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Atomic-scale strain analysis for advanced Si/SiGe heterostructure by using transmission electron microscopy

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Electron 2024年第2期2卷 29-52页

作者： Lan Li ran bi Zuoyuan Dong Changqing Ye Jing Xie Chaolun Wang Xiaomei Li Kin-Leong Pey Ming Li Xing Wu School of Integrated Circuits East China Normal UniversityShanghaiChina School of Integrated Circuits Peking UniversityBeijingChina Engineering Product Development Pillar Singapore University of Technology and DesignSingaporeSingapore

Three-dimensional stacked transistors based on Si/SiGe heterojunction are a potential candidate for future low-power and high-performance computing in integrated *** and accurately measuring strain in Si/SiGe heterojunctions is critical to increasing carrier mobility and improving device *** electron microscopy(TEM)with high spatial resolution and analytical capabilities provides technical support for atomic-scale strain measurement and promotes significant progress in strain mapping *** paper reviews atomic-scale strain analysis for advanced Si/SiGe heterostructure based on TEM ***-beam electron diffraction,nano-beam electron diffraction,dark-field electron holography,and high-resolution TEM with geometrical phase analysis,are comprehensively discussed in terms of spatial resolution,strain precision,field of view,reference position,and data ***,the advantages and critical issues of these strain analysis methods based on the TEM technique are sum-marized,and the future direction of TEM techniques in the related areas is prospected.

关键词： GPA heterostructure Si/SiGe strain transmission electron microscopy

援引科研资料磨砺科学思维——以“细胞器之间的分工合作”第2课时为例

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生物学教学 2024年第2期49卷 47-50页

作者：曹文竹沙汀毕然北京市怀柔区第一中学北京101400

援引gpa 3基因突变导致水稻减产的科研资料,设计挑战性的学习任务,驱动学生发现、分析和解决问题,揭示囊泡靶向液泡运输机制,发展学生基于证据进行逻辑推理的科学思维,建立“细胞各部分结构既分工又合作,共同执行细胞的各项生命活动”... 详细信息

援引gpa 3基因突变导致水稻减产的科研资料,设计挑战性的学习任务,驱动学生发现、分析和解决问题,揭示囊泡靶向液泡运输机制,发展学生基于证据进行逻辑推理的科学思维,建立“细胞各部分结构既分工又合作,共同执行细胞的各项生命活动”重要概念,并从生命的多样性与统一性视角审视动物细胞与植物细胞囊泡转运方向的异同。

关键词：科学思维科研情境囊泡转运高中生物学

液桥的动态界面特性对液-液自发渗吸的影响研究

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力学学报 2024年第4期56卷 1163-1177页

作者：张晟庭李靖陈掌星毕然强壮吴克柳王子怡中国石油大学(北京)油气资源与工程全国重点实验室北京102249 卡尔加里大学化学与石油工程系加拿大阿尔伯塔T2N1N4 中国石油勘探开发研究院北京100083

在自然界和工业应用中,多孔介质中的多相流动现象普遍存在,如地下水流动、油气开采、非饱和颗粒材料等.在这些过程中,液桥的存在对多相流动产生显著影响.基于改进的液-液自发渗吸理论模型及改进流-固作用力格式的两组分Shan-Chen模型,... 详细信息

在自然界和工业应用中,多孔介质中的多相流动现象普遍存在,如地下水流动、油气开采、非饱和颗粒材料等.在这些过程中,液桥的存在对多相流动产生显著影响.基于改进的液-液自发渗吸理论模型及改进流-固作用力格式的两组分Shan-Chen模型,研究了液桥的存在对毛细管内液-液自发渗吸的影响.结果表明:与不含液桥的渗吸过程相比,液桥的存在使得毛细管内产生3个界面,显著增大了系统的动态接触角,降低自发渗吸速度.随着润湿性的增强,液桥的存在使得界面动态变化特性增强的幅度更大.当液桥的黏度小于非润湿流体的黏度时,整个系统的动态接触角随着渗吸长度的增加而增强;若二者黏度相等,整个系统的动态接触角为一稳定值;而当液桥的黏度更大时,整个系统的动态接触角随着渗吸的进行逐渐减小.将模拟获得的实时动态接触角纳入至渗吸理论中,可以改善由液桥界面动态变化导致的渗吸长度的理论值与模拟结果间存在的偏差,并得到与模拟基本一致的结果.文章还利用模拟数据,系统地评价了Cox-Voinov模型对含有液桥以及不含液桥体系的渗吸过程中的界面动态变化特性及渗吸长度预测能力.

关键词：液-液自发渗吸格子Boltzmann方法液桥动态接触角两相流

High yield synthesis of nigerooligosaccharides by transglycosylation catalyzed by α-glucosidase TaAglA from Thermoplasma acidophilum

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Food bioscience 2022年第3期47卷 245-252页

作者： Wei Xia Yifan Wang ran bi Jing Wu State Key Laboratory of Food Science and Technology Jiangnan University1800 Lihu AvenueWuxi214122China School of biotechnology and Key Laboratory of Industrial biotechnology Ministry of Education Jiangnan University1800 Lihu AvenueWuxi214122China International Joint Laboratory on Food Safety Jiangnan University1800 Lihu AvenueWuxi214122China

Nigerooligosaccharides (NOS) is a new functional oligosaccharide containing α-1,3 glucosidic bond with good anti-digestive properties and intestinal *** catalyzed by α-glucosidase is an effective method for the preparation of ***,there are few reports on the enzymatic synthesis of nigerooligosaccharides by α-glucosidase at *** study was aimed to investigate the transglycosylation property of the GH31 α-glucosidase from Thermoplasma acidophilum,TaAglA,and also evaluate its application performance in the preparation of *** was found that TaAglA exhibited selectivity for α-1,3 and α-1,4 linkages when catalyzing hydrolysis,but for α-1,3 and α-1,6 linkages when catalyzing *** 10% glucose and 20% maltose as substrates,TaAglA yielded 88.5 g/L NOS under the condition of pH 6.0,80 ℃ and 1 U/mL enzyme addition,which was the highest level to our *** addition,components with higher polymerization degrees,*** and nigerosyl-glucose,occupied 53.6% proportion of the total NOS products,giving it better probiotic ***,after purification by glucoamylase digestion and yeast culture,the final yield of NOS was 26.1%,and the purity of the product was 93%.These findings on TaAglA were expected to provide a new candidate for large-scale enzymatic synthesis of NOS,and also have important theoretical significance for the study of GH31 α-glucosidase.

关键词： Nigerooligosaccharides α-glucosidase α-1,3 glucosidic bond Enzymatic synthesis Transglycosylation

Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF-κB and PI3K/AKT Signaling In Vitro and In Vivo

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Chinese Journal of Integrative Medicine 2022年第4期28卷 349-356页

作者： XUAN Lei HU Jing-hai bi ran LIU Si-qi WANG Chun-xi Department of Urology the First Hospital of Jilin UniversityChangchun130021China

Objective:To explore the influences of andrographolide(Andro)on bladder cancer cell lines and a tumor xenograft mouse model bearing 5637 ***:For in vitro experiments,T24 cells were stimulated with Andro(0-40μmol/L)and 5637 cells were stimulated with Andro(0 to 80μmol/L).Cell growth,migration,and infiltration were assessed using cel counting kit-8,colony formation,wound healing,and transwel *** rate was examined using flow *** in vivo study,the antitumor effect of Andro(10 mg/kg)was evaluated by 5637 tumor-bearing mice,and levels of nuclear factorκB(NF-κB)and phosphoinositide 3-kinase/AKT related-proteins were determined by ***:Andro suppressed growth,migration,and infiltraion of bladder cancer cells(P 0.05or P 0.01).Additionally,Andro induced intrinsic mitochondria-dependent apoptosis in bladder cancer cell ***,Andro inhibited bladder cancer growth in mice(P 0.01).The expression of p65,p-AKT were suppressed by Andro treatment in vitro and in vivo(P 0.05 or P 0.01).Conclusions:Andrographolide inhibits proliferation and promotes apoptosis in bladder cancer cel s by interfering with NF-κB and PI3K/AKT signaling in vitro and in vivo.

关键词： andrographolide Chinese medicine bladder cancer nuclear factorκB PI3K-AKT

超音速火焰喷涂铁基非晶纳米晶涂层的工艺参数与性能试验

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工程科学学报 2024年第5期46卷 844-852页

作者：毕然董安平孙益民马静娴王德成中国机械科学研究总院北京100044 上海交通大学材料科学与工程学院上海200240 安徽师范大学化学与材料科学学院芜湖241000

为了进一步深入研究铁基非晶涂层的制备和性能,利用人工神经网络和多因素多水平设计对超音速火焰喷涂技术制备的铁基非晶纳米晶涂层的工艺参数和性能进行了优化,以期对铁基非晶涂层的实际应用提供参考.多因素多水平试验通过设计分析方... 详细信息

为了进一步深入研究铁基非晶涂层的制备和性能,利用人工神经网络和多因素多水平设计对超音速火焰喷涂技术制备的铁基非晶纳米晶涂层的工艺参数和性能进行了优化,以期对铁基非晶涂层的实际应用提供参考.多因素多水平试验通过设计分析方法和设计实验参数,建立神经网络模型,研究了煤油量、氧气量、送粉率和喷涂距离四项工艺参数对涂层孔隙率、硬度、结合强度和沉积效率的影响规律.采用扫描电镜、透射电镜等手段表征了粉末及涂层的显微结构和内部微观组织形貌;采用X射线衍射仪、同步热分析仪等设备对粉末和涂层成分、相组成和非晶程度进行了观察分析.验证了工艺参数优化过程的计算机模拟结果,确定了最佳喷涂工艺参数范围,进一步提升了涂层的性能.讨论了喷涂过程中孔隙形成的微观过程和非晶纳米晶对涂层性能的影响机理.研究表明各工艺参数对涂层性能是多因素互相影响的,理论上最佳喷涂工艺参数为煤油量23 L·h^(-1)、氧气量51 L·h^(-1)、送粉率72 g·min^(-1)、喷涂距离280 mm,制备出的铁基非晶涂层厚度约为270μm、孔隙率约为1.3%、结合强度约为84 MPa、硬度约为1110 HV_(0.3).涂层非晶程度在80%左右,纳米晶尺寸为3~5 nm,涂层在600℃以下不会发生晶化过程.

关键词：超音速火焰喷涂多因素多水平试验设计方法神经网络喷涂工艺参数铁基非晶纳米晶

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寒冷地区高效热泵空调压缩机预热技术的研究

制冷与空调 2024年第1期24卷 56-61页

作者：刘文龙龙谭徐云松毕然胡斌广东美的制冷设备有限公司佛山市顺德区美的电子科技有限公司

随着热泵取暖逐渐流行,尤其是在寒冷地区,热泵取暖可以有效改善环境,提高制热效率。文章讨论了压缩机系统中经常出现的预热功率不足的问题,通过分解压缩机电机加热方式的功率组成,对预热有效功率进行分析,提出了高频注入涡流加热的方式... 详细信息

随着热泵取暖逐渐流行,尤其是在寒冷地区,热泵取暖可以有效改善环境,提高制热效率。文章讨论了压缩机系统中经常出现的预热功率不足的问题,通过分解压缩机电机加热方式的功率组成,对预热有效功率进行分析,提出了高频注入涡流加热的方式。经过数值分析、仿真分析和试验验证,压缩机电机加热效果可以通过提高注入频率和增加涡流功率来提升,从原有的加热的28W到利用电机加热实现0~75W可控调节。同时,可控电加热也可以用于改善热泵空调在寒冷地区的全季节能效。

关键词：热泵预热压缩机系统涡流加热

Formation mechanism of Fe-based amorphous powders produced by spark erosion

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Journal of Materials Science & Technology 2024年第3期170卷 33-46页

作者： Chekai Liu ran Li Jiazi bi Ding Ma Xiaobin Liu Tao Zhang School of Materials Science and Engineering Key Laboratory of Aerospace Materials and Performance(Ministry of Education)Beihang UniversityBeijing 100191China

Spark erosion is a convenient,flexible,and low-cost method to quickly produce fine powders of metals,alloys,and semiconductors in size ranging from nearly a hundred micrometers to submicrometer by repetitive spark *** to the complexity of the powder-forming journey,normally accompanied by high temperature,high pressure,decomposition,diffusion and rapid quenching caused by discharge plasma,the mechanisms of powder formation and possible contaminant infiltration are still controversial,posing a significant challenge to control particle size and chemical composition of the powder produced by this *** this study,Fe-based amorphous powders in different particle-size distributions with high sphericity were fabricated by spark erosion under different discharge-energy *** max-imum particle size of the resultant powders can be correlated with discharge parameters,crater depth,and crater radius,respectively.A multi-ring-breakup model is proposed to reveal the particle-size distribution of the powder formed from the electrode melt under a single-pulse ***,a dielectric-element infiltration model is provided to quantitatively evaluate the infiltration mass ratio of the contaminant elements,stemming from the decomposed products of dielectric liquid,in the resultant powder with different particle *** models verified through the experimental data are significant for the development of high-performance fine Fe-based amorphous powder with controlled particle size and chemical composition.

关键词： Amorphous alloy Particle Spark erosion Infiltration Modeling

ERAS理念在老年脊柱手术患者围术期中的应用研究

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中国伤残医学 2024年第1期32卷 22-25,35页

作者：王杰毕然冷辉李佳峰李宝妤赵松岩赤峰市医院内蒙古赤峰024000

目的:本研究立足于加速康复理念,通过制定综合性、连续性、全面性的脊柱外科手术围术期患者管理方案,探讨其应用效果。方法:通过组建MDT团队,制订加速康复方案,选取2019年6月—2022年5月赤峰市医院脊柱外科收治的244例老年脊柱手术患者... 详细信息

目的:本研究立足于加速康复理念,通过制定综合性、连续性、全面性的脊柱外科手术围术期患者管理方案,探讨其应用效果。方法:通过组建MDT团队,制订加速康复方案,选取2019年6月—2022年5月赤峰市医院脊柱外科收治的244例老年脊柱手术患者为研究对象,按手术方式分为4组:腰椎后路短节段内固定减压术组对照组、腰椎后路短节段内固定减压术组ERAS组、经皮椎体成形术(PVP)/椎体后凸成形术(PKP)组对照组、PVP/PKP组ERAS组。探讨不同手术方式的老年脊柱患者围术期的管理效果。结果:腰椎后路短节段内固定减压术组ERAS组住院时间、首次下地时间均短于腰椎后路短节段内固定减压术组对照组,住院费用少于腰椎后路短节段内固定组对照组,组间差异有统计学意义(P<0.05);PVP/PKP组ERAS组住院时间、首次下地时间均短于PVP/PKP组对照组,组间差异有统计学意义(P<0.05)。腰椎后路短节段内固定减压术组ERAS组腹胀、便秘、感染、心脑血管疾病、深静脉血栓(VTE)发生率低于腰椎后路短节段内固定减压术组对照组,差异有统计学意义(P<0.05);PVP/PKP组ERAS组腹胀、便秘、VTE发生率均低于PVP/PKP组对照组,组间差异有统计学意义(P<0.05)。结论:在老年脊柱手术患者围术期中应用ERAS理念,可以加快患者康复速度,缩短平均住院时间,减少住院费用,降低患者围术期的各种并发症,提高患者围术期舒适度。

关键词： ERAS理念加速康复外科老年患者脊柱手术围术期康复疗效