检索结果-南通市图书馆

Gender,medication use and other factors associated with esophageal motility disorders in non-obstructive dysphagia

Gastroenterology Report 2018年第3期6卷 177-183,I0002页

作者： Afrin Kamal Sampurna Shakya rocio Lopez Prashanthi N.Thota Department of Gastroenterology and Hepatology Digestive Diseases and Surgical InstituteCleveland Clinic9500 Euclid AvenueClevelandOH 44195USA Department of Qualitative Health Sciences Cleveland Clinic9500 Euclid AvenueClevelandOH 44195USA

Background:High-resolution esophageal manometry(HREM)is the diagnostic test of choice for evaluation of nonobstructive *** regarding the predictors of esophageal dysmotility are ***,our aim was to study the prevalence of and factors associated with esophageal motility disorders in patients with non-obstructive ***:We performed a retrospective review of all patients with non-obstructive dysphagia who underwent HREM in a tertiary center between 1 January 2014 and 31 December *** obtaining IRB approval(16–051),clinical records were scrutinized for demographic data,symptoms,medication use,upper endoscopic findings and esophageal pH *** plots were classified per Chicago Classification version *** outcome was prevalence of esophageal motility disorders;secondary outcomes assessed predictive ***:In total,155 patients with non-obstructive dysphagia(55616 years old,72%female)were *** diagnosis was normal in 49%followed by ineffective esophageal motility in 20%,absent contractility in 7.1%,achalasia type II in 5.8%,outflow obstruction in 5.2%,jackhammer esophagus in 4.5%,distal esophageal spasm in 3.9%,fragment peristalsis in 1.9%,achalasia type I in 1.9%,and achalasia type III in 0.6%.Men were five times more likely to have achalasia than women[odds ratio(OR)5.3,95%confidence interval(CI):2.0–14.2;P=0.001].Patients with erosive esophagitis(OR 2.9,95%CI:1.1–7.7;P=0.027)or using calcium channel blockers(OR 3.0,95%CI:1.2–7.4;P=0.015)were three times more likely to have hypomotility ***:From this study,we concluded that HREM diagnosis per Chicago Classification version 3.0 was normal in 49%of patients with non-obstructive *** gender,erosive esophagitis and use of calcium channel blockers were predictive of esophageal motility disorders.

关键词： Impaired swallowing high-resolution esophageal manometry esophageal motility disorders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula

引用

Gastroenterology Report 2016年第4期4卷 310-314,I0002页

作者： Richard H.Cartabuke rocio Lopez Prashanthi N.Thota Department of Internal Medicine Cleveland ClinicClevelandOHUSA Department of Biostatistics Cleveland ClinicClevelandOHUSA Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOHUSA

Objectives:Few studies have evaluated the long-term complications and outcomes of esophageal atresia with or without tracheoesophageal fistula(EA/TEF)beyond *** aim of our study was to characterize the esophageal and respiratory morbidity of EA/TEF through evaluation of clinical symptoms,diagnostic testing and therapeutic intervention at a tertiary care ***:Patients with congenital EA/TEF evaluated from 2011 to 2014 were *** characteristics,type and mode of repair of EA/TEF,clinical symptoms,radiographic,endoscopic,bronchoscopic and medication use data were ***:A total of 43 patients were *** median age of this predominantly Caucasian population was 8 years(interquartile range:3,20).Twenty(62.5%)had type C(EA with distal TEF)***-one(48.8%)patients had heartburn,19(44.1%)had acid regurgitation,and 31(72.1%)had dysphagia to *** swallow in 26 patients revealed strictures in 17(65.4%),dysmotility in 20(76.9%)and recurrent fistulas in four patients(15.4%).Thirty patients underwent upper endoscopy,of which 21(70.0%)had a stricture,and six(20.0%)had recurrent fistula requiring surgical ***(18.6%)patients underwent *** evaluation showed cough and choking in 31(72.1%)patients and dyspnea and wheezing in 32(53.4%)*** respiratory infections were reported in 19(44.2%).*** findings included tracheomalacia in 86.7% and restrictive lung disease in 54.5%of ***:There is a high burden of residual esophageal and pulmonary pathology in patients with EA/*** follow-up is required to monitor both the clinical symptoms and treatment responses.

关键词： esophageal atresia tracheoesophageal fistula gastroesophageal reflux disease(GERD) esophageal dysmotility aspiration pneumonia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Finding middle ground:Flow regimes designed for salmon and energy value

引用

Water Biology and Security 2023年第3期2卷 19-29页

作者： Henriette I.Jager rocio Uria-Martinez Oak Ridge National Laboratory Oak RidgeTN37831-6038USA

In regulated rivers,shaping seasonal flows to recover species at risk depends on understanding when to expect conflicts with competing water users and when their interests are ***-objective optimization can be used to reveal such conflicts and *** species are involved,multi-objective optimization is challenged by the need to simulate complex species responses to flow ***,we addressed that challenge by developing a simplified salmon model(Quantus)that defines cohorts of salmon by the river section and time in which they were *** in these space-time cohorts are tracked from the time redds(nests)are constructed until the cohort exits the tributary en route to the *** this study,we modeled seasonal patterns in energy value and developed a Pareto-optimal frontier of seasonal flow patterns to maximize in-river salmon survival and hydropower *** flow regimes were characterized by two pulse flows varying in magnitude,timing,and duration and constrained by a total annual flow near the historical *** analysis revealed times when economic and salmon objectives were aligned and times when they *** flows that favored higher energy value were timed to meet demand during extreme *** salmon and hydropower objectives produced optimal flow regimes with pulse flows in early summer,but only solutions favoring hydropower value included high flows in *** favoring higher age-0 salmon survival provided an extended pulse flow in late winter/early spring,which suggests that access to productive floodplain habitat allowed faster growth and earlier out-migration and reduced the need for higher temperature-moderating flows later in *** flows were also higher among solutions favoring salmon over *** tools used to produce these results can help to design simplified seasonal flow regimes by revealing compromise solutions that satisfy both fish and energy producers

关键词： Optimization Environmental flows Reservoir release schedule Genetic algorithm Pareto optimal frontier Electricity price model Fall chinook salmon Pulse flows Multi-objective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid-and long-term prediction of hepatocellular carcinoma among cirrhotic patients

引用

World Journal of Gastroenterology 2021年第48期27卷 8343-8356页

作者： Antonio Gil-Gómez Ángela Rojas Chang-Hai Liu rocio Gallego-Duran rocio Muñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-Gómez SeLiver Group Institute of Biomedicine of SevilleSeville 41013Spain CIBERehd Instituto de Salud Carlos IIIMadrid 28029Spain Mucosal Immunity Lab IRCCS Humanitas Research HospitalMilan 20089Italy Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610017Sichuan ProvinceChina State Key Laboratory of Biotherapy and Center of Infectious Diseases West China HospitalChengdu 610017Sichuan ProvinceChina Life Biotechnology Padua UniversityVenice 30175Italy Department of Clinical and Experimental Medicine University of PadovaPadova 35123Italy UCM Digestive Diseases Virgen del Rocío University HospitalSeville 41014Spain

BACKGROUND The combination of alpha-fetoprotein(AFP)and squamous cell carcinoma antigen immunocomplex(SCCA-IgM)have been proposed for its use in the screening of hepatocellular carcinoma(HCC).Current screening programs for all cirrhotic patients are controversial and a personalized screening is an unmet need in the precision medicine *** To determine the role of the combination of SCCA-IgM and AFP in predicting mid-and long-term appearance of *** Two-hundred and three cirrhotic patients(Child A 74.9%,B 21.2%,C 3.9%)were followed-up prospectively every six months to screen HCC by ultrasound and AFP according to European Association for the Study of the Liver *** estimation cohort was recruited in Italy(30.5%;62/203)and validation cohort from Spain(69.5%;141/203).Patients underwent to evaluate SCCA-IgM by enzyme-linked immunosorbent assay(Hepa-IC,Xeptagen,Italy)and AFP levels at *** were followed-up for 60 mo,being censored at the time of the appearance of *** There were 10.8%and 23.1%of HCC development at two-and five-years *** with HCC showed higher levels of SCCA-IgM than those without it(425.72±568.33 AU/mL vs 195.93±188.40 AU/mL,P=0.009)during the fiveyear *** multivariate analysis,after adjusting by age,sex,aspartate transaminase and Child-Pugh,the following factors were independently associated with HCC:SCCA-IgM[Hazard ratio(HR)=1.001,95%CI:1.000-1.002;P=0.003],AFP(HR=1.028,95%CI:1.009-1.046;P=0.003)and creatinine(HR=1.56495%CI:1.151-2.124;P=0.004).The log-rank test of the combination resulted in 7.488(P=0.024)in estimation cohort and 11.061(P=0.004)in the validation cohort,and a 100%of correctly classified rate identifying a low-risk group in both cohorts in the two-year *** We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method,which could be followed by tailored HCC surveillance for individual patients,esp

关键词： Squamous cell carcinoma antigen Hepatocellular carcinoma prediction Precision medicine Stratification of cirrhotic patient

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The promise of precision medicine:how biomarkers are shaping the future of cholangiocarcinoma treatment

引用

Hepatobiliary Surgery and Nutrition 2023年第3期12卷 457-461页

作者： rocio I.R.Macias Lorenza Rimassa Angela Lamarca Experimental Hepatology and Drug Targeting(HEVEPHARM) IBSALUniversity of SalamancaSalamancaSpain National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Health InstituteMadridSpain Department of Biomedical Sciences Humanitas UniversityPieve Emanuele(Milan)Italy Medical Oncology and Hematology Unit Humanitas Cancer CenterIRCCS Humanitas Research HospitalRozzano(Milan)Italy Department of Oncology OncoHealth InstituteFundación Jiménez Díaz University HospitalMadridSpain Department of Medical Oncology The Christie NHS FoundationManchesterUK Division of Cancer Sciences University of ManchesterManchesterUK

Cholangiocarcinoma(CCA)is the second most frequent primary malignant neoplasm of the hepatobiliary ***,CCA is often diagnosed at an advanced stage,when potentially curative surgical treatments are not *** probability of achieving complete resection in patients who undergo surgery is about 25%(1)and even when complete tumor removal is achieved,the risk of recurrence is greater than 50%.Identification and validation of reliable biomarkers is crucial for the early detection,accurate diagnosis,appropriate staging/prognosis,therapy selection and effective monitoring of patients with biliary tract cancers(BTCs)(Figure 1).Achieving early diagnosis remains a challenge to improve survival and,although many promising biomarkers have been identified(2),to date none have reached clinical practice.

关键词： Biliary cancer biomarker immunotherapy precision medicine targeted therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of the distinguishing features of Crohn’s disease and ischemic colitis using computed tomographic enterography

引用

Gastroenterology Report 2017年第3期5卷 219-225,I0002页

作者： Min Chen Erick M.Remer Xiuli Liu rocio Lopez Bo Shen Department of Gastroenterology/Hepatology Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Section of Abdominal Imaging Imaging InstituteCleveland Clinic FoundationClevelandOHUSA

Background and aims:The differential diagnosis between Crohn’s disease(CD)and ischemic colitis(ISC)is important as their clinical management is *** can easily be misdiagnosed as CD,especially in elderly *** distinctive radiographic features of the two disease entities have not been *** aim of this study is to assess the utility of computed tomographic enterography(CTE)in the differential diagnosis between CD and ***:Patients with confirmed CD and ISC were identified through an electronic medical record search of the Cleveland Clinic *** who had undergone CTE,with or without concurrent colonoscopy and histopathological specimens,were included in this *** images were blindly re-reviewed by an expert gastrointestinal *** sensitivities,specificities,accuracies and positive and negative predictive values for each of the CTE findings in differentiating CD from ISC were *** coefficients(j)were calculated tomeasure diagnosis agreement between CTE and the reference ***:A total of 34 eligible patients were included in this study with 17 having CD and 17 having *** differentiating CD from ISC,the presence ofmucosal hyperenhancement and absence of the“target sign”on CTE showed a sensitivity of 100% each for CD,while the two radiographic features yielded a low specificity of 35.3%and 76.5%,*** presence of stricture had a lower sensitivity of 64.7% for the detection of CD but had a high specificity of 100%.In distinguishing CD fromISC,the accuracy of presence ofmucosal hyperenhancement,stricture and absence of target sign were 67.7%,82.4% and 88.2%,*** combination of the presence ofmucosal hyperenhancement and the absence of the target sign achieved an accuracy of 100%for distinguishing CD from *** was a good correlation between CTE and the reference standard for distinguishing CD fromISC(k=0.882).Conclusions:CTE appeared to be clinically useful

关键词： computed tomographic enterography Crohn’s disease ischemic colitis differential diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现在和未来如何进行虚构文学创作——华文作家与西语作家圆桌对话

引用

世界华文文学论坛 2024年第1期 84-100页

作者：赵彦罗茜奥·奥维耶多史志龙(翻译) 不详马德里康普顿斯大学文学系西班牙拉美文学研究协会尼加拉瓜西班牙语学院北美西班牙语学院

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提... 详细信息

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提供了一些可能是消极也可能是积极的新手段,换句话说,现在它们也成了我们文本创新的一种工具。当然,这种“新的写作工具”也带来了一定程度上的困惑,甚至有可能对文学本身会造成一种伤害。

关键词：华文作家文本创作即时更新社交媒体虚构文学文学创作文本创新写作工具

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension

引用

World Journal of Gastroenterology 2008年第41期14卷 6370-6375页

作者： Jamilé Wakim-Fleming Nizar N Zein Ana Bennett rocio Lopez Janice Santisi William D Carey Department of Gastroenterology and Hepatology Cleveland Clinic Foundation Cleveland Department of Pathology/Immunology Cleveland Clinic Foundation Cleveland Department of Quantitative Health Sciences Cleveland Clinic Foundation Cleveland

AIM: To study the small bowel (SB) mucosa on biopsy in cirrhotic patients with portal hypertension and in non-cirrhotic controls and grade fi ndings according to the Marsh criteria. METHODS: We prospectively enrolled 51 consecutive patients undergoing an upper endoscopy for their routine medical care. Twenty f ive patients with cirrhosis and portal hypertension were compared to 26 controls. We obtained coeliac serology and multiple upper small bowel biopsies on all 51 patients. A GI pathologist interpreted biopsies and graded fi ndings according to the Marsh criteria. We assessed equivalence in Marsh grade between cirrhotic and non-cirrhotic controls using the Mann-Whitney test for equivalence. RESULTS: Gender, ethnicity and age were similar between both groups. Marsh grades were equivalent between the groups. Grade of 0 was present in 96% and grade of 1 was present in 4% of both groups and there was no villus atrophy or decrease in villus/crypt ratio in patients with portal hypertension. CONCLUSION: This study provides evidence for the lack of villus atrophy in patients with cirrhosis and portal hypertension, and supports the continuous reliance on the Marsh criteria when the diagnosis of coeliac disease is to be made in the presence of cirrhosis.

关键词： Cirrhosis Portal hypertension Coeliac disease Marsh criteria Small bowel mucosa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pain assessment and management in the newborn:A systematized review

引用

World Journal of Clinical Cases 2021年第21期9卷 5921-5931页

作者： Maria Teresa Garcia-Rodriguez Sergio Bujan-Bravo rocio Seijo-Bestilleiro Cristina Gonzalez-Martin Research in Nursing and Health Care Institute of Biomedical Research of A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SERGASAs Xubias 8415006 A Coruña Universidade da Coruña(UDC)A Coruña 15006Spain Health Sciences Complexo Hospitalario Universitario de A CoruñaA Coruña 15006Spain

BACKGROUND Neonatal pain has been underdiagnosed due to several false *** To determine the status of neonatal pain in newborns who are admitted to intensive care *** Different databases were *** reviews and research reports conducted in newborns that were written in English,Spanish,or Portuguese,published between 2010 and 2020,and having free access to the full text were selected.A total of 135 articles were found,and 18 articles were finally *** Newborns are exposed to numerous painful *** order to assess their pain levels,several scales have been used,although they are sometimes not correctly *** terms of pain management,the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological *** Nursing staff members must be well trained in order to identify pain and to interpret the scales ***,they have an important role in performing non-pharmacological procedures for pain management.

关键词： Neonatal pain Intensive care unit Nursing Management Treatment Systematized review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Value of routine stool testing for pathogenic bacteria in the evaluation of symptomatic patients with ileal pouches

引用

Gastroenterology Report 2018年第2期6卷 93-100,I0001页

作者： Amandeep Singh Jean Ashburn Gursimran Kochhar rocio Lopez Tracy L.Hull Bo Shen Department of Gastroenterology&Hepatology Digestive Disease and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Department of Colorectal Surgery Digestive Disease and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Department of Quantitative Health Sciences Digestive Disease and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA

Background:In symptomatic patients with an ileal pouch,stool studies are often sent to diagnose enteric *** of this study is to find the value of routine stool studies in the evaluation of symptomatic patients and the clinical implications of such pathogens in patients with ileal ***:Consecutive ileal pouch-anal anastomosis(IPAA)patients who had stool tests out of a 2283-case registry from 2002 to 2015 were included in the *** with positive stool cultures were compared with controls(symptomatic without positive stool culture)in a 1:4 *** to antibiotic therapy,recurrence rate and rate of hospitalization at 1 and 3 months were ***:A total of 643(28%)had stool cultures done and only 1.7%(11/643)were found to be positive for stool *** spp.(45%)was the most common pathogen followed by Aeromonas spp.(36%).Non-smokers and patients without any antibiotic use in the last 3 months were found to have higher prevalence of positive stool cultures than controls(p<0.001 and p¼0.023).Patients with pathogenic bacteria were found to have a higher risk of acute kidney injury(27.3%vs 4.5%,p¼0.049),hospitalization within 3 months of initial stool testing(36.4%vs 6.8%,p¼0.009)and mortality(18.2%vs 0%,p¼0.040).However,there were no statistically significant differences in the clinical outcomes in patients with positive stool cultures who received pathogen-directed ***:We found that the yield of stool tests for bacterial pathogens in symptomatic pouch patients was extremely low and the treatment of detected pathogens had a minimum impact on the disease course of *** clinical utility of routine stool culture in those patients warrants further study.

关键词： pouchitis ileal pouch enteric pathogens stool culture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：