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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Realizing High Thermoelectric Performance in n-Type Se-Free Bi2Te3 materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun Nam Yong-Jae Jung Jong Ho Won Jong-min Oh nguyen Van Du Gul Rahman Víctor m.García-Suárez ran He Kornelius Nielsch Jung Young Cho Won-Seon Seo Jong Wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon Ho Shin Leibniz Institute for Solid State and materials Research Advanced materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic materials Engineering Kwangwoon University Department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of materials Science and Engineering Yonsei University School of Nano & materials Science and Engineering Kyungpook National University Department of materials Science and Engineering University of Seoul School of materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

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Weatherability and heat resistance enhanced by interaction between AG25 and mg/AI-LDH

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Rare metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang Xiang-Cui Liu Yu-Chao Wang Huan-ran Zheng Jin-Xian Wang Jia-Yi Zheng m.ng-Jie Liu Dan-Ni Deng Yu Bai Ying-Bi Chen Tong Zhang Zhi-m.ng Liu Yong-Peng Lei State Key Laboratory of Powder metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into mg/Al-layered double hydroxides(mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-m(mg,Al)bonds between mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

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“Steric Armor”Strategy of Blue Fluorescent Emitters against Photooxidation-Induced Degradation

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Chinese Journal of Chemistry 2024年第11期42卷 1223-1229页

作者： Sha-Sha Wang Jing-Rui Zhang Kuan-De Wang Hao-ran Li Peng-Hui m.ng Yang Zhou Xiang Yu Ying Wei Quan-You Feng Yu-He Kan Ling-Hai Xie Centre for molecular Systems and Organic Devices(CmSOD) State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjingJiangsu210023 China Jiangsu Key Laboratory for Chemistry of Low-Dimensional materials School of Chemistry and Chemical EngineeringHuaiyin Normal UniversityHuai'anJiangsu223300 China

Stability against oxygen is an important factor affecting the performance of organic semiconductor *** photooxidation stability can prolong the service life of the device and maintain the mechanical and photoelectric properties of the ***,various encapsulation methods from molecular structure to macroscopic device level are used to improve photooxidation ***,we adopted a crystallization strategy to allow 14H-spiro[dibenzo[c,h]acridine-7,9′-fluorene](SFDBA)to pack tightly to resist fluorescence decay caused by *** this case,the inert group of SFDBA acts as a“steric armor”,protecting the photosensitive group from being attacked by ***,compared with the fluorescence quenching of SFDBA powder under 2 h of sunlight,SFDBA crystal can maintain its fluorescence emission for more than 8 h under the same ***,the photoluminescence quantum yields(PLQYs)of the crystalline film is 327%higher than that of the amorphous *** shows that the crystallization strategy is an effective method to resist oxidation.

关键词： Organic semiconductor Photooxidation Spirocyclic aromatic hydrocarbons Crystal engineering Fluorescence

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Precise separation and efficient recovery of Pd(Ⅱ) from high-level liquid waste by XAD-based adsorbents

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Rare metals 2024年第10期43卷 5372-5390页

作者： Hao-ran Dong Shun-Yan Ning Zeng-Yuan Li Si-Zhi Xu Feng-Tao Hu Feng Gao You-Bin Wang Li-Feng Chen Xiang-Biao Yin Toyohisa Fujita mohammed F.Hamza Yue-Zhou Wei School of Resources Environment and MaterialsGuangxi University School of Nuclear Science and Technology University of South China

Efficient separation of palladium (Pd（II）) from high-level liquid waste （HLLW） not only helps the safe disposal of nuclear waste,but also is a vital importan supplement to Pd（II） ***,16 kinds of nove Amberlite XAD resins-based adsorbents were prepared by vacuum impregnation method for the separation of Pd（II）from simulated HLLW,and the mmBT/XAD7HP prepared using 4-methyl-2-mercaptobenzothiazole （mmBT） as ligand and Amberlite XAD7HP resin （XAD7HP） as the carrier was selected as the optimal research *** analysis experiments proved the successful preparation of mmBT/XAD7HP,which exhibited ultrahigh adsorption selectivity for Pd（II）(distribution coefficient （Kd）≥12584.5 ml·g-1,separation factor (SFPd/m)≥2818.4) and superior adsorption capacity(Q≥130.1 mg·g-1).The adsorption kinetics and adsorption isotherms for Pd（II） matched with pseudo-secondorder （PSO） kinetics model and Langmuir model,indicating that the adsorption mode for Pd（II） by mmBT/XAD7 HP was monolayer chemical *** dynamic column experiments showed that mmBT/XAD7 HP achieved efficiently separation of Pd（II） from simulated HLLW,and the recovery rate was nearly 100% The adsorption mechanism was analyzed by Fourier transform infrared spectroscopy （FTIR）,X-ray photoelectron spectroscopy （XPS） and density functional theory（DFT）,and the ultrahigh selectivity of mmBT/XAD7 HP is attributed to the preferred affinity of the soft-N,S donor atoms in mmBT for Pd（II）.mmBT has the shortest frontline molecular orbital energy band gap （HOmO–LUmO） am.ng the four ligands,which makes it easier to become an electron donor to attract Pd2+to participate in ***3-participates in the adsorption to keep charge *** summary,mmBT/XAD7 HP has broad application prospects for the treatment of Pd（II） in HLLW

关键词： Adsorption Column experiments HLLW Palladium XAD

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3m syndrome patient with a novel mutation:A case rep

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World Journal of Clinical Cases 2024年第8期12卷 1454-1460页

作者： m.ng-ran Luo Si-m.ng Dai Yin Li Qian Wang Hao Liu Peng Gao Jia-Yun Liu Jian Chen Shu-Jie Zhao Guo-Yong Yin Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND A rare autosomal recessive genetic disorder,3m syndrome,is characterized by severe intrauterine and postnatal growth *** with 3m syndrome typically exhibit short stature,facial deformities,long tubular bones,and high vertebral bodies but generally lack mental abnormalities or other organ *** genes associated with 3m syndrome include CUL7,OBSL1 and *** clinical and molecular characteristics of patient with 3m syn-drome are unique and serve as important diagnostic *** SUmmARY In this case,the patient displayed square shoulders,scoliosis,long slender tubular bones,and normal neurological ***,the patient did not exhibit the typical dysmorphic facial features,relative macrocephaly,or growth retardation commonly observed in individuals with 3m *** exon sequencing revealed a novel heterozygous c.56681+1G>C(Splice-3)variant and a previously reported nonsense heterozygous c.3341G>A(***1114Ter)variant of ***,it is important to note that the clinical features of 3m syndrome may not always be observable,and genetic confirmation is often ***,the identification of the c.5683+1G>C variant in OBSL1 is notewor-thy because it has not been previously reported in public *** Our study identified a new variant(c.5683+1G>C)of OBSL1 that contributes to expanding the molecular profile of 3m syndrome.

关键词： 3m syndrome CUL7 OBSL1 CCDC8 Autosomal recessive Case report

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微型“智能战士”治疗癌症:刺激响应型微纳机器人在化疗药物递送中的应用

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Science China materials 2024年第8期67卷 2469-2476页

作者：马然侯仰龙王術人 Beijing Key Laboratory for magnetoelectric materials and Devices(BKL-mmD) School of Materials Science and EngineeringPeking UniversityBeijing 100871China School of materials Sun Yat-sen UniversityShenzhen 518107China

近年来,纳米技术的进步为刺激响应型微纳机器人的发展奠定了基础,它们在癌症治疗中扮演着“智能战士”的角色.本文首先总结了各种刺激响应的机制,包括磁场、光、超声、pH和过氧化氢等介导的刺激响应,这些机制被用于触发肿瘤微环境中微... 详细信息

近年来,纳米技术的进步为刺激响应型微纳机器人的发展奠定了基础,它们在癌症治疗中扮演着“智能战士”的角色.本文首先总结了各种刺激响应的机制,包括磁场、光、超声、pH和过氧化氢等介导的刺激响应,这些机制被用于触发肿瘤微环境中微纳机器人的运动和药物释放.随后,本文系统地归纳了用于化疗药物递送的微纳机器人的发展历程与最新进展.值得注意的是,虽然这些“智能战士”在精准化疗药物递送方面具有潜在的应用价值,但要充分发挥它们的作用,还需要持续的探索,以应对实现其在复杂体内微环境中的运动所面临的挑战.

关键词：药物递送癌症治疗肿瘤微环境纳米技术刺激响应机器人药物释放过氧化氢

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川藏交通廊道怒江段斜坡地质灾害发育特征及主控因素分析

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自然灾害学报 2024年第4期33卷 176-187页

作者：冉涛徐如阁李奇中国地质调查局成都地质调查中心(西南地质科技创新中心) 四川成都610218 自然资源部地质灾害风险防控工程技术创新中心四川成都611734 自然资源部成都地质灾害野外科学观测研究站四川成都610000

青藏高原东南三江流域地质环境脆弱,地质灾害频发。为了有效防控川藏交通廊道怒江段(洛隆―八宿)的地质灾害风险,采用遥感解译、现场调查、GIS空间分析、确定性系数(certainty factor,CF)分析以及敏感性指数(E)分析等方法,在研究区内共... 详细信息

青藏高原东南三江流域地质环境脆弱,地质灾害频发。为了有效防控川藏交通廊道怒江段(洛隆―八宿)的地质灾害风险,采用遥感解译、现场调查、GIS空间分析、确定性系数(certainty factor,CF)分析以及敏感性指数(E)分析等方法,在研究区内共识别出斜坡地质灾害(滑坡、崩塌、变形体)992处,分析了灾害的数量、规模和破坏模式等发育特征,揭示了灾害的易发区间和主控因素。研究表明:高程[2672,4500)m,坡度[20,35)°,坡向E、SE、S、SW、W是灾害易发的地形地貌区间;砂砾岩、泥页岩、灰岩岩组、砂板岩夹火山岩岩组、碳酸盐岩岩组、砂板岩夹煤层岩组、大理岩、灰岩夹片岩岩组、片岩、硅质岩和砂板岩岩组是灾害易发的地层岩组;距断裂和距水系距离小于1 km均为灾害易发范围。其中,高程[2672,3000)m、坡度[25,35)°、坡向SW、碳酸盐岩岩组和砂板岩夹煤层岩组是灾害最易发生的因子范围。选取的6个影响因子对斜坡地质灾害的影响大小依次为:高程、岩组、坡度、距水系距离、距断裂距离和坡向,其中前5个因子是灾害的主控因素。本文研究成果可以为川藏交通廊道怒江段的防灾减灾提供科学依据。

关键词：怒江川藏交通廊道斜坡地质灾害遥感解译破坏模式敏感性分析

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Nonreciprocal single-photon scattering mediated by a driven Λ-type three-level giant atom

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Communications in Theoretical Physics 2024年第11期 115-124页

作者： Xiaopei Zhang Haozhen Li ran Zeng miao Hu m.ngm.ng Xu Xuefang Zhou Yang Lan Xiuwen Xia Jingping Xu Yaping Yang School of Communication Engineering Hangzhou Dianzi University Zhejiang Province Key Laboratory of Quantum Technology and Device Zhejiang University Institute of Atomic and molecular Physics and Functional materials School of Mathematics and Physics Key Laboratory of Advanced micro-Structured materials of ministry of Education School of Physics Science and Engineering Tongji University

A waveguide-QED with giant atoms, which is capable of accessing various limits of a small one,provides a new paradigm to study photon scatterings. Thus, how to achieve nonreciprocal photon transmissions via such a giant atom setup is highly desirable. In this study, the nonreciprocal single-photon scattering characteristics of a double-driven Λ-type three-level giant atom, where one of the transition couples to a 1D waveguide at two separate points, and the other is driven by two coherent driving fields, are investigated. It is found that a frequency-tunable single-photon diode with an ideal contrast ratio can be achieved by properly manipulating the local coupling phases between the giant atom and the waveguide, the accumulation phase between the two waveguide coupling points, the Rabi frequencies and phase difference of the two driven fields. Compared to the previous single driving schemes, on the one hand, the presence of the second driving field can provide more tunable parameters to manipulate the nonreciprocal single-photon scattering behavior. On the other hand, here perfect nonreciprocal transmission for photons with arbitrary frequencies is achievable by tuning the driving phases while the two driving fields keep on turning, which provides an alternative way to control the nonreciprocal single-photon scattering. Furthermore, the results reveal that both the location and width of each optimal nonreciprocal transmission window is also sensitive to the driving detuning, and a single-photon diode with wide or narrow bandwidth can be realized based on demand. These results may be beneficial for designing nonreciprocal single-photon devices based on a double-driven giant atom setup.

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阴道分娩对猪子宫韧带力学性能的影响

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医用生物力学 2024年第4期39卷 736-741页

作者：王丽丽刘然太原理工大学生物医学工程学院太原030024 山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院) 太原030032

目的研究阴道分娩对子宫骶韧带(uterosacral ligaments,USLs)和主韧带(cardinal ligaments,CLs)生物力学性能的影响,进而探讨阴道分娩对盆腔器官脱垂(pelvic organ prolapse,POP)的影响。方法选用成年母猪(已育母猪5头,未育母猪5头)作... 详细信息

目的研究阴道分娩对子宫骶韧带(uterosacral ligaments,USLs)和主韧带(cardinal ligaments,CLs)生物力学性能的影响,进而探讨阴道分娩对盆腔器官脱垂(pelvic organ prolapse,POP)的影响。方法选用成年母猪(已育母猪5头,未育母猪5头)作为动物模型,通过单轴拉伸实验测量离体母猪的USLs和CLs被动力学行为,分析分娩对USLs和CLs生物力学性能的影响。结果猪子宫韧带组织的被动力学行为呈非线性。无论分娩与否,右骶韧带的最大应力大于左骶韧带(P0.05)。USLs最大应力均大于CLs,表明USLs比CLs承受的张力更大,USLs在POP中起到关键性作用。结论研究结果为认识USLs和CLs力学特性提供参考,可以指导更好治疗方法的发展,如POP手术重建,也为预防POP发生提供理论基础。

关键词：子宫骶韧带主韧带单轴拉伸测试非线性阴道分娩

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