

作者： FANG Yi-Ping zhu ran ZHANG Chen-Jia Golam RASUL Nilhari NEUPANE Institute of Mountain Hazards&Environment Chinese Academy of SciencesChengdu610041China College of Resource and Environment University of Chinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China International Centre for Integrated Mountain Development GPO Box3226KathmanduNepal Center of Research for Environment Energy and WaterKathmandu44600Nepal

Rural communities in the Koshi River basin,a trans-boundary river basin in the Hindu Kush-Himalayas,have been experiencing unprecedented difficulties for adapting with the livelihood challenges arising from floods,droughts and other climatic,environmental and socio-economic *** single purpose adaptation approach often fails to address the multiple challenges arises from cascading effects of climate change at different scales and *** fill this gap,we developed a multi-dimensional flexible adaptation framework looking at the four dimensions of adaptation,structure,issue,time,and space(SITS).The SITS framework provides a comprehensive approach for cascading adaptation at trans-boundary river basin level and it could effectively enhance the adaptive capacity and transform livelihood outcome if properly *** the SITS framework,we examined four cascading adaptation pathways for:i)reducing disaster stressors on livelihoods,ii)enhancing access to crucial livelihood capitals,iii)improving equal rights to livelihood,and iv)strengthening synergies and exploiting complementarities at trans-boundary river basin *** findings revealed that in the context of changing climate,it is necessary to employ different livelihood adaptation strategies and multiple responses simultaneously or sequentially to successfully adapt to the cascading effects of changing *** cascading adaptation may provide a sound basis on which to cope with the climate uncertainty through realistic scenarios of structure,issue,time and *** implementation,however,has several obstacles,for example,differences in national system,investment capacity,complexity of trans-boundary basin,remained particularly in trans-boundary river basin where managing transnational trade-offs and harness spatial synergies are critically important.

关键词： Cascading adaptation Rural livelihood Trans-boundary river basin SITS framework

Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6

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Protein & Cell 2014年第3期5卷 235-247页

作者： Jiao Meng Xiaoting Zou Rimao Wu ran Zhong Dahai zhu Yong Zhang The National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of MedicalSciences and School of Basic Medicine Peking Union Medical College Beijing 100005 China

RING finger protein 13 （RNF13） is a newly identified E3 ligase reported to be functionally significant in the reg- ulation of cancer development, muscle cell growth, and neuronal development. In this study, the function of RNF13 in cardiotoxin-induced skeletal muscle regener- ation was investigated using RNF13-knockout mice. RNF13-/- mice exhibited enhanced muscle regeneration --characterized by accelerated satellite cell proliferation --compared with wild-type mice. The expression of RNF13 was remarkably induced in macrophages rather than in the satellite cells of wild-type mice at the very early stage of muscle damage. This result indicated that inflammatory cells are important in RNF13-mediated satellite cell functions. The cytokine levels in skeletal muscles were further analyzed and showed that RNF13＂i＂ mice produced greater amounts of various cytokines than wild-type mice. Among these, IL-4 and IL-6 levels significantly increased in RNF13-/＂ mice. The accelerated muscle regeneration phenotype was abrogated by inhibiting IL-4/IL-6 action in RNF13＂/- mice with blocking antibodies. These results indicate that RNF13 deficiency promotes skeletal muscle regeneration via the effects on satellite cell niche mediated by IL-4 and IL-6.

关键词： RNF13 muscle regeneration satellite celniche. IL-4/IL-6

Development of the general chapters of the Chinese Pharmacopoeia 2020 edition: A review

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Journal of Pharmaceutical Analysis 2021年第4期11卷 398-404页

作者： Xinyi Xu Huayu Xu Yue Shang ran zhu Xiaoxu Hong Zonghua Song Zhaopeng Yang Chinese Pharmacopoeia Commission Beijing100061China

The Chinese Pharmacopoeia 2020 edition was reviewed and approved by the National Medical Products Administration and the National Health Commission of the People’s Republic of China in July *** current edition was officially implemented on December 30,*** general chapters of the Chinese Pharmacopoeia discuss the general testing methods and guidelines,which are the common requirements and basis for the implementation of drug standards in the Chinese *** to adherence to the principles of scientificity,versatility,operability,and sustainable development,there is an improvement in the general chapters of the 2020 edition over those of the previous ***,the application of advanced and mature analytical techniques has expanded,the development of testing methods for exogenous pollutants in traditional Chinese medicines has been strengthened,and technical requirements are now better harmonized with international *** updated edition provides technical and methodological support to ensure safety,effectiveness,and control of pharmaceuticals in China and will play an important and active role in encouraging the application of advanced technologies,improving the quality control of medicines,and strengthening the means of drug regulation in *** review provides a comprehensive introduction of the main features of and changes to the general chapters in the Chinese Pharmacopoeia 2020 edition and aims to provide reference for its correct understanding and accurate implementation.

关键词： Chinese pharmacopoeia 2020 edition General chapter Development Review

Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury

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Neural Regeneration Research 2023年第11期18卷 2489-2496页

作者： Zhourui Wu Chen Li ran zhu Yiqiu Cao Thomas C.Chen Liming Cheng Key Laboratory of Spine and Spinal cord Injury Repair and Regeneration(Tongji University) Ministry of EducationShanghaiChina Division of Spine Department of OrthopedicsTongji HospitalTongji University School of MedicineShanghaiChina Institute of Spinal and Spinal Cord Injury Tongji University School of MedicineShanghaiChina Department of Neurosurgery Keck School of MedicalUniversity of Southern CaliforniaLos AngelesCAUSA

DNA methylation is a critical epigenetic regulator in the occurrence and development of diseases and is closely related to various functional responses in relation to spinal cord *** investigate the role of DNA methylation in spinal cord injury,we constructed a library with reduced-representation bisulfite sequencing data obtained at various time points(day 0-42)after spinal cord injury in *** DNA methylation levels,specifically non-CpG(CHG and CHH)methylation levels,decreased modestly following spinal cord *** post-spinal cord injury were classified as early(day 0-3),intermediate(day7-14),and late(day 28-42)based on similarity and hie rarchical cluste ring of global DNA methylation *** non-CpG methylation level,which included CHG and CHH methylation levels,was markedly reduced despite accounting for a minor proportion of total methylation *** multiple genomic sites,including the 5’untranslated regions,promoter,exon,intron,and 3’untranslated regions,the non-CpG methylation level was markedly decreased following spinal cord injury,whereas the CpG methylation level remained unchanged at these *** one-half of the differentially methylated regions were located in intergenic areas;the other differentially methylated regions in both CpG and non-CpG regions were cluste red in intron regions,where the DNA methylation level was *** function of genes associated with differentially methylated regions in promoter regions was also *** Gene Ontology analysis results,DNA methylation was implicated in a number of essential functional responses to spinal cord injury,including neuronal synaptic connection creation and axon ***,neither CpG methylation nor non-CpG methylation was implicated in the functional response of glial or inflammatory *** summary,our work elucidated the dynamic pattern of DNA methylation in the spinal co rd following injury and identified reduced nonCpG meth

关键词： CpG methylation cytosine fraction differentially methylated regions DNA methylation DNA methyltransferases dynamic signatures Gene Ontology non-CpG methylation single-cell RNA-Seq spinal cord injury