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Congenital coronary artery anomalies silent until geriatric age： non-invasive assessment, angiography tips, and treatment

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Journal of Geriatric Cardiology 2015年第1期12卷 66-75页

作者： Gianluca Rigatelli Fabio Dell'Avvocata Nguyen Van Tan rames daggubati AravindaNanijundappa Section of Adult Congenital and Adult Heart Disease Cardiovascular Diagnosis and Endoluminal Interventions Rovigo General Hospital Rovigo Italy Department of Cardiology Thong Nhat Hospital Ho Chi Minh City Vietnam Brody School of Medicine at East Carolina University Greenville North Carolina USA CAMC Vascular Center of Excellence West Virginia University Charleston West Virginia USA

Coronary artery anomalies （CAAs） may be discovered more often as incidental findings during the normal diagnostic process for other cardiac diseases or less frequently on the basis of manifestations of myocardial ischemia. The cardiovascular professional may be involved in their angiographic diagnosis, fimctional assessment and eventual endovascular treatment. A complete angiographic definition is mandatory in order to understand the functional effects and plan any intervention in CAAs： computed tomography and magnetic resonance imaging are useful non-invasive tools to detect three-dimensional morphology of the anomalies and its relationships with contiguous cardiac structures, whereas coronary arteriography remains the gold standard for a definitive anatomic picture. A practical idea of the possible functional sig- nificance is mandatory for deciding how to manage CAAs： non-invasive stress tests and in particular the invasive pharmacological stress tests with or without intravascular ultrasound monitoring can assess correctly the functional significance of the most CAAs. Finally, the knowledge of the particular endovascular techniques and material is of paramount importance for achieving technical and clinical success. CAAs represent a complex issue, which rarely involve the cardiovascular professional at different levels. A timely practical knowledge of the main issues regarding CAAs is important in the management of such entities.

关键词： Coronary artery anomaly Congenital heart disease Coronary artery angiography Percutaneous coronary interventions

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IPET:测定独个生物大分子三维空间结构的实验方法

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化学进展 2013年第5期25卷 669-676页

作者：张腾彭云辉童慧敏 Matthew J rames 张磊任罡 The Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA 西安交通大学理学院

蛋白质的动态特性和结构活性对于蛋白质功能的调控具有根本意义。传统的结构确定方法(包括X射线和电子显微镜单颗粒分析技术等)往往需要成千上万不同蛋白质分子的平均信号,因此难以确定蛋白质分子的动态结构。而电子显微断层成像技术是... 详细信息

蛋白质的动态特性和结构活性对于蛋白质功能的调控具有根本意义。传统的结构确定方法(包括X射线和电子显微镜单颗粒分析技术等)往往需要成千上万不同蛋白质分子的平均信号,因此难以确定蛋白质分子的动态结构。而电子显微断层成像技术是一种对独个生物个体结构从不同的观测角度照相、并计算来恢复该个体的三维结构密度图的方法。传统的冷冻电子断层成像重构方法采用整个大尺寸电镜图像进行重构计算,通常用来研究细菌、细胞切片等大尺寸生物个体在较低分辨率下的结构;由于分辨率的限制,不足以获得小尺寸的蛋白质分子的结构细节。最近,任罡研究小组提出一种独个生物颗粒的电子显微断层成像方法(individual-particle electron tomography,IPET)。该方法通过减小图像尺寸(直至所选区域只包含单个蛋白质分子)的策略,运用提出的FETR(focused electron tomography reconstruction)算法来提高独个大分子重构的分辨率。此方法不需要初始模型和大量分子的平均信号,同时能够容忍一定的测角误差。本文综述了IPET/FETR方法在确定独个分子结构过程中的具体步骤以及如何应用该方法来研究蛋白动态特性和结构变化特征。期望通过该综述和国内同行交流,分享最新的前沿研究,为赶超世界科技前沿的建设添砖加瓦。

关键词：蛋白质动态结构独个蛋白质结构单分子电子断层成像方法 FETR 算法

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聚醚醚酮/介孔硅酸钙镁复合材料表面周期性微沟槽对细胞行为的影响

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功能高分子学报 2020年第4期33卷 350-356页

作者：韩航 rames Kaewmanee SYED Asadullah 沈学宁潘泳康钱军王雪红魏杰华东理工大学超细材料制备与应用教育部重点实验室上海200237

采用飞秒激光在聚醚醚酮/介孔硅酸钙镁复合材料表面构建了不同宽度(20、40μm和60μm)的周期性微沟槽,考察了微沟槽宽度对大鼠骨髓间充质干细胞黏附、增殖与分化的影响。结果表明:不同宽度的周期性微沟槽可以调控细胞的响应行为。经过... 详细信息

采用飞秒激光在聚醚醚酮/介孔硅酸钙镁复合材料表面构建了不同宽度(20、40μm和60μm)的周期性微沟槽,考察了微沟槽宽度对大鼠骨髓间充质干细胞黏附、增殖与分化的影响。结果表明:不同宽度的周期性微沟槽可以调控细胞的响应行为。经过飞秒激光精确而超快烧蚀,微沟槽的内表面形成了微纳结构,暴露出大量的介孔硅酸钙镁颗粒,其内表面粗糙度明显提高;随着微沟槽宽度的增加,复合材料表面的蛋白质吸附性能提高,而且明显促进了大鼠骨髓间充质干细胞响应;当微沟槽宽度为60μm时,复合材料表面显著地促进了细胞黏附、增殖与成骨分化,并且诱导细胞沿着沟槽方向生长。

关键词：聚醚醚酮介孔硅酸钙镁飞秒激光微沟槽

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Odour Removal in Leather Tannery

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Advances in Chemical Engineering and Science 2012年第2期2卷 199-203页

作者： rames C. Panda Chokalingam Lajpathi Rai Venkatasubramaniam Sivakumar Asit Baran Mandal Scientist Central Leather Research Institute (CSIR) Adyar India

Toxic odour causes pollution to environment. Removal of odour from wet processing sections of leather tanneries is important to preserve safety and occupational health. Such odour causing gases are identified in nature and are identified mostly as ammonia, Hydrogen sulfide and Volatile organic compounds. These gases, evolving from tanning drums, were experimentally quantified and analysed. Techniques for the abatement of odorous gases are designed using chemical methods. Scrubbing towers based on absorption of gases by liquid are designed and fabricated to evaluate the performance of the system in laboratory scale. Those gases were reduced in the concentration by absorbing through the packed bed vapour phase absorption using the activated carbon as the adsorbent. Results are helpful to conclude that the absorption technique presented here to reduce these toxic emission loads, seems to be simpler and economically cheaper.

关键词： Odour Packed Tower Absorbtion Tannery Pollution

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