检索结果-南通市图书馆

Hepatoprotection: A Hallmark of <i>Citrullus colocynthis</i>L. against Paracetamol Induced Hepatotoxicity in Swiss Albino Rats

引用

American Journal of Plant Sciences 2012年第7期3卷 1022-1027页

作者： Arshed Iqbal Dar ramesh Chandra Saxena Suresh kumar Bansal Pest Control & Ayurvedic Drug Research Lab. S.S.L Jain P.G College Vidisha India

Objective: To demonstrate the in-vivo hepatoprotective effect of the ethanolic extracts of Citrullus colocynthis (Linn.) against paracetamol induced hepatotoxicity in albino rats. Animal Model: Swiss Albino rats of either sex were used, divided into six groups with six in each group. Group 1-Normal control: The animals were maintained under normal control, which were given distilled water only. Group 2-Induction of hepatotoxicity: The animals received paracetamol 500 mg/kg b.w. (p.o) every 72 h for 10 Days. Groups 3 to 5: Animals received ethanolic extract of Citrullus colocynthis L. at 50, 100 & 200 mg/kg bw/day for 7 days (p.o). Group 6: The animals were treated with Silymarin (100 mg/kg p.o) which served as standard. Groups 3 to 6 were intoxicated with paracetamol (500 mg/kg bw) 1 h before the administration of extract or Silymarin for 10 days. Histopathological findings, different hepatic biochemical parameters viz. AST, ALT, ALP, Total bilirubin, Total cholesterol, Triglycerides, & the body weight before & after treatment were evaluated to investigate the hepatoprotective activity. Results: Paracetamol induced a significant rise in AST, ALT, ALP, Total Bilirubin, Total Cholesterol, Triglycerides. Administration of 200 mg/kg bw of ethanolic extract of Citrullus colocynthis L. effectively reduced these pathological damages caused by paracetamol intoxication. In addition to serum parameters treatment of 200 mg/kg bw of ethanolic extract of Citrulus colocynthis L. also promotes the body weight in albino rats as shown in Figure 6 respectively. Histopathological changes of the liver samples were compared with the normal control as shown in Figures 2-5 respectively. Conclusion: From our results we may infer that the mode of action of 90% ethanolic extract of Citrullus colocynthis L. (200 mg/kg bw) in affording the in-vivo hepatoprotective activity against paracetamol may be due to the cell membrane stabilization, hepatic cell regeneration & normalizing the serum param

关键词： Citrullus colocynthis L. Hepatoprotective Paracetamol Silymarin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genetic polymorphism of Glutathione S-Transferase P1 （GSTP1） and its association with susceptibilty to Chronic Myeloid Leukemia （CML）

Genetic polymorphism of Glutathione S-Transferase P1 （GSTP1...

引用

The 4th ISGO International Conference on Structural Genomics

作者： Prachi Bajpai Anil kumar tripathi Deepa Agrawal Industrial Toxicology Research Centre （ITRC）.Cardiovascular Tox.Div. M. G. Marg Lucknow226001. India King George’s Medical Universit （KGMU） Hemato-Oncology Unit Sahmeena Road Chowk Lucknow 226 003. India Industrial Toxicology Research Centre （ITRC） Cardiovascular Tox.Div. M. G.MargLucknow226001.India

＜正＞PURPOSE OF THE STUDY Glutathione S- Transferases （GSTs） are a polymorphic group of enzymes involved in the phase II detoxification of a wide range of xenobiotics ＆ chemotherapeutic agents by catalyzing the conjugation of reactive electrophiles to glutathione. In humans, five classes of GST enzymes have been identified （ α,μ,π,σ,and θ） .Each class is encoded by a separate gene or gene family. Allelic variants for each of these genes may result in less effective or absent enzymatic detoxification and thus increase susceptibility to

关键词： Genetic polymorphism GSTP1 CML.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Fast Converging Generalized Turbo Decoding Scheme with Enhanced Throughput for Mobile Radio

引用

Communications and Network 2013年第1期5卷 9-15页

作者： Ashok kumar Shankhwar Sachin Sharma Rajeev tripathi Arun Prakash Ashutosh Singh Electronics and Communication Engineering Department Motilal Nehru National Institute of Technology Allahabad India Electronics Engineering Department Harcourt Butler Technological Institute Kanpur India

The use of turbo codes enhances the data transmission efficiency and optimizes the performance of a communication system over wireless fading channels. In this paper, we present a brief overview of the various components of the turbo coding scheme, analyze the complexities of the most popular turbo decoding algorithms, and discuss the various implementation methods of the maximum a posteriori (MAP) algorithm. The paper considers the well-known log-MAP decoding algorithm by a linear approximation of the correction function used by the max* operator. We propose a generalized decoding scheme that optimizes the existing MAP algorithm for faster convergence and better throughput on the basis of varying channel conditions. The proposed scheme of decoding reduces complexity and enhances the throughput with only a negligible loss in BER performance.

关键词： Log-MAP Decoding Mobile Radio Turbo Decoder UMTS Wireless

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accessory breast poorly differentiated adenocarcinoma with positive HER2 gene amplification: A case report

引用

Case Reports in Clinical Medicine 2014年第2期3卷 79-81页

作者： Dinesh Francis Balasingam ramesh Thangaratnam Joel Sateeish kumar Department of General Surgery Serdang General Hospital Ka-jang Selangor Malaysia

Background: Primary poorly differentiated adenocarcinoma of the accessory breast is rare. We report such a case in a 56-year-old Malaysian woman of Indian ethnicity. Case Presentation: An axillary swelling measuring 5 × 5 cm on excisional biopsy revealed a poorly differentiated adenocarcinoma with positive HER2 gene amplification. Conclusion: Overall prognosis is similar to that of a carcinoma of the normal breast, therefore early diagnosis is imperative to ascertain curable status and improve prognosis.

关键词： Accessory Breast Breast Cancer Accessory Breast Cancer HER2 Gene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer assessment of the composition of a generic wound by image processing

引用

Plastic and Aesthetic Research 2015年第1期2卷 261-265页

作者： Rohit Nayak Pramod kumar ramesh R.Galigekere Department of Electrical and Computer Engineering University of RochesterRochesterNY 14623USA Department of Plastic Surgery King Abdulaziz Specialist HospitalSakaka 42421Al-JoufSaudi Arabia Department of Plastic Surgery and Burns Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Biomedical Engineering Manipal Institute of TechnologyManipal UniversityManipal 576104KarnatakaIndia

Aim:This paper addresses the assessment of the composition of a general wound,in terms of all identifiable categories of tissue and pigmentation in an attempt to improve accuracy in assessing and monitoring wound *** and Methods:A knowledgebase of clusters was built into the hue,saturation and intensity(HSI)color space and then used for assessing wound *** on the observation that the clusters are fairly distinct,two different algorithms,that is,Mahalanobis distance(MD)based and the rotated coordinate system(RCS)method,were used for *** methods exploit the shape,spread,and orientation of each ***:The clusters in the HSI color space,built from about 9,000(calibrated)pixels from 48 images of various wound beds,showed 8 fairly distinct *** inter-cluster distances were consistent with the visual *** efficacy of the MD and RCS based methods in 120 experiments taken from a set of 15 test images(in terms of average percent-match)was found to be 91.55 and 93.71,***:Our investigations established eight categories of tissue and pigmentation in wound *** findings help to determine the stage of wound healing more accurately and comprehensively than typically permitted through use of the 4-color model reported in the literature for addressing specific wound types.

关键词： Wound composition color-image processing hue saturation and intensity model classification Mahalanobis distance rotated coordinate system method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of anti-inflammatory potential of Nardostachys jatamansi rhizome in experimental rodents

引用

Journal of Coastal Life Medicine 2014年第1期 38-43页

作者： Rajnish kumar Singh Vaishali Susanta kumar Panda Padala Narasimha Murthy Ghanashyam Panigrahi Pramod kumar Sharma ramesh kumar Gupta Moradabad Educational Trust Group of Institution Faculty of PharmacyMoradabad-244001Uttar PradeshIndia Royal College of Pharmacy and Health Sciences Berhampur-760002OrissaIndia School of Medical&Allied Sciences Galgotias UniversityG.B.Nagar-201306Uttar PradeshIndia

Objective:To evaluate the anti-inflammatory effect of Nardostachys jatamansi(***)rhizome against acute,subacute and chronic models of inflammation in experimental ***:*** rhizome extract(150 and 300 mg/kg,p.o.)and the reference drugs phenylbutazone(100 mg/kg,p.o.)and acetylsalicylic acid(300 mg/kg,p.o.)were evaluated using models for inflammation(autacoids induced hind paw oedema,formaldehyde induced hind paw oedema,carrageenin-induced paw oedema,cotton pellet granuloma and subcutaneous air pouch model).Results:In acute inflammation as produced by carrageenin 29.06%and 55.81%,by histamine 25.0%and 39.28%,by 5-hydroxytryptamine 21.37%and 36.95%and by prostaglandin E2-induced hind paw oedema 31.03%and 44.82%protection was *** in subacute anti-inflammatory models using formaldehyde-induced hind paw oedema(after 1.5 h)13.88%and 33.33%and in chronic anti-inflammatory model using cotton pellet granuloma 7.4%and 17.58%protection from inflammation was *** rhizome extract also inhibited the inflammatory mediators(nitric oxide by 12.81%and 38.41%,by prostaglandin E212.58%and 47.82%while by TNF-α13.51%and 41.89%)produced in the ***:The results of this study strongly indicate the protective effect of *** rhizome extract against acute,subacute and chronic models of inflammation,which may be attributed to its anti-inflammatory potential.

关键词： Nardostachys jatamansi rhizome Anti-inflammatory Histamine Carrageenin Cotton pellet granuloma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

pharmacognostical study and establishment of quality parameters of aerial parts of Costus speciosus-a well known tropical folklore medicine

引用

Asian Pacific Journal of Tropical Biomedicine 2014年第6期4卷 486-491页

作者： Pradeep Singh Ratan Lal Khosa Shruti Srivastava Garima Mishra Keshri Kishor Jha Sourabh Srivastava Sangeeta ramesh kumar Verma Mohd Adil Tahseen Department of Pharmacognosy Teerthanker Mahaveer College of PharmacyTeerthanker Mahaveer University Department of Pharmacy Bharat Institute of TechnologyPartapur BypassDelhi Road MeerutUttar PradeshIndia

Objective:To evaluate the diagnostic pharmacognostical characters of Costus speciosus(aerial parts)along with their physico-chemical parameters and fluorosence ***:The pharmacognostical characters were determined in terms of macroscopy,microscopy,powder microscopy,leaf constant,fluorescence analysis and preliminary phytochemical ***:The findings of macroscopy revealed that leaves elliptic to oblong or oblong-lancoelate,thick,spirally arranged,with stem clasping sheaths up to 4 cm,flowers large,white,conelike terminal spikes,with bright red *** section of leaflet showed the presence of cuticularised epidermis with polygonal cells on adaxial surface and bluntly angled cells on abaxial surface of lamina,mesophyll cells differentiated in to single layered palisade cells on each surface and 2-3 layered spongy parenchyma,unicellular and uniseriate multicellular covering trichomes,paracytic stomata and vascular bundles surrounded by sclerenchymatous multicellular *** phytochemical screening exhibited the presence of various phytochemical groups like alkaloids,glycosides,steroids,phenolic ***,the leaf constants,powder microscopy and fluorescence characteristics indicated outstanding results from this investigation Conclusions:Various pharmacognostical and physico-chemical parameters have pivotal roles in identification,authentication and establishment of quality parameters of the species.

关键词： Costus speciosus Quality control Physico-chemical parameters Microscopy Fluorescence analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of Isoproturon Imprinted Polymer Membranes as a Selective Recognition Platform in a Resistance Based Electrochemical Sensor

引用

Open Journal of Applied Biosensor 2013年第1期2卷 20-28页

作者： Krishna Pal Singh ramesh kumar Prajapati Saurabh Ahlawat Sweeti Ahlawat Manjul Mungali Satish kumar Clay Product Environment Study Technology Division CSIR-Central Building Research Institute Roorkee India Membrane Biophysics & Nanobiosensor Research Laboratory CBSH G.B. Pant University of Agriculture & Technology Pantnagar India Membrane Biophysics & Nanobiosensor Research Laboratory CBSH G.B. Pant University of Agriculture & TechnologyPantnagar India

Methacrylic acid with isoproturon has been utilized to prepare molecularly imprinted polymeric (MIP) membrane on Whatman filter paper no. 5 for selective electrochemical estimation of isoproturon pesticide. MIP membrane was prepared by radical polymerization and characterized using Ultra Violet spectrophotometer, Fourier Transform Infra Red (FTIR) spectroscopy and Scanning Electron Microscopy (SEM). Contact angle study was used to determine the surface energy of the MIP membrane and electrical conductivity measurements were performed by applying a small-amplitude alternating voltage (20 mV) with frequencies varying from 20 Hz to 80 kHz generated by a low-frequency wave form generator. Different isoproturon concentrations in samples were tested and analyzed. Results indicate linear increase in membrane resistance with increasing isoproturon in 10-3 to 10-6 M range. The selectivity of the electrochemical sensor was confirmed by testing isoproturon in presence of the structurally related compounds monouran and diuran. Results reveal highly selective and sensitive sensor, which can be employed for regular estimation of isoproturon in fields.

关键词： Sensor Isoproturon Molecular Imprinting Monouran Diuran

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of Hearing Status by Pure Tone Audiogram—An Institutional Study

引用

International Journal of Otolaryngology and Head & Neck Surgery 2015年第5期4卷 375-380页

作者： Ganesh kumar Balasubramanian Ramanathan Thirunavukkarasu ramesh Babu Kalyanasundaram Gitanjali Narendran Thanjavur Medical College Thanjavur India

Aim: To assess the hearing status of the study subjects in terms of degree and type of hearing loss, and establish the burden of this disability in the society. Materials and methods: This is a prospective study conducted in patients who attend our OPD. After an otorhinolaryngeal examination, all the patients were subjected to pure tone audiometry using MAICA-MA52 audiometer. Results: Our study comprises 1012 males (64%) and 563 females (36%). Out of this, about 15% have conductive deafness and 42% have sensorineural hearing loss. About 29% suffer from mild hearing loss, 26% moderate and 11% severe hearing loss. The alarming information is that about 5% have total hearing loss of Sudden Sensorineural type (SSNHL). Conclusion: Pure tone audiometry is cost effective and easy to perform. Early diagnosis and timely intervention will reduce the morbidity of deafness in our country. Hence it is necessary to identify and treat sudden sensorineural hearing loss and noise induced hearing loss at an early stage.

关键词： Pure Tone Audiogram Conductive Deafness Sudden Sensorineural Hearing Loss Ototoxicity Presbyacusis Noise Induced Hearing Loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Audit of Sino-Nasal Diseases in a Tertiary Care Centre—A Prospective Study

引用

International Journal of Otolaryngology and Head & Neck Surgery 2015年第5期4卷 369-374页

作者： Ganesh kumar Balasubramanian Ramanathan Thirunavukkarasu ramesh Babu Kalyanasundaram Gitanjali Narendran Thanjavur Medical College Thanjavur India

Aims of the study: 1) To study the distribution of various Sino-nasal diseases in our region;2) To emphasize the significance of Functional Endoscopic Sinus Surgery. Material and methods: This surgical study was carried out in the Department of Otorhinolaryngology and Head and Neck Surgery, Thanjavur Medical College, Thanjavur. The study period was from 21st March 2014 to 20th March 2015 (267 cases). After a preliminary examination, all patients were subjected to Diagnostic Nasal Endoscopy followed by radiological examination. Based on the symptoms and the findings, patients were treated by surgery (mainly FESS), pharmacotherapy, and chemo-radiotherapy. Results: In our study, the majority of cases were deviated nasal septum with sinusitis about 62% (165 cases). The other cases were antrochoanal polyp 8% (21 cases), ethmoidal polyposis 9% (23 cases) and others 21% (51 cases). The age group vulnerable for these diseases is 20 - 40 years. Males are affected more commonly than females. Conclusion: Majority of the cases were treated by Functional Endoscopic Sinus Surgery. So we have to improve the surgical skills in this field to achieve a good outcome.

关键词： Pure Tone Audiogram Conductive Deafness Sudden Sensorineural Hearing Loss Ototoxicity Presbyacusis Noise Induced Hearing Loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：