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从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用

Engineering 2024年第1期32卷 41-56页

作者： ram prasad Aganja Amal Senevirathne Chandran Sivasankar John Hwa Lee Department of Veterinary Public Health College of Veterinary MedicineJeonbuk National UniversityIksan 54596Republic of Korea Department of Preventive Medicine College of Veterinary MedicineChungnam National UniversityDaejeon 34134Republic of Korea

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza *** this study,a strategy called computationally optimized broadly reactive antigen(COBRA)was used to generate a consensus sequence of the hemagglutinin globular head portion(HA1)of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed *** carrying different HA1regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RNA-dependent RNApolymerase(RdRp)-based eukaryotic expression system,*** protein expression was confirmed by Western blot and immunofluorescence *** immunized with the designed constructs produced a humoral response,with a significant increase in immunoglobulin G(IgG)levels,and a cell-mediated immune response,including a 1.5-fold increase in CD4^(+) and CD8^(+)T ***,constructs #1 and #5 increased the production of interferon-γ(IFN-γ)producing CD4^(+)and CD8^(+)T cells,skewing the response toward the T helper type 1 cell(Th1)***,interleukin-4(IL-4)-producing T cells were upregulated *** efficacy was demonstrated,with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer>40 against the selected viral *** designed constructs conferred a broadly protective immune response,resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34,A/Brisbane/59/2007,A/California/07/2009,KBPV VR-92,and NCCP 43021 *** discovery revolutionizes influenza vaccine design and delivery;Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation *** approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.

关键词： COBRA Influenza A Salmonella Vaccine Broad spectral protection

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尼泊尔桑可西河流域新格地子流域滑坡评价

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Journal of Resources and Ecology 2024年第2期15卷 431-438页

作者： BASNET Bhuwan JOSHI Rajeev SHARMA ram prasad SUBEDI Rajan 特里布万大学林业研究所(博卡拉校区) 尼泊尔博卡拉33700 尼泊尔农林大学自然资源管理学院林学系尼泊尔卡塔里56310

山体滑坡是尼泊尔山区的主要灾害,主要是由于其脆弱的地貌、强烈的降雨、不当的土地管理和在修建山区道路过程中没有采取必要的稳定措施所导致的。由于频繁的山体滑坡,下游地区人类的生命财产遭受了巨大损失,并导致生态系统生产力和功... 详细信息

山体滑坡是尼泊尔山区的主要灾害,主要是由于其脆弱的地貌、强烈的降雨、不当的土地管理和在修建山区道路过程中没有采取必要的稳定措施所导致的。由于频繁的山体滑坡,下游地区人类的生命财产遭受了巨大损失,并导致生态系统生产力和功能下降,河道泥沙淤积。土地利用与土地覆被、地形、道路、排水、地质环境和降雨等多种空间因素与滑坡的发生紧密相关,并决定了该地区滑坡的易感性。了解滑坡现象及其引发的相关因素,对于采取适当的预防、控制和恢复措施至关重要。本研究在尼泊尔桑科西河流域的新格地子流域进行,旨在了解滑坡危害、引发的相关因素以及为最大限度地减少可能的危害而采取的最佳预防策略。滑坡评估是通过使用时序谷歌影像和实地调查,对滑坡体进行识别和数字化来进行的。利用GIS软件对滑坡危险性进行评估,编制影响因子图,并对现场观测数据进行分析的基础上,计算了滑坡的规模。此外,在相关家庭的问卷调查(n=60)中,进行目的性抽样,探讨人们对山体滑坡、对生计资产的主要影响因素的看法。并采用Friedman非参数检验评估滑坡对当地人感知的最主要影响因素。根据现场调查,在研究区域的不同位置共调查了46处滑坡体,滑坡总面积为4.77km^(2)。通过使用Friedman检验的比较矩阵分析,本研究确定了滑坡发生的主要原因是农村道路、施工、边坡因素、降雨和土地利用与土地覆被。距离道路200-500 m造成最高比率的滑坡灾害,东南方向坡度30°-45°的山体对滑坡的易感性最高。与其他土地利用相比,因为在林内松软地区修建道路,茂密的森林更易受到山体滑坡的影响。比较道路建设前后滑坡的影响,约80%的受访者认为对滑坡有重要影响。

关键词：滑坡灾害滑坡评估滑坡因素分析

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尼泊尔桑可西河流域新格地子流域滑坡评价（英文）

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Journal of Resources and Ecology 2024年第2期 431-438页

作者： BASNET Bhuwan JOSHI Rajeev SHARMA ram prasad SUBEDI Rajan 特里布万大学林业研究所(博卡拉校区) 尼泊尔农林大学自然资源管理学院林学系

山体滑坡是尼泊尔山区的主要灾害，主要是由于其脆弱的地貌、强烈的降雨、不当的土地管理和在修建山区道路过程中没有采取必要的稳定措施所导致的。由于频繁的山体滑坡，下游地区人类的生命财产遭受了巨大损失，并导致生态系统生产力和... 详细信息

山体滑坡是尼泊尔山区的主要灾害，主要是由于其脆弱的地貌、强烈的降雨、不当的土地管理和在修建山区道路过程中没有采取必要的稳定措施所导致的。由于频繁的山体滑坡，下游地区人类的生命财产遭受了巨大损失，并导致生态系统生产力和功能下降，河道泥沙淤积。土地利用与土地覆被、地形、道路、排水、地质环境和降雨等多种空间因素与滑坡的发生紧密相关，并决定了该地区滑坡的易感性。了解滑坡现象及其引发的相关因素，对于采取适当的预防、控制和恢复措施至关重要。本研究在尼泊尔桑科西河流域的新格地子流域进行，旨在了解滑坡危害、引发的相关因素以及为最大限度地减少可能的危害而采取的最佳预防策略。滑坡评估是通过使用时序谷歌影像和实地调查，对滑坡体进行识别和数字化来进行的。利用GIS软件对滑坡危险性进行评估，编制影响因子图，并对现场观测数据进行分析的基础上，计算了滑坡的规模。此外，在相关家庭的问卷调查(n=60)中，进行目的性抽样，探讨人们对山体滑坡、对生计资产的主要影响因素的看法。并采用Friedman非参数检验评估滑坡对当地人感知的最主要影响因素。根据现场调查，在研究区域的不同位置共调查了46处滑坡体，滑坡总面积为4.77km2。通过使用Friedman检验的比较矩阵分析，本研究确定了滑坡发生的主要原因是农村道路、施工、边坡因素、降雨和土地利用与土地覆被。距离道路200-500 m造成最高比率的滑坡灾害，东南方向坡度30°-45°的山体对滑坡的易感性最高。与其他土地利用相比，因为在林内松软地区修建道路，茂密的森林更易受到山体滑坡的影响。比较道路建设前后滑坡的影响，约80%的受访者认为对滑坡有重要影响。

关键词：滑坡灾害滑坡评估滑坡因素分析

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Mushrooms in the Mountains: Assessing the Role of Fungi on the Ecosystem-based Adaptation (EbA) Practices in Nepal Himalaya

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Journal of Resources and Ecology 2022年第6期13卷 1030-1036页

作者： DEVKOTA Shiva SHRESTHA Uttam Babu POUDEL Sanjeev CHAUDHARY ram prasad Global Institute for Interdisciplinary Studies Kathmandu 3084Nepal Himalayan Climate&Science Institute Washington DC 20007USA Research Centre for Applied Science and Technology Tribhuvan UniversityKirtipur 1030Nepal

To achieve the Sustainable Development Goals(SDGs), thereby meet the post 2020 global biodiversity targets and increase resilience to climate change, nature-based approaches such as ecosystem-based adaptation(EbA) is suggested as a promising and integrated adaptation strategy. EbA comprises adaptation strategies that value the role of ecosystems in reducing social vulnerability to climate change. Among the different biological groups on earth, fungi play not only an important role to maintain the biogeochemical cycle/nutrient cycle in ecosystems(supporting and regulating services), but also contribute to the socio-economic and cultural benefits of societies(provisioning and cultural services). Here, we present our knowledge and scientific understanding on how these neglected groups of biodiversity-fungi are crucial for ecosystem-based adaptation(EbA) approach based on our field experience, review and associated expertise on caterpillar fungus(Ophiocordyceps sinensis), and other wild mushrooms found in Nepal. Several species of fungi are used by local communities as food, medicines, and environmental income. Fungi are important sources of household income for mountain communities in Nepal providing a cushion during shocks and disasters and supporting food security, health care, education and building shelter. For the holistic EbA approach, it is essential to strengthen local institutions as well as indigenous local knowledge which could be an important policy intervention for the identification, conservation, and sustainable management of ecologically, socially and economically useful fungal species.

关键词： EbA environmental income indigenous local knowledge mushrooms Ophiocordyceps sinensis

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Phytogenic Synthesis of Metal/Metal Oxide Nanoparticles for Degradation of Dyes

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Journal of Renewable Materials 2022年第7期10卷 1911-1930页

作者： Arpita Roy H.CAnanda Murthy Hiwa M.Ahmed Mohammad Nazmul Islam ram prasad Department of Biotechnology School of Engineering&TechnologySharda UniversityGreater Noida201310India Department of Applied Chemistry School of Applied Natural ScienceAdama Science and Technology UniversityAdama1888Ethiopia Sulaimani Polytechnic University Slemani46001Iraq Department of Horticulture University of RaparinRanya46012Iraq Department of Pharmacy International Islamic University ChittagongChittagong4318Bangladesh Department of Botany Mahatma Gandhi Central UniversityMotihari845401India

Now-a-days nanotechnology is one of the booming fields for the *** the increase in industrialization mainly textile,paper,medicine,plastic industry,there is an increase in concentration of organic dyes as *** of harmful dyes in water bodies has become a serious issue,as most of the dyes are carcinogenic and mutagenic in nature and causes various ***,there is a requirement to find out new approaches for efficient treatment of effluent containing *** are one of the potential solutions to this *** can be synthesized from different methods,however synthesis of nanoparticles from different plant parts(leaf,root or stem extract)is economical as well as *** nanoparticles have various environmental applications and one of them is remediation of *** aim of this review is to provide an overview of last five years studies about catalytic and photocatalytic degradation of various harmful dyes by plant synthesized nanoparticles,mechanism of degradation and advantages and disadvantages of phytogenic synthesis.

关键词： Nanoparticles green synthesis plants dyes remediation,metal oxide

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Synthesis of Metallic Nanoparticles Based on Green Chemistry and Their Medical Biochemical Applications:Synthesis of Metallic Nanoparticles

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Journal of Renewable Materials 2023年第6期11卷 2575-2591页

作者： Kakudji Kisimba Anand Krishnan Mbuso Faya Kahumba Byanga Kabange Kasumbwe Kaliyapillai Vijayakumar ram prasad Department of Pharmaceutical Sciences University of Kwazulu-NatalPrivate Bag X54001DurbanSouth Africa Department of Chemical Pathology School of PathologyFaculty of Health SciencesUniversity of the Free StateBloemfonteinSouth Africa Faculty of Pharmaceutical Sciences University of LubumbashiLubumbashiDemocratic Republic of Congo Department of Biotechnology and Food Sciences Durban University of TechnologyDurbanSouth Africa Department of Chemistry M.Kumarasamy College of EngineeringKarurTamilnaduIndia Department of Botany Mahatma Gandhi Central UniversityMotihariBiharIndia

Nanoparticles have distinct properties that make them potentially valuable in a variety of *** a result,emerging approaches for the manufacture of nanoparticles are gaining a lot of scientific *** biological pathway of nanoparticle synthesis has been suggested as an effective,affordable,and environmentally safe *** of nanoparticles through physical and chemical processes uses unsafe materials,expensive equipment and adversely affects the *** a result,in order to support the increased utilization of nanoparticles across many sectors,nanotechnology research activities have shifted toward environmentally safe and cost-effective techniques that outperform chemical and/or biological *** use of organisms to produce metal nanoparticles is among the most frequently discussed *** appear to be the best candidates among these organisms for large-scale nanoparticle *** plants have been employed as reducing agents and NP stabilizers to minimize the toxicity of NPs in both the environment and the human ***,the presence of certain functional components in plant extracts may be extremely useful and effective for the human ***,for example,which may have antioxidant properties,might intercept free radicals before they interact with other biomolecules and cause considerable *** current article analyzes the most recent developments and improvements in the green synthesis of metal nanoparticles by different plants and the use of these nanoparticles for various biomedical applications and hopes to provide insights into this exciting research frontier.

关键词： Biosynthesis nanoparticles antimicrobial anticancer antioxidant medicinal plants

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Choice of precipitant and calcination temperature of precursor for synthesis of NiCo_2O_4 for control of CO–CH_4 emissions from CNG vehicles

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Journal of Environmental Sciences 2018年第3期30卷 62-71页

作者： Suverna Trivedi ram prasad Department of Chemical Engineering &Technology Indian Institute of Technology (BHU)

Compressed natural gas（CNG）is most appropriate an alternative of conventional fuel for ***,emissions of carbon-monoxide and methane from such vehicles adversely affect human health and ***,to abate emissions from CNG vehicles,development of highly efficient and inexpensive catalysts is ***,the present work attempts to scan the effects of precipitants（Na2CO3,KOH and urea）for nickel cobaltite（Ni Co2O4）catalysts prepared by co-precipitation from nitrate solutions and calcined in a lean CO-air mixture at 400℃.The catalysts were used for oxidation of a mixture of CO and CH4（1：1）.The catalysts were characterized by X-ray diffractometer,Brunauer–Emmett–Teller surface-area,X-ray photoelectron spectroscopy;temperature programmedreductionandScanningelectronmicroscopycoupledwith Energy-Dispersive X-Ray *** Na2CO3was adjudged as the best precipitant for production of catalyst,which completely oxidized CO-CH4mixture at the lowest temperature（T（100）=350℃）.Whereas,for catalyst prepared using urea,T（100）=362℃.On the other hand the conversion of CO-CH4mixture over the catalyst synthesized by KOH limited to 97%even beyond 400℃.Further,the effect of higher calcination temperatures of 500 and600℃ was examined for the best *** total oxidation of the mixture was attained at higher temperatures of 375 and 410℃ over catalysts calcined at 500 and 600℃ ***,the best precipitant established was Na2CO3and the optimum calcination temperature of 400℃ was found to synthesize the Ni Co2O4catalyst for the best performance in CO-CH4oxidation.

关键词： CNG vehicular emissions CO-CH4 oxidation NiG0204 Precipitants Calcinations

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A Comprehensive Review on Oxygen Reduction Reaction in Microbial Fuel Cells

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Journal of Renewable Materials 2022年第3期10卷 665-697页

作者： Pooja Dange Nishit Savla Soumya Pandit rambabu Bobba Sokhee P.Jung Piyush Kumar Gupta Mohit Sahni ram prasad Amity Institute of Biotechnology Amity UniversityMumbai410206India Department of Life Sciences School of Basic Sciences and ResearchSharda UniversityGreater Noida201306India Department of Physics Southern University and A&M CollegeBaton Rouge70813USA Department of Environment and Energy Engineering Chonnam National UniversityGwangju61186Korea Department of Physics School of Basic Sciences and ResearchSharda UniversityGreater Noida201306India Department of Botany Mahatma Gandhi Central UniversityBihar845401India

The focus of microbial fuel cell research in recent years has been on the development of materials,microbes,and transfer of charges in the system,resulting in a substantial improvement in current density and improved power *** cathode is generally recognized as the limiting factor due to its high-distance proton transfer,slow oxygen reduction reaction(ORR),and expensive *** heterogeneous reaction determines power gen-eration in *** comprehensive review describes-recent advancements in the development of cathode mate-rials and catalysts associated with *** recent studies indicated the utilization of different metal oxides,the ferrite-based catalyst to overcome this *** studies conclude that some cathode materials,in parti-cular,graphene-based conductive polymer composites with non-precious metal catalysts provide substantial ben-efits for sustainable development in the field of ***,it also highlights the potentiality to replace the conventional platinum air cathode for the large-scale production of the next generation of *** was evi-dent from the experiments that cathode catalyst needs to be blended with conductive carbon materials to make cathode conductive and efficient for *** review discusses various antifouling strategies for cathode biofoul-ing and its effect on the MFC ***,it also depicts cost estimations of various catalysts essential for further scale-up of MFC technology.

关键词： Cathode catalyst microbial fuel cell(MFC) nanomaterials oxygen reduction reaction(ORR) biofouling biocathode

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Ethanol steam reforming study over ZSM-5 supported cobalt versus nickel catalyst for renewable hydrogen generation

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Chinese Journal of Chemical Engineering 2019年第3期27卷 677-684页

作者： Ashutosh Kumar ram prasad Yogesh Chandra Sharma Department of Chemistry Indian Institute of Technology (Banaras Hindu University) Varanasi Department of Chemical Engineering & Technology Indian Institute of Technology (Banaras Hindu University) Varanasi

The renewable hydrogen generation through ethanol steam reforming is one of the anticipated areas for sustainable hydrogen generation. To elucidate the role of Ni and Co with ZSM-5 support, catalysts were prepared by wet impregnation method and ethanol steam reforming(ESR) was performed. The catalysts were characterized by HR-XRD, ATR–FTIR, HR-SEM, TEM with SAED, EDAX, surface area analyzer and TPR. It had shown complete ethanol conversion at 773 K, but the selectivity in hydrogen generation was found higher for 10% Ni/ZSM-5 catalyst as compared to 10% Co/ZSM-5. The 10% Ni/ZSM-5 catalyst has about 72% hydrogen selectivity at temperature 873 K. It indicates that Ni is a more sustainable catalyst as compared to Co with ZSM-5 support for ESR. The C_2H_4 was found major undesirable products up to 823 K temperature. Nevertheless, the 10% Ni/ZSM-5 catalyst had shown its stability for high temperature(873 K) ESR performance.

关键词： Ethanol steam reforming Zeolite Hydrogen Renewable energy Catalyst

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Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.:A review

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BIOCELL 2023年第5期47卷 1159-1176页

作者： VIJAY KUMAR PRAVEEN C.ramAMURTHY SIMRANJEET SINGH DALJEET SINGH DHANJAL PARUL PARIHAR DEEPIKA BHATIA ram prasad JOGINDER SINGH Central Ayurveda Research Institute JhansiUttar Pradesh284003India Interdisciplinary Centre for Water Research Indian Institute of SciencesBangalore560012India Department of Biotechnology Lovely Professional UniversityPhagwaraPunjab144411India Department of Botany Lovely Professional UniversityPhagwaraPunjab144411India Department of Biotechnology Baba Farid CollegeBathindaPunjab151001India Department of Botany Mahatma Gandhi Central UniversityMotihari845401India Department of Microbiology Lovely Professional UniversityPhagwaraPunjab144411India

Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese *** several decades,the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever,diabetes,constipation,jaundice,ulcers,biliousness,anemia,anorexia,and *** the traditional system,Indian gooseberry has various ethnomedicinal *** the Ayurvedic system,different methods of administration(anupan)have shown different ethnomedicinal properties of Indian *** well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation,among which the flavonoids and phenols are most *** the toxicity perspective,it is considered a safe herb in India,and is taken as a food supplement in European *** wide-spectrum pharmacological activities of the crude extracts and isolates of Indian gooseberry are attributed to the predominance of phenols and ***,it is important to study the exact mechanism of the activity of the phytochemicals in Indian gooseberry,especially in anti-cancer *** of Indian gooseberry enhances proliferation in several cancer cells in vitro,including stem cells like ovarian cancer(OC)cells,and also has been observed to possess anti-proliferative characteristics in *** review intends to explore the therapeutic potential of Indian gooseberry based on scientific reports and attempts to find the gaps for future research.

关键词： Phyllanthus emblica Amla Vitamin C Antioxidant Stem cells Phytochemistry Pharmacology

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