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Age,blood tests and comorbidities and AIMS65 risk scores outperform Glasgow-Blatchford and pre-endoscopic Rockall score in patients with upper gastrointestinal bleeding

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World Journal of Clinical Cases 2023年第19期11卷 4513-4530页

作者： Bianca Codrina Morarasu Victorita Sorodoc Anca Haisan Stefan Morarasu Cristina Bologa raluca ecaterina haliga Catalina Lionte Emilia Adriana Marciuc Mohammed Elsiddig Diana Cimpoesu Gabriel Mihail Dimofte Laurentiu Sorodoc Department of Internal Medicine and Toxicology Saint Spiridon University Regional Emergency HospitalFaculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700111Romania Department of Emergency Medicine Saint Spiridon University Regional Emergency HospitalFaculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700111Romania Second Department of Surgical Oncology Regional Institute of OncologyFaculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700111Romania Department of Radiology Emergency Hospital“Prof.Dr.N.Oblu”Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700309Romania Department of Gatroenterology Beaumont HospitalDublin D09V2N0Ireland

BACKGROUND Upper gastrointestinal(GI)bleeding is a life-threatening condition with high mortality *** To compare the performance of pre-endoscopic risk scores in predicting the following primary outcomes:In-hospital mortality,intervention(endoscopic or surgical)and length of admission(≥7 d).METHODS We performed a retrospective analysis of 363 patients presenting with upper GI bleeding from December 2020 to January *** calculated and compared the area under the receiver operating characteristics curves(AUROCs)of Glasgow-Blatchford score(GBS),pre-endoscopic Rockall score(PERS),albumin,international normalized ratio,altered mental status,systolic blood pressure,age older than 65(AIMS65)and age,blood tests and comorbidities(ABC),including their optimal cut-off in variceal and non-variceal upper GI bleeding *** subsequently analyzed through a logistic binary regression model,if addition of lactate increased the score *** All scores had discriminative ability in predicting in-hospital mortality irrespective of study ***65 score had the best performance in the variceal bleeding group(AUROC=0.772;P<0.001),and ABC score(AUROC=0.775;P<0.001)in the non-variceal bleeding ***,ABC score,at a cut-off value of 5.5,was the best predictor(AUROC=0.770,P=0.001)of inhospital mortality in both *** score was a good predictor for endoscopic treatment(AUC=0.604;P=0.046)in the variceal population,while GBS score,(AUROC=0.722;P=0.024),outperformed the other scores in predicting surgical *** of lactate to AIMS65 score,increases by 5-fold the probability of in-hospital mortality(P<0.05)and by 12-fold if added to GBS score(P<0.003).No score proved to be a good predictor for length of *** ABC score is the most accurate in predicting in-hospital mortality in both mixed and non-variceal bleeding *** and GBS should be used to determine need for endoscopic and surgical intervention,respective

关键词： Glasgow-Blatchford Pre-endoscopic Rockall Age older than 65 Age,blood tests and comorbidities Risk score Gastrointestinal bleeding

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Surface Properties and Compatibility with Blood of New Quaternized Polysulfones

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Journal of Biomaterials and Nanobiotechnology 2011年第2期2卷 114-123页

作者： raluca Marinica Albu ecaterina Avram Iuliana Stoica Emil Ghiocel Ioanid Dumitru Popovici Silvia Ioan 不详

The paper describes some properties of new quaternized polysulfones obtained by quaternization of chloromethylated polysulfone with different tertiary amines - N,N-dimethylethylamine and N,N-dimethyloctylamine. Hydrophilic/hydrophobic properties, morphological aspects and compatibility with red blood cells and platelets are affected by the alkyl radicals and by history of the formed films. The results obtained are useful in biomedical applications, including evaluation of bacterial adhesion to the surfaces, or utilization of modified polysulfones as semipermeable membranes.

关键词： Quaternized polysulfones Surface properties Blood compatibility

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