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Role of chromosome 1q copy number variation in hepatocellular carcinoma

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World Journal of Hepatology 2021年第6期13卷 662-672页

作者： nathan R Jacobs Pamela A Norton Department of Microbiology and Immunology Drexel University College of MedicinePhiladelphiaPA 19102United States

Chromosome 1q often has been observed to be amplified in hepatocellular *** review summarizes literature reports of multiple genes that have been proposed as possible 1q amplification *** largely fall within *** addition,publicly available copy number alteration data from The Cancer Genome Atlas project were used to identify additional candidate genes involved in *** most frequent location for gene amplification was 1q22,consistent with the results of the literature *** genes TPM3 and NUF2 were found to be candidates whose amplification and/or mRNA up-regulation was most highly associated with poorer hepatocellular carcinoma outcomes.

关键词： Liver cancer Chromosomal amplification Hepatocellular carcinoma The Cancer Genome Atlas

Singapore’s economicdevelopment:pro-or anti-Washington Consensus?

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Economic and Political Studies 2018年第1期6卷 30-52页

作者： nathan Peng Sock-Yong Phang School of Social Sciences Singapore Management UniversitySingapore School of Economics Singapore Management UniversitySingapore

Singapore's remarkable economic development in the past five decades since independence has attracted much policy *** article first provides a brief overview of Singapore's economic *** second part discusses Singapore's development strategies that are aligned with the Washington Consensus:globalisation,conservative fiscal and monetary policies,investments in education and *** also discusses the policies adopted to further enhance the outcomes of such *** third part focusses on policies that are inconsistent with the prescriptions of the Washington Consensus:the visible hand of government direction of industry,the important role of state owned enterprises,as well as growth-enhancing social *** concludes with the present challenges facing the city-state.

关键词： Washington Consensus economic development policies politicaleconomy Singapore trade liberalisation financial liberalisation governance institutions

Inflammatory response related scoring systems in assessing the prognosis of patients with pancreatic ductal adenocarcinoma:a systematic review

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 474-481页

作者： Jawad Ahmad nathan Grimes Shahid Farid Gareth Morris-Stiff HPB Surgery Mater Hospital Department of Surgery Kettering General Hospital Department of Surgery Belfast City Hospital

BACKGROUND： Various scoring systems based on assessment of the systemic inflammatory response help assessing the prognosis of patients with pancreatic ductal *** the present systematic review we evaluated the validity of four pre-intervention scoring systems： Glasgow prognostic score（GPS） and its modified version（mGPS）, platelet lymphocyte ratio（PLR）, neutrophil lymphocyte ratio（NLR）, and prognostic nutrition index（PNI）.DATA SOURCES： MOOSE guidelines were followed and EMBASE and MEDLINE databases were searched for all published studies until September 2013 using comprehensive text word and MeSH terms. All identified studies were analyzed, and relevant studies were included in the systematic ***： Six studies were identified for GPS/mGPS with3 reporting statistical significance for GPS/mGPS on both univariate analysis（UVA） and multivariate analysis（MVA）.Two studies suggested prognostic significance on UVA but not MVA, and in the final study UVA failed to show *** studies evaluated the prognostic value of NLR. Six of them reported prognostic significance for NLR on UVA that persisted at MVA in 4 studies, and in the remaining 2 studies NLR was the only significant factor on UVA. In the remaining5 studies, all in patients undergoing resection, there was no significance on UVA. Seven studies evaluated PLR, with only one study demonstrated its prognostic significance on both UVAand MVA, the rest did not show the significance on UVA. Of the two studies identified for PNI, one demonstrated a statistically significant difference in survival on both UVA and MVA, and the other reported no significance for PNI on ***： Both GPS/mGPS and NLR may be useful but further better-designed studies are required to confirm their value. PLR might be little useful, and there are at present inadequate data to assess the prognostic value of PNI. At present, no scoring system is reliable enough to be accepted into routine use for the prognosi

关键词： pancreatic ductal adenocarcinoma Glasgow prognostic score modified Glasgow prognostic score platelet lymphocyte ratio neutrophil lymphocyte ratio prognostic nutrition index

Abdominal wall procedures: the beneifts of prehabilitation

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Plastic and Aesthetic Research 2020年第2期7卷 37-50页

作者： nathan Knapp Breanna Jedrzejewski Robert Martindale Division of Gastrointestinal and General Surgery Department of Surgery Oregon Health and Science UniversityPortlandOR 97239USA Division of Plastic and Reconstructive Surgery Department of SurgeryOregon Health and Science UniversityPortlandOR 97239USA

Prehabilitation for abdominal wall procedures provides an opportunity to further modify patient risk factors for surgical *** includes interventions that optimize nutrition,glycemic control,functional status,and utilization of the patient's microbiome pre-,intra-,and *** a multidisciplinary and anticipatory approach to patients'existing co-morbidities,the physiological stress of surgery may be attenuated to ultimately minimize perioperative morbidity in the elective *** increasing data to support the efficacy of prehabilitation in optimizing surgical outcomes and decreasing hospital length of stay,it is incumbent on the surgeon to employ these practices in elective abdominal wall *** research on the effects of prehabilitation interventions will help to shape and inform protocols that may be implemented beyond abdominal wall procedures in an effort to continually improve best practices in surgical care.

关键词： Prehabilitation perioperative optimization abdominal wall reconstruction minimize co-morbidities

Iron and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第36期22卷 8112-8122页

作者： Laurence J Britton V nathan Subramaniam Darrell HG Crawford Gallipoli Medical Research Institute The University of Queensland Greenslopes Private Hospital Brisbance Queensland 4120 Australia The Princess Alexandra Hospital Queensland 4120 Australia QIMR Berghofer Medical Research Institute Queensland 4120 Australia

The mechanisms that promote liver injury in non-alcoholic fatty liver disease(NAFLD) are yet to be thoroughly elucidated. As such, effective treatment strategies are lacking and novel therapeutic targets are required. Iron has been widely implicated in the pathogenesis of NAFLD and represents a potential target for treatment. Relationships between serum ferritin concentration and NAFLD are noted in a majority of studies, although serum ferritin is an imprecise measure of iron loading. Numerous mechanisms for a pathogenic role of hepatic iron in NAFLD have been demonstrated in animal and cell culture models. However, the human data linking hepatic iron to liver injury in NAFLD is less clear, with seemingly conflicting evidence, supporting either an effect of iron in hepatocytes or within reticulo-endothelial cells. Adipose tissue has emerged as a key site at which iron may have a pathogenic role in NAFLD. Evidence for this comes indirectly from studies that have evaluated the role of adipose tissue iron with respect to insulin resistance. Adding further complexity, multiple strands of evidence support an effect of NAFLD itself on iron metabolism. In this review, we summarise the human and basic science data that has evaluated the role of iron in NAFLD pathogenesis.

关键词： Iron Fatty liver Liver steatosis Insulin resistance Steatohepatitis Diabetes mellitus Adipose tissue

Individual automatic detection and identification of big cats with the combination of different body parts

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Integrative Zoology 2023年第1期18卷 157-168页

作者： Chunmei SHI Jing XU nathan James ROBERTS Dan LIU Guangshun JIANG College of Mathematics and Computer Science Zhejiang Agriculture and Forestry UniversityHangzhouChina Department of Mathematics School of ScienceNortheast Forestry UniversityHarbinChina Feline Research Center National Forestry and Grassland AdministrationCollege of Wildlife and Protected AreasNortheast Forestry UniversityHarbinChina Siberian Tiger Park HarbinChina

The development of facial recognition technology has become an increasingly powerful tool in wild animal indi-vidual *** this paper,we develop an automatic detection and recognition method with the combinations of body features of big cats based on the deep convolutional neural network(CNN).We collected dataset including 12244 images from 47 individual Amur tigers(Panthera tigris altaica)at the Siberian Tiger Park by mobile phones and digital camera and 1940 images and videos of 12 individual wild Amur leopard(Panthera pardus orientalis)by infrared ***,the single shot multibox detector algorithm is used to perform the automatic detection process of feature regions in each *** the different feature regions of the image,like face stripe or spots,CNNs and multi-layer perceptron models were applied to automatically identify tiger and leopard individuals,*** results show that the identiﬁcation accuracy of Amur tiger can reach up to 93.27%for face front,93.33%for right body stripe,and 93.46%for left body ***,the combination of right face,left body stripe,and right body stripe achieves the highest accuracy rate,up to 95.55%.Consequently,the combination of different body parts can improve the individual identiﬁcation ***,it is not the higher the number of body parts,the higher the accuracy *** combination model with 3 body parts has the highest *** identiﬁcation accuracy of Amur leopard can reach up to 86.90%for face front,89.13%for left body spots,and 88.33%for right body *** accuracy of different body parts combination is lower than the independent *** wild Amur leopard,the combination of face with body spot part is not helpful for the improvement of identiﬁcation *** most effective identiﬁcation part is still the independent left or right body spot *** can be applied in long-term monitoring of big cats,including big data analysis for animal behavior,and be helpful

关键词： combination of body parts individual automatic identiﬁcation object detection Panthera pardus orientalis Panthera tigris altaica

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.Miller nathan K.Evanson J.Michael Taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh June 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

Robotic surgery in urology:Recent advances

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Asian Journal of Urology 2023年第4期10卷 385-387,I0001页

作者： Riccardo Autorino Senthil nathan Department of Urology Rush University Medical CenterChicagoILUSA Department of Urology University College Hospital LondonLondonUK

The adoption of robotic-assisted surgery has determined a paradigm shift in delivery of urological surgery in the last two *** has been a privilege for us to serve as guest editors for this special issue of the Asian ... 详细信息

关键词： surgery field advances

Knee osteoarthritis:Therapeutic alternatives in primary care

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World Journal of Orthopedics 2017年第2期8卷 187-191页

作者： Allison L Evaniew nathan Evaniew Division of Orthopaedics Department of SurgeryMcMaster University

AIM To discusses pharmacological and non-pharmacological therapeutic alternatives for managing knee osteoarthritis in primary care by primary health care nurse *** A case example is presented, the evidence-based guideline recommendations of the Osteoarthritis Research Society International and the American Academy of Orthopaedic Surgeons are reviewed, and a plan of care is *** Osteoarthritis is the most common form of arthritis seen in primary care, and it is a major public health issue because the aging population and widespread obesity have drastically increased incidence. Osteoarthritis is clinically associated with escalating chronic pain, physical disability, and decreased quality of life. Early diagnosis of mild osteoarthritis in relatively young patients presents an opportunity for primary health care providers to manage pain, increase quality of life, and decrease risk of disability. CONCLUSION Primary health care providers can implement these recommendations in their own practices to provide care to patients with knee osteoarthritis based on current best evidence.

关键词： Osteoarthritis Knee Primary care Nurse practitioner Guidelines