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Efficacy of a Diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, Dietary and Gut Health Markers in Adults with Type 2 Diabetes: An RCT

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Food and Nutrition Sciences 2024年第8期15卷 846-867页

作者： Deepti Khanna Hema S. Gopalan Kuzhandaivelu Abirami Vasudevan Sudha Rajagopal Gayatri Kejal Joshi-Reddy Jaladhi Bhatt raman ganesh jeevan Karthikeyan Parkavi Vadivel Deepika Manoj Pareek Ranjit Mohan Anjana Viswanathan Mohan R&D Department Hindustan Unilever Limited Gurugram India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohans Diabetes Specialities Centre Chennai India

With increasing incidence of diabetes, use of diabetes specific nutrition supplements (DSNS) is common for better management of the disease. To study effect of 12-week DSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above Range (TIR/TAR)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either DSNS with standard care (DSNS + SC;n = 105) or standard care alone (SC alone;n = 105). After 12 weeks, significant differences between DSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl;p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl;p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg;p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2;p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm;p = 0.01]. HbA1C and low-density lipoprotein (LDL) were significantly reduced in DSNS + SC [−0.2 ± 0.9;p = 0.04 and −5 mg/dl;p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between DSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl;p < 0.01], TAR 180 [−9 ± 42 vs 7 ± 45 mg/dl;p = 0.04], TAR 250 [−3 ± 27 vs 9 ± 38 mg/dl;p = 0.05], iAUC [−192 (1.1) vs −48 (1.1) mg/dl;p = 0.03]. MAGE was significantly reduced for both DSNS + SC (−19 ± 67;p < 0.001) and SC alone (−8 ± 70;p = 0.04), with reduction being more pronounced for DSNS + SC. DSNS + SC reported a decrease in carbohydrate energy % [−9.4 (−11.3, −7.6) %;p < 0.0001] and amount [−47.4 (−67.1, −27.7) g;p < 0.0001], increased dietary fiber [9.5 (7.2, 11.8) g;p < 0.0001] and protein energy % [0.9 (0.5, 1.3) %;p < 0.0001] versus SC alone. DSNS + SC reported signi

关键词： Diabetes Specific Nutrition Supplement Standard of Care Diabetes Glycemic Markers HbA1C

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Glycemic Index and Response of a Plant Based Nutritional Supplement and Its Subjective Satiety Following Its Use in Indian Adults

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Food and Nutrition Sciences 2019年第8期10卷 937-946页

作者： Bhoite Rachana Parthasarthy Vijayalakshmi raman jeevan ganesh Viswanathan Gopinath Karthikeyan Parkavi Vasudevan Kavitha Nagamuthu Gayathri Rajagopal Gayathri Shanmugam Shobana Ranjit Mohan Anjana Ranjit Unnikrishnan Vasudevan Sudha Mehta Suyog Archana Toppo Panda Acharya Shivani Viswanathan Mohan Dr. Reddy’s Laboratories Hyderabad India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohan’s Diabetes Specialities Centre Chennai India

Background: Diet plays a vital role in managing diabetes. Foods with a low glycemic index provide lower postprandial glucose spikes and induce satiety. The objective of this study was to assess the Glycemic index (GI) without milk and Glycemic response (GR) with milk of two different flavours of a plant-based supplement which is high in protein and fibre, along with a subjective assessment of satiety. Methods: Fifteen overweight/obese subjects aged 18 - 45 years were recruited. After overnight fasting, blood samples were drawn at 5 mins before food consumption (-5), 0, 15, 30, 45, 60, 90 and 120 minutes. Participants underwent 3 days of reference food testing and 1 day of test food in random order with 2 days of wash-out period. The GI was assessed using a validated protocol recognized by FAO/WHO, as well as the guidelines by the International Dietary Carbohydrate Task Force for GI Methodology. The satiety index was measured using the Visual Analog Scale (VAS). The dietary intake of the subjects was measured by 24-hour dietary recall. The Incremental Area Under the Curve (IAUC) was calculated using the trapezoid rule. Results: Both the flavours of the supplement had low GI & GR. The GI and GR of Flavour 1 were 27.3 ± 4.8 & 16.4 ± 2.6 (Mean ± SEM) respectively. For Flavour 2 the GI and GR were 36.7 ± 4.4 & 25.7 ± 2.3 (Mean ± SEM). For Flavour 1, 60% and for flavour 2 66.7% of subjects reported feeling hungry only after 3 hours, showing good satiety. Conclusion: The plant-based high fibre high protein supplement in both flavours showed a low glycemic index and hence may be useful to include in the diets to reduce the postprandial glycemic response and could improve satiety.

关键词： Glycemic Index High Protein High Fiber Satiety Visual Analog Scale

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Structural, vibrational, optical, photoluminescence, thermal,dielectric, and mechanical studies on zinc(tris) thiourea sulfate single crystal: A noticeable effect of organic dye

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Chinese Physics B 2018年第5期27卷 304-312页

作者： Mohd Shkir V ganesh S AlFaify I S Yahia Mohd Anis Advanced Functional Materials & Optoelectronic Laboratory Department of PhysicsFaculty of ScienceKing Khalid University Department of Physics Sant Gadge Baba Amravati University

In this work, uranine-dyed zinc（tris） thiourea sulfate（ZTS） monocrystals, 26 mm×15 mm×10 mm in size, were synthesized by the solution method at ambient temperature. Their purity, crystallinity, lattice parameters, and functional modes were studied by x-ray diffraction, Fourier transform-infrared spectroscopy（FT-IR）, and FT-raman spectroscopy analyses. The sodium ion content of the crystals from the dye was confirmed by elemental analysis. The diffused reflectance spectral analysis of the dyed crystal revealed a characteristic absorption band at 490 nm attributed to the presence of the dye. The calculated band gaps of the non-dyed and dyed crystals were 4.53 and 4.57 e V, respectively. A green emission peak at ～（512 ± 4） nm was observed in the photoluminescence spectrum of the uranine-dyed crystals. A differential scanning calorimetry study confirmed that the thermal stability improved owing to the addition of the dye. Dielectric and microhardness studies were conducted to examine the significant improvements in the corresponding properties of dyed crystals. The results demonstrated the competency of the dyed ZTS crystals for applications in optoelectronic devices.

关键词： crystal growth dielectric properties luminescence thermal properties mechanical properties

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Influence of laser peening on microstructure and fatigue lives of Ti-6Al-4V

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Transactions of Nonferrous Metals Society of China 2014年第10期24卷 3111-3117页

作者： S.ANAND KUMAR R.SUNDAR S.ganesh SUNDARA raman H.KUMAR R.KAUL K.RANGANATHAN S.M.OAK L.M.KUKREJA K.S.BINDRA Department of Metallurgical and Materials Engineering IIT Madras Chennai-600036 India Solid State Laser Division RRCAT Indore 452013 India Laser Material Processing Division RRCAT Indore 452013 India

The influence of low energy laser peening on fatigue lives of Ti-6Al-4V was investigated. Laser peening was carried out on Ti-6Al-4V samples. Laser peened samples were characterized by residual stress analysis, surface roughness measurements, X-ray diffraction, optical microscopy, nanoindentation hardness tests, scanning and transmission electron microscopy and fatigue testing. Laser peening resulted in the formation of nanocrystallites on the surface and near surface regions with associated increase in hardness and introduction of compressive residual stress. Owing to positive influence of nanostructured surface and compressive residual stress, fatigue lives of the laser peened samples were significantly increased compared to the unpeened samples.

关键词： Ti-6Al-4V laser peening fatigue nanostructured surface

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Exploring the electromagnetic shielding behavior of lanthanum doped calcium nanoferrites

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Journal of Rare Earths 2024年第11期42卷 2128-2136,I0005页

作者： E.Ahilandeswari K.Sakthipandi R.Rajesh Kanna G.Rajkumar B.ganesh Babu S.Arunmetha Aslam Hossain P.Sakthivel V.Rajendran M.Srinidhi Raghavan Department of Physics SRM TRP Engineering CollegeTiruchirappalli621105Tamil NaduIndia Department of Electronics and Communication Engineering M.Kumarasamy College of EngineeringKarur639113Tamil NaduIndia Department of Physics Easwari Engineering CollegeChennai600089Tamil NaduIndia Department of Mechanical Engineering SRM TRP Engineering CollegeTiruchirappalli621105Tamil NaduIndia Centre for Advanced Energy Studies Department of Electronics and Communication EngineeringKoneru Lakshmaiah Education FoundationGunturAndhra Pradesh522502India Smart Materials Research Institute Southern Federal UniversitySladkova 178/24344090Rostov-on-DonRussia Centre for Materials Science Department of PhysicsScience and HumanitiesFaculty of EngineeringKarpagam Academy of Higher EducationCoimbatore641021Tamil NaduIndia Centre for Nanotechnology Academy of Maritime Education and Training(Deemed to be University)Chennai603112Tamil NaduIndia Department of Chemistry and Centre for Nano-Materials and Displays B.M.S.College of EngineeringBengaluru560019KarnatakaIndia

The present study focuses on the synthesis and characterization of lanthanum(La^(3+))-doped calcium nanoferrites(CaLa_(x)Fe_(2-x)O_(4):x=0.025,0.050,0.075 and 0.100)using the sonochemical *** techniques were employed to analyze the effect of La^(3+)infusion,raman spectroscopy confirms the presence of active A_(1g),T_(2g)and E_g modes in the CaLa_(x)Fe_(2-x)O_(4)nanoferrite,indicating the formation of an active ferrite *** introduction of La^(3+)doping results in a significant increase in the band gap energy,rendering the nanoferrites insulating(3.23-3,57 eV).At higher frequencies,the impedance studies reveal minimal losses and better AC conductivity,pointing to improved dielectric *** higher frequencies,the Q-factor of La-doped calcium nanoferrites shows lower electromagnetic *** M-H curve exhibits ferromagnetic behavior,with La^(3+)-doped calcium nano ferrites displaying a saturation magnetization ranging from 12.72 to 18.10 emu/*** incorporation of La^(3+)also induces enhanced electrical polarization,leading to notable dielectric loss and increased absorption of electromagnetic ***,these CaLa_(x)Fe_(2-x)O_(4)nanoferrites demonstrate potential as effective microwave absorbers across a wide frequency range,with significant shielding absorption observed at 8.8-9.1 GHz.

关键词： Nanoferrites Structural properties Rare earths Dielectric Magnetism Microwave absorption

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