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山药多糖对减糖猪肉糜脯风味的影响

肉类研究 2024年第1期38卷 51-60页

作者：肖燃杜明静刘超峰谢婷婷陈从贵合肥工业大学食品与生物工程学院安徽合肥230601 合肥工业大学动物源食品绿色制造与资源挖掘安徽省重点实验室安徽合肥230601 三只松鼠股份有限公司安徽芜湖241000

研究山药多糖添加量(0.0%、0.5%、1.0%、1.5%、2.0%和2.5%)对减糖猪肉糜脯(sugar-reduced dried mincedporkslice,SDMS)风味的影响,并分析SDMS中的风味物质、脂质和蛋白质氧化、美拉德反应及感官品质。结果表明:添加0.5%山药多糖能够通... 详细信息

研究山药多糖添加量(0.0%、0.5%、1.0%、1.5%、2.0%和2.5%)对减糖猪肉糜脯(sugar-reduced dried mincedporkslice,SDMS)风味的影响,并分析SDMS中的风味物质、脂质和蛋白质氧化、美拉德反应及感官品质。结果表明:添加0.5%山药多糖能够通过促进SDMS中游离氨基酸的产生、美拉德反应和Strecker降解显著提高挥发性化合物中杂环化合物、酮类等的相对含量,并抑制SDMS中腥味物质三甲胺的生成,显著改善SDMS的风味(P<0.05);而添加过多的山药多糖(1.5%~2.5%)会阻碍SDMS中挥发性风味物质的生成,导致其香气化合物含量减少和感官评分下降。因此,添加适量的山药多糖可有效提升SDMS的风味。

关键词：减糖猪肉糜脯山药多糖风味蛋白和脂质氧化美拉德反应

Wide Pulse Width Electroacupuncture Ameliorates Denervation-Induced Skeletal Muscle Atrophy in Rats via IGF-1/PI3K/Akt Pathway

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Chinese Journal of Integrative Medicine 2021年第6期27卷 446-454页

作者： HUANG xiao-qing XU Jin-sen YE xiao-ran CHEN Xuan Key Laboratory of Acupuncture Instrument Fujian Academy of Chinese Medical SciencesFuzhou(350003)China Fujian Key Laboratory of Propagated Sensation along Meridian Institute of Meridians and Collaterals MedicineFujian Academy of Chinese Medical SciencesFuzhou(350003)China

Objective:To evaluate the effect of the pulse width of electroacupuncture(EA)in the treatment of denervation-induced skeletal muscle atrophy in rats and examine the role of insulin-like growth factor 1(IGF-1)/phosphatidylinositol 3-kinase(PI3 K)/Akt signaling pathway during ***:Sciatic nerve functional index(SFI),muscle wet weight and the cross-sectional area(CSA)of the gastrocnemius muscle were analyzed after treatment in model rats with EA of various pulse widths(0.5,50,100 and 200 ms).The apoptosis index(AI)and paired box(PAX)3 and PAX7 protein expression were also ***,the mRNA and protein expressions of components of IGF-1/PI3 K/Akt pathway and their downstream targets were determined,along with the inhibiting effect of the pathway with a PI3-specific ***:EA with a pulse width of 200 ms was found to have the best effect with regard to increasing SFI,CSA and muscle weight,decreasing AI,and increasing the expression of PAX3 and *** IGF-1/PI3 K/Akt pathway was found to be activated by denervation,although the downstream forkhead box O(FoxO)pathway was not suppressed by its *** PI3 K/Akt pathway and its downstream molecule mammalian target of rapamycin(mTOR)were up-regulated further by EA to promote muscle protein ***,the expressions of downstream FoxO and F-box protein 32(ATROGIN-1)were down-regulated to reduce protein ***:EA with 200-ms pulse width was found to have a more significant effect than 0.5-ms *** positive effects of EA disappeared after inhibition of the PI3 K/Akt pathway.

关键词： denervation muscle atrophy electroacupuncture pulse width IGF-1/PI3K/Akt pathway

DIFFERENCE IN BIOLOGICAL CHARACTERISTICS AND SENSITIVITY TO CHEMOTHERAPY AND RADIOTHERAPY BETWEEN INTRAHEPATIC AND EXTRAHEPATIC CHOLANGIOCARCINOMA CELLS IN VITRO

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Chinese Medical Sciences Journal 2008年第1期23卷 54-59页

作者： xiao-ran He xiao-peng Wu Department of Emergency Tongren Hospital Capital Medical University Beijing 100730 Department of General Surgery Qilu Hospital Shandong University Jinan 250012

Objective To investigate and compare the biological characteristics and sensitivity to chemotherapy and radiotherapy of intrahepatic and extrahepatic cholangiocarcinoma cells in *** The intrahepatic and extrahepatic cholangiocarcinoma cell lines were established,and cells with steady passage were chosen to study the biological characteristics including morphology,growth dynamics,chromosome,and levels of cancer antigen(CA)125,CA19-9,alpha-fetoprotein(AFP),and carcino-embryonic antigen(CEA).Meanwhile,MTT assay was used to determine the sensitivity of both kinds of cells to 6 chemotherapeutic drugs,including cisplatin,paclitaxel,harringtonine,5-fluorouracil,vincristine,and aclacimomycin,and the inhibitory rate of cells under the irradiation of 10 Gy ray was also *** The intrahepatic cholangiocarcinoma cells were mostly fusiform in shape,and extrahepatic cholangiocarcinoma cells were mostly round or polygon in *** doubling time was 26.3 hours and 23.1 hours,*** average number of chromosomes was 59(range,38-84)and 67(range,49-103),*** chromosome karyotypes of most intrahepatic cholangiocarcinoma cells were hyperdiploid and hypotriploid,while hypertriploid was predominant in extrahepatic cholangiocarcinoma *** level of CA 125 in supernatant of extrahepatic cholangiocarcinoma cells increased obviously,while levels of other determined tumor markers in both kinds of cells were all within normal *** intrahepatic cholangiocarcinoma cells were low sensitive to cisplatin and paclitaxel,but not sensitive to the other 4 chemotherapeutic *** extrahepatic cholangiocarcinoma cells were high sensitive to cisplatin,but not sensitive to the other 5 *** kinds of cells had poor sensitivity to *** Intrahepatic and extrahepatic cholangiocarcinoma cells show differences in shape,doubling time,chromosome karyotype,tumor marker level,and chemosensitivity,whereas they both have poor radiosen

关键词： cholangiocarcinoma cell line chromosome chemosensitivity radiosensitivity

新时期南水北调中线工程水源地水质监测体系建设构想

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长江科学院院报 2024年第10期41卷 1-5,22页

作者：秦赫潘璐彭晓然倪雪峰黄玄敏南水北调中线水源有限责任公司湖北十堰442700

构建与国家战略水源地相适应的中线水源工程水质安全保障体系是新时期南水北调工程运行管理的重要内容。基于丹江口库区及其上游流域水质监测的新需求和新目标,提出了构建新时期南水北调中线工程水源地监测站网、水质监测、风险防范、... 详细信息

构建与国家战略水源地相适应的中线水源工程水质安全保障体系是新时期南水北调工程运行管理的重要内容。基于丹江口库区及其上游流域水质监测的新需求和新目标,提出了构建新时期南水北调中线工程水源地监测站网、水质监测、风险防范、科技支撑四大体系的建设构想,阐述了体系的基本内涵和要义。“四大体系”将在全面覆盖、关键预警、智慧先进、立体感知、重点监控、科技研究等方面对水质监测体系进行改造与提升,保障“一泓清水永续北上”。

关键词：南水北调中线工程丹江口水库水质监测体系水质安全保障

中国共产党文化使命的百年历史演进与现实启示

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天水行政学院学报（哲学社会科学版） 2024年第5期25卷 15-20页

作者：张消然王金磊中央民族大学马克思主义学院北京100081

中国共产党作为使命型政党,自成立之日起就肩负着实现中华文化伟大复兴的使命。回顾中国共产党文化使命的百年历史演进,大致经历了化解文化危机、实现文化转型、推进文化改革、铸就中华文化新辉煌四个阶段,总体呈现出阶段性与整体性、... 详细信息

中国共产党作为使命型政党,自成立之日起就肩负着实现中华文化伟大复兴的使命。回顾中国共产党文化使命的百年历史演进,大致经历了化解文化危机、实现文化转型、推进文化改革、铸就中华文化新辉煌四个阶段,总体呈现出阶段性与整体性、继承性与发展性的演进态势。深入分析探究其历史演进过程,可以进一步把握社会主义文化建设规律,为中国共产党担负好新时代新的文化使命提供重要的现实启示。

关键词：中国共产党文化使命历史演进

Engineering bacteria for enhanced polyhydroxyalkanoates(PHA)biosynthesis

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Synthetic and Systems Biotechnology 2017年第3期2卷 192-197页

作者： Guo-Qiang Chen xiao-ran Jiang School of Life Sciences Tsinghua UniversityBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Tsinghua UniversityBeijing 100084China Center for Nano and Micro Mechanics Tsinghua UniversityBeijing 100084China MOE Key Lab of Industrial Biocatalysis Dept Chemical EngineeringTsinghua UniversityBeijing 100084China

Polyhydroxyalkanoates(PHA)have been produced by some bacteria as bioplastics for many *** their commercialization is still on the way.A few issues are related to the difficulty of PHA commercialization:namely,high cost and instabilities on molecular weights(Mw)and structures,thus instability on thermo-mechanical *** high cost is the result of complicated bioprocessing associated with sterilization,low conversion of carbon substrates to PHA products,and slow growth of microorganisms as well as difficulty of downstream *** engineering on PHA producing microorganisms should be focused on contamination resistant bacteria especially extremophiles,developments of engineering approaches for the extremophiles,increase on carbon substrates to PHA conversion and controlling Mw of *** concept proof studies could still be conducted on *** or Pseudomonas *** are easily used for molecular *** this review,we will use *** and halophiles as examples to show how to engineer bacteria for enhanced PHA biosynthesis and for increasing PHA competitiveness.

关键词： PHB Polyhydroxyalkanoates Extremophiles Halophiles Next generation industrial biotechnology NGIB Metabolic engineering Pathway engineering Morphology engineering Contents

乌鲁木齐地区育龄女性脊髓性肌萎缩症携带者筛查胚胎植入前诊断及产前诊断情况分析

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中国妇幼保健 2024年第3期39卷 417-421页

作者：刘翛然武爽韩锐新疆医科大学第一附属医院新疆乌鲁木齐830054 新疆生殖免疫临床医学研究中心

目的了解乌鲁木齐地区脊髓性肌萎缩症(SMA)的人群携带率,对乌鲁木齐地区孕前女性进行携带者筛查,并召回携带者配偶进行检测,对筛查出的高风险夫妻行单基因病胚胎遗传学检测(PGT-M),对曾生育过SMA患儿的高风险夫妻行产前诊断,为该地区SM... 详细信息

目的了解乌鲁木齐地区脊髓性肌萎缩症(SMA)的人群携带率,对乌鲁木齐地区孕前女性进行携带者筛查,并召回携带者配偶进行检测,对筛查出的高风险夫妻行单基因病胚胎遗传学检测(PGT-M),对曾生育过SMA患儿的高风险夫妻行产前诊断,为该地区SMA的一级预防和二级预防提供指导。方法选取2020年1月—2023年7月在新疆医科大学第一附属医院就诊的选择做SMA携带者筛查的育龄期女性7 158例为研究对象,均无SMA表型及相关疾病史。携带者筛查用PCR-熔解曲线法,检测SMN1基因E7、E8的拷贝数,统计乌鲁木齐地区育龄期女性SMA携带者频率;用二代测序的方法对高风险夫妻的胚胎进行PGT-M;对高风险胎儿,用多重连接依赖式探针扩增(MLPA)的方法进行产前诊断。结果在7 158例育龄期女性中,共检出117例SMA携带者,携带频率为1.63%(1/61);检出双方均为携带者的夫妇1对,而PGT-M技术为这对高风险夫妻选择出未携带突变的整倍体囊胚1枚,携带父源突变单拷贝的整倍体囊胚1枚;产前诊断夫妻的胎儿SMN1基因E7、E8均为2个拷贝数,胎儿出生后随访1年发育未见异常。结论初步获得乌鲁木齐地区育龄女性SMA携带率为1.63%;对于明确缺失类型和基因型的SMA携带者夫妻,PGT-M技术能够阻断SMA致病基因向后代的传递;对于高风险胎儿,MLPA可给出明确诊断,阻止SMA患儿的出生。该研究有效完成了SMA的一级预防和二级预防,对乌鲁木齐地区出生缺陷防控具有重要意义。

关键词：脊髓性肌萎缩症携带者筛查胚胎植入前诊断产前诊断

Spin polarization and production rate studies of surface muons in a novel solenoid capture system based on CSNS

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Nuclear Science and Techniques 2017年第8期28卷 61-68页

作者： ran xiao Yan-Fen Liu xiao-Jie Ni Zi-Wen Pan Bang-Jiao Ye State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China Institute of High Energy Physics Chinese Academy ofSciences Beijing 100049 China

A novel surface muon capture system with a large acceptance was proposed based on the China spallation neutron source(CSNS).This system was designed using a superconducting solenoid where a long graphite target was put inside ***,the spin polarization evolution was studied in a constant uniform magnetic *** the magnetic field can interact with the spin of the surface muon,both the spin polarization and production rate of the surface muons collected by the new capture system were calculated by the *** results showed that the surface muons could still keep a high spin polarization([90%)with different magnetic fields(0–10 T),and the larger magnetic field is,the more surface muons can be ***,the proton phase space,Courant–Snyder parameters,and intensities of surface muons of different beam fractions were given with magnetic fields of 0 and *** solenoid capture system can focus proton and surface muon beams and collect p?and l?*** can also provide an intense energetic positron source.

关键词：自旋极化率采集系统 μ介子表面电磁生产均匀磁场自旋相互作用

融合多尺度CNN与双向LSTM的唐卡问句分类模型

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科学技术与工程 2024年第22期24卷 9490-9497页

作者：王铁君闫悦郭晓然王铠杰饶强西北民族大学数学与计算机科学学院兰州730000 西北民族大学中国民族语言文字信息技术教育部重点实验室兰州730000

当前大语言模型的兴起为自然语言处理、搜索引擎、生命科学研究等领域的研究者提供了新思路,但大语言模型存在资源消耗高、推理速度慢,难以在工业场景尤其是垂直领域应用等方面的缺点。针对这一问题,提出了一种多尺度卷积神经网络(convo... 详细信息

当前大语言模型的兴起为自然语言处理、搜索引擎、生命科学研究等领域的研究者提供了新思路,但大语言模型存在资源消耗高、推理速度慢,难以在工业场景尤其是垂直领域应用等方面的缺点。针对这一问题,提出了一种多尺度卷积神经网络(convolutional neural network,CNN)与双向长短期记忆神经网络(long short term memory,LSTM)融合的唐卡问句分类模型,本文模型将数据的全局特征与局部特征进行融合实现唐卡问句分类任务,全局特征反映数据的本质特点,局部特征关注数据中易被忽视的部分,将二者以拼接的方式融合以丰富句子的特征表示。通过在Thangka数据集与THUCNews数据集上进行实验,结果表明,本文模型相较于Bert模型在精确度上略优,在训练时间上缩短了1/20,运算推理时间缩短了1/3。在公开数据集上的实验表明,本文模型在文本分类任务上也表现出了较好的适用性和有效性。

关键词：文本分类长短期记忆多尺度卷积神经网络唐卡