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Journal of Environmental Science and Engineering(A) 2020年第2期9卷 56-65页

作者： Luis Miguel Rodríguez vázquez Ana Irán Prieto valles ramón silva vázquez Héctorávalos Loya EduardoHerrera Peraza Emilio Yanez Terrazas Francisco Rueda Ever Ulysses Torres Carrillo Leonor CortésPalacios Gilberto Sandino Aquino Department of Chemical Engineering Tecnológico Nacional de México-Instituto Tecnológico de ParralHidalgo del ParralChihuahua 33850México Department of Renewable Energies and Environmental Protection Centro de Investigación en Materiales AvanzadosS.C.ChihuahuaChihuahua 31109México Faculty of Zootechnics and Ecology Universidad Autónoma de Chihuahua(UACH)ChihuahuaChihuahua 31000México

The degree of adaptability and phytoremediation potential of the plant species, Zacate Garrapata, Zacate Banderita, Chivatillo, Oregano, Chamizo and Sotol were evaluated on different substrates (S) composed of tailing (JM) and agricultural land (TA) in different proportions in mass: S1 = 100% TA, S2 = 100% JM, S3 = 50% TA and 50 % JM, S4 = 25% JM and 75% TA, S5 = 75% JM and 25% TA. With the combination of species and substrates, 30 treatments were generated. The heavy metals evaluated were Pb, As, Cu. Fe, Cr and Zn, in root, leaf and stem. The results showed significant statistical differences (p nd Zacate Garrapata species being the ones with the highest degree of adaptability and accumulation of heavy metals in interaction with S3. These two species can be used in the remediation of open pit tailing dam.

关键词： Adaptability plant species substrate mix heavy metals abandoned tailing dams

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

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BIOCELL 2024年第6期48卷 897-904页

作者： CARLOS ALBERTO-silva BREnDA RUFInO DA silva natural and Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological proﬁles,allowing for the discovery of new medicinal products and therapeutic *** review speciﬁcally examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake *** also includes a brief evaluation of short peptides that are being considered as potential therapeutic ***-rich peptides and tryptophyllin family peptides isolated from the crude venom of viperidae family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial *** signiﬁcant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces n-methyl-D-aspartate(nMDA)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关键词： neuroprotective peptides neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides

A Review of nILM Applications with Machine Learning Approaches

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Computers, Materials & Continua 2024年第5期79卷 2971-2989页

作者： Maheesha Dhashantha silva Qi Liu School of Electronic and Information Engineering Nanjing University of Information Science and TechnologyNanjing210044China

In recent years,non-Intrusive LoadMonitoring (nILM) has become an emerging approach that provides affordableenergy management solutions using aggregated load obtained from a single smart meter in the power ***, by integrating Machine Learning (ML), nILM can efficiently use electrical energy and offer less ofa burden for the energy monitoring process. However, conducted research works have limitations for real-timeimplementation due to the practical issues. This paper aims to identify the contribution of ML approaches todeveloping a reliable Energy Management (EM) solution with nILM. Firstly, phases of the nILM are discussed,along with the research works that have been conducted in the domain. Secondly, the contribution of machinelearning approaches in three aspects is discussed: Supervised learning, unsupervised learning, and *** highlights the limitations in the applicability of ML approaches in the field. Then, the challenges in the realtimeimplementation are concerned with six use cases: Difficulty in recognizing multiple loads at a given time,cost of running the nILM system, lack of universal framework for appliance detection, anomaly detection andnew appliance identification, and complexity of the electricity loads and real-time demand side ***, options for selecting an approach for an efficientnILMframework are suggested. Finally, suggestionsare provided for future research directions.

关键词： non-intrusive load monitoring transfer learning machine learning feature extraction

Small-scale self-driving cars:A systematic literature review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 271-292页

作者： Felipe Caleffi Lauren da silva Rodrigues Joice da silva Stamboroski Brenda Medeiros Pereira Autonomous vehicles Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil Mobility and Logistics Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil

The autonomous vehicle(Av)technology has the potential to significantly improve safety and efficiency of the transportation and logistics ***-scale Av testing is limited by time,space,and cost,while simulation-based testing often lacks the necessary accuracy of Av and environmental *** recent years,several initiatives have emerged to test autonomous software and hardware on scaled *** systematic literature review provides an overview of the literature surrounding small-scale self-driving cars,summarizing the current autonomous platforms deployed and focusing on the software and hardware developments in this *** studies published in English-language journals or conference papers that present small-scale testing of self-driving cars were *** of Science,Scopus,Springer Link,Wiley,ACM Digital Library,and TRID databases were used for the literature *** systematic literature search found 38 eligible *** gaps in the reviewed papers were identified to provide guidance for future *** key takeaway emerging from this manuscript are:(i)there is a need to improve the models and neural network architectures used in autonomous driving systems,as most papers present only preliminary results;(ii)increasing datasets and sharing databases can help in developing more reliable control policies and reducing bias and variance in the training process;(iii)small-scaled vehicles to ensure safety is a major benefit,and incorporating data about unsafe driving behaviors and infrastructure problems can improve the accuracy of predictive models.

关键词： Self-driving car Autonomous vehicle Small-scale vehicle Systematic literature review

Supplementation of vitamin E or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia v.silva‑Guillen Consuelo Arellano Jeffrey Wiegert R.Dean Boyd Gabriela E.Martinez Eric van Heugten Department of Animal Science North Carolina State UniversityRaleighNC 27695USA Department of Statistics North Carolina State UniversityRaleighNC 27695USA Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Animal nutrition Research LLCAlvatonKY 42122USA.

Background Heat stress has severe negative consequences on performance and health of pigs,leading to significant economic *** objective of this study was to investigate the effects of supplemental vitamin E and a botanical extract in feed or drinking water on growth performance,intestinal health,and oxidative and immune status in grow-ing pigs housed under heat stress *** Duplicate experiments were conducted,each using 64 crossbred pigs with an initial body weight of 50.7±3.8 and 43.9±3.6 kg and age of 13-week and 12-week,***(n=128)were housed individually and assigned within weight blocks and sex to a 2×4 factorial arrangement consisting of 2 environments(thermo-neutral(21.2℃)or heat-stressed(30.9℃))and 4 supplementation treatments(control diet;control+100 IU/L of D-α-tocopherol in water;control+200 IU/kg of DL-α-tocopheryl-acetate in feed;or control+400 mg/kg of a botanical extract in feed).Results Heat stress for 28 d reduced(P≤0.001)final body weight,average daily gain,and average daily feed intake(-7.4 kg,-26.7%,and-25.4%,respectively)but no effects of supplementation were detected(P>0.05).Serum vitamin E increased(Pvitamin E supplementation in water and in feed(1.64 vs.3.59 and 1.64 vs.3.24),but not for the botanical extract(1.64 vs.1.67 mg/kg)and was greater when supplemented in water ***(P=0.002).Liver vitamin E increased(Pvitamin E supplementations in water(3.9 vs.31.8)and feed(3.9 vs.18.0),but not with the botanical extract(3.9 vs.4.9 mg/kg).Serum malondialdehyde was reduced with heat stress on d 2,but increased on d 28(interaction,Pnd was greater(Pntioxidant supplementation compared to *** proliferation was reduced(P=0.037)in the jejunum under heat stress,but increased in the ileum when vitamin E was supplemented in feed and water under heat stress(interaction,P=0.04).Tumor necrosis factor-αin jejunum and ileum mucosa decreased by heat stress(Pnd was re

关键词： Botanical extract Growing pigs Heat stress Immune status Oxidative status Tocopherol Water

Plant community on a volcano mountaintop reveals unique high-altitude vegetation in southeastern Brazil

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Journal of Mountain Science 2024年第9期21卷 3018-3030页

作者： Igor Musauer KESSOUS Ruy Josévalka ALvES nílber Gonçalves da silva Amilcar Walter SAPORETTI JUnIOR Biodiversity Laboratory Federal Institute of EducationScience and Technology of Southern Minas Gerais(IFSULDEMINAS)Av.Dirce Pereira Rosa300-Jardim Esperança37713-100Poços de CaldasMGBrazil Department of Botany National MuseumFederal University of Rio de JaneiroQuinta da Boa Vista s.n.São Cristóvão20949-040Rio de JaneiroRJBrazil Gothenburg Global Biodiversity Centre Carl Skottsbergs Gata 22BSE 41319GothenburgSweden

Mountains exhibit a high degree of endemism and diversity,however,quantifying their biodiversity can be *** to islands,species isolation in mountainous regions results in comparable patterns of evolution and extinction,rendering their biodiversity unique and highly susceptible to anthropogenic *** topographic relief in mountains plays a crucial role in creating habitat complexity,which in turn contribute to high plant ***,we investigated plant diversity in the volcano mountaintop vegetation on the Poços de Caldas Plateau,a region situated in the ecotone between the Atlantic Forest and Cerrado,characterized by natural radiation and significant anthropogenic *** employed an automated approach through the filtering of georeferenced and non-georeferenced data to obtain a list of plant species in the ***,we statistically investigated the similarity among different high-altitude vegetations belonging to the campos de altitude from the Atlantic Forest and campos rupestres from the *** plateau exhibits high plant diversity,including 1,659 specific and infraspecific taxa,especially belonging to Asteraceae and *** analyses suggest that geographical distance is a strong predictor of dissimilarity and that the Poços de Caldas Plateau is more floristically related to the campos rupestres,despite being associated with campos de *** region possesses a unique set of biodiversity,indicating that it may be a distinct ***,we hypothesize that Pleistocene events likely influenced the conformation of the current floristic composition in the region through species interchange between the Cerrado and Atlantic *** study also highlights the few taxa assessed for conservation status and anthropogenic threats that this habitat is facing.

关键词： Atlantic Forest Biogeography Cerrado Community ecology Grassland

Materials advancements for the safety and patency of implantable cardiovascular devices

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nano Research 2024年第10期17卷 8977-8989页

作者： Zulmari silva Pedraza Bo Liu Xudong Wang Department of Materials Science and Engineering University of Wisconsin−MadisonMadisonWisconsin 53706USA Departments of Cell and Regenerative Biology University of Wisconsin-MadisonMadisonWisconsin 53705USA

Implantable cardiovascular devices have revolutionized the management of cardiovascular diseases,significantly enhancing patients’quality of *** the increasing demand of cardiac implantable electronic devices,the imperative for novel device development is *** review article first elaborates the mechanisms underlying foreign body response and infection,elucidating the complex interplay between implanted constructs and host *** discussion then focuses on current advancements in materials science and engineering aimed at mitigating these *** innovations,such as drugeluting materials,surface modifications,and biomimetic materials,are explored as strategies to modulate these responses and to prevent fibrotic or thrombotic complications and ***,future directions in materials development for implantable cardiovascular devices are *** addressing safety and patency concerns through innovative material strategies,this article aims to guide the research and development of advanced materials for both current and future cardiovascular implantable devices,ultimately improving patient outcomes and advancing cardiovascular disease treatment.

关键词： biomaterials implantable devices cardiovascular diseases implantable materials

Unveiling DnA methylation in Alzheimer’s disease:a review of array-based human brain studies

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neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： victoria Cunha Alves Eva Carro Joana Figueiro-silva neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in neuroscience Autonoma de Madrid UniversityMadridSpain neurotraumatology and Subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life Science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DnA *** review comprehensively surveys recent human-centered studies that investigate whole genome DnA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DnA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,AnK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIn1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease AnK1 BIn1 DnA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

Breaking paradigms: Long non-coding RnAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina Beatriz silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RnAs(lncRnAs)are non-coding RnAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DnA,RnA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRnAs are susceptible to form gene fusions with mRnAs or other IncRnAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRnA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRnAs ncRnAs Therapy

Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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Journal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael silva de Oliveira Patrícia viera de Oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da silva Júnior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,SFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** SFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production