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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 52-53页

作者： ramirez p.t. Slomovitz B.M. Soliman p.t. 李欢 Department of Gynecologic Oncology The University of Texas M. D. Anderson Cancer CenterUnit 1362PO Box 301439HoustonTX 77230-1439United States

Objective.:to retrospectively evaluate the feasibility and morbidity of total laparoscopic radical hysterectomy and lymphadenectomy. Methods.:We performed a retrospective review of all p.t.ents who underwent a total laparoscopic radical hysterectomy at our institution between May 2004 and August 2005. Data collected included age,body mass index,stage,histop.t.ologic subtype,tumor grade,estimated blood loss,perioperative blood transfusions,number and status of lymph nodes obtained,status of surgical margins,length of hosp.t.l stay,time to resumption of normal bladder function,intraoperative and postoperative complications,and disease-free interval. Results.:twenty p.t.ents underwent total laparoscopic radical hysterectomy during the study period. None of the surgeries required conversion to laparotomy. the median p.t.ent age was 41.5 years (range,25-76). Eighteen p.t.ents had cervix cancer (5 stage IA2 and 13 stage IB1),and 2 had endometrial cancer (1 stage IB and 1 stage IIIA). Among those with cervix cancer,12 had adenocarcinoma,4 squamous cell carcinoma,and 2 adenosquamous carcinoma. the median weight was 70 kg (range,49-112). the median number of resected pelvic lymph nodes was 13 (range,9-26). One p.t.ent had nodal disease. the surgical margins were free of disease in all cases. the median blood loss was 200 ml (range,25-700 ml). Only 1 p.t.ent required an intraoperative blood transfusion (1 U packed red blood cells). the median length of hosp.t.l stay was 1 day (range,1-5). there were 3 short-term complications-unintentional cystotomy,pulmonary embolus,and pneumomediastinum with subcutaneous emphysema. there were 2 long-term complications-vaginal eviscerations and a lymphocyst. the median time to resumption of normal bladder function was 16 days (range,13-29). the median follow-up.t.me was 8 months range (1-16). All p.t.ents remain free of disease at the time of this report. Conclusions.:total laparoscopic radical hysterectomy can be performed safely with minim

关键词：子宫根治术淋巴结切除术完全腹腔镜癌症中心脏器除去术淋巴囊肿膀胱功能盆腔淋巴结淋巴结转

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服用它莫西芬是否影响发生子宫内膜癌的乳腺癌患者的预后

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 35-36页

作者： Slomovitz B.M. ramirez p.t. 张丽娟

OBJECtIVE: the use of tamoxifen to prevent breast cancer and decrease recurr en ce is not controversial. However, the effect that tamoxifen may have in women wi th a history of breast cancer in whom endometrial cancer develops is unclear. th e purpose of this study was to estimate whether a history of tamoxifen use is a prognostic factor for such p.t.ents. MEtHODS: Between 1990 and 2002, p.t.ents se en at the University of texas M. D. Anderson Cancer Center with a history of bre ast cancer who developed endometrial cancer were identified. Medical records wer e reviewed to identify clinical, p.t.ologic, and outcome information. RESULtS: E ighty-nine p.t.ents with a history of breast cancer in whom endometrial carcino ma developed were identified. Fifty-two percent (46/89) had a history of tamoxi fen use (median duration 48 months; range 2-120 months). there were no signific ant differences in the clinical or p.t.ologic features between tamoxifen users a nd nonusers. A history of tamoxifen use was associated with a shorter interval f rom breast cancer to endometrial cancer diagnosis (77.2 versus 121.3 months for nonusers; p = .01). there was no significant difference in overall survival betw een tamoxifen users and nonusers (39.2 months versus 48.3 months, p = .27), and there was no difference in endometrial cancer-specific survival duration betwee n tamoxifen users and nonusers (55.7 versus 51.0 months, p = .92). CONCLUSION: A mong tamoxifen users, the interval from breast cancer to endometrial cancer diag nosis was significantly shorter than that in nonusers. In this cohort, a history of tamoxifen use was not associated with a worse overall or disease-specific s urvival.

关键词：它莫西芬存活期德克萨斯大学疾病特异性安德森癌症中心无显著性差异队列研究持续时间

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卵巢混合型高分化腺癌乙状结肠非典型转移瘤

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 57-58页

作者： Zighelboim I. Broaddus R. ramirez p.t. 朱国栋 Gy-necologic Oncology Univ. Texas M. D. Anderson Cancer C. Houston TX United States

Background. Intraperitoneal seeding is the most common form of dissemination of ep.t.elial ovarian cancer. Metastasis to the bowel mucosa can occur by invasion from the serosal surface or infiltration of the submucosal capillary network. Hematogenous dissemination usually occurs in the presence of advanced peritoneal disease. Case. A 39-year-old gravida 3 para 2 woman was diagnosed in October 2000 with a large pelvic mass. She underwent an exploratory laparotomy and a left salpingooophorectomy with multiple abdominal and pelvic biopsies. She was diagnosed with an ovarian tumor of low malignant p.t.ntial, and no further treatment was recommended. Six months later, she developed abdominal discomfort and constip.t.on. A colonoscopy was performed, and a biopsy showed metastatic carcinoma of ovarian origin. the p.t.ent presented to the University of texas M.D. Anderson Cancer Center in September 2001 for consultation. the surgical p.t.ology evaluation from her previous surgery indicated highgrade ovarian carcinoma. the p.t.ent underwent a total abdominal hysterectomy, right salpingooophorectomy,infracolic omentectomy, right pelvic lymph node sampling, and segmental resection with primary endtoend sigmoid colon anastomosis. the tumor within the colon was a polypoid mass arising from the mucosa with no involvement of the colonic wall. Microscopically, the tumor was a highgrade ovarian papillary serous carcinoma with areas of endometrioid adenocarcinoma. the colonic tumor was immunohistochemically positive for cytokeratin-7 and negative for cytokeratin-20. the p.t.ent was treated with six cycles of carboplatin and paclitaxel. the p.t.ent then incidentally developed disseminated sarcoidosis. At the time of this report, the p.t.ent had no evidence of recurrent or metastatic disease for 2 years. Conclusions. Ep.t.elial ovarian carcinomas may recur as intraluminal bowel lesions with serosal sparing even in the absence of peritoneal disease. Immunohistochemical staining usi

关键词：高分化腺癌卵巢肿瘤肿瘤复发右侧附件细胞角蛋白子宫内膜样腺癌全子宫切除术镜下病理淋巴结活检血道转移

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正电子发射计算机体层扫描联合Ct可以发现复发性卵巢黏液性腺癌

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 48-49页

作者： Martnez-Román S. ramirez p.t. Oh J. 侯巍 Department of Gynecologic Oncology University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 United States

Background. the role of combined positron emission tomography and comp.t.d tomography (p.t. Ct) in the diagnosis of recurrent ovarian mucinous adenocarcinoma is uncertain because of previous reports that p.t.has limited sensitivity in the detection of mucinous neoplasms. Case. A 71- year- old white woman presented with complaints of right lower quadrant pain and a palpable adnexal mass. physical examination and transvaginal ultrasonography revealed a 12 × 13 cm cystic mass in the left side of the pelvis. Exploratory laparotomy, optimal tumor- reductive surgery, total abdominal hysterectomy, bilateral salpingo- oophorectomy, appendectomy, and omentectomy were performed. the diagnosis was FIGO stage IIIC welldifferentiated ovarian mucinous adenocarcinoma. the p.t.ent was treated with 6 cycles of carboplatin and paclitaxel. Four months after completing chemotherapy, the p.t.ent was noted to have an elevated serum CA125 level (72 U/mL), being otherwise asymptomatic. Findings on abdominal and pelvic Ct were comp.t.ble with postsurgical changes. p.t.Ct was performed and revealed increased metabolism along the posterior aspect of the right rectus abdominis muscle and abutting the anterior wall of an adjacent loop of bowel. Conclusion. p.t.Ct may identify clinically occult recurrent ovarian mucinous adenocarcinoma.

关键词：黏液性腺癌计算机体层扫描 Ct 正电子发射肿瘤细胞减灭术网膜切除术联合化疗阑尾切除术腹腔镜探查体格检查

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Venopulmonary ECMO Improved Hypoxemia and Supported the Right Ventricle in a p.t.ent with Decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery 2024年第1期14卷 7-19页

作者： Daniel Manzur-Sandoval Gian Manuel Jiménez-Rodríguez Edgar García-Cruz Ramón Espinosa-Soto Erika Yamali ramirez-Marcano Yessenia Máyory téllez-López José Luis Elizalde-Silva Gustavo Rojas-Velasco Cardiovascular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECMO) has become a standard of care for p.t.ents with circulatory (venoarterial) and/or respiratory (venovenous) failure refractory to standard therapies. Adult p.t.ents with congenital heart disease are an increasingly recognized and growing population and include various groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these p.t.ents are prone to developing p.t.ologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserves and organic damage associated with the underlying heart disease, which makes them candidates for ECMO. these p.t.ents represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, venopulmonary artery ECMO, which provides hemodynamic and respiratory support, and may be ideal for p.t.ents with shunts and/or right ventricular dysfunction. to our knowledge, this is the first report of this configuration in p.t.ents with congenital heart diseases.

关键词： Eisenmenger Syndrome Venopulmonary Artery ECMO Refractory Hypoxemia Right Ventricular Dysfunction

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Feasibility of the 2-point method to determine the load-velocity relationship variables during the countermovement jump exercise

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Journal of Sport and Health Science 2023年第4期12卷 544-552,F0003页

作者： Alejandro pérez-Castilla Rodrigo ramirez-Campillo John F.t.Fernandes Amador García-Ramos Department of physical Education and Sport Faculty of Sport SciencesUniversity of GranadaGranada 18011Spain Human performance Laboratory Department of Physical Activity SciencesUniversidad de Los LagosSantiago 5170000Chile Centro de Investigacion en Fisiologıa del Ejercicio Facultad de CienciasUniversidad MayorSantiago 8580745Chile Higher Education Sport Hartpury UniversityHartpury GL193BEUK Department of Sports Sciences and physical Conditioning Faculty of EducationUniversidad Catolica de la Santısima ConcepcionConcepcion 4090541Chile

purpose:this study aimed to examine the reliability and validity of load-velocity(L-V)relationship variables obtained through the 2-point method using different load combinations and velocity ***:twenty men performed 2 identical sessions consisting of 2 countermovement jumps against 4 external loads(20 kg,40 kg,60 kg,and80 kg)and a heavy squat against a load linked to a mean velocity(MV)of 0.55 m/s(load_(0.55)).the L-V relationship variables(load-axis intercept(L_(0)),velocity-axis intercept(v_(0)),and area under the L-V relationship line(A_(line)))were obtained using 3 velocity variables(MV,mean propulsive velocity(MpV),and peak velocity)by the multiple-point method including(20-40-60-80-load_(0.55))and excluding(20-40-60-80)the heavy squat,as well as from their respective 2-point methods(20-load_(0.55)and 20-80).Results:the L-V relationship variables were obtained with an acceptable reliability(coefncient of variation(CV)≤7.30%;intra-class correlation coefficient>0.63).the reliability of L_(0)and v_(0)was comparable for both methods(CV_(ratio)(calculated as higher value/lower value):1.11-1.12),but the multiple-point method provided Al_(ine)with a greater reliability(CV_(ratio)=1.26).the use of a heavy squat provided the L-V relationship variables with a comparable or higher reliability than the use of a heavy countermovement jump load(CV_(ratio):1.06-1.19).the peak velocity provided the load-velocity relationship variables with the greatest reliability(CV_(ratio):1.15-1.86)followed by the MV(CV_(ratio):1.07-1.18),and finally the *** 2-point methods only revealed an acceptable validity for the MV and MpV(effect size≤0.19;pearson s product-moment correlation coefficient≥0.96;Lin's concordance correlation coefficient≥0.94).Conclusion:the 2-point method obtained from a heavy squat load and MV or MpV is a quick,safe,and reliable procedure to evaluate the lower-body maximal neuromuscular capacities through the L-V relationship.

关键词： Force-velocity relationship Mean velocity Multiple-point method peak velocity Velocity-based training

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Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats

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Food Science and Human Wellness 2023年第6期12卷 2022-2028页

作者： Maria Rosana ramirez Debora Manuale Juan Carlos Yori Instituto Universitario de Ciencias de la Salud Fundación BarcelóCONICETCenteno 710CP 3340Santo TomeCorrientesArgentina Consejo Nacional de Investigaciones Científi cas técnicas(CONICEt) Buenos Aires C1033AAJArgentina Instituto de Investigaciones en Catálisis y p.t.oquímica(INCApE)FIQ-UNL-CONICEt Parque Tecnológico Litoral Centro 3000Santa FeArgentina Facultad de Ingeniería Química Universidad nacional del Litoral 3000Santa FeArgentina

this present study was conducted to evaluate the metabolic effects of isolated fi ber of carrot supplementation in *** properties of fi ber were *** groups were as follows:animals fed a standard diet,control group;high fi ber supplementation(70 mg);low fi ber supplementation(35 mg);for 12 *** samples were collected at the time of sacrifi *** weights of heart,liver,kidneys and spleen of the experimental rats with respect to body weight were *** kits were used to determine serum glucose concentration,lipid profi le(cholesterol,HDL-cholesterol,triglycerides),and the two main aminotransferases glutamic-oxalacetic transaminase(GOt)/glutamate-pyruvate transaminase(Gpt).A histop.t.ological assay was performed on the heart,liver,and spleen tissues of *** with fi ber favors weight loss in female((242.03±23.73)-(197.81±10.45)g);and male rats((262.50±32.21)-(213.96±12.56)g and induces a decrease in glucose levels in the supplemented *** the exception of total high-density lipoprotein cholesterol,the other lipid fractions decrease signifi cantly in rats *** supplementation did not induce changes in the dissected organs of the supplemented *** conclusion supplementation of fiber,improves glucose control,lower plasma lipid concentrations and reduced body weight in normal rats.

关键词： Carrot fiber Oral supplementation Animal studies

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A techno-economic and life cycle assessment for the production of green methanol from CO_(2): catalyst and process bottlenecks

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Journal of Energy Chemistry 2022年第5期31卷 255-266页

作者： tomas Cordero-Lanzac Adrian ramirez Alberto Navajas Lieven Gevers Sirio Brunialti Luis MGandía Andrés t.Aguayo S.Mani Sarathy Jorge Gascon Department of Chemical Engineering University of the Basque Country(UPV/EHU)PO Box 64448080 BilbaoSpain King Abdullah University of Science and technology KAUST Catalysis Center(KCC)Advanced Catalytic MaterialsThuwal 23955Saudi Arabia Department of Science Public University of Navarre(UPNA)Arrosadía Campus s/n31006 PamplonaSpain Institute for Advanced Materials and Mathematics(InaMat2) Universidad Pública de Navarra(UPNA)Edificio Jerónimo de AyanzCampus de ArrosadiaPamplona-Iruña 31006Spain King Abdullah University of Science and technology Clean Combustion Research Center(CCRC)Thuwal 23955Saudi Arabia

the success of catalytic schemes for the large-scale valorization of CO_(2) does not only depend on the development of active,selective and stable catalytic materials but also on the overall process *** we present a multidisciplinary study(from catalyst to plant and techno-economic/lifecycle analysis)for the production of green methanol from renewable H2 and CO_(2).We combine an in-depth kinetic analysis of one of the most promising recently reported methanol-synthesis catalysts(InCo)with a thorough process simulation and techno-economic *** then perform a life cycle assessment of the simulated process to gauge the real environmental impact of green methanol production from CO_(2).Our results indicate that up.t. 1.75 ton of CO_(2) can be abated per ton of produced methanol only if renewable energy is used to run the process,while the sensitivity analysis suggest that either rock-bottom H2 prices(1.5$kg1)or severe CO_(2) taxation(300$per ton)are needed for a profitable methanol ***,we herein highlight and analyze some critical bottlenecks of the *** attention has been paid to the contribution of H2 to the overall plant costs,CH4 trace formation,and purity and costs of raw *** addition to providing important information for policy makers and industrialists,directions for catalyst(and therefore process)improvements are outlined.

关键词： CO_(2) Methanol Kinetic modeling process simulation Life cycle assessment

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关于LACC试验几个质疑的解答

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中国实用妇科与产科杂志 2020年第4期36卷 303-307页

作者： pedro t.ramirez 安德森癌症中心妇科肿瘤与生殖医学系美国德克萨斯州德州大学休斯顿77030

广泛性全子宫切除术(radical hysterectomy,RH)联合盆腔淋巴结切除是早期子宫颈癌的标准治疗术式,可使早期子宫颈癌患者5年生存率达到90%以上。20世纪后,随着大量的回顾性研究及前期随机对照试验(randomized controlled trial,RCt)结果... 详细信息

广泛性全子宫切除术(radical hysterectomy,RH)联合盆腔淋巴结切除是早期子宫颈癌的标准治疗术式,可使早期子宫颈癌患者5年生存率达到90%以上。20世纪后,随着大量的回顾性研究及前期随机对照试验(randomized controlled trial,RCt)结果支持腹腔镜和机器人技术,微创技术在子宫颈癌手术治疗中得到广泛开展和运用,微创理念已深入人心。即使仍然缺乏高质量的生存结局证据,临床上也普遍认为微创广泛性全子宫切除术肿瘤结局并不劣于开腹手术。2018年前的美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)子宫颈癌指南亦推荐腹腔镜手术途径为可选的开腹RH的替代方案。然而,2018年末安德森癌症中心ramirez教授在《新英格兰医学杂志》上基于多中心参与的RCt研究"Laparoscopic Approach to Cervical Cancer,LACC"发表的论文"Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer"比较了早期子宫颈癌微创和开腹RH手术生存结局差异,得出了出乎意料的结论。这项前瞻性多中心随机对照临床试验结果显示在早期子宫颈癌中,微创手术比开腹手术具有更高的复发率和更低的总生存率。这项高质量的Ⅰ类证据,颠覆了关于腹腔镜子宫颈癌手术的普遍认知,在全球妇科界引起了轩然大波及广泛讨论。2019年第4版NCCN子宫颈癌临床实践指南指出开腹手术为早期子宫颈癌的标准途径,并强调了腹腔镜RH(LRH)的肿瘤学风险。LACC研究的问世使子宫颈癌腹腔镜手术面临巨大挑战和争议,同时,LACC结果也遭受了国际学术界一些质疑。在2019年中国珠海"国际子宫颈癌腹腔镜手术治疗临床研究暨妇科临床解剖研究进展"专题会议上,LACC研究的总负责人,美国安德森癌症中心ramirez教授亲自对这些质疑问题进行了解答,现总结如下,供大家参考。

关键词：腹腔镜手术子宫颈癌广泛性全子宫切除术

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Venopulmonary ECMO Improved Hypoxemia and Supported the Right Ventricle in a p.t.ent with Decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery（心血管外科国际期刊） 2024年第1期

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