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A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

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Animal Models and Experimental Medicine 2024年第5期 591-605页

作者： Mohammad Yasin Zamanian Niloofar Taheri Montather F.ramadan Yasser Fakri Mustafa Safa Alkhayyat Klunko Nataliya Sergeevna Hashem O.Alsaab Ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar Department of Physiology School of Medicine Hamadan University of Medical Sciences Department of Pharmacology and Toxicology School of Pharmacy Hamadan University of Medical Sciences School of Medicine Shahroud University of Medical Sciences College of Dentistry Al-Ayen University Department of Pharmaceutical Chemistry College of Pharmacy University of Mosul College of Pharmacy The Islamic University Department of Training of Scientific and Scientific-Pedagogical Personnel Russian New University Department of Pharmaceutics and Pharmaceutical Technology Taif University Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Department of Clinical Biochemistry School of Medicine Rafsanjan University of Medical Sciences Department of Surgery School of Medicine Hamadan University of Medical Sciences

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription *** results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase-2 and wingless-related integration site(Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin-dependent kinase 2 and cyclin-dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2(CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y-box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal-regulated kinase 1/2, and disrupting the repair process of DNA double-strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α(PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase(PI3K) expressio

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Does wet-cupping therapy improve repeated sprint ability,perceived wellness,and rating of perceived exertion in young active males?

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Sports Medicine and Health Science 2024年第4期6卷 378-384页

作者： Ismail Dergaa Amine Ghram Mohamed Romdhani Amine Souissi Achraf Ammar ramadan Abdelmoez Farahat Mohamed Saifeddin Fessi Khadijeh Irandoust Morteza Taheri Tasnim Masmoudi Mohamed Amine Dergaa Nizar Souissi Omar Hammouda Katja Weiss Karim Chamari Helmi Ben Saad Beat Knechtle Primary Health Care Corporation(PHCC) DohaP.O.Box 26555Qatar Research Unit Physical Activity Sportand HealthUR18JS01National Observatory of SportTunis 1003Tunisia High Institute of Sport and Physical Education University of SfaxSfaxTunisia Department of Cardiac Rehabilitation Heart HospitalHamad Medical CorporationDohaQatar Universite de Sousse Faculte de Medecine de SousseHopital Farhat HACHEDLaboratoire de Recherche(Insuffisance CardiaqueLR12SP09)SousseTunisia Healthy Living for Pandemic Event Protection(HL-PIVOT)Network ChicagoILUSA Interdisciplinary Laboratory in Neurosciences Physiology and Psychology:Physical ActivityHealth and LearningUFR STAPSUPLParis Nanterre UniversityNanterreFrance Department of Training and Movement Science Institute of Sport ScienceJohannes Gutenberg-University Mainz55128 MainzGermany Research Laboratory Molecular Bases of Human PathologyLR19ES13Faculty of Medicine of SfaxUniversity of SfaxSfax 3029Tunisia Faculty of Medicine Kafrelsheikh UniversityKafrelsheikh33511Egypt Department of Behavioral and Cognitive Sciences in Sport Faculty of Sport Sciences and HealthUniversity of TehranIran University of Sousse Farhat HACHED HospitalForensic ServiceSousseTunisia Medbase St.Gallen Am Vadianplatz St.GallenSwitzerland Aspetar Orthopaedic and Sports Medicine HospitalFIFA Medical Centre of ExcellenceDohaP.O.Box 29222Qatar Institute of Primary Care University of ZurichZurichSwitzerland

Wet-cupping therapy(WCT)is one of the oldest known medical techniques,used as a traditional and complementary therapy with a wide application all around the world for general *** on the effects of WCT on sports performance are sparse and ***,we aimed to explore the effects of WCT on repeated sprint ability,wellness,and exertion in young active ***-nine active adult males(age:[28±5]years;body height[177±8]cm;body mass:[79±7]kg;body mass index:[25.4±1.8]kg/m^(2))were selected for the *** participants performed a running-based sprint test on two separate occasions(Control and Post-WCT).WCT was performed 24 h before the testing *** completed the Hooper questionnaire to assess their well-being(i.e.,sleep,stress,fatigue,and soreness)before each *** rating of perceived exertion(RPE)was collected after each testing session.A higher maximum power(p<0.05,effect size[ES]=0.6),mean power(p<0.01,ES=0.5)and minimum power(p<0.01,ES=0.6)were recorded post-WCT as compared to Control session along with a better perceived sleep(p<0.01,ES=0.85).Perceived stress(p<0.01,ES=0.6)and RPE(p<0.001;ES=1.1)were lower during the post-WCT compared to the Control *** present findings demonstrated that WCT moderately enhanced repeated sprint ability and had positive effects on perceived sleep,stress,and *** may be an effective ergogenic aid to improve repeated sprint ability and general wellbeing in young adult *** large-scale multicentric clinical studies are paramount to confirm the results of our study.

关键词： Alternative medicine Complementary medicine Hijama Short-term maximal performance Sports medicine

URBAN PLANNING:A TOOL FOR URBAN POVERTY ALLEVIATION IN SUDAN

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Chinese Geographical Science 2004年第2期14卷 110-116页

作者： Elnazir ramadan Department of Urban and Resources Sciences Nangjing University Nanjing 210093. P. R. China Department of Geography University of Juba 321/1 Khartoum Sudann the past few dacades urbanization and urban growth have been increasing rapidly in many of the developing countries. It is expected that over 50% of the world population will live in cities in 2005. The growing trend indicates that as many as one fifth of all households still remain with housing tenure problems which they try to solve through very expensive rentals insecurity socially and environmentally-hazardous squatting or unhealthy overcrowding sometimes ending up with none at all. And hence propcr planning is necessary in urban development policies to improve human settlement managements in a sustainable way. This article has tried to handle urban poverty in the Sudan to a reasonable level of detail. It dealt with selected areas with regard to promotion of sustainable human settlement. The study managed to identity some recent progress in Sudanese human settlements that is however still accompanied by numerous serious instances of decline in the urban environment especially that of the greater Khartoum. Such instances of environmental deterioration are profiled and analyzed by the study with respect to all human settlement aspects of management land-use infrastructure energy and transport. The paper's conclusion emphasized that improving all these aspects is of high priority.

In the past few dacades, urbanization and urban growth have been increasing rapidly in many of the developing countries. It is expected that over 50% of the world population will live in cities in 2005. The growing trend indicates that as many as one fifth of all households still remain with housing tenure problems, which they try to solve through very expensive rentals, insecurity, socially and environmentally-hazardous squatting or unhealthy overcrowding, sometimes ending up with none at all. And hence, proper planning is necessary in urban development policies to improve human settlement managements in a sustainable way. This article has tried to handle urban poverty in the Sudan to a reasonable level of detail. It dealt with selected areas with regard to promotion of sustainable human settlement. The study managed to identity some recent progress in Sudanese human settlements, that is, however, still accompanied by numerous serious instances of decline in the urban environment, especially that of the greater *** instances of environmental deterioration are profiled and analyzed by the study with respect to all human settlement aspects of management, land-use, infrastructure, energy and transport. The paper's conclusion emphasized that improving all these aspects is of high priority.

关键词：城市规划贫困经济发展苏丹

Inelastic displacement ratio of low-to mid-rise BRBFs designed under variable levels of seismicity

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 763-775页

作者： Hamdy Abou-Elfath Mostafa ramadan Faculty of Engineering Alexandria UniversityAlexandria 21544Egypt

Buckling-restrained braces(BRBs)have shown their capability to provide building structures with stiffness,strength,and *** the seismic drifts of buckling-restrained braced frames(BRBFs)is an important design step to control structural and non-structural *** current practice of seismic design,the estimation of seismic drifts of BRBFs is performed by using empirical calculations that are independent upon either the type of the structural system or the design level of *** these empirical calculations,the seismic drifts are estimated by amplifying the reduced elastic drifts obtained under design lateral loading with a displacement amplification factor(DAF).The value of DAF is considered equal to the product of the response modification factor R and the inelastic displacement ratioρ.The goal of the current research is to assess the value ofρfor low-to mid-rise BRBFs designed under low and high levels of *** goal has been achieved by conducting a series of elastic and inelastic time-history analyses pertaining to an ensemble of earthquake records on 3-,6-and 9-story *** results indicate that theρ-ratio increases with an increase in design seismic intensity and an increase in experienced *** range ofρfor low seismicity designs ranges from 0.63 to 0.9,while for high seismicity designs this range stretches from 0.83 to *** has been found that the consideration of a generalρ-ratio of 1.0 is a reasonable estimation for the design of the BRBFs considered in this study.

关键词： displacement amplification factor inelastic displacement ratio seismicity buckling-restrained brace seismic drift seismic design

Friction and wear of sand-contaminated lubricated sliding

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Friction 2018年第4期6卷 457-463页

作者： Mohamed Ahmed ramadan Faculty of Engineering at Helwan Helwan University

This paper reports a test investigation of friction and wear responses from sand contaminated lubricated sliding. The influence of sand contaminants on wear and friction is characterized. Analyses are completed utilizing segments of piston ring sliding against the cylinder liner. Paraffin oil, with and without sand contaminants, is utilized. The effects of the concentration and particle size of sand are examined. Based on the observations in the present work, we found that friction and wear increase with sand concentration in the lube. Solid proposals ought to be considered, in order to enlighten the general population on the importance of changing a car engine's oil filter regularly.

关键词： sand contamination lubrication oil abrasive wear lubricated sliding

Hyoscine N-butylbromide inhalation:they know,how about you?

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World Journal of Emergency Medicine 2023年第1期14卷 81-82页

作者： Hayri ramadan Department of Emergency Medicine Ankara Training and Research HospitalUniversity of Health SciencesAnkara 06230Turkey

Dear editor,Hyoscine N-butylbromide(HNB)is a quaternary ammonium compound with an anticholinergic effect and is commonly used as an antispasmodic drug.[1,2]HNB decreases motility in the gastrointestinal and genitourin... 详细信息

关键词： editor quaternary ammonium

A survey of recent interactive image segmentation methods

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Computational Visual Media 2020年第4期6卷 355-384页

作者： Hiba ramadan Chaymae Lachqar Hamid Tairi Department of Informatics Faculty of Sciences Dhar El MahrazUniversity of Sidi Mohamed Ben AbdellahFez 30000Morocco Faculty of Medicine and Pharmacy University of Sidi Mohamed Ben AbdellahFez 30000Morocco

Image segmentation is one of the most basic tasks in computer vision and remains an initial step of many applications. In this paper, we focus on interactive image segmentation(IIS), often referred to as foreground–background separation or object extraction, guided by user interaction. We provide an overview of the IIS literature by covering more than 150 publications, especially recent works that have not been surveyed before. Moreover, we try to give a comprehensive classification of them according to different viewpoints and present a general and concise comparison of the most recent published works. Furthermore, we survey widely used datasets,evaluation metrics, and available resources in the field of IIS.

关键词： interactive image segmentation user interaction label propagation deep learning superpixels

Assessing the lifetime performance index of weighted Lomax distribution based on progressive type-Ⅱ censoring scheme for bladder cancer

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International Journal of Biomathematics 2021年第4期14卷 49-66页

作者： Dina A.ramadan Department of Mathematics Faculty of Science Mansoura UniversityMansouraEgypt

In this paper,Health-related quality of life has not been adequately measured in bladder cancer.A recently developed reliable and disease-specific quality of life instrument(Bladder Cancer Index,RCI)was used to *** type Ⅱ censoring schemes have potential usefulness in practice where budget constraints in place or there is a necessity for the speedy *** test the process capability,the lifetime performance index Cl is widely recommended for evaluating the performance of the producfs lifetime and evaluating the lifetime performance index GL for the three-parameter Weighted-Lomax distribution(WLx)under progressive type-II censoring sample for a lower specification limit(L).The statistical inference concerning CL is conducted via obtaining the maximum likelihood of Cl on the base of progressive type-II *** asymptotic normal distribution of the MLE of CL and the confidence interval is ***,the hypothesis testing of CL for evaluating the lifetime performance of WLx data is ***,assuming the conjugate prior distribution and squared error loss function,this study constructs a Bayes estimator of *** Bayes estimator of CL is then utilized to develop a credible interval in the condition of known ***,we propose a Bayesian test to assess the lifetime performance of *** also propose a Bayesian test to assess the lifetime performance of ***,two examples are given,one of them is considering a real life data of the remission times of bladder cancer patients in endurance lifetime test and the other is a simulated example to illustrate the usage of the proposed procedure.

关键词： Lifetime performance index Weighted-Lomax distribution progressively type-II right censoring

Comparative Study of Different Decoupling Schemes for TITO Binary Distillation Column via PI Controller

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IEEE/CAA Journal of Automatica Sinica 2018年第4期5卷 869-877页

作者： Mohamed Hamdy Abdalhady ramadan Belal Abozalam Industrial Electronics and Control Engineering Department Faculty of Electronic EngineeringMenoufia UniversityMenouf-23952Egypt Badr Petroleum Company(BAPETCO) CairoEgypt

This paper presents a comparative study of different decoupling control schemes for a two-input, two-output(TITO) binary distillation column via proportional-integral(PI)controller. The key idea behind this paper is designing two novel fuzzy decoupling schemes that depend on human knowledge,instead of the system mathematical model used in conventional decoupling schemes. Based on conventional and inverted decoupling schemes, fuzzy and inverted fuzzy decoupling schemes are developed. The control effect is compared using simulation results for the proposed two schemes with conventional decoupling and inverted decoupling. The proposed fuzzy decoupling schemes are easy to realize and simple to design, besides they have a good decoupling capability. Two methods are used to prove asymptotic stability of each loop and the entire closed-loop system by applying the proposed fuzzy decoupling-based PI *** Wood and Berry model of a binary distillation column is used to illustrate the applicability of the proposed schemes.

关键词： Binary distillation column conventional decoupling fuzzy decoupling proportional-integral(PI) controller stability analysis