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Nogo-A aggravates oxidative damage in oligodendrocytes

Neural Regeneration Research 2021年第1期16卷 179-185页

作者： Yang-Yang Wang na Han Dao-Jun Hong Jun Zhang Department of Neurology Peking University People’s HospitalBeijingChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous *** is mainly expressed by *** previous studies have found regulatory roles for Nogo-A in neurite outgrowth inhibition,neuronal homeostasis,precursor migration,plasticity,and neurodegeneration,its functions in the process of oxidative injury are largely *** this study,oligodendrocytes were extracted from the cerebral cortex of newborn Sprague-Dawley *** used hydrogen peroxide(H2O2)to induce an in vitro oligodendrocyte oxidative damage model and found that endogenously expressed Nogo-A is significantly upregulated in *** recombinant virus Ad-ZsGreen-rat Nogo-A infection of oligodendrocytes,Nogo-A expression was increased,and the infected oligodendrocytes were more susceptible to acute oxidative insults and exhibited a markedly elevated rate of cell ***,knockdown of Nogo-A expression in oligodendrocytes by Ad-ZsGreen-shRna-Nogo-A almost completely protected against oxidative stress induced by exogenous *** with a Nogo-66 antibody,a LINGO1 blocker,or Y27632,an inhibitor in the Nogo-66-NgR/p75/LINGO-1-RhoA-ROCK pathway,did not affect the death of ***-ZsGreen-shRna-Nogo-A also increased the levels of phosphorylated extracellular signal-regulated kinase 1/2 and inhibited BCL2 expression in *** conclusion,Nogo-A aggravated reactive oxygen species damage in oligodendrocytes,and phosphorylated extracellular signal-regulated kinase 1/2 and BCL2 might be involved in this *** study was approved by the Ethics Committee of Peking University People’s Hospital,China(approval No.2018PHC081)on December 18,2018.

关键词： BCL2 H2O2 LINGO1 NgR Nogo-A oligodendrocytes phosphorylated extracellular signal-regulated kinase 1/2 reactive oxygen species

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Recent advances in phosphoric acid-based membranes for high-temperature proton exchange membrane fuel cells

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Journal of Energy Chemistry 2021年第12期30卷 393-429,I0010页

作者： Zunmin Guo Maria perez-Page Jianuo Chen Zhaoqi Ji Stuart M.Holmes Department of Chemical Engineering and Analytical Science The University of Manchester.Ml39PLUnited Kingdom

High-temperature proton exchange membrane fuel cells(HT-PEMFCs)are pursued worldwide as efficient energy conversion *** efforts have been made in the area of designing and developing phosphoric acid(PA)-based proton exchange membrane(PEM)of *** review focuses on recent advances in the limitations of acid-based PEM(acid leaching,oxidative degradation,and mechanical degradation)and the approaches mitigating the membrane *** multilayer or polymers with continuous network,adding hygroscopic inorganic materials,and introducing PA doping sites or covalent interactions with PA can effectively reduce acid *** oxidative degradation can be alleviated by synthesizing crosslinked or branched polymers,and introducing antioxidative groups or highly oxidative stable *** to get a compact structure,blending with stable polymers and inorganic materials,preparing polymer with high molecular weight,and fabricating the polymer with PA doping sites away from backbones,are recommended to improve the membrane mechanical ***,by comparing the running hours and decay rate,three current approaches,*** via thermally curing or polymeric crosslinker,*** hygroscopic inorganic materials,*** membrane layers or introducing strong basic groups and electron-withdrawing groups,have been concluded to be promising approaches to improve the durability of *** overall aim of this review is to explore the existing degradation challenges and opportunities to serve as a solid basis for the deployment in the fuel cell market.

关键词： High-temperature proton exchange membrane fuel cells Acid leaching Oxidative degradation Mechanical degradation Durability

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Methods for enhancing the capacity of electrode materials in low-temperature lithium-ion batteries

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Chinese Chemical Letters 2021年第3期32卷 973-982页

作者： Ying na Xiaohong Sun Anran Fan Shu Cai Chunming Zheng School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China School of Chemistry and Chemical Engineering State Key Laboratory of Hollow-fiber Membrane Materials and Membrane ProcessesTiangong UniversityTianjin 300387China

Lithium-ion batteries(LIBs)have evolved into the mainstream power source of ene rgy sto rage equipment by reason of their advantages such as high energy density,high power,long cycle life and less *** the expansion of their applications in deep-sea exploration,aerospace and military equipment,special working conditions have placed higher demands on the low-temperature performance of ***,at low temperatures,the severe polarization and inferior electrochemical activity of electrode materials cause the acute capacity fading upon cycling,which greatly hindered the further development of *** this review,we summarize the recent important progress of LIBs in low-temperature operations and introduce the key methods and the related action mechanisms for enhancing the capacity of the various cathode and anode *** aims to promote the development of high-performance electrode materials and broaden the application range of LIBs.

关键词： Lithium-ion batteries Low-temperature capacity Cathode materials Anode materials Optimizing methods

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杭州地区臭氧污染及台风烟花过程影响

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中国环境科学 2024年第3期44卷 1195-1203页

作者：张嘉月康娜邵生成牛彧文程昊张佳欣浩翔杲先亮齐冰南京信息工程大学中国气象局气溶胶-云-降水重点开放实验室江苏南京210044 金华市气象局浙江金华321000 浙江省气象科学研究所浙江杭州310056 力合科技(湖南)股份有限公司湖南长沙410000 杭州市气象局浙江杭州310051

为探究杭州地区臭氧的污染问题及影响因素,利用2018~2021年杭州地区空气质量、气象要素,选取2021年杭州台风烟花中后期后向轨迹数据与臭氧小时数据,进行后向轨迹聚类及潜在源区域分析.结果表明:2018~2021年杭州地区总体空气质量改善良好... 详细信息

为探究杭州地区臭氧的污染问题及影响因素,利用2018~2021年杭州地区空气质量、气象要素,选取2021年杭州台风烟花中后期后向轨迹数据与臭氧小时数据,进行后向轨迹聚类及潜在源区域分析.结果表明:2018~2021年杭州地区总体空气质量改善良好,臭氧污染一直较为严重,主要集中在每年的4~10月份.臭氧污染与相对湿度呈负相关性,温度呈正相关性,同时风速对臭氧的生成和扩散也有一定的影响.以2021年台风烟花为例,台风期间降雨量大,风速强,各污染物浓度下降,台风过境后,高温低湿促使了臭氧浓度的上升.对2021年7月25~30日(台风过境后)进行聚类与潜在源分析,得到7条气团传输路径,主要气团来自西北方向,途经江西、湖北等地区.而WPSCF和WCWT的臭氧浓度高值区的一致性较好,臭氧污染受一定的区域传输影响,主要受金华、上饶、南昌、武汉等城市影响,涉及浙江、江西、湖北3个省份.

关键词：空气质量臭氧后向轨迹来源分析杭州影响因素

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A Reverse-Design Strategy for the Track Error of the Qi Tai Telescope Based on Pointing Accuracy

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Engineering 2022年第6期8卷 209-216页

作者： na Li Baoyan Duan Xiangyang Li Bin Zheng Jiang Wu Key Laboratory of Electronic Equipment Structure Design Ministry of EducationXidian UniversityXi’an 710061China

The Qi Tai Telescope(QTT),which has a 110 m aperture,is planned to be the largest scale steerable tele-scope in the ***,the telescope’s repeated pointing accuracy error should be less than 2.5 arc seconds(arcsec);thus,the telescope structure must satisfy ultra-high precision *** this pur-suit,the present research envisages a reverse-design method for the track surface to reduce the difficulty of the telescope’s design and ***,the distribution characteristics of the test data for the track error were verified using the skewness coefficient and kurtosis coefficient *** to the distribution characteristics,the azimuth track error was simulated by a two-scale *** error of the long period and short amplitude was characterized as large-scale and described by a trigonometric function,while the short period and high amplitude error was characterized as small-scale and simulated by a fractal *** on the two-scale model,effect of the error on the pointing accuracy was ***,the relationship between the root mean square(RMS)of the track error and the RMS of the pointing accuracy error of the telescope was ***,the allowable RMS value of the track error was derived from the allowable pointing accuracy *** validate the effectiveness of the new design method,two typical radio telescopes(the Green Bank Telescope(GBT)and the Large Millimeter Telescope(LMT))were selected as experimental *** comparison,the theoretical calculated values of the pointing accuracy of the telescope were consistent with the measured values,with a maximum error of less than 10%.

关键词： Reverse design Track error Large radio telescope Two-scale model Pointing accuracy

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Sn/n3O4-x heterostructure rich in oxygen vacancies with enhanced visible light photocatalytic oxidation performance

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International Journal of Minerals,Metallurgy and Materials 2021年第1期28卷 150-159页

作者： Rui-qi Yang na Liang Xuan-yu Chen Long-wei Wang Guo-xin Song Yan-chen Ji na Ren Ya-wei Lü Jian Zhang Xin Yu Institute for Advanced Interdisciplinary Research(IAIR) University of JinanJinan 250022China School of physics and electronics Hunan UniversityChangsha 410082China Institute Charles Gerhardt UMR 5253CNRS-UM-ENSCMUniversitéde MontpellierPlace Eugène BataillonF-34095 Montpellier cedex 5France

Sn3O4, a common two-dimensional semiconductor photocatalyst, can absorb visible ***, owing to its rapid recombination of photogenerated electron-hole pairs, its absorption is not sufficient for practical *** this work, a Sn nanoparticle/Sn3O4-x nanosheet heterostructure was prepared by in situ reduction of Sn3O4 under a H2 *** Schottky junctions formed between Sn and Sn3O4-x can enhance the photogenerated carrier separation *** the hydrogenation process, a portion of the oxygen in the semiconductor can be extracted by hydrogen to form water, resulting in an increase in oxygen vacancies in the *** heterostructure showed the ability to remove Rhodamine *** cytocompatibility experiments proved that Sn/Sn3O4-x can significantly enhance cell compatibility and reduce harm to *** work provides a new method for the fabrication of a Schottky junction composite photocatalyst rich in oxygen vacancies with enhanced photocatalytic performance.

关键词： photocatalysis tin oxide oxygen vacancy Schottky junction photodegradation

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A multi-sensor relation model for recognizing and localizing faults of machines based on network analysis

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机械工程前沿:英文版 2023年第2期18卷 267-281页

作者： Shuhui WANG Yaguo LEI na LU Xiang LI Bin YANG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China Systems Engineering Institute Xi’an Jiaotong UniversityXi’an 710049China

Recently,advanced sensing techniques ensure a large number of multivariate sensing data for intelligent fault diagnosis of *** the advantage of obtaining accurate diagnosis results,multi-sensor fusion has long been studied in the fault diagnosis ***,existing studies suffer from two ***,the relations of multiple sensors are either neglected or calculated only to improve the diagnostic accuracy of fault ***,the localization for multi-source faults is seldom investigated,although locating the anomaly variable over multivariate sensing data for certain types of faults is *** article attempts to overcome the above weaknesses by proposing a global method to recognize fault types and localize fault sources with the help of multi-sensor relations(MSRs).First,an MSR model is developed to learn MSRs automatically and further obtain fault recognition ***,centrality measures are employed to analyze the MSR graphs learned by the MSR model,and fault sources are therefore *** proposed method is demonstrated by experiments on an induction motor and a centrifugal *** show the proposed method’s validity in diagnosing fault types and sources.

关键词： fault recognition fault localization multi-sensor relations network analysis graph neural network

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中医药通过调节caspase家族改善多发性骨髓瘤的研究进展

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世界中西医结合杂志 2024年第5期19卷 1057-1060页

作者：孙婧萱程志李娜石琳河南中医药大学第二临床医学院河南郑州450002 河南省中医院血液科河南郑州450002

中医药通过调节caspase家族对于多发性骨髓瘤(Multiple myeloma,MM)患者具有明显的改善作用。近年来,国内外研究发现,含半胱氨酸的天冬氨酸蛋白水解酶(caspase)家族与MM细胞凋亡的关系十分密切,在细胞凋亡后期都需要Caspase家族的激活... 详细信息

中医药通过调节caspase家族对于多发性骨髓瘤(Multiple myeloma,MM)患者具有明显的改善作用。近年来,国内外研究发现,含半胱氨酸的天冬氨酸蛋白水解酶(caspase)家族与MM细胞凋亡的关系十分密切,在细胞凋亡后期都需要Caspase家族的激活。中药单体及经方调节caspase家族治疗多发性骨髓也取得良好疗效,其多是通过调节激酶级联苏氨酸激酶4(threonine kinase 4,STK4)/是相关蛋白1(variant 1,YAP1)通路、调节兔抗人单克隆抗体(bcl-2 associated x protein,BAX)水平,下调存活蛋白(survivn)转录水平,进而激活caspase凋亡程序,促进MM细胞凋亡。

关键词：中医药多发性骨髓瘤研究进展

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Logging-while-drilling formation dip interpretation based on long short-term memory

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Petroleum Exploration and Development 2021年第4期48卷 978-986页

作者： SUN Qifeng LI na DUAN Youxiang LI Hongqiang TANG Haiquan College of Computer Science and Technology in China University of Petroleum Qingdao 266580China Drilling Technology Research Institute of Shengli Petroleum Engineering Corporation Limited SinopecDongying 257000China Measurement and Control Technology Research Institute of Shengli Petroleum Engineering Corporation Limited.Dongying 257000 China

Azimuth gamma logging while drilling(LWD)is one of the important technologies of geosteering but the information of real-time data transmission is limited and the interpretation is *** study proposes a method of applying artificial intelligence in the LWD data interpretation to enhance the accuracy and efficiency of real-time data *** examining formation response characteristics of azimuth gamma ray(GR)curve,the preliminary formation change position is detected based on wavelet transform modulus maxima(WTMM)method,then the dynamic threshold is determined,and a set of contour points describing the formation boundary is *** classification recognition model based on the long short-term memory(LSTM)is designed to judge the true or false of stratum information described by the contour point set to enhance the accuracy of formation ***,relative dip angle is calculated by nonlinear least square *** of azimuth gamma data and application of real-time data processing while drilling show that the method proposed can effectively and accurately determine the formation changes,improve the accuracy of formation dip interpretation,and meet the needs of real-time LWD geosteering.

关键词： logging while drilling azimuth gamma stratigraphic identification artificial intelligence long short-term memory wavelet transform

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调经止痛丸对子宫内膜异位症气滞血瘀证患者腹腔镜术后CA125的影响

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湖南中医药大学学报 2024年第5期44卷 817-821页

作者：陈秀英陈娜崔建涛高娜翟倩卞欣张士表河北省沧州中西医结合医院妇一科河北沧州061000

目的观察调经止痛丸对子宫内膜异位症(endometriosis,EMS)气滞血瘀证患者腹腔镜术后临床症状及癌胚抗原125(carcinoembryonic antigen 125,CA125)的影响。方法选取河北省沧州中西医结合医院120例接受腹腔镜手术治疗的EMS气滞血瘀证患者... 详细信息

目的观察调经止痛丸对子宫内膜异位症(endometriosis,EMS)气滞血瘀证患者腹腔镜术后临床症状及癌胚抗原125(carcinoembryonic antigen 125,CA125)的影响。方法选取河北省沧州中西医结合医院120例接受腹腔镜手术治疗的EMS气滞血瘀证患者,随机分为对照组和观察组,各60例。对照组术后予以常规西药进行治疗,观察组在对照组基础上服用调经止痛丸,连续治疗6个月。比较两组临床疗效、中医证候积分、血清CA125、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平及不良反应。结果观察组总有效率96.67%,高于对照组85.00%(P0.05)。结论调经止痛丸可有效减轻EMS气滞血瘀证患者腹腔镜术后临床症状,改善TNF-α及CA125水平。

关键词：子宫内膜异位症调经止痛丸气滞血瘀证腹腔镜手术癌胚抗原125 肿瘤坏死因子-α

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