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Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease

World Journal of Diabetes 2015年第11期6卷 1186-1197页

作者： ramiro a sanchez Hugo Sanabria Cecilia de los Santos Agustin J Ramirez Arterial Hypertension and Metabolic Unit University Hospital Fundación Favaloro Diabetes Unit Instituto Cardiovascular de Buenos Aires Santos Medical Affairs Department Boehringer Ingelheim

Hyperglycemia is associated with an increased risk of cardiovascular disease,and the consequences ofintensive therapy may depend on the mechanism of the anti-diabetic agent(s)used to achieve a tight *** animal models,stable analogues of glucagon-like peptide-1(GLP-1)were able to reduce body weight and blood pressure and also had favorable effects on ischemia following coronary *** a similar way,dipeptidyl peptidase IV(DPPIV)showed to have favorable effects in animal models of ischemia/*** could be due to the fact that DPPIV inhibitors were able to prevent the breakdown of GLP-1 and glucose-dependent insulinotropic polypeptide,but they also decreased the degradation of several vasoactive *** data for GLP-1,its derivatives and inhibitors of the DPPIV enzyme degradation suggests that these agents may be able to,besides controlling glycaemia,induce cardio-protective and vasodilator *** the many favorable cardiovascular effects of GLP-1/incretins reported in different studies,many questions remain unanswered due the limited number of studies in human beings that aim to examine the effects of GLP-1 on cardiovascular *** this reason,long-term trials searching for positive cardiovascular effects are now in process,such as the CAROLINA and CARMELINA trials,which are supported by small pilot studies performed in humans(and many more animal studies)with incretin-based *** the other hand,selective renal sodium-glucose co-transporter 2 inhibitors were also evaluated in the prevention of cardiovascular outcomes in type 2 ***,it is quite early to draw conclusions,since data on cardiovascular outcomes and cardiovascular death are limited and long-term studies are still *** this review,we will analyze the mechanisms underlying the cardiovascular effects of incretins and,at the same time,we will present a critical position about the real value of these compounds in the cardiovas

关键词： Incretins Hypertension Cardiovascular effects Dipe

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Modelling potential distribution of a pine bark beetle in Mexican temperate forests using forecast data and spatial analysis tools

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Journal of Forestry Research 2020年第2期31卷 649-659页

作者： Antonio Gonzalez-Hernandez Rene Morales-Villafana Martin Enrique Romero-sanchez Brenda Islas-Trejo ramiro Perez-Miranda Conservation and Enhancement of Forest Ecosystems National Institute of ForestryAgriculture and Livestock ResearchProgreso 504010 Coyoacan Mexico CityMexico Geography Department The National Autonomous University of MexicoUniversidad 300004010 Coyoacan Mexico CityMexico

Accurate and reliable predictions of pest species distributions in forest ecosystems are urgently needed by forest managers to develop management plans and monitor new areas of potential ***-only species distribution models are commonly used in these *** maximum entropy algorithm(MaxEnt)has gained popularity for modelling species ***,MaxEnt was used to model the spatial distribution of the Mexican pine bark beetle(Dendroctonus mexicanus)in a daily fashion by using forecast data from the Weather Research and Forecasting *** study aimed to exploit freely available geographic and environmental data and software and thus provide a pathway to overcome the lack of costly data and technical guidance that are a challenge to implementing national monitoring and management strategies in developing *** results showed overall agreement values between 60 and 87%.The results of this research can be used for *** monitoring and management and may aid as a model to monitor similar species.

关键词： Spatial analysis Dendroctonus mexicanus Geodatabases MaxEnt Forest modelling

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Transcatheter aortic valve implantation in very elderly patients： immediate results and medium term follow-up

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Journal of Geriatric Cardiology 2015年第4期12卷 340-345页

作者： Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-sanchez José M Hemández ramiro Trillo-Nouche César Morís Area del Corazón Hospital Universitario Central de Asturias Av. Roma Oviedo Asturias Spain Department of Cardiology Hospital Universitario Virgen de la Victoria Campus de Teatinos Málaga Spain Department of Cardiology Complejo Hospitalario Universitario de Santiago de Compostela Travesla da Choupana A Coru a Spain

Objective To evaluate immediate transcatheter aortic valve implantation （TAVI） results and medium-term follow-up in very elderly pa- tients with severe and symptomatic aortic stenosis （AS）. Methods This multicenter, observational and prospective study was carried out in three hospitals. We included consecutive very elderly （〉 85 years） patients with severe AS treated by TAVI. The primary endpoint was to evaluate death rotes from any cause at two years. Results The study included 160 consecutive patients with a mean age of 87 ± 2.1 years （range from 85 to 94 years） and a mean logistic EuroSCORE of 18.8% ± 11.2% with 57 （35.6%） patients scoring 〉 20%. Procedural success rate was 97.5%, with 25 （15.6%） patients experiencing acute complications with major bleeding （the most frequent）. Global mortality rate during hospitalization was 8.8% （n = 14） and 30-day mortality rate was 10% （n = 16）. Median follow up period was 252.24± 232.17 days. During the follow-up period, 28 （17.5%） patients died （17 of them due to cardiac causes）. The estimated two year overall and cardiac survival rates using the Kaplan-Meier method were 71% and 86.4%, respectively. Cox proportional hazard regression showed that the variable EuroSCORE ≥ 20 was the unique vari- able associated with overall mortality. Conclusions TAVI is safe and effective in a selected population of very elderly patients. Our findings support the adoption of this new procedure in this complex group of patients.

关键词： Aortic stenosis High surgical risk Transcatheter aortic valve Very elderly patients

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Case Series of 11 Patients Operated with Axial-LIF Technique in a Single Center in Mexico

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Open Journal of Modern Neurosurgery 2023年第3期13卷 129-136页

作者： Alfonso Vega Sosa Sergio Ivan Reyna Heredia Apolinar De la Luz Laguna Ivanka Berenice Moreno Villa Marlene de la Peña Gutiérrez ramiro López Elizalde Cuauhtémoc Gil Ortiz Andres Jaime Aguirre Ivan Alejandro Mendez Guerrero Edwin Rolando sanchez Vallejo Alejandra Grisel Mendoza Zuñiga Ricardo Cazares Mejía Carlos Erosa Velázquez Universidad Nacional Autónoma de México Mexico City Mexico Centro Medico Nacional 20 de Noviembre Mexico City Mexico Centro Médico Naval Mexico City Mexico

Introduction: Since the earliest description of spinal fusion in 1911 and later by Dr. Fred H. Albee, it has become one of the most commonly performed procedures by orthopedist and neurosurgeons. The spinal fusion is now used to treat a variety of indications, such as traumatic injuries, deformities, primary and secondary tumors, infections and degenerative conditions of the spine. The risk of iatrogenic injury during traditional anterior, posterior, and transforaminal open fusion surgery is significant. The axial lumbar interbody fusion (Axia-LIF) is a minimal invasive technique which uses the retroperitoneumpresacral anatomical corridor to fuse the lumbar vertebral bodies L4-L5-S1 avoiding manipulation of the annular ligament, paravertebral muscles and facet joints. Methods: In this retrospective series, we report all the cases made in the Centro Medico Naval in México City in two years. A total of eleven patients with degenerative disc disease and spondylolisthesis underwent Axia-LIF one or two level systems with a 36 months clinical and radiographic follow-up. The outcomes included Oswestry Disability Index (ODI) score and leg/back pain severity. Radiographic outcome was evaluated with dynamics and orthogonal x-ray, as well as lumbosacral tomography scan to evaluate fusion status. Results: Nine patients underwent Axia-LIF one level system (L5-S1) and the rest two levels system (L4-S1). Ten patients were fixated with transpedicular percutaneous screws and one with facets joints screws. No intraoperative complications were reported. The mean back pain severity improved 57% in 12 months, and the mean leg pain severity improved 50% in the same time (P < 0.001). Mean ODI scores improved 58%, from 60% ± 16% at baseline to 25% ± 8% at twelve months (P < 0.001). At one year, a patient developed pseudoarthrosis that required posterolateral arthrodesis with transpedicular percutaneous screws. At 36 months monitoring, 100% patients presented a total interbody fusion in the

关键词： Spine Surgery Axial-LIF Procedure Axial-LIF CMN 20 de Noviembre Spinal Fusion Centro Médico Naval

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Transcatheter aortic valve implantation in very elderly patients:immediate results and medium term follow-up

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Journal of Geriatric Cardiology 2015年第04期 340-345页

作者： Isaac Pascual Antonio J Muoz-Garcia Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Bélen Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-sanchez José M Hernández ramiro Trillo-Nouche César Moris Area del Corazon Hospital Universitario Central de Asturias Department of Cardiology Hospital Universitario Virgen de la VictoriaCampus de Teatinos Department of Cardiology Complejo Hospitalario Universitario de Santiago de Compostela

Objective To evaluate immediate transcatheter aortic valve implantation(TAVI) results and medium-term follow-up in very elderly patients with severe and symptomatic aortic stenosis(AS).Methods This multicentcr,observational and prospective study was carried out in three *** included consecutive very elderly(> 85 years) patients with severe AS treated by *** primary endpoint was to evaluate death rates from any cause at two *** The study included 160 consecutive patients with a mean age of 87 ± 2.1 years(range from 85 to 94 years) and a mean logistic EuroSCORE of 18.8%± 11.2%with 57(35.6%) patients scoring ≥ 20%.Procedural success rate was 97.5%,with 25(15.6%) patients experiencing acute complications with major bleeding(the most frequent).Global mortality rate during hospitalization was 8.8%(n = 14) and 30-day mortality rate was 10%(n= 16).Median follow up period was 252.24 ±232.17 *** the follow-up period.28(17.5%) patients died(17 of them due to cardiac causes).The estimated two year overall and cardiac survival rates using the Kaplan-Meier method were 71%and 86.4%,*** proportional hazard regression showed that the variable EuroSCORE ≥20 was the unique variable associated with overall *** TAVI is safe and effective in a selected population of very elderly *** findings support the adoption of this new procedure in this complex group of patients.

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Case Series of 11 Patients Operated with Axial-LIF Technique in a Single Center in Mexico

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Open Journal of Modern Neurosurgery 2023年第3期

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