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Transarterial chemoembolization plus stent placement for hepatocellular carcinoma with main portal vein tumor thrombosis:A meta-analysis

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World Journal of Clinical Oncology 2024年第3期15卷 447-455页

作者： Wei-Fan sui Jian-Yun Li Jian-Hua Fu Department of Interventional Radiology Zhenjiang First People's HospitalZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND Portal vein tumor thrombus is an important indicator of poor prognosis in patients with hepatocellular carcinoma.Transarterial chemoembolization is recommended as the standard first-line therapy for unresectable hepatocellular carcinoma.Portal vein stent placement is a safe and effective therapy for promptly restoring flow and relieving portal hypertension caused by tumor thrombus.AIM To assess the clinical significance of transarterial chemoembolization plus stent placement for the treatment of hepatocellular carcinoma with main portal vein tumor thrombosis.METHODS We searched English and Chinese databases,assessed the quality of the included studies,analyzed the characteristic data,tested heterogeneity,explored heterogeneity,and tested publication bias.RESULTS In total,eight clinical controlled trials were included.The results showed that the pressure in the main portal vein after stent placement was significantly lower than that with no stent placement.The cumulative stent patency and survival rates at 6 and 12 months were lower in the transarterial chemoembolization+stent placement group than in the transarterial chemoembolization+stent placement+brachytherapy/radiotherapy group.The survival rates of patients treated with transarterial chemoembolization+stent placement for 6 and 12 months were higher than those of patients treated with transarterial chemoembolization alone.CONCLUSION For Chinese patients with hepatocellular carcinoma with main portal vein tumor thrombosis,transarterial chemoembolization plus stenting is effective.Transarterial chemoembolization+stent placement is more effective than transarterial chemoembolization alone.Transarterial chemoembolization+stent placement+brachytherapy/radiotherapy is more effective than transarterial chemoembolization+stenting.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Portal vein tumor thrombus Stent Meta-analysis

Phase field modeling of grain stability of nanocrystalline alloys by explicitly incorporating mismatch strain

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Rare Metals 2024年第7期43卷 3370-3382页

作者： Min Zhou Hong-Hui Wu Yuan Wu Hui Wang Xiong-Jun Liu sui-He Jiang Xiao-Bin Zhang Zhao-Ping Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology Beijing Institute for Carbon Neutrality University of Science and Technology Institute of Materials Intelligent Technology Liaoning Academy of Materials

Ab st ra ct Nanocrystalline materials exhibit unique properties due to their extremely high grain boundary(GB) density.However,this high-density characteristic induces grain coarsening at elevated temperatures,thereby limiting the widespread application of nanocrystalline materials.Recent experimental observations revealed that GB segregation and second-phase pinning effectively hinder GB migration,thereby improving the stability of nanocry stalline materials.In this study,a mouified phase-field model that integrates mismatch strain,solute segregation and precipitation was developed to evaluate the influence of lattice misfit on the thermal stability of nanocrystalline alloys.The simulation results indicated that introducing a suitable mismatch strain can effectively enhance the microstructural stability of nanocrystalline alloys.By synergizing precipitation with an appropriate lattice misfit,the formation of second-phase particles in the bulk grains can be suppressed,thereby facilitating solute segregation/precipitation at the GBs.This concentrated solute segregation and precipitation at the GBs effectively hinders grain migration,thereby preventing grain coarsening.These findings provide a new perspective on the design and regulation of nanocrystalline alloys with enhanced thermal stability.

关键词： Phase field model Mismatch strain Second-phase precipitation Grain boundary segregation Nanocrystalline alloys

面向进程多变体软件系统的攻击面定性建模分析

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网络与信息安全学报 2022年第5期8卷 121-128页

作者：邢福康张铮隋然曲晟季新生信息工程大学河南郑州450001 中央军委后勤保障部信息中心北京100089

攻击面是衡量软件系统安全性的一个重要指标,采用攻击面描述可以通过集合的方式描述软件系统的安全性并对其进行度量。一般的攻击面模型基于I/O自动机模型对软件系统进行建模,其一般采用非冗余的架构,难以应用于类似多变体系统这类异构... 详细信息

攻击面是衡量软件系统安全性的一个重要指标,采用攻击面描述可以通过集合的方式描述软件系统的安全性并对其进行度量。一般的攻击面模型基于I/O自动机模型对软件系统进行建模,其一般采用非冗余的架构,难以应用于类似多变体系统这类异构冗余的系统架构。Manadhatad等提出了一种在非相似余度系统中进行攻击面度量的方式,但其采用的系统架构表决粒度和表决方式与多变体系统不同,无法准确度量多变体系统的攻击面。因此,在传统攻击面模型基础上,结合多变体系统异构冗余架构的特点,对传统攻击面模型进行扩展,并构建多变体系统的攻击面模型;使用形式化方式表示多变体系统的攻击面,根据多变体系统在系统出口点处的表决机制对传统攻击面模型进行改进,以使其能解释多变体系统攻击面缩小的现象,通过该建模方式,能够说明采用多变体架构的多变体系统在运行过程中攻击面的变化。采用了两组多变体执行架构的软件系统进行实例分析,分别通过与未采用多变体架构的功能相同的软件系统在未受攻击和遭受攻击两种情境下进行攻击面的对比分析,体现多变体系统在攻击面上的变化。结合攻击面理论与多变体执行系统的特点提出了一种面向多变体执行系统的攻击面建模方法,目前可以定性分析多变体执行系统攻击面的变化,未来将在定量分析多变体执行系统攻击面的方向继续进行深入研究。

关键词：多变体攻击面攻击面度量网络安全

Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury

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Neural Regeneration Research 2024年第11期19卷 2499-2512页

作者： Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao sui Jie Chang Xiaojian Cao Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Trauma Surgery Subei People’s Hospital of JiangsuClinical Medical College of Yangzhou UniversityYangzhouJiangsu ProvinceChina Department of Orthopedics Zhongda HospitalSoutheast UniversityNanjingJiangsu ProvinceChina Department of Orthopedic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina

The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arthritis,and managing inflammatory cytokine storms.Although studies have shown the neuroprotective potential of ruxolitinib in neurological trauma,the exact mechanism by which it enhances functional recovery after spinal cord injury,particularly its effect on astrocytes,remains unclear.To address this gap,we established a mouse model of T10 spinal cord contusion and found that ruxolitinib effectively improved hindlimb motor function and reduced the area of spinal cord injury.Transcriptome sequencing analysis showed that ruxolitinib alleviated inflammation and immune response after spinal cord injury,restored EAAT2 expression,reduced glutamate levels,and alleviated excitatory toxicity.Furthermore,ruxolitinib inhibited the phosphorylation of JAK2 and STAT3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-B and the expression of inflammatory factors interleukin-1β,interleukin-6,and tumor necrosis factor-α.Additionally,in glutamate-induced excitotoxicity astrocytes,ruxolitinib restored EAAT2 expression and increased glutamate uptake by inhibiting the activation of STAT3,thereby reducing glutamate-induced neurotoxicity,calcium influx,oxidative stress,and cell apoptosis,and increasing the complexity of dendritic branching.Collectively,these results indicate that ruxolitinib restores glutamate homeostasis by rescuing the expression of EAAT2 in astrocytes,reduces neurotoxicity,and effectively alleviates inflammatory and immune responses after spinal cord injury,thereby promoting functional recovery after spinal cord injury.

关键词： astrocytes EAAT2 excitotoxicity glutamate homeostasis JAK-STAT pathway locomotor function neurotoxicity ruxolitinib spinal cord injury transcriptome analysis

基于层次分析法多标准决策分析的产品全生命周期方案选择

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上海交通大学学报 2007年第4期41卷 520-524,531页

作者：于随然陶璟王佳伟上海交通大学机械与动力工程学院上海200240

提出了产品全生命周期方案的生成方法,并从平衡用户、制造商和产品环境影响三方面的要求入手,提出了评价产品生命周期设计方案的评价基准.建立了以选出最优设计方案为目的评价基准和设计方案之间的层次结构关系.通过成对比较和综合评价... 详细信息

提出了产品全生命周期方案的生成方法,并从平衡用户、制造商和产品环境影响三方面的要求入手,提出了评价产品生命周期设计方案的评价基准.建立了以选出最优设计方案为目的评价基准和设计方案之间的层次结构关系.通过成对比较和综合评价选出最优方案.最后用一个实例说明了该方法的使用,灵敏度分析表明了该方法的“鲁棒性”.该方法对家电类产品的绿色设计具有指导意义.

关键词：决策分析全生命周期方案层次分析法灵敏度分析

Inversion of O_(2) 1.27 μm nightglow emissions: A climatological analysis using satellite Limb-Viewed spectra and Harmonic analysis method

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Earth and Planetary Physics 2024年第4期8卷 632-640页

作者： YiYi sui YaJun Zhu QiuYu Chen MaoSheng He JiYao Xu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China

This study employs a linear inversion algorithm to retrieve volume emission rates(VERs)of molecular O_(2) nightglow at 1.27μm,utilizing Limb-Viewed spectra obtained from the SCanning Imaging Absorption spectroMeter for Atmospheric for CHartographY(SCIAMACHY)payload on board the Envisat satellite.The retrieved results are compared with VERs data from the SABER payload on the Thermosphere Ionosphere Mesosphere Energetics and Dynamics(TIMED)satellite,exhibiting consistency.This will help to facilitate accurate revelation of spatial distribution and periodic variation in O_(2) nightglow.VERs are extracted monthly within the altitude range of 75-110 km from 2002 to 2012,yielding a climatology of spatial and temporal distributions.The meridional structure exhibits two maxima,at the equator and at 45°N.Between August and October,the VERs exhibit a meridional bimodal structure,with the weaker one above the equator and the stronger one above 45°N.In April,the VERs reach their annual maximum.Additionally,harmonic analysis reveals significant temporal variations on different scales.The emission shows characteristics of annual and semi-annual variation,and a non-linear long-term trend associated with solar cycle activity.

关键词： VERs O_(2)1.27μm nightglow SCIAMACHY

Fe_(3)O_(4) nanoparticles encapsulated in graphitized and inplane porous carbon nanocages derived from emulsified asphalt for a high-performance lithium-ion battery anode

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Frontiers of Materials Science 2024年第2期18卷 89-100页

作者： Dandan Hu Linxiu sui Jinjin Shi Dongfeng Li Yuxuan Zhang Yimeng Li Bingbing Hu Xiaoya Yuan School of Materials Science and Engineering Chongqing Jiaotong UniversityChongqing 400074China Institute of Advanced Functional Materials Chongqing Jiaotong UniversityChongqing 400074China Chongqing 2D Materials Institute Liangjiang New AreaChongqing 400044China

In this work,C@Fe_(3)O_(4) composites were prepared through a typical template method with emulsified asphalt as carbon source,ammonium ferric citrate as transition metal oxide precursor,and NaCl as template.As an anode for lithium-ion batteries,the optimized C@Fe_(3)O_(4)-1:2 composite exhibits an excellent reversible capacity of 856.6 mA·h·g^(-1)after 100 cycles at 0.1A·g^(-1)and a high capacity of 531.1mA·h·g^(-1)after 300 cycles at 1 A·g^(-1),much better than those of bulk carbon/Fe_(3)O_(4) prepared without NaCl.Such remarkable cycling performance mainly benefits from its well-designed structure:Fe_(3)O_(4) nanoparticles generated from ammonium ferric citrate during pyrolysis are homogenously encapsulated in graphitized and in-plane porous carbon nanocages derived from petroleum asphalt.The carbon nanocages not only improve the conductivity of Fe_(3)O_(4),but also suppress the volume expansion of FesO4 effectively during the charge discharge cycle,thus delivering a robust electrochemical stability.This work realizes the high value-added utilization of low-cost petroleum asphalt,and can be extended to application of other transition-metal oxides-based anodes.

关键词： emulsified asphalt Fe_(3)O_(4)nanoparticle in-plane pore lithium-ion battery anode

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基于多传感器的采煤机滑靴受力检测系统研究

煤炭学报 2020年第4期45卷 1547-1556页

作者：田立勇李文政隋然辽宁工程技术大学机械工程学院辽宁阜新123000 中国葛洲坝集团建设工程有限公司云南昆明650217

采煤机实际运行过程中工况环境恶劣,滑靴作为连接采煤机与刮板输送机的重要部件,在剧烈的非线性冲击载荷下极易损坏,直接影响采煤机工作效率,降低煤矿井下生产效益。为研究斜切工况下采煤机滑靴力学特性,以MG500/1130-WD型电牵引采煤机... 详细信息

采煤机实际运行过程中工况环境恶劣,滑靴作为连接采煤机与刮板输送机的重要部件,在剧烈的非线性冲击载荷下极易损坏,直接影响采煤机工作效率,降低煤矿井下生产效益。为研究斜切工况下采煤机滑靴力学特性,以MG500/1130-WD型电牵引采煤机为研究对象,构建斜切工况下采煤机整机空间力学模型。根据煤岩截割理论,结合煤岩性质与采煤机结构参数,利用Matlab求解计算采煤机滚筒截割载荷与滑靴各接触载荷,提出一种基于平滑靴销轴传感器、导向滑靴销轴传感器、导向滑靴销轴拉力传感器等多传感器融合的采煤机滑靴受力检测系统,并依托国家能源煤矿采掘机械装备研发试验中心进行现场实验验证。实验结果表明:采煤机工作过程中,同种滑靴受力大小基本相同,后侧滑靴所受载荷略大于前侧滑靴所受载荷,平滑靴支撑力大于导向滑靴支撑力且导向滑靴轴向载荷明显大于竖直方向载荷。实验过程中滑靴最大载荷出现在斜切进刀阶段,受刮板输送机位姿、落煤等因素影响,实验值均大于理论值。利用Solidworks建立滑靴三维模型,将现场实验数据导入ANSYS对滑靴进行有限元仿真分析,得到采煤机滑靴最大斜切受载下的应力云图与位移云图,为滑靴结构优化提供基础。

关键词：平滑靴导向滑靴采煤机力学特性有限元分析

Metal complexes of bipyridine-functionalized covalent organic frameworks as efficient electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 3096-3106页

作者： Zhuang-Zhuang Wu Tian Xia Ying Liang Yong-Peng Li Zhu-Yin sui Li-Juan Feng Dao-Xiong Wu Xin-Long Tian Qi Chen State Key Laboratory of Marine Resource Utilization in South China Sea School of Marine Science and EngineeringHainan University School of Chemistry and Chemical Engineering Yantai University School of Bioengineering Zhuhai Campus of Zunyi Medical University

Electrocatalytic water splitting is considered a clean and practic al method for producing energy.In this study,COF-Bpy,a bipyridine-functionalized covalent organic framework（COF）,was prepared via post-synthetic modification,after which electrocatalysts for the oxygen evolution reactions（OER） were formed through coordination to single- or double-transition metals（Fe,Co,Ni,FeCo,FeNi or CoNi）.COF-Bpy@FeNi delivered the best OER performance among the studied electrocatalysts,with an overpotential of 399 mV at 10 mA·cm-2in an alkaline electrolyte(1.0 mol·L-1KOH aqueous).Notably,the electrocatalytic performance of COF-Bpy@FeNi showed slight degradation during durability testing,which is ascribable to its irreversible benzoquinoline structure and strong metal coordination.As expected,COF-Bpy@FeNi exhibited a low overpotential of 347 mV at a turnover frequency（TOF） of 0.1 s-1,which suggests that COF-Bpy@FeNi possesses excellent intrinsic electroc atalytic OER activity.Finally,density functional theory（DFT） calculations reveal that the Ni site plays a major role,while the Fe site adjusts the electronic structure of the Ni ions,which rationalizes the excellent OER properties of COF-Bpy@FeNi.This study not only provides a simple and efficient method for complexing COFs with transition metals,but also offers a novel strategy for designing porous organic polymer electrocatalysts.

关键词： Covalent organic framework Oxygen evolution reactions (OER) electrocatalyst Nickel–iron synergy Water splitting