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Double-Blind, Parallel Group Study to Compare the Clinical Effectiveness of Calcium Dobesilate 500 mg BID vs. Calcium Dobesilate LP 1 g OD, in Patients with Chronic Venous Insufficiency of the Lower Limbs

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International Journal of Clinical medicine 2024年第5期15卷 211-223页

作者： ramón téllez méndez maria González Yibirin David Rincón matute Centro Clnico Prevaler Pampatar Nueva Esparta Venezuela Grupo Leti Guarenas Miranda Venezuela

Background: Chronic venous insufficiency (CVI) describes a condition that affects the venous system of the lower extremities due to venous hypertension (VH. the prevalence is between 5% - 30%. CVI is associated with older age, smoking, lower extremity trauma, presence of an arteriovenous shunt, and elevated estrogen levels. All patients should be initially treated with conservative management. Venoactive drugs like calcium dobesilate are useful. Objectives: the primary objective compared the clinical improvement in patients with CVI, grades 0 - 3 of the CEAP classification of chronic venous disease, produced by two formulations of calcium dobesilate: calcium dobesilate LP 1 g OD vs calcium dobesilate 500 mg BID, immediate release. the secondary objective assessed the side effects of both formulations. method: All patients took one tablet and one capsule at 7 am, and one capsule at 7 pm, for 8 weeks. One group received dobesilate 1 g OD and the other group received dobesilate 500 md BID. they were evaluated after 15, 30 and 60 days of treatment, using the symptom evaluation scale. Results: In both groups, there was a significant decrease in the symptom score after 15 days. Four patients in the Dobesilate OD group: had adverse effects, which did not require suspension of treatment. In the BID dobesilate group, there was one therapeutic failure, and one case of gastric discomfort. Conclusions: Prolonged-release Calcium dobesilate 1 g OD is as effective as calcium dobesilate 500 mg BID for the treatment of patients with chronic venous insufficiency.

关键词： Chronic Venous Insufficiency (CVI) Calcium Dobesilate CEAP Classification Adverse Effects treatment Adherence

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Randomized, Double-Blind, Double-masked, Parallel Group Clinical Study to Compare the Effectiveness of Diclofenac Potassium 150 mg, LP OD, vs Diclofenac Potassium 50 mg, tID, three times a Day, in Knee Osteoarthritis

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International Journal of Clinical medicine 2023年第5期14卷 239-249页

作者： ramón téllez méndez Luis Cabeza maria González Yibirin David Rincón matute Jose Antonio Herrera Centro Clínico Prevaler Pampatar Venezuela Policlínica Las mercedes Caracas Venezuela Grupo Leti Guarenas Venezuela Hospital Jose maría Vargas Caracas Venezuela

Background: Osteoarthritis is a chronic disease associated with pain, inflammation, stiffness and synovial effusion, with progressive functional limitation, compromising quality of life. It progressively leads to loss or decrease in joint function. Pharmacological and non-pharmacological therapy seeks symptomatic management, complicated by a lack of adherence. After acetaminophen, non-steroidal anti-inflammatory drugs such as diclofenac are the most widely used medications. Objectives: the primary objective compared the analgesic effect of diclofenac 150 mg once daily vs. 50 mg three times daily in patients with knee osteoarthritis. the secondary objective assessed changes in quality of life. method: One group received diclofenac 150 mg OD with placebo ttD. Another group received placebo OD and 50 mg active diclofenac (reference) ttD, both for 30 days. the evaluation of pain was carried out by a visual analog scale (VAS), at the beginning, 2, 3, 4, 15 and 30 days, quality of life (the WOmAC scale) and adverse effects, at 15 and 30 days. Results: Pain decreased significantly on days 15 and 30, compared to day 0, in both groups, without differences between groups. the total results in the WOmAC scale showed a very marked improvement at 15 and 30 days, without differences between groups. the most frequent adverse effects were constipation 6% in the reference group, and gastric discomfort 30.3% in the reference group vs 28.1%, in the test group. Conclusions: Prolonged-release diclofenac 150 mg OD is as effective as diclofenac 50 mg tID for the treatment of patients with knee osteoarthritis.

关键词： Knee Osteoarthritis Diclofenac Visual Analog Scale WOmAC Scale

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From prediction to prevention:machine learning revolutionizes hepatocellular carcinoma recurrence monitoring

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World Journal of Gastroenterology 2024年第7期30卷 631-635页

作者： mariana michelle ramírez-mejía nahum méndez-Sánchez Plan of Combined Studies in medicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of medicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this editorial,we comment on the article by Zhang et al entitled Development of a machine learning-based model for predicting the risk of early postoperative recurrence of hepatocellular *** carcinoma(HCC),which is characterized by high incidence and mortality rates,remains a major global health challenge primarily due to the critical issue of postoperative *** recurrence,defined as recurrence that occurs within 2 years posttreatment,is linked to the hidden spread of the primary tumor and significantly impacts patient *** predictive factors,including both patient-and treatment-related factors,have limited predictive ability with respect to HCC *** integration of machine learning algorithms is fueled by the exponential growth of computational power and has revolutionized HCC *** study by Zhang et al demonstrated the use of a groundbreaking preoperative prediction model for early postoperative HCC *** persist,including sample size constraints,issues with handling data,and the need for further validation and *** study emphasizes the need for collaborative efforts,multicenter studies and comparative analyses to validate and refine the *** these challenges and exploring innovative approaches,such as multi-omics integration,will enhance personalized oncology *** study marks a significant stride toward precise,efficient,and personalized oncology practices,thus offering hope for improved patient outcomes in the field of HCC treatment.

关键词： Hepatocellular carcinoma Early recurrence machine learning XGBoost model Predictive precision medicine Clinical utility Personalized interventions

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Solution of the Center Problem for a Class of Polynomial Differential Systems

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Acta mathematica Sinica,English Series 2024年第7期40卷 1685-1696页

作者： Chang Jian Liu Jaume Llibre Rafael ramírez Valentín ramírez School of mathematics(Zhuhai) Sun Yat-sen UniversityZhuhai519086P.R.China Departament de matemàtiques Universitat Autònoma de Barcelona08193BellaterraBarcelonaCataloniaSpain Departament d’Enginyeria Informàtica i matemàtiques Universitat Rovira i VirgiliAvinguda dels Paiïsos Catalans 2643007TarragonaCataloniaSpain

Consider the polynomial differential system of degree m of the form x=-y(1+μ(a_(2)x-a_(1)y))+x(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),y=x(1+μ(a_(2)x-a_(1)y))+y(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),whereμandνare real numbers such that(μ^(2)+v^(2))(μ+v(m-2))(a_(1)^(2)+a_(2)^(2))≠m>2 andΩ_(m−1)(x,y)is a homogenous polynomial of degree m−1.A conjecture,stated in *** Equations 2019,suggests that whenν=1,this differential system has a weak center at the origin if and only if after a convenient linear change of variable(x,y)→(X,Y)the system is invariant under the transformation(X,Y,t)→(−X,Y,−t).For every degree m we prove the extension of this conjecture to any value ofνexcept for a finite set of values ofμ.

关键词： Center problem polynomial differential system

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Understanding the Link:Emotional Attention in Italian Families and Children’s Social Development

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International Journal of mental Health Promotion 2024年第9期26卷 709-718页

作者： Catalda Corvasce Juan Pedro martínez-ramón Francisco manuel morales-Rodríguez Lidia Pellicer-García Inmaculada méndez Cecilia Ruiz-Esteban Liceo Statale“Carlo Cafiero” Barletta(BT)76121Italy Department of Developmental Psychology and Education University of MurciaMurcia30100Spain Department of Developmental Psychology and Education University of GranadaCampus of La CartujaGranadaCP 18071Spain Department of Spanish Language and General Linguistics University of MurciaCampus of La MercedMurciaCP 30001Spain

Background:Emotional attention refers to the capacity to recognize and properly respond to one’s and others’emotional *** another note,family is a primary source of socialization that influences the development of various social *** another line,adolescence is a complex stage that has been associated with emotional difficulties that could be related to competences such as prosociability and *** is inferred that through the family context and the attention that is processed,a series of competencies are transmitted to the youngsters,but this relationship is still *** this reason,the study’s purpose was to examine the relationship between the emotional attention of mothers and fathers and the social and prosocial competencies of their ***:to accomplish this,a cross-sectional study and ex post facto design were *** trait-meta mood Scale(tmmS-24)-to assess emotional attention-,the Strengths and Difficulties Questionnaire(SDQ)-to determine the prosociality dimension-,and the test on Passing Developmental tasks in Adolescence(tCS-A)-to measure social inclusionwere *** participants were n=228 families composed of n=114 mothers/fathers(67.5%females)and n=114 daughters/sons(38.5%females)selected through non-probabilistic sampling using a convenience sample in the Bari region of Italy.A descriptive and inferential analysis-Student’s test and Pearson’s correlation-was performed with the statistic package SPSS version 28(significance level pts:the findings showed that the families possessed an adequate background in emotional attention and that their daughters and sons were also generally well-adjusted in social inclusion and *** also found certain signs that the prosocial competence of the children could be related to the behavior of their mothers and ***:In conclusion,social inclusion is related to prosocial behavior,and maybe primarily cultivated within families where paren

关键词： Educational style coping strategies stress social inclusion emotional attention prosociality

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A Generalized Array Factor for time-modulated Hexagonal Based Antenna Array Geometry With novel trapezoidal Switching

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1967-1972页

作者： Gopi ram Department of Electronics and Communication Engineering National Institute of TechnologyWarangal 506004India

the concept of the time-modulated array has been emerging as an alternative to the complex phase shifters,which lowers the cost of the array feeding network due to the utilization of radio frequency(RF)*** various forms of hexagonal antenna array geometries can be used for applications like surveillance tracking in phased array radar and wireless communication *** work proposes the generalized array factor(AF)for the hexagonal antenna array geometry based on time *** time modulation in generalized hexagonal geometry can maintain the fixed static amplitude excitation,giving more flexibility over ***,a novel trapezoidal switching function is also proposed and applied to the generalized array factor to enable future researchers to use this array factor in the field of advancement to observe how switching schemes like trapezoidal and rectangular affect the array pattern's side lobe level(SLL).the generalized equation can be utilized for the analysis and synthesis of radiation characteristics of the time-modulated hexagonal array(tmHA),time-modulated concentric hexagonal array(tmCHA),time-modulated hexagonal cylindrical array(tmHCA),and time-modulated hexagonal concentric cylindrical array(tmHCCA).the numerical result illustrates the generation of AF of time-modulated hexagonal structures and also shows that the trapezoidal switching sequence outperforms the rectangular switch using the cat swarm optimization(CSO)approach.

关键词： Hexagonal array geometry radiation pattern time-modulation trapezoidal pulse

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A Probabilistic trust model and Control Algorithm to Protect 6G networks against malicious Data Injection Attacks in Edge Computing Environments

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Computer modeling in Engineering & Sciences 2024年第10期141卷 631-654页

作者： Borja Bordel Sánchez ramón Alcarria tomás Robles Department of Computer Systems Universidad Politécnica de MadridMadrid28031Spain Department of Geospatial Engineering Universidad Politécnica de MadridMadrid28031Spain

Future 6G communications are envisioned to enable a large catalogue of pioneering *** will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential *** provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and *** full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and *** particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control ***,Denialof-Service attacks can be executed by inundating the network with valueless *** anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical *** based on an exhaustive data collection to detect anomalies are precise but extremely *** models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors *** paper introduces a probabilistic trust model and control algorithm designed to address this *** model determines the probability of any node to be *** channels are pruned for those nodes whose probability is below a given *** trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and ***,anomalous nodes are identified using Gaussian mixture models and clustering ***,traffic patterns are studied using digital Bessel functions and the functional scalar ***,the in

关键词： 6G networks noise injection attacks Gaussian mixture model Bessel function traffic filter Volterra filter

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Influence of biomass burning on ozone levels in the megalopolis of Central mexico during the COVID-19 lockdown

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Journal of Environmental Sciences 2024年第9期143卷 99-115页

作者： Victor Almanza Luis Gerardo Ruiz-Suárez Ricardo torres-Jardón Agustín García-Reynoso Iván Y.Hernández-Paniagua Institute for Atmospheric Sciences and Climate Change National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

the massive reductions in anthropogenic emissions resulting from the COVID-19 lockdown provided a unique opportunity to evaluate the effect of mitigation measures aiming to abate air *** mexico,the total lockdown period took place during the dry-hot season when biomass burning activity is ***,we investigate the role of biomass burning emissions on regional ozone levels in the megalopolis of Central *** studied period covers the lockdown phases 2 and 3,and the first month of the new *** applied a factor separation technique and process analysis to estimate the pure and synergistic contributions of emission reductions under lockdown and that from biomass burning to daily ozone maximum concentrations in 7 metropolitan areas of different states in the *** results revealed that biomass burning plumes likely masked the effect of massive reductions from mobile emissions,impacted the PBL development during phase 3 and favored transition and mixed nO_(x)-limited and VOC-limited regional *** contributed to increased ozone production in the middle to lower PBL by changing the regional background levels which potentially could bias high ozone production efficiency *** the megalopolis contribution to economic and societal development at national scale,our study suggests that ozone mitigation measures during the dry-hot season targeting mainly mobile emissions will likely be offset by biomass burning plumes.A regional and synergic policy aiming to control biomass burning would help to reduce the occurrence of high ozone levels in Central mexico with the co-benefit of tackling short-lived climate pollutants.

关键词： COVID-19 mexico megalopolis Ozone Factor Separation Process Analysis

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Sex-dependent resilience to extreme drought events: implications for climate change adaptation of a South American endangered tree species

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Ecological Processes 2024年第2期13卷 48-60页

作者： Sergio Piraino martín Ariel Hadad Yanina Antonia Ribas-Fernández Fidel Alejandro Roig Laboratorio de Dendrocronología e Historia Ambiental (IAnIGLA COnICEt ) Facultad de Ciencias Agrarias Universidad Nacional de Cuyo Laboratorio de Dendrocronología de Zonas áridas (CIGEOBIO COnICEt ) Gabinete de Geología Ambiental (INGEO UNSJ) Hémera Centro de Observación de la tierra Facultad de Ciencias Universidad Mayor

Background Recent changes in climatic trends are resulting in an increased frequency and intensity of extreme events, with unknown effect on ecosystem dynamics in the near future. Extreme drought episodes are recognized as disturbance factors capable of modifying forest dynamics and tree growth. Within this context, dioecious tree species may be impacted by climatic extremes, affecting male/female proportions and, consequently, reproductive processes and species persistence. therefore, there is an urgent need for species-specific assessments of growth tolerance to extreme dry spells in dioecious tree species, to establish effective conservation strategies for these particular natural resources. Araucaria araucana(araucaria), an endangered dioecious Patagonian tree species, has recently undergone decay and mortality episodes in response to increasing dry climatic conditions. While sex-dependent tolerance to extreme drought episodes has been assessed in the species' humid distribution range, there is still a lack of information on the gender-based resilience of trees growing in the drier environments of the species' *** We reconstructed, through dendrochronological methods, the sex-dependent response of 105 araucaria individuals(55 female and 50 male trees) to five regional extreme dry spells employing a set of different indices. Resistance, recovery period, and average growth reduction of standardized tree-ring growth were examined, analysing the effect of biotic(sex, pre-drought stem tree growth) and abiotic(local climatic conditions before, during, and after extreme climatic episodes) factors on tree *** Sex influences only the species resistance to climatic disturbance, with male individuals showing lower tolerance to extreme drought events. Pre-drought radial growth rates and local meteorological conditions preceding, during, and following extreme dry spells strongly modulated araucaria radial growth resilience regardless of tree s

关键词： Araucaria Climate change Dendrochronology Extreme drought event Resilience

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Using fused filament fabrication to improve the tribocorrosion behaviour of 17-4 PH SS in comparison to other metal forming techniques

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Friction 2024年第10期12卷 2325-2343页

作者： Cristina GARCÍA-CABEZÓn Juan Alfonso nARAnJO Celia GARCÍA-HERnÁndez Cristina BERGES Gemma HERRAnZ Fernando mARtÍn-PEDROSA materials Engineering E.I.I.Universidad de ValladolidValladolid 47011Spain InEI-Escuela técnica Superior de Ingeniería Industrial(EtSII) Universidad de Castilla La ManchaCastilla-La Mancha 13071Spain

Fused filament fabrication(FFF)is one of the additive manufacturing processes which has gained more interest because of its simplicity and *** technology is similar to the conventional metal injection moulding(mIm)process,consisting of the feedstock preparation of metal powder and polymer binders,followed by layer-by-layer 3D printing(FFF)or injection(mIm)to create green parts and,finally,debinding and ***,both technologies provide near-dense *** work presents an in-depth study of the processing method’s *** porosity,microstructure,hardness,corrosion,and tribocorrosion behaviour are compared for 17-4 PH SS samples processed from powder by additive manufacturing using FFF and mIm,as well as conventional powder metallurgy(Pm)*** samples exhibited the highest macro and microhardness,while corrosion behaviour was similar for both mIm and FFF samples,but superior in comparison to conventional Pm ***,the FFF-as fabricated samples displayed a significant improvement in tribocorrosion resistance that could be explained by the higher proportion of delta ferrite and retained austenite in their microstructure.

关键词： 17-4 PH SS fused filament fabrication(FFF) metal injection moulding(mIm) corrosion behaviour powder metallurgy(Pm) tribocorrosion behaviour

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