检索结果-南通市图书馆

Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第3期16卷 225-235页

作者： rama Krishna Gurram Jinfang Zhu Molecular and Cellular Immunoregulation Section Laboratory of Immune System BiologyNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMD 20892USA

The type 2 immune response is critical for host defense against large parasites such as *** the other hand,dysregulation of the type 2 immune response may cause immunopathological conditions,including asthma,atopic dermatitis,rhinitis,and ***,a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding *** classical model of type 2 immunity mainly involves the differentiation of type 2 T helper(Th2)cells and the production of distinct type 2 cytokines,including interleukin-4(IL-4),IL-5,and *** 2 innate lymphoid cells(ILC2s)were recently recognized as another important source of type 2 *** eosinophils,mast cells,and basophils can also express type 2 cytokines and participate in type 2 immune responses to various degrees,the production of type 2 cytokines by the lymphoid lineages,Th2 cells,and ILC2s in particular is the central event during the type 2 immune *** this review,we discuss recent advances in our understanding of how ILC2s and Th2 cells orchestrate type 2 immune responses through direct and indirect interactions.

关键词： Type 2 immune response type 2 T helper cell(Th2) Group 2 innate lymphoid cell(ILC2) Allergy and asthma

Tribological Properties of A356.2/RHA Composites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2012年第4期28卷 367-372页

作者： D. Siva Prasad A. rama Krishna Department of Mechanical Engineering GITAM University Visakhapatnam Andhra Pradesh India Department of Mechanical Engineering ANDHRA University Visakhapatnam Andhra Pradesh India

Rice husk ash （RHA） is one of the industrial waste byproduct available abundantly in the world. In the present work, an attempt is made to incorporate the RHA particles in the molten aluminum A356,2 alloy. The RHA particles were added into the matrix melt by creating a vortex with the help of a mechanical stirrer and the melt temperature was maintained between 800 and 850 ℃. Dry sliding wear experiments were performed in a pin on disc wear equipment against a chromium steel disc at 30 ℃. Scanning electron microscopy is used to study the wear characteristics of the unreinforced AI alloy and the A356.2/RHA composites. From the experiments it is observed that the composites exhibit higher hardness and resistance to wear as compared to unreinforced AI alloy,

关键词： Rice husk ash A356.2 Aluminum alloy Wear

Induction of osteoblast differentiation in human adipose derived stem cells by lanthanum ions

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2014年第11期32卷 1080-1088页

作者： Harini D Indra R Rajaram A rama Rajaram Department of Biochemistry Central Leather Research Institute Department of Biophysics Central Leather Research Institute

Adipose derived stem cells represent a readily available source of adult stem cells for various biomedical applications. In this study, the proliferation and osteogenic differentiation potential of lanthanum nitrate（La3＋） on human adipose derived mesenchymal stem cells（hADSCs） were investigated for the first time and compared with that of dexamethasone（Dex）. Our results provided evidence that La3＋ at 50 μmol/L concentration promoted proliferation of hADSCs upto 2.4 fold when treated for 21 d in DMEM medium. Treatment of hADSCs with La3＋ containing osteogenic induction medium（α-MEM with ascorbic acid and β-glycerophosphate） for 7 d resulted in higher calcium deposition than that in the presence of Dex（0.1 μmol/L） as shown by Alizarin red S and von Kossa staining. Scanning electron micrographs also showed more extracellular matrix mineralization in the presence of La3＋. After 7 d of treatment with La3＋（10 μmol/L） the expression of RunX2, osteopontin（OP） and osteocalcin（OC） increased 3.4, 5.5 and 2.7 fold respectively. Our results provided evidence that in the presence of La3＋ osteogenic differentiation occurred earlier than that in the presence of Dex.

关键词： hADSCs lanthanum osteoblast differentiation genes calcium deposition SEM RunX2 rare earths

Moisture dependent physical properties of Lagenaria siceraria seed

在线全文

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2013年第4期6卷 111-120页

作者： Prashant Pandharinath Said rama Chandra Pradhan Department of Farm Engineering Institute of Agricultural SciencesBanaras Hindu UniversityVaranasiUttar Pradesh 221005India

The investigation was done to evaluate the effect of moisture content on some physical properties of Lagenaria siceraria *** study was conducted at five moisture levels including 8.84%,10.10%,11.89%,12.60%and 15.10%(w.b.).Results showed that the mean value of principal dimensions,average diameters,surface area and 1000 seed mass increased linearly but aspect ratio decreased with increase in moisture *** sphericity increased in the moisture range of 8.84%to 11.89%but decreased with further raise in the moisture up to 15.10%.Gravimetric properties like bulk density increased with increase in moisture content however true density and porosity decreased linearly with increase in moisture *** of repose and terminal velocity increased linearly with moisture content of the *** coefficient of friction increased linearly with seed moisture content on five experimental surfaces(plywood,galvanized iron,glass and plastic).The information pertaining to moisture dependant physical properties of Lagenaria siceraria seeds may become an essential part in design of processing machines and its unit operations,design of dehulling,oil expression and other processing equipments.

关键词： Lagenaria siceraria physical properties angle of repose aspect ratio gravimetric properties sphericity

Performance enhancement of cantilever piezoelectric energy harvesters by sizing analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Smart and Nano Materials 2020年第2期11卷 93-116页

作者： Peyman Hajheidari Ion Stiharu rama Bhat Department of Mechanical Industrial and Aerospace Engineering(MIAE)University of ConcordiaMontrealQuébecCanada

This paper presents the results of the performance of piezoelectric cantilever beams in relation to their *** total produced power represents the main indicator of performance of a piezoelectric harvesting system while the area of the beams stays *** design is an important aspect in any industry,mainly in the *** this study,the effects of non-uniformity on the efficiency and power output are *** element method(FEM)with the application of superconvergent element(SCE)is adopted here to solve the *** is observed that the trapezoidal geometry(converging beam)provides a higher output power while the efficiency ***,in order to prove that the power enhancement is achievable while the amount of piezoelectric material consumed is constant the new configuration is *** the configuration,an array of uniform beams connected in series is used instead of one single rectangular *** proposed setting generates an output power of 1.817mWat a resonant frequency of 284.6 Hz when excited by an input acceleration of 1 *** only challenge is the fundamental frequency difference which ismet with the application of proof mass and thinner substrate and piezoelectric layers.

关键词： Piezoelectric energy harvester superconvergent element tapered beam performance enhancement sizing

Regulation of inflammasomes by ubiquitination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2016年第6期13卷 722-728页

作者： Joseph S Bednash rama K Mallampalli Division of Pulmonary Allergy and Critical Care Medicine Department of Medicine Acute Lung injury Center of Excellence University of Pittsburgh Pittsburgh PA 15213 USA Department of Cell Biology and Physiology and Bioengineering University of Pittsburgh Pittsburgh PA 15213 USA Medical Specialty Service Line Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA 15240 USA

Inflammasomes are multi-protein complexes that regulate the innate immune response by facilitating the release of inflammatory cytokines in response to pathogen exposure or cellular damage. Pro-inflammatory inflammasome signaling is vital to host defense and helps initiate the process of tissue repair following an insult to the host, but can be injurious, when excessive or chronic. As such, inflammasome activity is tightly regulated. Here we discuss one critical mechanism of inflammasome regulation, ubiquitination, that functions as a universal modulator of protein stability and trafficking. Recent studies have provided important insights into the regulation of inflammasome activation by protein ubiquitination. We review the molecular regulation of inflammasome function, specifically, as it relates to ubiquitination, and discuss the implications for the development of theraoeutics to soecificallv target aberrant inflammasome signaling.

关键词： deubiquitinase E3 ligase inflammasome innate immunity ubiqutin

Effect of organo-modified montmorillonite nanoclay on mechanical,thermal and ablation behavior of carbon fiber/phenolic resin composites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2021年第3期17卷 812-820页

作者： Golla rama Rao Ivautri Srikanth K.Laxma Reddy Advanced Systems Laboratory DRDOHyderabadIndia National Institute of Technology WarangalIndia

The mechanical,thermal and ablation properties of carbon phenolic(C-Ph)composites(Type-I)reinforced with different weight percentages of organo-modified montmorillonite(o-MMT)nanoclay have been studied *** milling was used to disperse different weight(wt)percentages(0,1,2,4,6 wt.%)of nanoclay into phenolic *** changes to resin due to nanoclay was *** the other hand,nanoclay added phenolic matrix composites(Type-II)were prepared to study the dispersion of nanoclay in phenolic matrix by small angle X-ray scattering and thermal stability changes to the matrix by thermogravimetric analyser(TGA).This data was used to understand the mechanical,thermal and ablation properties of Type-I *** laminar shear strength(ILSS),flexural strength and flexural modulus of Type I composites increased by about 29%,12%and 7%respectively at2 wt.%addition of nanoclay beyond which these properties *** was attributed to reduced fiber volume fraction(%Vf)of Type-I composites due to nanoclay addition at such high *** ablation rate of Type-I composites was evaluated using oxy acetylene torch test at low heat flux(125 W/cm^(2))and high heat flux levels(500 W/cm^(2)).Mass ablation rates have increased at both flux levels marginally up to 2 wt.%addition of nanoclay beyond which it has increased *** is in contrast to increased thermal stability observed for Type-I and Type-II composites up to 2 wt.%addition of *** ablation rates due to nanoclay addition was attributed to higher insulation efficiency of nanolcay,which accumulates more heat energy in limited area behind the ablation front and self-propagating ablation mechanisms triggered by thermal decomposition of organic part of nanoclay.

关键词： Carbon/phenolic Nanoclay Mechanical properties Thermal stability Ablation rate

A generalization of Poisson-Sujatha distribution and its applications to ecology

在线全文

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2019年第2期12卷 37-47页

作者： rama Shanker Kamlesh Kumar Shukla Department of Statistics College of Science Eritrea Institute of TechnologyAsmaraEritrea

A generalization of Poisson Sujatha distribution(AGPSD),which includes Poisson-Lindley distribution(PLD)and Poisson-Sujatha distribution(PSD)as particular cases,has been proposed and *** moments and moments-based measures including coefficient of variation,skewness,kurtosis and index of dispersion have been obtained and their behaviors have been *** estimation of its parameters has been discussed with maximum likelihood *** applications of the proposed distribution has been explained through two examples of count data from ecology and the goodness of fit of the distribution has been compared with Poisson distribution,PLD and PSD.

关键词： Sujatha distribution Poisson-Sujatha distribution generalization of Sujatha distribution moments and moments-based measures maximum likelihood estimation applications

Effects of oxidation pretreatment temperature on Kovar used as CO_2 reforming catalyst

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

燃料化学学报 2014年第5期42卷 573-581页

作者： Sharon Rose de la rama Hiroshi Yamada Tomohiko Tagawa Department of Chemical Engineering Nagoya University Chikusa

The effect of oxidation pretreatment temperature(500 ~ 1 000 ℃) on the catalytic activity of Kovar applied on hydrocarbon CO2reforming was examined. Catalytic performance evaluation using tetradecane at 800 ℃ with 70 μmol/s CO2revealed 700 and 1 000 ℃ as the best pre-oxidation temperature in producing CO and H2,respectively. XRD and SEM-EDX analyses showed that a separate metal oxide layer composed of iron oxide(Fe2O3and F3O4),nickel,cobalt,and possibly their respective oxides started to form when oxidation was conducted at 700 ℃ or *** presence of iron enhanced the stability of nickel in the structure while the compact structure of Fe3O4resulted into the formation of a thick and rigid metal oxide layer on the surface of the Kovar tube. The strong physical bond between the metal oxide layer and Kovar tube provided the catalyst good mechanical strength and consequently good catalytic activity.

关键词：燃烧化学化学原理理论研究