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Comparison of protein concentrations in serum versus plasma from Alzheimer’s patients

Advances in Alzheimer's Disease 2012年第3期1卷 51-58页

作者： Ryan M. Huebinger Guanghua Xiao Kirk C. Wilhelmsen ramon diaz-arrastia Fan Zhang Sid E. O'Bryant Robert C. Barber Center for Neuroscience and Regenerative Medicine Uniformed Services University of the Health Sciences Bethesda USA Department of Academic and Institutional Resources and Technology University of North Texas Health Science Center Fort Worth USA Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas USA Department of Internal Medicine University of North Texas Health Science Center Fort Worth USA Departments of Genetics and Neurology The Carolina Center for Genome Sciences and the Bowles Center for Alcohol Studies University of North Carolina Chapel Hill USA Institute for Aging and Alzheimer’s Disease Research University of North Texas Health Science Center Fort Worth USA

Background: There is great interest in developing blood-based biomarkers for Alzheimer’s disease (AD);however, there is no consensus as to what blood fraction is most appropriate for analyzing particular markers. The current study provides empirical evidence regarding how blood-based proteins vary depending on whether they are assayed in serum or plasma. Methods: Weanalyzed concentrations of 100 proteins in matched samples of serum and plasma from 39 Caucasian AD participants from the Texas Alzheimer’s Research and Care Consortium bymultiplex immunoassay. Results: Concentrations of 40 proteins were highly correlated (r2≥ 0.75) between plasma and serum while the remaining proteins were moderately to weakly correlated (r2< 0.75). Discussion: Whether plasma vs. serum is assayed can have a large impact on the observed concentration of some proteins, including several proteins that are of great interest to AD pathophysiology. The current findings may explain the significant discrepancies often times reported in the AD biomarker field.

关键词： Alzheimer’s Disease Serum Proteins Plasma Proteins

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Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 161-163页

作者： Tuenchit Khammapirad Jenjeera Prueksadee Concepcion diaz-arrastia Shaleen K Botting Morton Leonard Louisea Bonoan-Deomampo Mahmoud A Eltorky Department of Radiology University of Texas Medical Branch at Galveston Department of Radiology King Chulalongkorn Memorial HospitalFaculty of MedicineChulalongkorn University Department of Obstertric-Gynecology University of Texas Medical Branch at Galveston Department of Pathology University of Texas Medical Branch at Galveston

We reported a case of an African American woman who went to the hospital with palpable right breast lump with bloody nipple discharge at University of Texas Medical Brand at Galvestion. The modalities of breast imagings included mammography and *** method used for viral identification was Linear Array HPV genotyping test Intraductal papilloma revealed as high density tubular or rounded lobular masses with partially circumscribed,obscured margins and clustered punctate microcalcifications on *** showed as intraductal masses with dilated *** core biopsy demonstrated duct filled with papillary lesion and post excision revealed intraductal *** DNA types 16,33,58 and 71 were detected after use of Linear Array HPV genotyping test.

关键词： Human papilloma virus Preoncogenic gene Breast cancer Mammography Ultrasound

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