检索结果-南通市图书馆

Salivary Active MMP-2 of Breast Cancer Patients Is Inhibited by Guava Leaves PBS Extract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2022年第5期13卷 650-658页

作者： ramanuj mukherjee Syandan Sinha Ray Subhajit Mondal Amitava Chatterjee R G Kar Medical College Kolkata India Ramakrishna Mission Vivekananda Educational & Research Institute Kolkata India

Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.

关键词： MMP-2 Inhibitor Saliva Breast Cancer

Comparative investigation towards machinability improvement in hard turning using coated and uncoated carbide inserts： part Iexperimental investigation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Manufacturing 2018年第1期6卷 52-70页

作者： ramanuj Kumar Ashok Kumar Sahoo Purna Chandra Mishra Rabin Kumar Das School of Mechanical Engineering Kalinga Institute of Industrial Technology BhubaneswarOdisha 751024 India

The investigation of low cost uncoated andcoated carbide insert in the hard turning of hardened AISID2 steel （≥55 HRC） will definitely open up a new arena asan economical alternative suitable to industrial machiningsectors. Thus, this paper reports the comparative machin-ability assessment for the hard turning of AISI D2 steel（（55 ± 1） HRC） by coated and uncoated carbide insert in adry environment. Micro hardness and abrasion tests werecarried out to assess resistance capability against wear. Theabove test results confirmed the greater wear resistanceability of AIaO3 coated carbide insert over uncoated car-bide. Based on the extensive investigation of comparativemachinability, the coated carbide insert （TiN-TiCN-A12O3）outperformed the uncoated carbide insert with regard tosurface roughness, flank wear, chip-tool interface temper-ature, and chip morphology. Abrasion and diffusion wereobserved as the principal tool wear mechanisms in theinvestigated range. The uncoated carbide failed completelydue to the severe chipping and quick dulling of the cuttingedge, which led to its unsuitability for machining hardenedsteel.

关键词： Coated and uncoated carbide Hard turning Machinability Flank wear Surface roughness Chipmorphology Cutting temperature

Comparative study on machinability improvement in hard turning using coated and uncoated carbide inserts： part II modeling, multi-response optimization, tool life, and economic aspects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Manufacturing 2018年第2期6卷 155-175页

作者： ramanuj Kumar Ashok Kumar Sahoo Purna Chandra Mishra Rabin Kumar Das School of Mechanical Engineering Kalinga Institute of Industrial Technology Bhubaneswar-24 Odisha India

The present study focused on mathematical modeling, multi response optimization, tool life, and eco- nomical analysis in finish hard turning of AISI D2 steel （（55 4- 1） HRC） using CVD-coated carbide （TiN/TiCN/ A1203） and uncoated carbide inserts under dry environ- mental conditions. Regression methodology and the grey relational approach were implemented for modeling and multi-response optimization, respectively. Comparative economic statistics were carried out for both inserts, and the adequacy of the correlation model was verified. The experimental and predicted values for all responses were very close to each other, implying the significance of the model and indicating that the correlation coefficients were close to unity. The optimal parametric combinations for A1203 coated carbide were dl-fl-v2 （depth of cut = 0.1 mm, feed = 0.04 mm/r and cutting speed = 108 m/min）, and those for the uncoated tool were dl-（0.1 mm）-fl （0.04 mm/r）-vl （63 rn/min）. The observed tool life for the coated carbide insert was 15 times higher than that for the uncoated carbide insert, considering flank wear criteria of 0.3 mm. The chip volume after machining for the coated carbide insert was 26.14 times higher than that of the uncoated carbide insert and could be better utilized for higher material removal rate. Abrasion, diffusion, notch- ing, chipping, and built-up edge have been observed to be the principal wear mechanisms for tool life estimation. Use of the coated carbide tool reduced machining costs by about 3.55 times compared to the use of the uncoated carbide insert, and provided economic benefits in hard turning.

关键词： Machinability Hard turning Regression Grey relational analysis Tool life Economic analysis

Protocol Based Approach for Tacit to Explicit Knowledge Conversion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Technology and Application 2011年第1期2卷 75-79页

作者： David Kulandaisamy t Balasubramanian ramanuj am Department of Computer Science ＆ Engineering Bharathidasan University Trichy 620023 India Faculty of Computer Applications Erode Builder Educational Trust＇s Group of Institutions Kangeyam Taluk 638 108 India

In the knowledge management domain, the conversion of tacit knowledge to explicit knowledge is critical because it is a prerequisite to the knowledge amplification process wherein knowledge becomes part of an organization＇s knowledge network. Although codified knowledge and its capture is commonplace, tacit knowledge has up until recent years proved elusive in its inclusion within the organization＇s knowledge base. In this paper, the conversion process has been dealt with the help of protocols. It is learned that while structure may significantly improve the tacit to explicit conversion process, it also may matter how the structure is employed. It is anticipated that eventual successful modeling of such knowledge will ultimately be undertaken in several organizations with a view to improving information capture and transference.

关键词： Tacit knowledge explicit knowledge knowledge transfer knowledge management.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基层医疗中的抑郁症:第2部分——管理

英国医学杂志中文版 2019年第8期22卷 456-470页

作者： Parashar ramanuj Erin K Ferenchick Harold Alan Pincus 祁祯楠(译) 周国鹏(校) Center for Family and Community Medicine Columbia University Medical Center New York NY USA Royal National Orthopaedic Hospital RAND Europe Department of Psychiatry Columbia University New York State Psychiatric Institute New York NY USA Irving Institute for Clinical and Translational Research Columbia University New York NY USA RAND Corporation PittsburghPA USA 北京大学第一医院健康管理中心

抑郁症是一种社区常见疾病,具有普遍性、多样性、慢性反复发作的病程特点。全科医生在管理抑郁患者及其合并症中承担了重要角色,也在诊断和治疗的过程中面临挑战。在这两个系列中,我们回顾了可以帮助指导全科医生识别和管理抑郁症患者... 详细信息

抑郁症是一种社区常见疾病,具有普遍性、多样性、慢性反复发作的病程特点。全科医生在管理抑郁患者及其合并症中承担了重要角色,也在诊断和治疗的过程中面临挑战。在这两个系列中,我们回顾了可以帮助指导全科医生识别和管理抑郁症患者的证据。第一部分的文献综述讲解了在社区识别和诊断抑郁症的方法。第二部分的文献回顾了在基层医疗中基于循证医学的抑郁症治疗方法,详细介绍了生活方式、药物和个人心理干预治疗,同时强调了基层医疗机构在组织层面有效管理抑郁症的战略措施。

关键词：基层医疗机构有效管理抑郁症心理干预治疗抑郁患者全科医生治疗方法常见疾病

基层医疗中的抑郁症:第1部分——筛查和诊断

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2019年第8期22卷 448-456页

作者： Erin K Ferenchick Parashar ramanuj Harold Alan Pincus 高畅(译) 张家玮(译) 郑凌霄(译) 高畅(校) Center for Family and Community Medicine Columbia University Medical Center New York NY USA Royal National Orthopaedic Hospital RAND Europe Department of Psychiatry Columbia University New York State Psychiatric Institute New York NY USA Irving Institute for Clinical and Translational Research Columbia University New York NY USA RAND Corporation PittsburghPA USA 北京大学第一医院健康管理中心

关键词：基层医疗机构抑郁症诊断筛查心理干预治疗有效管理抑郁患者全科医生