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Effects of TYROBP Deficiency on Neuroinflammation of a Alzheimer’s Disease Mouse Model Carrying a PSEN1 p.G378E Mutation

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Chinese Medical Sciences Journal 2022年第4期37卷 320-330页

作者： Ran LI Zhanyun Lv Yanxin li Wei li Yanlei Hao School of Basic Medical Sciences Shandong UniversityJinan 250012China Zhejiang University Medical Center Hangzhou 311121China Department of Neurology Pingdu People’s HospitalQingdaoShandong 266799China Department of Neurology Affiliated Hospital of Jining Medical CollegeJiningShandong 272007China

Objective To study the effects of TYRO protein kinase-binding protein(TYROBP)deficiency on learning behavior,glia activation and pro-inflammatory cycokines,and Tau phosphorylation of a new Alzheimer’s disease(AD)mouse model carrying a PSEN1 p.G378E mutation.Methods A new AD mouse model carrying PSEN1 p.G378E mutation was built based on our previously found AD family which might be ascribed to the PSEN1 mutation,and then crossed with TYROBP deficient mice to produce the heterozygous hybrid mice(PSEN1^(G378E)/WT;Tyrobp^(+/-))and the homozygous hybrid mice(PSEN1^(G378E/G378E);Tyrobp^(-/-)).Water maze test was used to detect spatial learning and memory ability of mice.After the mice were sacrificed,the hippocampus was excised for further analysis.Immunofluorescence was used to identify the cell that expresses TYROBP and the number of microglia and astrocyte.Western blot was used to detect the expression levels of Tau and phosphorylated Tau(p-Tau),and EliSA to measure the levels of pro-inflammatory cytokines.Results Our results showed that TYROBP specifically expressed in the microglia of mouse hippocampus.Absence of TYROBP in PSEN1^(G378E) mutation mouse model prevented the deterioration of learning behavior,decreased the numbers of microglia and astrocytes,and the levels of interleukin-6,interleukin-1βand tumor necrosis factor-αin the hippocampus(all Plia and astrocyte activation,and release of pro-inflammatory cytokines,and p-Tau pathology needs further study.

关键词： TYRO protein kinase-binding protein PSEN1 p.G378E mutation Tau phosphorylation neuroinflammation microglia cells astrocytes Alzheimer's disease

Hawking radiation and page curves of the black holes in thermal environment

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Communications in Theoretical Physics 2021年第7期73卷 106-114页

作者： Ran LI Jin Wang School of Physics Henan Normal UniversityXinxiang 453007China Department of Chemistry SUNYStony BrookNY 11794United States of America Department of Chemistry and of Physics and Astronomy State University of New York at Stony BrookStony BrookNY 11794-3400United States of America

As realistic objects in the Universe,the black holes are surrounded by complex environment.By taking the effect of thermal environment into account,we investigate the evaporation process and the time evolutions(page curves)of the entanglement entropies of Hawking radiation of various types of black holes.It is found that the black holes with the thermal environments evaporate slower than those without the environments due to the environmental contribution of the energy flux in addition to Hawking radiation.For Schwarzschild black hole and Reissner-Nordstr?m black hole in flat spaces,when the initial temperature of the black hole is higher than the environment temperature,the black holes evaporate completely and the Hawking radiation is eventually purified.For Schwarzschild-Ad S black hole,it will evaporate completely and the Hawking radiation is purified when the environment temperature is lower than the critical temperature.Otherwise,it will reach an equilibrium state with the environment and the radiation is maximally entangled with the black hole.Our results indicate that the final state of the black hole is determined by the environmental temperature and the temporal evolution and the speed of the information purification process characterized by the page curve of the Hawking radiation is also influenced by the thermal environment significantly.

关键词： Hawking radiation page curve black hole thermal environment entanglement entropy

Acoustic Emission Recognition Based on a Three-Streams Neural Network with Attention

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Computer Systems Science & Engineering 2023年第9期46卷 2963-2974页

作者： Kang Xiaofeng Hu Kun Ran LI College of Information and Engineering Xuzhou University of TechnologyXuzhouJiangsu221000China College of Electrical and Power Engineering China University of Mining and TechnologyXuzhouJiangsu221116China Department of Electrical Electronic and Computer EngineeringUniversity of Western AustraliaPerthAustralia

Acoustic emission(AE)is a nondestructive real-time monitoring technology,which has been proven to be a valid way of monitoring dynamic damage to materials.The classification and recognition methods of the AE signals of the rotor are mostly focused on machine learning.Considering that the huge success of deep learning technologies,where the Recurrent Neural Network(RNN)has been widely applied to sequential classification tasks and Convolutional Neural Network(CNN)has been widely applied to image recognition tasks.A novel three-streams neural network(TSANN)model is proposed in this paper to deal with fault detection tasks.Based on residual connection and attention mechanism,each stream of the model is able to learn the most informative representation from Mel Frequency Cepstrum Coefficient(MFCC),Tempogram,and short-time Fourier transform(STFT)spectral respectively.Experimental results show that,in comparison with traditional classification methods and single-stream CNN networks,TSANN achieves the best overall performance and the classification error rate is reduced by up to 50%,which demonstrates the availability of the model proposed.

关键词： Convolutional neural network attention mechanism acoustic emission fault detection

A Class of m-Complex Symmetric Operators on Hardy Space

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Journal of Mathematical Research with Applications 2024年第1期44卷 63-80页

作者： Jia FU Xinmei li Ran LI School of Mathematics Liaoning Normal University

In this paper,we study the necessary and sufficient condition that the Toeplitz operators with respect to the conjugations of one permutation are 2-complex symmetric.Firstly,we introduce a class of conjugations called the conjugations of one permutations on the classical Hardy space.Secondly,Toeplitz operators are completely characterized as 2-complex symmetric structure under this class of conjugations.The matrix representation of Toeplitz operators in the classical regular orthogonal basis on Hardy space is used to describe this class of 2-complex symmetric Toeplitz operators.Finally,we add two preconditions fn=-f-nand fn=f-nrespectively to the Toeplitz operators,and we get more simplified results.Under the second condition,we study the 3-complex symmetry of Toeplitz operators,and we get the same result for Tfis a 3-CSO with the conjugation C((i,j)) and 2-CSO’s.

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Real-time GNSS precise point positioning with smartphones for vehicle navigation

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Satellite Navigation 2022年第3期3卷 140-161,I0004页

作者： Zishen li liang Wang Ningbo Wang Ran LI Ang liu Aerospace Information Research Institute(AIR) Chinese Academy of Sciences(CAS)Beijing100094China School of Electronic Electrical and Communicating EngineeringUniversity of Chinese Academy of Sciences19A Yuquan RoadShijingshan DistrictBeijing100049China

The availability of raw Global Navigation Satellite System(GNSS)measurements from Android smart devices gives new possibilities for precise positioning solutions,e.g.,Precise Point Positioning(PPP).However,the accuracy of the PPP with smart devices currently is a few meters due to the poor quality of the raw GNSS measurements in a kinematic scenario and in urban environments,particularly when the smart devices are placed inside vehicles.To promote the application of GNSS PPP for land vehicle navigation with smart devices,this contribution studies the real-time PPP with smartphones.For data quality analysis and positioning performance validation,two vehicle-based kinematic positioning tests were carried out using two Huawei Mate30 smartphones and two Huawei P40 smartphones with different installation modes:the vehicle-roof mode with smartphones mounted on the top roof outside the vehicle,and the dashboard mode with smartphones stabilized on the dashboard inside the vehicle.To realize high accuracy positioning,we proposed a real-time smartphone PPP method with the data processing strategies adapted for smart devices.Positioning results show that the real-time PPP can achieve the horizontal positioning accuracy of about 1–1.5 m in terms of root-mean-square and better than 2.5 m at the 95th percentile for the vehicle-based kinematic positioning with the experimental smartphones mounted on the dashboard inside the vehicle,which is the real scenario in vehicle navigation.

关键词： Global Navigation Satellite System Smartphone positioning Precise point positioning Raw GNSS measurements Land vehicle navigation

Shale gas transport in nanopores with mobile water films and water bridge

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Petroleum Science 2023年第2期20卷 1068-1076页

作者： Ran LI Zhangxin Chen Keliu Wu Jinze Xu Department of Chemical and Petroleum Engineering University of CalgaryCalgaryAlbertaT2N 1N4Canada State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China

Gas flow properties in nanopores are significantly determined by the flow patterns. Slug flow pattern is a potential water–gas two phase flow pattern, in which gas molecules flow in form of gas slugs and water molecules separate gas slugs. Considering water slippage, a portion of water molecules accumulates at the wall with lower mobility, while the remaining water molecules take the shape of a water bridge. Adopting foam apparent viscosity model to represent slug rheological behavior, how water bridge disturbs on gas flow capacity is estimated. The results are compared with the water–gas two phase flow model that assumes annular flow pattern as well as the single gas flow model without the consideration of water. The comparison illustrates that gas molecular movement is significantly hindered by flow space reduction and loss of gas slippage. The impact from water phase of slug flow pattern is more significant than that of annular flow pattern on gas flow capacity. It is discovered that larger nanopores improve gas flow capacity while maintaining bulk water layer thickness and increasing water bridge thickness tend to reduce gas transport ability. A better understanding of the structure and transport of water and gas molecules is conducive to figure out the specific gas–water flow behavior and predict shale gas production.

关键词： Shale gas Water bridge Water film Nanopore

Observed Vertical Structure of Precipitation over the Southeastern Tibetan Plateau in Summer 2021

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Journal of Meteorological Research 2023年第1期37卷 90-106页

作者： Gaili WANG Renran ZHOU Jingyi ZHANG Ran LI State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081

Mêdog County,with its mountains and valleys,is located in the southeastern Tibetan Plateau(TP)and at the lower reaches of the Yarlung Zangbo River.This area has the highest annual rainfall amount over the TP,and in situ measurements are very scarce due to frequent debris flows and transportation difficulties.A monitoring campaign focused on cloud and precipitation observations was established in Mêdog in 2019 as a part of the Second Tibetan Plateau Scientific Expedition and Research Program.This paper evaluates the accuracy of micro rain radar(MRR)measurements and investigates the variations in precipitation vertical structure in Mêdog using observations collected from the MRR,disdrometer,and rain gauges in summer 2021.The measurements from the three instruments show a strong consistency,with correlation coefficients exceeding 0.93.Although the profiles of integral rain parameters for different rain rate categories in Mêdog are similar to those in other regions,the vertical evolution of raindrop size distributions shows significant differences.For lightest rain,the evaporation of small raindrops and breakup of large raindrops are clear during their descent.For the rainfall rate category of 0.2–2.0 mm h−1(2.0–20.0 mm h−1),concentrations of small and medium(large)drops show almost uniform vertical structures,while the large(medium)drop number displays a positive(negative)gradient.A disturbance at height of 1.5–2.0 km above ground level(AGL)is observed in the heavy rainfall due to strong updrafts.In general,the MRR measurements in Mêdog are robust.The raindrop breakup process is more apparent in Mêdog than in other regions,resulting in high concentration of sizelimited raindrops.In addition,it is found that the interaction between steep terrain and Mêdog convective rain causes the strong updrafts between 1.5 and 2.0 km AGL.

关键词： precipitation vertical structure Tibetan Plateau raindrop size distribution(DSD) micro rain radar strong updraft

Translation and rotation of particles in different flow pattern areas of a silo

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Particuology 2023年第2期73卷 68-77页

作者： Ran LI Quan Chen Hongze li Wenzheng Xiu Vladimir Zivkovic Hui Yang School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai200093China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China School of Engineering Newcastle UniversityNE17RUUnited Kingdom

The present paper reports the results obtained for translational and rotational velocity profiles of spherical particles for the mixed flow in a conical silo.The discrete element method(DEM)based on Hertz-Mindlin(no slip)with RVD rolling friction contact model is used for simulations.Opposite correlations are found between translational and rotational velocities in different flow areas of the silo.In particular,the abrasion caused by rotation is dominant in the funnel flow area.In addition,increase of the mass flow rate of silo can effectively reduce the abrasion induced by rotation.This highlights that understanding of dynamic characteristics of particles is helpful for optimization of silos and reduction of granular material abrasion.

关键词： Translational velocity Rotational velocity Rolling contribution rate Mass flow index

End wall effect on particle motion in a chute flow

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Particuology 2021年第1期19卷 102-108页

作者： ran Wang Ran LI Shuaishuai Wang Quan Chen Hui Yang School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China

The influence of the end wall of a chute on the rotation of internal characteristic particles is mainly on the z-axis.A measurement device based on inertial measurement technology does not require the assistance of external information;hence,it is especially suitable for measuring the angular and translational velocities of internal characteristic particles.To study the influence of the end wall of the chute on the motions of the internal characteristic particles,the z-axis rotational and translational velocities of the internal characteristic particles in the chute were measured,and it was found that the rotational velocity about the z-axis differs according to the initial position.The z-axis angular velocity of a characteristic particle at the centre fluctuates near 0,and the average value approaches 0.The z-axis angular velocity of a characteristic particle at the left end wall is typically negative.This phenomenon is due to the influence of the end wall on the rotational motions of particles with initial positions that are near the end wall.In addition,the average translational velocity of the characteristic particles is also affected by the end wall.The distributions of the average z-axis angular velocity and the average translational velocity are quantitatively analysed,and the correlation between the tilt angle of the chute and the end wall effect is studied.

关键词： Chute Particle rotation End wall