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Flow-based queue management for fairness control in high-bandwidth network

Science China(Information Sciences) 2016年第6期59卷 261-263页

作者： Wonjun CHOI ramneek sekhon Woojin SEOK Department of Science and Technology Information Science Korea University of Science & Technology Department of Advanced KREONET Application Support Korea Institute of Science and Technology Information

Dear editor,With the development of information equipment and growth of broadband network,the progress of Internet has changed from the network with modem speed in the past to the *** essential problem in the use of the network in a variety of fields is to use the network resource efficiently distributing the limited bandwidth[1].If congestion occurs in high-bandwidth network,slow rate flow and fast rate flow will experience

关键词： Flow-based queue management for fairness control in high-bandwidth network high

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Silver Dopant-Induced Effect on Structural and Optoelectronic Properties of CdSe Thin Films

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Acta Metallurgica Sinica(English Letters) 2019年第5期32卷 541-549页

作者： Jagdish Kaur ramneek Kaur S.K.Tripathi PG Department of Physics DAV College Department of Physics Akal University Department of Physics Panjab University

Thin films of CdSe and silver(Ag)-doped CdSe have been prepared on glass substrates by thermal evaporation in argon gas atmosphere. X-ray diffraction pattern indicates the presence of hexagonal structure with preferred orientation along (100) plane. Elemental composition of the thin films has been analyzed using energy dispersive X-ray analysis. Scanning electron microscopy has been used to investigate the morphology of the thin films. Transmission electron microscope reveals spherical nature of nanoparticles. A decrease in the band gap due to the formation of band tails in the band gap with increase in Ag doping in CdSe lattice has been observed. Photoluminescence spectra indicate redshift in band edge emission peak with increase in Ag doping in CdSe. Electrical conductivity measurements are also studied, and two types of conduction mechanisms taking part in the transport phenomena are observed. Hall measurements indicate n-type behavior of undoped and Ag-doped CdSe thin films.

关键词： Semiconductors Thin films Vapor deposition Electron microscopy Electrical properties

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Handmade cloning:recent advances,potential and pitfalls

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Journal of Animal Science and Biotechnology 2015年第4期6卷 378-387页

作者： Geetika Verma JS Arora RS Sethi CS Mukhopadhyay ramneek Verma School of Animal Biotechnology Post Graduate Institute of Veterinary Education and ResearchGuru Angad Dev Veterinary and Animal Sciences University

Handmade cloning （HMC） is the most awaited, simple and micromanipulator-ffee version of somatic cell nuclear transfer （SCNT）. The requirement of expensive micromanipulators and skilled expertise is eliminated in this technique, proving it as a major revolution in the field of embryology. During the past years, many modifications have been incorporated in this technique to boost its efficiency. This alternative approach to micromanipulator based traditional cloning O-C） works wonder in generating comparable or even higher birth rates in addition to declining costs drastically and enabling cryopreservation. This technique is not only applicable to intraspecies nuclear transfer but also to interspecies nuclear transfer （iSCNT） thus permitting conservation of endangered species. It also offers unique possibilities for automation of SCNT which aims at production of transgenic animals that can cure certain human diseases by producing therapeutics hence, providing a healthier future for the wellbeing of humans. The present review aims at highlighting certain aspects of HMC including recent advancements in procedure and factors involved in elevating its efficiency besides covering the potentials and pitfalls of this technique

关键词： Handmade cloning Micromanipulator Somatic cell nuclear transfer Transgenic Zona free cloning

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Coronary Physiology in the Management of CAD Patients: Position Paper Regarding the Current Scenario in India

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World Journal of Cardiovascular Diseases 2023年第11期13卷 795-810页

作者： Sridhar Kasturi ramneek Kaur Manish Narang Surinder Kher Department of Cardiology Sunshine Heart Institute Secunderabad Hyderabad India Department of Medical Affairs Abbott Vascular Abbott Healthcare Pvt Ltd. Delhi India Asia Pacific & Japan Department of Medical Affairs Abbott Vascular Abbott Healthcare Pvt Ltd. Delhi India Independent Clinical Research Professional Bangalore India

Fractional flow reserve (FFR), a physiology-based diagnostic method, has emerged as an important decision-making tool in determining the borderline or intermediate coronary lesions requiring revascularization. As per the guidelines recommended by European and American cardiology associations, functional assessment of indeterminate lesions is to be considered strongly prior to PCI. However, in India, FFR continues to be a much-underutilized tool due to limited facilities, and many times, physicians are reluctant to advise FFR because of its time-consuming nature with additional cost implications of simple diagnostic tests. Notably, for stenoses ranging between 50% - 70% where the choice between revascularization and medication becomes ambiguous, FFR provides invaluable insight. Without such guidance, there is a risk of improper decisions and strategies while planning revascularization procedures, which might adversely influence clinical outcomes, escalation of the cost due to unnecessary procedures, and prolonged hospitalization as a result of simple vs complex procedures. Landmark studies have validated the efficacy of FFR in enhancing outcomes in coronary artery disease (CAD) patients, especially when paired with a coronary angiogram. This combination provides robust evidence of the functional significance of stenosis in stable CAD. Additionally, non-hyperemic pressure ratio indices correlate well with conventional FFR. Hence, adopting FFR-guided management can have transformative effects on the clinical and economic facets of treating severe CAD with intermediary lesions in Indian settings.

关键词： Coronary Physiology Fractional Flow Reserve Percutaneous Coronary Intervention Revascularization

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Synthesis and Characterization of <i>Citrus limonum</i>Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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Journal of Biomaterials and Nanobiotechnology 2020年第4期11卷 215-236页

作者： Harleen Kaur Pranav Pancham ramneek Kaur Shriya Agarwal Manisha Singh Amity Institute of Biotechnology Amity University Noida U.P. India Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida U.P. India School of Medicine Western Sydney University Campbelltown New South Wales Australia

Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (Smix). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 - 104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi’s model in comparison to burst release of LO alone. Lastly, the stability analysis of the optimised formulation (LO-NE) and LO was estimated through antioxidant assay and subjecting them for thermodynamic stability after 6 months. The results attained, showed higher stability and anti-oxidant capability of LO-NE than LO alo

关键词： Lemon Oil Surfactants Particle Size Analysis Ternary Phase Diagrams Release Kinetics Thermodynamic Stability

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<i>In-Silico</i>Validation and Development of Chlorogenic Acid (CGA) Loaded Polymeric Nanoparticle for Targeting Neurodegenerative Disorders

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Journal of Biomaterials and Nanobiotechnology 2020年第4期11卷 279-303页

作者： Vinayak Agarwal Shriya Agarwal ramneek Kaur Pranav Pancham Harleen Kaur Siddhi Bhardwaj Manisha Singh Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida U.P. India School of Medicine Western Sydney University Campbelltown New South Wales Australia Amity Institute of Biotechnology Amity University Noida U.P. India

Background: Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also been widely investigated in Neurodegenerative disorders (NDDs) and Chlorogenic acid (CGA), a polyphenolic compound having potential anti-inflammatory and anti-oxidative properties, emerged as a promising compound in ameliorating NDDs. Owing to its poor stability, bioavailability and release kinetics, CGA needed a suitable nanocarrier based pharmaceutical design for targeting NDDs. Objective: The current study is aimed at the in-silico validation of CGA as an effective therapeutic agent targeting various NDDs followed by the fabrication of polymeric nanoparticles-based carrier system to overcome its pharmacological limitations and improve its stability. Methods: A successful in-silico validation using molecular docking techniques along with synthesis of CGA loaded polymeric nanoparticles (CGA-NPs) by ionic gelation method was performed. The statistical optimisation of the developed CGA-NPs was done by Box Behnken method and then the optimized formulation of CGA-NPs was characterised using particle size analysis (PSA), Transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) along with in-vitro release kinetics analysis. Results & Conclusion: The results attained exhibited average particle size of 101.9 ± 1.5 nm, Polydispersibility (PDI) score of 0.065 and a ZP of −17.4 mV. On a similar note, TEM results showed a size range of CGA-NPs between 90 - 110 nm with a spherical shape of NPs. Also, the data from in-vitro release kinetics showed a sustained release of CGA from the NPs following the first-order kinetics suggesting the appropriate designing of nanoformulation.

关键词： Antioxidant Anti-Inflammatory Polymeric Nanoparticles Release Kinetics Box Behnken Design Molecular Docking Particle Size Analysis

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