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Evaluation of Clinical Characteristics and Plasma Cortisol Concentrations in Individuals with COVID-19 and Post-COVID Syndrome

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Case Reports in Clinical Medicine 2024年第1期13卷 12-24页

作者： David Alejandro García López Stephania ramos Hernández Yamile López-Hernández María Argelia López Luna Elena Donaji ramírez Alvarado Rosa María ramírez Santoyo Sergio Hugo Sánchez Rodríguez Laboratorio de Biología Celular y Neurobiología Universidad Autónoma de Zacatecas México Zacatecas Unidad Académica de Ciencias Químicas Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Metabolómica y Proteómica Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Bacterias y Hongos filamentosos Universidad Autónoma de Zacatecas México Zacatecas

COVID-19 generates systematic alterations in humans both in active stages of infection and over time, called post-COVID syndrome. Cortisol is a hormone that is overexpressed in inflammation and cellular stress processes. Its main function is to return to physiological homeostasis, so its evaluation together with other clinical parameters can allow us to determine the degree of systemic affectation by COVID-19. Objective: To evaluate changes in clinical parameters and plasma cortisol concentrations in patients with active COVID-19 and post-COVID syndrome. Material and Methods: Healthy patients, in stages of mild infection, critical and with post-COVID syndrome, were recruited, obtaining, through clinical diagnoses and interviews, their main clinical characteristics, in addition to plasma, in which cortisol concentrations were determined using competitive ELISA. Results: The critical stage group had higher frequencies of comorbidities, clinical symptoms, as well as more altered laboratory parameters compared to the other subgroups. In the post-COVID syndrome group after the initial infection, most laboratory parameters recovered, however, several clinical symptoms remained latent over time. The determination of cortisol showed an increase in its concentration, being higher in patients in critical stage and with post-COVID syndrome. Conclusion: COVID-19 disease generates clinical alterations that trigger an increase in plasma cortisol. These alterations increase as the stages of infection become more severe and some of them remain altered in patients with post-COVID syndrome.

关键词： COVID-19 Cortisol Post-COVID Syndrome

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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

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Descriptive and Comparative Histology of the Urinary System of the Hematophagous Bats Desmodus rotundus and Diphylla ecaudata

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Open Journal of Veterinary Medicine 2024年第7期14卷 180-191页

作者： María Guadalupe ramírez-Muñoz Samantha Jardon-Xicotencatl José Ignacio Olave-Leyva Armando Zepeda-Bastida Juan Ocampo-López Histology and Histopathology Laboratory Academic Area Veterinary Medicine and Zootechnics Academic Area Veterinary Biotechnology Institute of Agricultural Sciences Autonomous University of the Hidalgo State (UAEH) Tulancingo Mexico Multidisciplinary Research Unit L4 (Veterinary Morphology and Cell Biology) UNAM-FESC Campus 4 Cuautitln Izcalli Mexico Academic Area Veterinary Medicine and Zootechnics Institute of Agricultural Sciences Autonomous University of the Hidalgo State (UAEH) Tulancingo Mexico Cellular and Molecular Biology Laboratory Academic Area Veterinary Medicine and Zootechnics Institute of Agricultural Sciences Autonomous University of the Hidalgo State (UAEH) Tulancingo Mexico

Desmodus rotundus and Diphylla ecaudata, both of which are mammals of the order Chiroptera, Desmodontidae family, their diet consisting exclusively of blood. D. rotundus is the main vector and transmitter of the rabies virus, which affects human beings as well as several livestock species so the study of this bat species is of high importance within the fields of animal agriculture and public health. The present study describes and compares the histologic characteristics of the urinary system of two hematophagous bat species. A total of 5 bats from each species were captured in the municipalities of Progreso de Obregón, Hidalgo (D. rotundus), and Huayacocotla, Veracruz (D. ecaudata). Organs belonging to the urinary system were extracted: kidneys, ureters, urinary bladder, and urethra;samples were fixed using 10% formalin and processed by the paraffin embedding technique, obtaining sections of 5 µm thickness, which in turn were stained using hematoxylin-eosin (H-E) and Gomori trichrome (GT) stains. From the obtained histologic preparations, a descriptive and comparative analysis of the structural organography of the urinary system of both species was made, and no noteworthy histological differences between samples were noted. The present research is intended to provide a framework for future studies of these species’ currently understudied microscopic anatomy.

关键词： Microscopic Anatomy Vampire Bats Kidneys Comparative Morphology

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互利作用促进了高山树线幼苗的存活

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Journal of Plant Ecology 2024年第3期17卷 115-127页

作者： Wensheng Chen Jiangrong Li Jesús Julio Camarero Huihui Ding Fangwei Fu Yueyao Li Xiangyu Zheng Xiaoxia Li Wei shen shalik ram Sigdel Steven W.Leavitt Eryuan Liang Institute of Tibet Plateau Ecology Tibet Agricultural&Animal Husbandry UniversityNyingchi 860000China Key Laboratory of Forest Ecology in Tibet Plateau(Tibet Agricultural&Animal Husbandry University) Ministry of EducationNyingchi 860000China National Forest Ecosystem Observation&Research Station of Nyingchi Tibet Nyingchi 860000China Key Laboratory of Alpine Vegetation Ecological Security in Tibet Nyingchi 860000China Zhejiang Zhoushan Archipelago Observation and Research Station Zhejiang Tiantong Forest Ecosystem National Observation and Research Stationand Shanghai Key Lab for Urban Ecological Processes and Eco-RestorationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Instituto Pirenaico de Ecología(IPE-CSIC) Zaragoza 50059Spain Anhui Province Key Lab of Farmland Ecological Conservation and Pollution Prevention Key Laboratory of JiangHuai Arable Land Resources Protection and Eco-restorationMinistry of Natural ResourcesCollege of Resources and EnvironmentAnhui Agricultural UniversityHefei 230036China Laboratory of Tree-Ring Research University of ArizonaTucsonAZ 85721USA

高山树线被视为记录气候变化对树木和森林影响的生态监测器。迄今为止,大多数树线研究都集中在气候变化如何驱动树线动态的变化。然而,关于生物相互作用如何调节树线变化,特别是在树木更新这一树线动态的瓶颈方面,人们知之甚少。本研究... 详细信息

高山树线被视为记录气候变化对树木和森林影响的生态监测器。迄今为止,大多数树线研究都集中在气候变化如何驱动树线动态的变化。然而,关于生物相互作用如何调节树线变化,特别是在树木更新这一树线动态的瓶颈方面,人们知之甚少。本研究假设种间和种内促进作用决定了高山树线树苗的定居和存活。为了验证这一假设,我们在青藏高原东南部的色季拉山高山树线交错区(海拔4300–4500 m)的3个生长生境(林冠内、林冠外和草地)中共计移植了630株不同年龄(4–6年、7–9年和10–15年)的急尖长苞冷杉(Abies georgei ***)幼苗,连续3年监测了移植后幼苗的微气候、高度生长、死亡率和叶片功能性状。结果发现,叶片功能性状的变化是由微气候驱动的。移植后,叶片可溶性糖和淀粉浓度以及C:P比增加,而叶面积减小。幼苗的资源利用逐渐转向更保守的策略,其背后机制主要受到了生理性状(非结构性碳水化合物和植物养分)的介导。同时,由结构方程模型发现太阳辐射、温度和水分条件在植物相互作用下,通过介导叶片形态性状的变化最终影响了幼苗的死亡率和年生长。上述研究结果表明,植物间的互利作用通过改变太阳辐射和叶片功能性状,最终在决定幼苗生长和存活上起到至关重要的作用,同时也为理解全球气候变化背景下高山树线动态变化的驱动机制提供了新的见解。

关键词：青藏高原移栽实验叶片功能性状太阳辐射

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爱上工作的五个理由

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商业评论 2024年第7期 22-24页

作者：卡梅丽娅·拉姆徐黄兆 Korn Ferry公司组织战略实践部门杜克大学企业教育学院拉夫堡大学 EDHEC商学院

从领导者的个人视角来看,当前有两股截然相反的潮流正在塑造工作的性质和领域.一方面,大量机遇改变着我们所从事的工作.在"大辞职"潮(Great Resignation)*期间,混合办公(hybrid working)模式的兴起、工作周数的缩短便是明证.另一方面,...

从领导者的个人视角来看,当前有两股截然相反的潮流正在塑造工作的性质和领域.一方面,大量机遇改变着我们所从事的工作.在"大辞职"潮(Great Resignation)*期间,混合办公(hybrid working)模式的兴起、工作周数的缩短便是明证.另一方面,由于技术的高歌猛进,现有技能组合的市场受欢迎程度也受到威胁.面对自动化的日益普及和工作角色的扩充,以及生活成本的不断飙升,一些人可能会因此感到力不从心,怀疑自己究竟能做些什么来塑造他们的工作.

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喜马拉雅山不同森林群落主要树种叶片元素性状与生物量之间的关系

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中国科学：地球科学 2024年第5期54卷 1544-1555页

作者： Nita DYOLA 梁尔源 Josep PEÑUELAS JJulio CAMARERO shalik ram SIGDEL Sugam ARYAL 林文涛刘向刘永稳徐兴良 Sergio ROSSI 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101 中国科学院大学北京100049 Laboratoire sur lesécosystèmes terrestres boréaux Département des Sciences FondamentalesUniversitédu QuébecàChicoutimi555Boulevard de l′UniversitéChicoutimi(QC)G7H2B1Canada CSIC Global Ecology Unit CREAF-CSIC-UABBellaterraE-08193 CataloniaSpain CREAF Cerdanyola del VallèsE-08193 CataloniaSpain Instituto Pirenaico de Ecología(IPE-CSIC) Avenida Montañana 1005Zaragoza 50059Spain Friedrich-Alexander-Universität Erlangen-Nürnberg Institut für GeographieErlangen 91058Germany 兰州大学生态学院草种创新与草地农业生态系统全国重点实验室兰州730000 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101

植物需要多种基本元素调节并保持其特定比例以维持生长发育,叶片元素含量反映了植物的功能及其对环境的适应性.然而,在森林海拔梯度上,我们对于资源获取、光合作用和生长相关的叶片元素如何调节森林生物量仍知之甚少.本研究在喜马拉雅... 详细信息

植物需要多种基本元素调节并保持其特定比例以维持生长发育,叶片元素含量反映了植物的功能及其对环境的适应性.然而,在森林海拔梯度上,我们对于资源获取、光合作用和生长相关的叶片元素如何调节森林生物量仍知之甚少.本研究在喜马拉雅山干城章嘉峰地区沿热带森林(海拔80m)至高山树线(海拔4200m)设置海拔梯度样带,每间隔海拔100m设置一个样点,对116个树种的1859个个体测定了叶片中10种元素(C、N、P、K、Ca、Mg、Zn、Fe、Cu和Mn)的含量,通过计算叶片元素含量的群落加权平均值(反映优势物种的性状优势度,表征质量比效应)和功能离散度(反映物种在生态位空间内的聚集或者离散程度,表征互补效应),探究叶片元素含量及其离散程度沿海拔梯度分异特征,解析其对森林群落生物量的影响.研究结果表明,较强的叶片元素质量比效应和较弱的互补效应有利于森林群落生物量的积累.叶片元素性状多样性与海拔的共同作用对生物量的解释量(解释方差:52.2%)高于元素性状多样性的解释量(解释方差:0.05%~21%).海拔调节了树种性状多样性在生物量积累中的作用,互补效应在低海拔和高海拔地区对生物量的影响分别体现为积极和消极作用,这表明海拔和互补效应之间也存在交互作用.此外,海拔和质量比效应的交互作用对海拔梯度上生物量的影响也存在异质性.本研究表明,不同森林群落生物量的积累可能受到由海拔调控的性状多样性的影响.尽管较高的性状分异不利于生物量的积累,但能增强高海拔地区树种对胁迫环境的适应性.

关键词：生态系统功能海拔梯度功能多样性功能性状叶片元素生态位互补

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Global prevalence and gender inequalities in at least 60 min of self-reported moderate-to-vigorous physical activity 1 or more days per week:An analysis with 707,616 adolescents

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Journal of Sport and Health Science 2024年第5期13卷 709-716页

作者： Raphael H.O.Araujo AndrúO.Werneck Clarice L.Martins Luciana L.Barboza Rafael M.Tassitano Nicolas Aguilar-Farias Gilmar M.Jesus Robinson ramírez-Véelez Riki Tesler Adewale L.Oyeyemi Ellen C.M.Silva Robert G.Weaver Mark S.Tremblay Javier Brazo-Sayavera Grégore I.Mielke Danilo R.P.Silva Graduation Program in Health Sciences Londrina State University(UEL)Londrina 86057-970Brazil Center for Epidemiological Research in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Department of Physical Education Federal University of ParaıbaParaıba 58051-900Brazil Research Centre of Physical Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal Postgraduate Program in Physical Education University of BrasıliaBrasılia 70910-900Brazil Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA Department of Physical Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile Department of Health State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiomed Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facultad de Ciencias de la Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia Health Management Department Faculty of Heath sciencesAriel UniversityAriel 40700Israel College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Arnold School of Public Health University of South CarolinaColumbiaSC 29208USA Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Department of Health Sciences Carleton UniversityOttawaON K1S 5B6Canada Department of Sports and Computer Science Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Universitario Regional Noreste Universidad de la RepublicaRivera 40000Uruguay School of Public Health The University of QueenslandBrisbaneQLD 4006Australia Department of Physical Education

Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).However,using only this cut-off could hide important *** instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate ***,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity ***,the current study aims to estimate the prevalence of≥60 min of MVPA≥1 days per week among adolescents globally,and to describe any relevant gender ***:We used representative datasets from 146 countries/territories collected between 2003 and *** was *** were grouped into younger(≤14 years old)and older(>14 years old)*** Poisson regression models were used to identify the relative differences in≥60 min of MVPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled *** were stratified by country and ***:Approximately 80%of both younger and older adolescents reported≥60 min of MVPA≥1 days per *** prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions were14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of MVPA≥1 days per week,with notable differences between *** differences were observed in several countries,especially among the oldest *** fo

关键词： Global School-based Student Health Survey Health Behaviour Among School-aged Children survey Inequality Surveillance Youth

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Chemotherapy and radiotherapy:Could they contribute to the development of new tumors and metastases?

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Life Research 2024年第1期7卷 24-27页

作者： Joséramón Toro López An independent researcher Sevilla 41500Spain.

Objective: Both chemotherapy and radiotherapy have demonstrated high effectiveness as the best mechanisms in the fight against cancer;however, various studies seem to confirm that they could also favor the development of other unwanted effects of great importance for the patient. The main objective of this study is to find out the possible existence of this type of links. Method: This is a systematic literature review that seeks to find out which and how long cases of late interactions related to chemotherapy and radiotherapy treatments have been known. The bibliographic review was carried out based on references published in the last five years. Results: Various studies confirm the possible relationship between chemotherapy and radiotherapy treatments with the development of new undesirable side effects, especially as a consequence of the hepatotoxicity generated in the case of chemotherapy and radiation in radiotherapy. However, in this last type of treatment, the problems raised are really few. Conclusions: The existence of a risk of suffering new unwanted side effects after different types of treatment seems to have been demonstrated, especially in the case of chemotherapy. In the case of radiotherapy, adverse effects are practically non-existent, although they are no less important.

关键词： Chemotherapy radiotherapy tumor cancer metastasis hepatotoxicity radiation

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Venopulmonary ECMO Improved Hypoxemia and Supported the Right Ventricle in a Patient with Decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery 2024年第1期14卷 7-19页

作者： Daniel Manzur-Sandoval Gian Manuel Jiménez-Rodríguez Edgar García-Cruz ramón Espinosa-Soto Erika Yamali ramirez-Marcano Yessenia Máyory Téllez-López José Luis Elizalde-Silva Gustavo Rojas-Velasco Cardiovascular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECMO) has become a standard of care for patients with circulatory (venoarterial) and/or respiratory (venovenous) failure refractory to standard therapies. Adult patients with congenital heart disease are an increasingly recognized and growing population and include various groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to developing pathologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserves and organic damage associated with the underlying heart disease, which makes them candidates for ECMO. These patients represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, venopulmonary artery ECMO, which provides hemodynamic and respiratory support, and may be ideal for patients with shunts and/or right ventricular dysfunction. To our knowledge, this is the first report of this configuration in patients with congenital heart diseases.

关键词： Eisenmenger Syndrome Venopulmonary Artery ECMO Refractory Hypoxemia Right Ventricular Dysfunction

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An Evolutionary Approach to Improve the Beam Steering Performance over Conventional Approach in CHAA

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Journal of Communications and Information Networks 2023年第2期8卷 164-170页

作者： K Akhitha Gopi ram National Institute of Technology Warangal 506004India

In this work,evolutionary algorithms are applied for the first time to achieve better radiation characteristics over the conventional beamforming algorithm in the concentric hexagonal antenna array(CHAA),which improves the performance of wireless *** signal classification(MUSIC)algorithm is employed for direction of arrival(DoA)*** conventional adaptive beam steering algorithm,least mean-square(LMS)algorithm,is used to steer the ***,the proposed approach is employed by novel particle swarm optimization(NPSO)to reduce sidelobe level(SLL)even further.A six-ring CHAA with 126 elements for DoA estimation and beam steering is *** simulation results of the MUSIC,LMS,NPSO,and particle swarm optimization(PSO)algorithms are provided for various DoAs.

关键词： smart antenna hexagonal array PSO MUSIC algorithm LMS algorithm DoA estimation beam steering NPSO

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