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Albumin–bilirubin grade as a predictor of survival in hepatocellular carcinoma patients with thrombocytopenia

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1763-1772页

作者： Zhong-ran Man Xuan-Kun Gong Kang-lin Qu Qing Pang Bin-Quan Wu Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND The models for assessing liver function,mainly the Child–Pugh(CP),albuminbilirubin(ALBI),and platelet–ALBI(PALBI)classifications,have been validated for use in estimating the prognosis of hepatocellular carcinoma(HCC)patients.However,thrombocytopenia is a common finding and may influence the prognostic value of the three models in HCC.AIM To investigate and compare the prognostic performance of the above three models in thrombocytopenic HCC patients.METHODS A total of 135 patients with thrombocytopenic HCC who underwent radical surgery were retrospectively analyzed.Preoperative scores on the CP,ALBI and PALBI classifications were estimated accordingly.Kaplan–Meier curves with logrank tests and Cox regression models were used to explore the significant factors associated with overall survival(OS)and recurrence-free survival(RFS).RESULTS The preoperative platelet counts were significantly different among the CP,ALBI and PALBI groups.After a median follow-up of 28 mo,39.3%(53/135)of the patients experienced postoperative recurrence,and 36.3%(49/135)died.Univariate analysis suggested thatα-fetoprotein levels,tumor size,vascular invasion,and ALBI grade were significant predictors of OS and RFS.According to the multivariate Cox regression model,ALBI was identified as an independent prognostic factor.However,CP and PALBI grades were not statistically significant prognostic indicators.CONCLUSION The ALBI grade,rather than CP or PALBI grade,is a significant prognostic indicator for thrombocytopenic HCC patients.

关键词： Hepatocellular carcinoma Thrombocytopenia Child-Pugh Albumin-bilirubin Platelet-albumin-bilirubin

Practical Synthesis of Valbenazine via 1,3-Dipolar Cycloaddition

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Chinese Journal of Chemistry 2024年第8期42卷 841-845页

作者： Yalan Peng Zuming lin Lili Zhu Shiqing Han Sha-Hua Huang ran Hong College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingJiangsu211816 China School of Environmental and Chemical Engineering Shanghai Institute of TechnologyShanghai201418 China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China Innovation Research Institute of Traditional Chinese Medicine(IRI) Shanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai201203 China

Comprehensive Summary,Valbenazine(Ingrezza),a potent and highly selective inhibitor of vesicular monoamine transporter type 2(VMAT2)through the active metabolite hydrotetrabenazine(HTBZ),has been approved for the treatment of tardive dyskinesia and,very recently,for chorea,which is associated with Huntington's disease.Despite numerous synthetic efforts dedicated to the synthesis of HTBZ,the industrial preparation of valbenazine uses dihydroisoquinoline as a starting material and the chiral resolution of racemic HTBZ derived from ketone reduction.Herein,we present a practical synthesis of HTBZ and valbenazine featuring a highly stereoselective 1,3-dipolar cycloaddition and enzymatic kinetic resolution.The cascade process includes cycloaddition,N—O bond cleavage,and lactamization,which proved to be operationally simple.The allure of the enzymatic resolution developed in this work offers a rapid access toward affording tetrahydroisoquinoline(THIQ)-fused piperidine in the production of medically significant compounds,such as yohimbine and reserpine.

关键词： Cycloaddition Chemoenzymatic |Kinetic resolution Prodrugs VMAT2 inhibitor

Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

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China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE Shuang-yi GAO Jian LI Yong-ran JIANG Shu-xin ZHANG Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly established.The effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency domain.The results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked condition.The model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile OWTs.To ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

Comprehensive evaluations of heat transfer performance with conjugate heat dissipation effect in high-speed rotating free-disk modeling of aero-engines

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Fundamental Research 2024年第3期4卷 611-623页

作者： Aqiang lin Gaowen Liu ran Chang Yan Chen Qing Feng School of Power and Energy Northwestern Polytechnical UniversityXi'an 710129China Shaanxi Key Laboratory of Thermal Science in Aero-engine System Northwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwester

Thermal boundary conditions of the turbine disk cavity system are of great importance in the design of secondary air systems in aero-engines.This study aims to investigate the complex heat transfer mechanisms of a rotating turbine disk under high-speed conditions.A high-speed rotating free-disk model with Dorfman empirical solutions is developed to evaluate the heat transfer performance considering various factors.Specifically,the influence of compressibility,variable properties,and heat dissipation is determined using theoretical and numerical analyses.In particular,a novel combined solution method is proposed to simplify the complex heat transfer problem.The results indicate that the heat transfer performance of a free disk is primarily influenced by the rotating Mach number,rotating Reynolds number,Rossby number,and wall temperature ratio.The heat transfer temperature and Nusselt number of the free disk are strongly correlated with the rotating Mach number and rotating Reynolds number.Analysis reveals that heat dissipation is a critical factor affecting the accurate evaluation of the heat transfer performance of the turbine disk.Thus,the combined solution method can serve as a reference for future investigations of flow and heat transfer in high-speed rotating turbine disk cavity systems in aero-engines.

关键词： Aero-engine Rotating turbine disk Dimensional analysis Compressibility Heat dissipation Dorfman empirical solution

Groundwater Quality and Vulnerability Assessment in a Semiarid Karst Region of Northern China

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Journal of Earth Science 2024年第1期35卷 313-316页

作者： ran An Shu Wang Zongjun Gao Zhenyan Wang Wei Li Qijun Deng Lü lin Yuanqing Liu Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Shandong University of Science and Technology Qingdao 266510China Center for Hydrogeology and Environmental Geology Survey China Geological SurveyBaoding 071051China

Groundwater plays a critical role in maintaining ecological balance and ensuring social operations,especially in arid and semiarid regions(Hu et al.,2023;Han et al.,2022;Ma et al.,2014).The over-exploitation of groundwater,coupled with the influx of pollutants from human activities into the soil,significantly degrades the environment in certain regions(Jia et al.,2019;Famiglietti,2014;Giordano,2009;Konikow and Kendy,2005;Bohlke,2002;Shah et al.,2000).

关键词： groundwater Groundwater Vul

Transparent micropatterned conductive films based on highlyordered nanowire network

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Nano Research 2024年第5期17卷 4288-4297页

作者： Xin-ran Zhang Hai-Tao Deng Xu Zeng Yi-lin Wang Peng Huang Xiao-Sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable electronics.However,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical challenge.Herein,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire network.The large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture self-assembly.Six typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed approach.The homogeneity and controllability of this approach were verified for multiple assemblies.With the assembly cycles increasing,the optical transmittance decreases slightly.In addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is presented.Finally,the feasibility of this approach for piezoresistive strain sensors is verified.This fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.

关键词： flexible electronics transparent conductive network micropatterning nanowires micro electromechanical systems(MEMS)

Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

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BIOCELL 2024年第7期48卷 1011-1022页

作者： JUN-FENG ZHAO YI-ran JIANG TIAN-lin GUO YONG-QING JIAO XUN WANG Department of Neurointervention Center Dalian No.3 People’s HospitalDalian Medical UniversityDalianChina Department of Clinical Medicine China Medical UniversityShenyangChina

Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the neurons.They are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of neurons.As the global population ages rapidly,increased people are being diagnosed with neurodegenerative diseases.It has been established that the onset of Alzheimer’s disease(AD)is closely linked with increasing age and its major pathological features include amyloid-beta plaques(Aβ),Tau hyperphosphorylation,Neuroﬁbrillary tangles(NFTs),neuronal death as well as synaptic loss.The involvement of microglia is crucial in the pathogenesis and progression of AD and exhibits a dual role.For instance,in the early stage of AD,microglia surface membrane proteins or receptors can participate in immunophagocytosis,and anti-inﬂammatory functions and act as a physical barrier after recognizing various ligands such as Aβand NFTs.However,in the later stage of the disease,membrane receptors on the surface of microglia can cause its activation to release a substantial quantity of pro-inﬂammatory factors.Which can amplify the neuroinﬂammatory response.The rapid decline of normal immune phagocytosis can result in the continuous accumulation of abnormal proteins,leading to neuronal dysfunction and destruction of the formed physical barrier as well as the neurovascular microenvironment.It can also increase the transformation of microglia from anti-inﬂammatory phenotype M2 to pro-inﬂammatory phenotype M1,induce severe neuronal injury or apoptosis,and aggravate the progression of AD.Due to few articles have focused on the AD-related membrane protein receptors on microglia,thus in this paper,we have reviewed several representative microglial membrane proteins or receptors about their speciﬁc roles and functions implicated in AD,and expect that there will be more in-depth research and scientiﬁc research results in the treatment of AD by targeted regulation of microglia membrane protein receptors in the future

关键词： Neurodegeneration Glial cell Receptor Alzheimer’s disease

The Earth Summit Mission-2022:Successful ozone soundings contribute to source identification in the north Mt.Qomolangma region

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Journal of Environmental Sciences 2024年第2期136卷 412-421页

作者： Jinqiang Zhang Chunxiang Ye Yuejian Xuan Zhixuan Bai Weili lin Dan Li lingkun ran Baofeng Jiao YaomingMa Weiqiang Ma Nan Yao Yunshu Zeng Daren Lv Tong Zhu Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Environmental Sciences and Engineering Center for Environment and HealthPeking UniversityBeijing 100871China Key Laboratory of Ecology and Environment in Minority Areas(Minzu University of China) National Ethnic Affairs CommissionBeijing 100081China Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Land-Atmosphere Interaction and Its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemResources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan Electronic Engineering College Chengdu University of Information TechnologyChengdu 610225China

As part of“The Earth Summit Mission-2022”during the second Tibetan Plateau Scientific Expedition and Research(STEP)in April and May 2022,we conducted the ozone sounding experiment(an ozonesonde mated to a radiosonde)at Mt.Qomolangma Base Camp(MQBC;86.85°E,28.14°N;5200 m),a location at an extremely high altitude.A total of ten sounding profiles were obtained between April 30 and May 06,2022,of which seven profiles were above35 km in altitude,with a maximum detection altitude up to 39.0 km.This study presents the temporal variation and vertical distributions of atmospheric temperature,humidity,and ozone during the MQBC campaign.The averaged ozone concentration was high(68.3 ppbv)at the surface and then increased smoothly until peaking(~110 ppbv)in the middle troposphere(approximately 10 km),and afterward,the ozone concentration increased rapidly from the upper troposphere to a maximum of~10 ppmv at~30 km.The enhanced ozone concentration in the middle troposphere was associated with the blocking high pressure,and transport from the southern flank of the Himalayas occurred during the campaign period.The average total ozone column was 291.9±21.4 DU for the seven profiles exceeding 35km in altitude.The ozonesonde measurements were also compared with the vertical ozone profiles retrieved from the space-borne ozone products from the Microwave Limb Sounder(MLS)onboard the Aura satellite and the Atmospheric Infrared Sounder(AIRS)onboard the Aqua satellite.

关键词： Ozone soundings Mt.Qomolangma Vertical ozone structure Ozone source Satellite data

Delayed neurological dysfunction following posterior laminectomy with lateral mass screw fixation:A case report and review of literature

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World Journal of Clinical Cases 2024年第7期12卷 1356-1364页

作者： Rui-Zhong Yan Chao Chen Chu-ran lin Yan-Hui Wei Zhi-Jian Guo Ya-Kun Li Quan Zhang He-Yi Shen Hao-lin Sun Department of Orthopedics Taiyuan Central HospitalTaiyuan 030009Shanxi ProvinceChina Department of Orthopedics Graduate School Shanxi University of Traditional Chinese MedicineTaiyuan 030024Shanxi ProvinceChina Department of Orthopedics Peking University First HospitalBeijing 100034China

BACKGROUND While most complications of cervical surgery are reversible,some,such as symptomatic postoperative spinal epidural hematoma(SEH),which generally occurs within 24 h,are associated with increased morbidity and mortality.Delayed neurological dysfunction is diagnosed in cases when symptoms present>3 d postoperatively.Owing to its rarity,the risk factors for delayed neurological dysfunction are unclear.Consequently,this condition can result in irreversible neurological deficits and serious consequences.In this paper,we present a case of postoperative SEH that developed three days after hematoma evacuation.CASE SUMMARY A 68-year-old man with an American Spinal Injury Association(ASIA)grade C injury was admitted to our hospital with neck pain and tetraplegia following a fall.The C3-C7 posterior laminectomy and the lateral mass screw fixation surgery were performed on the tenth day.Postoperatively,the patient showed no changes in muscle strength or ASIA grade.The patient experienced neck pain and subcutaneous swelling on the third day postoperatively,his muscle strength decreased,and his ASIA score was grade A.Magnetic resonance imaging showed hypointense signals on T1 weighted image(T1WI)and T2WI located behind the epidural space,with spinal cord compression.Emergency surgical intervention for the hematoma was performed 12 h after onset.Although hypoproteinemia and pleural effusion did not improve in the perioperative period,the patient recovered to ASIA grade C on day 30 after surgery,and was transferred to a functional rehabilitation exercise unit.CONCLUSION This case shows that amelioration of low blood albumin and pleural effusion is an important aspect of the perioperative management of cervical surgery.Surgery to relieve the pressure on the spinal cord should be performed as soon as possible to decrease neurological disabilities.

关键词： Delayed postoperative spinal epidural hematoma Complications Spinal surgery Hypoproteinemia Risk factor Case report