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Artificial intelligence for characterization of diminutive colorectal polyps:A feasibility study comparing two computer-aided diagnosis systems

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第1期5卷 11-22页

作者： Quirine Eunice Wennie van der Zander ramon m schreuder Ayla Thijssen Carolus H J Kusters Nikoo Dehghani Thom Scheeve Bjorn Winkens mirjam C m van der Ende-van Loon Peter H N de With Fons van der Sommen Ad A m masclee Erik J Schoon Department of Gastroenterology and Hepatology Maastricht University Medical CenterMaastricht 6202 AZNetherlands GROW School for Oncology and ReproductionMaastricht UniversityMaastricht 6200 MDNetherlands Division of Gastroenterology and Hepatology Catharina Hospital EindhovenEindhoven 5602 ZANetherlands Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBNetherlands Department of methodology and Statistics Maastricht UniversityPostbus 6166200 MD MaastrichtNetherlands School for Public Health and Primary Care Maastricht UniversityMaastricht 6200 MDNetherlands

BACKGROUND Artificial intelligence(AI)has potential in the optical diagnosis of colorectal *** To evaluate the feasibility of the real-time use of the computer-aided diagnosis system(CADx)AI for ColoRectal Polyps(AI4CRP)for the optical diagnosis of diminutive colorectal polyps and to compare the performance with CAD EYE^(Tm)(Fujifilm,Tokyo,Japan).CADx influence on the optical diagnosis of an expert endoscopist was also *** AI4CRP was developed in-house and CAD EYE was proprietary software provided by *** CADxsystems exploit convolutional neural *** polyps were characterized as benign or premalignant and histopathology was used as gold ***4CRP provided an objective assessment of its characterization by presenting a calibrated confidence characterization value(range 0.0-1.0).A predefined cut-off value of 0.6 was set with valuesmalignant colorectal *** confidence characterizations were defined as values 40%around the cut-off value of 0.6(0.76).Self-critical AI4CRP’s diagnostic performances excluded low confidence *** AI4CRP use was feasible and performed on 30 patients with 51 colorectal ***-critical AI4CRP,excluding 14 low confidence characterizations[27.5%(14/51)],had a diagnostic accuracy of 89.2%,sensitivity of 89.7%,and specificity of 87.5%,which was higher compared to *** EYE had a 83.7%diagnostic accuracy,74.2%sensitivity,and 100.0%*** performances of the endoscopist alone(before AI)increased nonsignificantly after reviewing the CADx characterizations of both AI4CRP and CAD EYE(AI-assisted endoscopist).Diagnostic performances of the AI-assisted endoscopist were higher compared to both CADx-systems,except for specificity for which CAD EYE performed *** Real-time use of AI4CRP was *** confidence values provided by a CADx is novel and self-critical AI4CRP sho

关键词： Artificial intelligence Colorectal polyp characterization Computer aided diagnosis Diminutive colorectal polyps Optical diagnosis Self-critical artificial intelligence

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Beyond cotton and polyester: An evaluation of emerging feedstocks and conversion methods for the future of fashion industry

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Journal of Bioresources and Bioproducts 2024年第2期9卷 130-159页

作者： Ryen m.Frazier Keren A.Vivas Ivana Azuaje ramon Vera Alonzo Pifano Naycari Forfora Hasan Jameel Ericka Ford Joel J.Pawlak Richard Venditti Ronalds Gonzalez Department of Forest Biomaterials North Carolina State UniversityRaleighNC 27695USA Department of Textile Engineering Chemistry and ScienceThe Nonwovens InstituteNorth Carolina State UniversityRaleighNC 27695USA

As the global population grows,the demand for textiles is increasing ***,this puts immense pressure on manufacturers to produce more *** synthetic fibers can be pro-duced cheaply,they have a negative impact on the *** the other hand,fibers from wool,sisal,fique,wood pulp(viscose),and man-made cellulose fibers(mmCFs)from cotton can-not alone meet the growing fiber demand without major stresses on land,water,and existing markets using these *** a greater emphasis on transparency and circular economy practices,there is a need to consider natural non-wood alternative sources for mmCFs to supple-ment other fiber ***,introducing new feedstocks with different compositions may require different biomass conversion ***,based on existing work,this review ad-dresses the technical feasibility of various alternative feedstocks for conversion to textile-grade ***,alternative feedstocks are introduced,and then conventional(dissolving pulp)and emerging(fibrillated cellulose and recycled material)conversion technologies are evaluated to help select the most suitable and promising processes for these emerging alternative sources of *** is important to note that for alternative feedstocks to be adopted on a meaningful scale,high biomass availability and proximity of conversion facilities are critical *** North America,soybean,wheat,rice,sorghum,and sugarcane residues are widely available and most suitable for conventional conversion through various dissolving pulp production methods(pre-hydrolysis kraft,acid sulfite,soda,SO2-ethanol-water,and potassium hydroxide)or by emerging cellulose fibrillation *** dissolving pulp conversion is well-established,fibrillated cel-lulose methods could be beneficial from cost,efficiency,and environmental ***,the authors strongly encourage more work in this growing research ***,conducting thorough cost and sustainability assessment

关键词： Non-wood Residue Regenerated cellulose Dissolving pulp man-made cellulose fiber Apparel textile

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microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Casta?er ramon Estruch Emili Ros Rosa m.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition Service， Institut d'Investigacions Biomèdiques August Pi i Sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， Institut Hospital del mar de Investigaciones médicas (ImIm) Department of Preventive medicine and Public Health， University of Navarra Departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXII Department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain Department of Internal medicine， Hospital Clinic， Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS)， University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)， Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (mPm) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDImED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary mPm (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and mPm， and a score was calculated as the weighted sum of mPm. A higher mPm score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-mPm was associated with better frontal cognitive performance in an older mediterranean population.

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Occult hepatitis B virus infection:A complex entity with relevant clinical implications

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World Journal of Gastroenterology 2011年第12期17卷 1529-1530页

作者： Juan-ramon Larrubia Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Occult hepatitis B virus(HBV) infection is a world-wide entity,following the geographical distribution of detectable hepatitis *** entity is defined as the persistence of viral genomes in the liver tissue and in some instances also in the serum,associated to negative HBV surface antigen *** molecular basis of the occult infection is related to the life cycle of HBV,which produces a covalently closed circular DNA that persists in the cell nuclei as an episome,and serves as a template for gene *** mechanism responsible for the HBsAg negative status in occult HBV carriers is a strong suppression of viral replication,probably due to the host’s immune response,co-infection with other infectious agents and epigenetic *** is emerging evidence of the potential clinical relevance of occult HBV infection,since this could be involved in occult HBV transmission through orthotopic liver transplant and blood transfusion,reactivation of HBV infection during immunosuppression,impairing chronic liver disease outcome and acting as a risk factor for hepatocellular *** it is important to bear in mind this entity in cryptogenetic liver diseases,hepatitis C virus/ HIV infected patients and immunosupressed *** is also necessary to increase our knowledge in this fascinating field to define better strategies to diagnose and treat this infection.

关键词： Hepatitis B virus Occult infection Persistent infection

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía m.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.m.meziani J.m.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y materia Estructurada(LUmES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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machine learning-based zero-touch network and service management:a survey

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Digital Communications and Networks 2022年第2期8卷 105-123页

作者： Jorge Gallego-madrid ramon Sanchez-Iborra Pedro m.Ruiz Antonio F.Skarmeta Department of Information and Communication Engineering University of Murcia30100MurciaSpain Department of Engineering and Applied Techniques University Center of Defense30729San Javier Air Force BaseSpain

The exponential growth of mobile applications and services during the last years has challenged the existing network ***,the arrival of multiple management solutions to cope with this explosion along the end-to-end network chain has increased the complexity in the coordinated orchestration of different segments composing the whole *** Zero-touch Network and Service management(ZSm)concept has recently emerged to automatically orchestrate and manage network resources while assuring the Quality of Experience(QoE)demanded by *** Learning(mL)is one of the key enabling technologies that many ZSm frameworks are adopting to bring intelligent decision making to the network management *** paper presents a comprehensive survey of the state-of-the-art application of mL-based techniques to improve ZSm *** this end,the main related standardization activities and the aligned international projects and research efforts are deeply *** this dissection,the skyrocketing growth of the ZSm paradigm can be ***,different standardization bodies have already designed reference architectures to set the foundations of novel automatic network management functions and resource *** with these advances,diverse mL techniques are being currently exploited to build further ZSm developments in different aspects,including multi-tenancy management,traffic monitoring,and architecture coordination,among ***,different challenges,such as the complexity,scalability,and security of mL mechanisms,are also identified,and future research guidelines are provided to accomplish a firm development of the ZSm ecosystem.

关键词： Zero-touch network and service management(ZSm) Next generation networks(NGN) Artificial intelligence(AI) machine learning(mL)

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Dothiorella vidmadera, a novel species from grapevines in Australia and notes on Spencermartinsia

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Fungal Diversity 2013年第4期61卷 209-219页

作者： Wayne m.Pitt Jose ramonÚrbez-Torres Florent P.Trouillas National Wine and Grape Industry Centre School of Agricultural and Wine SciencesCharles Sturt UniversityLocked Bag 588Wagga WaggaNSW 2678Australia Pacific Agri-Food Research Centre 4200 Highway 97Box 5000SummerlandBC V0H1Z0Canada Department of Plant Pathology University of CaliforniaDavisCA 95616USA

Strains of a coelomycete isolated from grapevine cankers in southeastern Australia and identified as Dothiorella iberica in previous studies are redescribed in this study as a novel species based on morphological characters and phylogenetic analyses of DNA sequences of the internal transcribed spacer region(ITS1-5.8S-ITS2),and partial sequences of the translation elongation factor 1-αandβ-tubulin *** vidmadera *** most closely related to ***,*** and ***,but differs in morphological characters and DNA *** four species are known to be associated with Botryosphaeria dieback of ***,an unidentified ascomycete isolated from dead wood of grapevines in Western Australia is ***,strains were most closely related to Spencermartinsia viticola,and bore conidia with morphological characters and dimensions consistent with published ***,ascospores were shorter and narrower than previously reported and lacked the terminal apiculi that typify the genus.

关键词： Botryosphaeriaceae Grapevine trunk diseases Grapevine canker multigene phylogeny Taxonomy

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Tumor organoids to study gastroesophageal cancer: a primer

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Journal of molecular Cell Biology 2020年第8期12卷 593-606页

作者： ramon U.Jin Jason C.mills Division of Oncology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63130USA Division of Gastroenterology Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63130USA Department of Developmental Biology Washington University School of MedicineSt.LouisMO 63130USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63130USA

Gastroesophageal cancers are leading causes of cancer *** attempts at adopting molecularly based treatment approaches have been slow and ineffective even though we begin to identify specific targetable gene mutations and *** is dear that we should no longer treat all gastroesophageal cancers as a homogeneous disease,which is what we do when we use nonspecific ***,we currently cannot monitor successful gene/pathway targeting,nor understand how/when tumors develop resistance,nor predict which patients will derive maximal *** improve outcomes,we must precisely detail the heterogeneity of these tumors to then individualize cancer therapy as well as develop novel avenues to study and predict treatment effects in individual *** this end,patient-derived organoids,in which tumor cells from individual patients are grown in a Petri dish,are a new versatile system that allows for timely expandability,detailed molecular characterization,and genetic manipulation with the promise of enabling predictive assessment of treatment *** this review,we will explore the development and basic techniques for organoid generation,and discuss the current and potential future applications of this exciting technology to study the basic science of carcinogenesis and to predict/guide cancer patient care in the clinics.

关键词： targeted therapy precision oncology cancer model tumor heterogeneity cancer evolution personalized medicine

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Photoluminescent Tb^(3+)-based metal-organic framework as a sensor for detection of methanol in ethanol fuel

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Journal of Rare Earths 2019年第3期37卷 225-231页

作者： ramon R.F.Fonseca Rafael D.L.Gaspar Ivo m.Raimundo Jr. Priscilla P.Luz Department of Chemistry Federal University of Espírito Santo Institute of Chemistry University of Campinas

The sensing capability of a Tb^(3+)-metal-organic framework, based on its photoluminescence, was used for detection of methanol in ethanol fuel. It was synthesized using terbium and trimesic acid as a metal ion center and ligand, respectively. Powder X-ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy were employed to characterize the synthesized mOF-76 structural features. According to the results, mOF-76 was successfully obtained with minor synthetic modification and its activated form(named TbTmA) was tested as a sensor for methanol. Tb^(3+) luminescence intensity increases as the methanol concentration in ethanol fuel also increases and the water content does not affect this response. Our findings indicate TbTmA as an appropriate sensor for evaluating ethanol fuel adulteration by methanol addition above the allowed limit.

关键词： Lanthanide metal-organic frameworks Luminescence Ethanol fuel Sensor Adulteration

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Systematic mechanism-orientated approach to chronic pancreatitis pain

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World Journal of Gastroenterology 2015年第1期21卷 47-59页

作者： Stefan AW Bouwense marjan de Vries Luuk TW schreuder Soren S Olesen Jens B Frokjær Asbjorn m Drewes Harry van Goor Oliver HG Wilder-Smith Pain and Nociception Neuroscience Research Group Department of SurgeryRadboud University Medical Center6500HB GelderlandThe Netherlands Department of Gastroenterology and Hepatology and Clinical medicine Aalborg University Hospital9100 AalborgDenmark Center for Sensory-motor Interaction Department of Health Science and TechnologyAalborg University9100 AalborgDenmark Department of Anaesthesiology Pain and Palliative MedicineRadboud University Medical Center6500HB GelderlandThe Netherlands

Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar *** causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic ***,CP pain continues to be a major clinical *** is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain *** this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically *** central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance *** techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain *** present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms *** research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and *** we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders.

关键词： Chronic pancreatitis Pain Pain treatment Central sensitization Quantitative sensory testing Electroencephalograpy magnetic resonance imaging

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