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A Probabilistic Trust Model and Control Algorithm to Protect 6G networks against Malicious Data Injection Attacks in Edge Computing Environments

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 631-654页

作者： Borja Bordel Sánchez ramón Alcarria Tomás Robles Department of Computer Systems Universidad Politécnica de MadridMadrid28031Spain Department of Geospatial Engineering Universidad Politécnica de MadridMadrid28031Spain

Future 6G communications are envisioned to enable a large catalogue of pioneering *** will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential *** provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and *** full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and *** particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control ***,Denialof-Service attacks can be executed by inundating the network with valueless *** anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical *** based on an exhaustive data collection to detect anomalies are precise but extremely *** models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors *** paper introduces a probabilistic trust model and control algorithm designed to address this *** model determines the probability of any node to be *** channels are pruned for those nodes whose probability is below a given *** trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and ***,anomalous nodes are identified using Gaussian mixture models and clustering ***,traffic patterns are studied using digital Bessel functions and the functional scalar ***,the in

关键词： 6G networks noise injection attacks Gaussian mixture model Bessel function traffic filter Volterra filter

Optimizing mechanical properties of HIPS fabricated with low-cost desktop 3D printers:investigating the impact of process parameters

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Advances in manufacturing 2024年第2期12卷 379-395页

作者： Jin-Ting Xu Guang-Wei Zhang man-man Chen School of Automotive Engineering Dalian University of TechnologyDalian116024People’s Republic of China

Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread ***,most users cannot test the strength of printed parts,and little information is available about the mechanical properties of printed high-impact polystyrene(HIPS)parts using desktop 3D *** this study,the user-adjustable parameters of desktop 3D printers,such as crisscross raster orientation,layer thickness,and infill density,were *** experimental plans were designed using the Box-Behnken method,and tensile,3-point bending,and compression tests were carried out to determine the mechanical responses of the printed *** prediction models of the process parameters were regressed to produce the optimal combination of process *** experimental results showcase that the crisscross raster orientation has significant effects on the flexural and compression strengths,but not on the tensile *** an increase in the layer thickness,the tensile,flexural,and compression strengths first decreased and then increased,reaching their minimum values at approximately 0.16 mm layer *** addition,they all increased with an increase of infill *** was demonstrated that when the raster orientation,layer thickness,and infill density were 13.08°/–76.92°,0.09 mm,and 80%,respectively,the comprehensive mechanical properties of the printed HIPS were *** results can help end-users of desktop 3D printers understand the effects of process parameters on the mechanical properties,and offer practical suggestions for setting proper printing parameters for fabricating HIPS parts.

关键词： Desktop three-dimensional(3D)printers Fused deposition modeling(FDM) High-impact polystyrene(HIPS) Process parameters

Influence of the Acoustic Liner in Large Eddy Simulation of Longitudinal Thermoacoustic Instability in a Model Annular Combustor

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Journal of Thermal Science 2024年第2期33卷 710-724页

作者： MEnG Sheng ZHAnG man GAO Yi AECC Commercial Aircraft Engine Co. Ltd.Shanghai200241China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

Although extensive efforts have been made to dampen the thermoacoustic instability,successfully controlling the pressure oscillations in modern gas turbines or aeroengines remains *** influence of the acoustic liner on the longitudinal thermoacoustic mode in a model annular combustor is investigated by Large Eddy Simulation(LES) in this *** result of the self-excited longitudinal thermoacoustic instability without the liner agrees well with the frequency and acoustic analysis of the pressure mode based on experimental *** different bias flow velocities of the liner located downstream of the combustor are then *** results reveal that the existence of the liner influences not only the acoustic field but also the flow *** the bias velocity is large,it leads to intense turbulence-induced fluctuations,and the pressure oscillation is modulated *** shows that the weak coupling between flow and pressure oscillations plays a significant role in the onset of the intermittency of a thermoacoustic *** on the dynamic analysis of the thermoacoustic system with the acoustic liner,this intermittency is caused by the influence of the flow field on the flame-acoustic ***,a low-order modeling method based on Van der Pol(VdP) oscillator with additive stochastic forcing is conducted to reproduce the evolving dynamics of the thermoacoustic *** the numerical cases demonstrated in this work are relatively simpler than those in a practical combustion system,the results are helpful for us to understand the effect of the acoustic liner and show the attractive potential to apply this device to suppress thermoacoustic instability.

关键词： thermoacoustic instability acoustic liner Large Eddy Simulation low-order modeling

Bioinspired strategies for biomimetic actuators from ultrafast to ultraslow

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nano Research 2024年第2期17卷 570-586页

作者： man Yang Feilong Zhang Shutao Wang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science CAS Center for Excellence in NanoscienceTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Motile plant tissues can control their configurations and regulate their motion speed according to their specific requirements,which offer various protypes for biomimetic actuators with controlled motion *** this perspective,we focus on the speed control of plant tissues and the bioinspired strategies for speed regulation of artificial *** begin with a summary to the strategies and mechanisms of motile plant tissues for controlling motion speed,ranging from ultrafast to *** then exemplify the models for fabricating bioinspired artificial actuators and briefly discuss current application scenarios of actuators with varying speeds from ultrafast to ***,we propose potential strategies for the speed regulation of actuators.

关键词： biomimetic actuator motile plant speed regulation ultrafast ultraslow

Recurrent malignant hyperthermia after scoliosis correction surgery

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World Journal of Emergency Medicine 2024年第1期15卷 70-72页

作者： Junfeng Su man Huang Department of General Intensive Care Unit the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310052China Key Laboratory of Early Warning and Intervention of Multiple Organ Failure Ministry of Education of the People's Republic of ChinaHangzhou 310052China

Malignant hyperthermia(MH)is a genetic disorder of skeletal muscle cells that affects muscle cytoplasmic calcium homeostasis,with high mortality and low ***,it presents with non-specific signs of a hypermetabolic response,including high fever,tachycardia,and elevated end-tidal carbon dioxide(ETCO_(2)).The successful treatment lies in the timely recognition and early use of dantrolene.[1]As an inhibitor of Ca2+release through ryanodine receptor(RYR)channels,the skeletal muscle relaxant dantrolene has proven to be both a valuable experimental probe of intracellular Ca2+signaling and a lifesaving treatment for MH.[2]Dominant mutations in the skeletal muscle RYR1 gene are well-recognized causes of both malignant hyperthermia susceptibility(MHS)and central core disease(CCD).

关键词： hyperthermia malignant elevated

Evaluating the historical,clinical,and cultural value of the Tian Hui Yi Jian

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Journal of Traditional Chinese Medicine 2024年第1期44卷 220-221页

作者： YU Linyong GU man China Academy of Chinese Medical Sciences Beijing 100700China Institute for History of Medicine and Medical Literature China Academy of Chinese Medical SciencesBeijing 100700China

Tian Hui Yi Jian was compiled by the Tianhui Medical manuscripts Compilation Group,which includes scholars from the Institute for History of Medicine and Medical Literature of the China Academy of Chinese Medical Sciences(CACMS),Chengdu University of Traditional Chinese Medicine,Chengdu Institute of Cultural Relics and Archaeology,and Jingzhou Cultural Relics Protection *** was published by the Cultural Relics Press in november *** volume includes images of eight medical manuscripts,along with the Team's annotations,and photographs of a lacquered figurine with meridian-channels and words on its surface.

关键词： surface Chengdu Tian

Seedling potential of trees species along the elevational gradient in temperate hill forest of central nepal

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Journal of Mountain Science 2024年第4期21卷 1329-1344页

作者： DAnI ram Sharan BAnIYA Chitra Bahadur Central Department of Botany Tribhuvan UniversityKirtipur 44618Nepal

Regeneration status of tree species along elevation gradient in temperate hill forest was not understood *** research examined the tree diversity and its regeneration patterns along an elevation gradient in temperate hill forest,central *** were collected from 300 sample plots within vertical elevation bands of 10,ranging from 1365 to 2450 m asl.A random sampling method was used for data collection in three seasons,winter,pre-monsoon and post monsoon *** at breast height(DBH)was used to broadly categorize the plant individual into trees,saplings and *** tree species richness ranged from 12 to 25 with density of 350 to 1200 individuals per *** richness of tree and sapling showed statistically significant unimodal pattern,which peaked at *** showed a strong and positive linear correlation with the seedling density(Deviance=0.99,pnd a significant hump-shaped relationship with sapling density(Deviance=0.95,pns showed a statistically significant negative hump-shaped relationship with all trees,saplings and seedling stages(Deviances=0.89,0.87 and 0.57).The highest values of the Shannon-Wiener index and the lowest value of the Simpson index were found at mid-elevation for all growth *** 92%of tree species were found at regenerating stage;49%in a good renewal regeneration status,32%in fair renewal regeneration,and 11%at a poor regenerating ***,4%of tree species were reported as non-regenerating stages and 4%were newly introduced ***,the regeneration status of the study area was considered fairly well since sapling(78.5%)>seedling(10.6%)≤mature(10.9%).Among tested environmental variables,elevation and annual mean rainfall were the most influential factors in the regeneration of tree species.

关键词： Regeneration potential Chandragiri hill Altitudinal gradient Species diversity Tree species richness

Adverse effects of early-life stress:focus on the rodent neuroendocrine system

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neural Regeneration Research 2024年第2期19卷 336-341页

作者： Seung Hyun Lee Eui-man Jung Department of Molecular Biology College of Natural SciencesPusan National UniversityBusanRepublic of Korea

Early-life stress is associated with a high prevalence of mental illnesses such as post-traumatic stress disorders,attention-deficit/hyperactivity disorder,schizophrenia,and anxiety or depressive behavior,which constitute major public health *** the early stages of brain development after birth,events such as synaptogenesis,neuron maturation,and glial differentiation occur in a highly orchestrated manner,and external stress can cause adverse long-term effects throughout *** body utilizes multifaceted mechanisms,including neuroendocrine and neurotransmitter signaling pathways,to appropriately process external *** individuals first exposed to early-life stress deploy neurogenesis as a stress-defense mechanism;however,in adulthood,early-life stress induces apoptosis of mature neurons,activation of immune responses,and reduction of neurotrophic factors,leading to anxiety,depression,and cognitive and memory *** process involves the hypothalamus-pituitary-adrenal axis and neurotransmitters secreted by the central nervous system,including norepinephrine,dopamine,and *** rodent early-life stress model is generally used to experimentally assess the effects of stress during *** paper reviews the use of the early-life stress model and stress response mechanisms of the body and discusses the experimental results regarding how early-life stress mediates stress-related pathways at a high vulnerability of psychiatric disorder in adulthood.

关键词： early-life stress hypothalamic-pituitary-adrenergic axis maternal separation mental illness neurodevelopmental disorder neuroendocrine system neurotransmitter

Development of novel 5-FU modified siRnA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

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Genes & Diseases 2024年第1期11卷 23-25页

作者： Andrew Fesler Ga-ram Hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the major obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRnA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRnA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRnA using a siRnA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified