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Hepatic Alarmins and mitochondrial Dysfunction under Residual Hyperlipidemic Stress Lead to Irreversible NAFLD

Journal of Clinical and Translational Hepatology 2023年第2期11卷 284-294页

作者： Luminita Ivan Elena Uyy Viorel I.Suica raluca m.boteanu Aurel Cerveanu-Hogas Rune Hansen Felicia Antohe Department of Proteomics Institute of Cellular Biology and Pathology“Nicolae Simionescu”of the Romanian AcademyBucharestRomania Department of Health Research SINTEF DigitalTrondheimNorway Department of Circulation and medical Imaging Norwegian University of Science and TechnologyTrondheimNorway

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)includes a range of progressive disorders generated by excess lipid accumulation in the liver leading to hepatic steatosis and eventually *** aimed to identify by high performance mass spectrometry-based proteomics the main signaling pathways and liver proteome changes induced by hypercholesterolemia in a rabbit atherosclerotic model that induced high accumulation of lipids in the ***:The effect of combined lipid-lowering drugs(statins and anti-PCSK9 monoclonal antibody)were used after the interruption of the hypercholesterolemic diet to identify also the potential mediators,such as alarmins,responsible for the irreversible NAFLD build up under the hyperlipidemic sustained ***:Proteomic analysis revealed a number of proteins whose abundance was *** were components of metabolic pathways including fatty-acid degradation,glycolysis/gluconeogenesis,and nonalcoholic fatty liver *** dysfunction indicated alteration at the mitochondrial respiratory chain level and down-regulation of NADH:ubiquinone *** expression of a majority of cytochromes(P4502E1,b5,and c)were up-regulated by lipid-lowering ***-term hyperlipidemic stress,even with a low-fat diet and lipid-lowering treatment,was accompanied by alarmin release(annexins,galectins,HSPs,HmGB1,S100 proteins,calreticulin,and fibronectin)that generated local inflammation and induced liver steatosis and aggressive fibrosis(by high abundance of galectin 3,fibronectin,and calreticulin).Conclusions:The novel findings of this study were related to the residual effects of hyperlipidemic stress with consistent,combined lipid-lowering treatment with statin and inhibitor of PCSK9.

关键词： Nonalcoholic fatty liver disease Atherosclerosis Proteomic Alarmins Fibrosis

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Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal of Animal Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn Gabriel A.Zayas Eduardo E.Rodriguez Laura m.Jensen raluca G.mateescu Peter J.Hansen Department of Animal Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied Systems Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, more than 50% of the energy input to produce a unit of beef is consumed by the female that produced the calf. Development of genomic tools to identify females with high genetic merit for reproductive function could increase the profitability and sustainability of beef *** Genome-wide association studies(GWAS) were performed using a single-step genomic best linear unbiased prediction approach on pregnancy outcome traits from a population of Angus–Brahman crossbred heifers. Furthermore, a validation GWAS was performed using data from another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of timed artificial insemination(AI) followed by natural mating for 3 months. Two phenotypes were analyzed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritability was estimated as 0.149 and 0.122 for PAI and PEBS, respectively. In the PAI model, one quantitative trait locus(QTL), located between 52.3 and 52.5 mb on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS model, a large QTL on BTA7 was synonymous with the QTL for PAI, with minor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural mating. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In summary, QTLs and candidate SNPs identified were associated with pregnancy outcomes in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattle Fertility GWAS QTL

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H?LDER CONTINUITY FOR THE PARABOLIC ANDERSON mODEL WITH SPACE-TImE HOmOGENEOUS GAUSSIAN NOISE

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Acta mathematica Scientia 2019年第3期39卷 717-730页

作者： raluca m BALAN Lluís QUER-SARDANYONS 宋健 Department of mathematics and Statistics University of Ottawa Departament de matemàtiques Universitat Autònoma de Barcelona School of mathematics Shandong University

In this article,we consider the Parabolic Anderson model with constant initial condition,driven by a space-time homogeneous Gaussian noise,with general covariance function in time and spatial spectral measure satisfying Dalang's ***,we prove that the solution (in the Skorohod sense) exists and is continuous in Lp(Ω).Then,we show that the solution has a modification whose sample paths are H(o)lder continuous in space and time,under the minimal condition on the spatial spectral measure of the noise (which is the same as the condition encountered in the case of the white noise in time).This improves similar results which were obtained in [6,10] under more restrictive conditions,and with sub-optimal exponents for H(o)lder continuity.

关键词： Gaussian noise stochastic partial differential equations malliavin calculus

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magnetic glass-ceramics

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Journal of Advanced Ceramics 2012年第2期1卷 138-143页

作者： Viorel SANDU mirela Sidonia NICOLESCU Victor KUNCSER raluca DAmIAN Elena SANDU National Institute of materials Physics Magurele 077125Romania “Horia Hulubei”National Institute of Nuclear Physics and Engineering Magurele 077125Romania

We present the magnetic properties of magnetic glass ceramics obtained by crystallization of Fe containing borosilicate *** types of nucleators have been used:Cr2O3 and *** role of the nucleators proved to be crucial in the size and morphology of the crystallites developed within glassy matrix as well in the magnetic *** former stimulates the growth of regular single crystals uniformly dispersed within the matrix whereas the latter leads to the formation of grains made of tiny(30 nm),*** magnetic response depends on the amount of Fe ions left dispersed within glassy matrix as paramagnetic *** P2O5 leads to the best structural magnetite,almost 42%of Fe ions are left dispersed in the matrix without magnetic *** the case of Cr2O3,the paramagnetic Fe is decreased to 12%but structural deficiency in the occupancy of the Fe sites of magnetite is revealed by mössbauer spectroscopy.

关键词： glass ceramics Fe3O4 mössbauer spectroscopy grain growth

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Growth and chemical composition of silver birch:Comparative study between Lithuania and Romania

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Journal of Forestry Research 2021年第5期32卷 2111-2120页

作者： Valda Araminienė Lucian Dinca Iveta Varnagirytė-Kabašinskiene raluca Enescu Vlad Crisan Vidas Stakėnas Institute of Forestry Lithuanian Research Centre for Agriculture and ForestryLiepųstr.1 Girionys53101 Kaunas districtLithuania The National Institute for Research and Development in Forestry“marin Drăcea” Closca str.13BrasovRomania

The effects of different climatic conditions on growth and chemical composition of Betula pendula in geographically different European regions,Lithuania and Romania,were *** species in the entire area have a wide natural distribution,but *** is commercially more important in Lithuania than in *** we evaluated tree ring width,wood density and foliar chemical composition of mature birch trees in two European *** at the Lithuanian sites had greater radial growth and wood density with no clear changes in foliar chemistry than those at the Romanian *** wood density was 600-700 kg m^(-3) at Lithuanian and 350-450 kg m^(-3) at Romanian *** width of wood ring,earlywood and latewood for Lithuanian birch trees were several times higher than the means for Romanian birch *** hypothesized that the main differences in birch radial growth and wood density were due to the different climatic conditions in the studied ***,K and mg concentrations were significantly higher and Fe and mn were lower in the birch foliage at the Lithuanian sites compared those at the Romanian *** assessment of growth showed that silver birch cultivation is more appropriate for colder climate regions and that birch growth may change in the context of a warming climate.

关键词： Betula pendula Ring width Ood density Foliage chemistry

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Ito Formula for Integral Processes Related to Space-Time Levy Noise

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Applied mathematics 2015年第10期6卷 1755-1768页

作者： raluca m.Balan Cheikh B.Ndongo Department of mathematics and Statistics University of OttawaOttawaCanada

In this article, we give a new proof of the Itôformula for some integral processes related to the space-time Lévy noise introduced in [1] [2] as an alternative for the Gaussian white noise perturbing an SPDE. We discuss two applications of this result, which are useful in the study of SPDEs driven by a space-time Lévy noise with finite variance: a maximal inequality for the p-th moment of the stochastic integral, and the Itôrepresentation theorem leading to a chaos expansion similar to the Gaussian case.

关键词： Levy Processes Poisson Random measure Stochastic Integral Ito Formula Ito Representation Theorem

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100 GHz silicon–organic hybrid modulator

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Light(Science & Applications) 2014年第1期3卷 196-199页

作者： Luca Alloatti Robert Palmer Sebastian Diebold Kai Philipp Pahl Baoquan Chen raluca Dinu maryse Fournier Jean-marc Fedeli Thomas Zwick Wolfgang Freude Christian Koos Juerg Leuthold Institutes IPQ and ImT Karlsruhe Institute of Technology(KIT)76131 KarlsruheGermany Institute IHE Karlsruhe Institute of Technology(KIT)76131 KarlsruheGermany GigOptix Inc. BothellWAUSA CEA Leti38054 GrenobleFrance Institute of Photonic Systems Swiss Federal Institute of

Electro-optic modulation at frequencies of 100 GHz and beyond is important for photonic-electronic signal processing at the highest *** date,however,only a small number of devices exist that can operate up to this *** this study,we demonstrate that this frequency range can be addressed by nanophotonic,silicon-based *** exploit the ultrafast Pockels effect by using the silicon–organic hybrid(SOH)platform,which combines highly nonlinear organic molecules with silicon *** now,the bandwidth of these devices was limited by the losses of the radiofrequency(RF)signal and the RC(resistor-capacitor)time constant of the silicon *** RF losses are overcome by using a device as short as 500 μm,and the RC time constant is decreased by using a highly conductive electron accumulation layer and an improved gate *** this method,we demonstrate for the first time an integrated silicon modulator with a 3dB bandwidth at an operating frequency beyond 100 *** results clearly indicate that the RC time constant is not a fundamental speed limitation of SOH devices at these *** device has a voltage–length product of only V_(π)L=11 V mm,which compares favorably with the best silicon-photonic modulators available *** cladding materials with stronger nonlinearities,the voltage–length product is expected to improve by more than an order of magnitude.

关键词： 100GHz high-speed silicon modulator nanophotonics silicon–organic hybrid

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B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma

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World Journal of Gastroenterology 2017年第7期23卷 1250-1261页

作者： raluca Niculina Ciurea Ion Rogoveanu Daniel Pirici Georgica-Costinel Tartea Costin Teodor Streba Cristina Florescu Bogdan Catalin Ileana Puiu Elena-Anca Tartea Cristin Constantin Vere Department of Pathology University of Medicine and Pharmacy of Craiova Department of Gastroenterology University of Medicine and Pharmacy of Craiova Department of Research methodology University of Medicine and Pharmacy of Craiova Department of Internal medicine University of Medicine and Pharmacy of Craiova Department of Cardiology University of Medicine and Pharmacy of Craiova Department of Physiology University of Medicine and Pharmacy of Craiova Department of Pediatrics University of Medicine and Pharmacy of Craiova

AIm To study the morphology of the enteric nervous system and the expression of beta-2 adrenergic(B2A) receptors in primary colorectal *** In this study, we included forty-eight patients with primary colorectal cancer and nine patients for control tissue from the excision of a colonic segment for benign conditions. We determined the clinicopathological features and evaluated the immunohistochemical expression pattern of B2 A receptors as well as the morphological changes of the enteric nervous system(ENS). In order to assess statistical differences, we used the student t-test for comparing the means of two groups and one-way analysis of variance with Bonferroni's post hoc analysis for comparing the means of more than two groups. Correlations were assessed using the Pearson's correlation *** B2 A receptors were significantly associated with tumor grading, tumor size, tumor invasion, lymph node metastasis(P 0.05). We observed, on one hand, a decrease of the relative area for both Auerbach and meissner plexuses with the increase of the tumor grading, and on the other hand, an increase of the relative area of other nervous elements not in the meissner plexus or in the Auerbach plexus with the tumor grading. For G1 tumors we found that epithelial B2 A area showed an inverse correlation with the Auerbach plexus areas [r(14) =-0.531, P mors, epithelial B2 A areas showed an indirect variation with both the Auerbach plexus areas [r(14) =-0.453, P meissner areas [r(14) =-0.825, P mors, the inverse dependence increased for both Auerbach [r(14) =-0.587, P meissner [r(14) =-0.934, P mportant role in colorectal carcinogenesis and can be utilized as prognostic factors. Furthermore, study of the ENS in colorectal cance

关键词： Beta-2 肾上腺素能的受体伤寒神经系统 Colorectal 腺癌光谱 unmixing immunohistochemistry 分级的肿瘤

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