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A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast

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Neural Regeneration Research 2020年第10期15卷 1931-1936页

作者： Prashant Bharadwaj ralph Martins Centre of Excellence for Alzheimer’s Disease Research and Care School of Medical and Health SciencesEdith Cowan UniversityWestern AustraliaAustralia School of Pharmacy and Biomedical Sciences Curtin Health and Innovation Research Institute(CHIRI)Faculty of Health SciencesCurtin UniversityWestern AustraliaAustralia School of Psychiatry and Clinical Neuroscience.University of Western Australia Western AustraliaAustralia School of Biomedical Science Macquarie UniversitySydneyNSWAustralia

Multiple lines of evidence show that soluble oligomer forms of amyloidβprotein(Aβ42)are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer’s *** many studies have used mammalian cells to investigate oligomer Aβ42 toxicity,the use of more simple eukaryotic cellular systems offers advantages for large-scale screening *** have previously established and validated budding yeast,Saccharomyces cerevisiae to be a simple and a robust model to study the toxicity of Aβ.Using colony counting based methods,oligomeric Aβ42 was shown to induce dose-dependent cell death in *** have adapted this method for high throughput screening by developing an absorbance-based growth *** further validated the assay with treatments previously shown to protect oligomer Aβ42 induced cell death in mammalian and yeast *** assay offers a platform for studying underlying mechanisms of oligomer Aβ42 induced cell death using gene deletion/overexpression libraries and developing novel agents that alleviate Aβ42 induced cell death.

关键词： Alzheimer’s disease amyloid toxicity autophagy Aβ42 oligomer high-throughput screening latrepirdine neuroprotection yeast model

Evaluation for Small Visual Difference Between Conforming Meshes on Strain Field

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Journal of Computer Science & Technology 2009年第1期24卷 65-75页

作者：边哲胡事民 ralph R.Martin Department of Computer Science and Technology Tsinghua University School of Computer Science Cardiff UniversityCardiffU.K.

This paper gives a method of quantifying small visual differences between 3D mesh models with conforming topology, based on the theory of strain fields. Strain field is a geometric quantity in elasticity which is used to describe the deformation of elastomer. In this paper we consider the 3D models as objects with elasticity. The further demonstrations are provided： the first is intended to give the reader a visual impression of how our measure works in practice; and the second is to give readers a visual impression of how our measure works in evaluating filter algorithms. Our experiments show that our difference estimates are well correlated with human perception of differences. This work has applications in the evaluation of 3D mesh watermarking, 3D mesh compression reconstruction, and 3D mesh filtering.

关键词： 3D conforming meshes mesh comparison perception strain fields

3D Morphing Using Strain Field Interpolation

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Journal of Computer Science & Technology 2007年第1期22卷 147-155页

作者：严寒冰胡事民 ralph R Martin National Computer Network Emergency Response Technical Team/Coordination Center of China Beijing 100029 China Department of Computer Science and Technology Tsinghua University Beijing 100084 China School of Computer Science Cardiff University Cardiff U.K.

In this paper, we present a new technique based on strain fields to carry out 3D shape morphing for applications in computer graphics and related areas. Strain is an important geometric quantity used in mechanics to describe the deformation of objects. We apply it in a novel way to analyze and control deformation in morphing. Using position vector fields, the strain field relating source and target shapes can be obtained. By interpolating this strain field between zero and a final desired value we can obtain the position field for intermediate shapes. This method ensures that the 3D morphing process is smooth. Locally, volumes suffer minimal distortion, and no shape jittering or wobbling happens： other methods do not necessarily have these desirable properties. We also show how to control the method so that changes of shape （in particular, size changes） vary linearly with time.

关键词： morphing strain field interpolation

Challenges and Requirements for the Application of Industry 4.0:A Special Insight with the Usage of Cyber-Physical System

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1050-1057页

作者： Egon Mueller Xiao-Li Chen ralph Riedel Department of Factory Planning and Factory Management Technische Universitt Chemnitz

Considered as a top priority of industrial devel- opment, Industry 4.0 （or Industrie 4.0 as the German ver- sion） has being highlighted as the pursuit of both academy and practice in companies. In this paper, based on the review of state of art and also the state of practice in dif- ferent countries, shortcomings have been revealed as the lacking of applicable framework for the implementation of Industrie 4.0. Therefore, in order to shed some light on the knowledge of the details, a reference architecture is developed, where four perspectives namely manufacturing process, devices, software and engineering have been highlighted. Moreover, with a view on the importance of Cyber-Physical systems, the structure of Cyber-Physical System are established for the in-depth analysis. Further cases with the usage of Cyber-Physical System are also arranged, which attempts to provide some implications to match the theoretical findings together with the experience of companies. In general, results of this paper could be useful for the extending on the theoretical understanding of Industrie 4.0. Additionally, applied framework and proto- types based on the usage of Cyber-Physical Systems are also potential to help companies to design the layout of sensor nets, to achieve coordination and controlling of smart machines, to realize synchronous production with systematic structure, and to extend the usage of information and communication technologies to the maintenance scheduling.

关键词： Industrie 4.0 - Internet of Things Cyber-Physical System Smart factory Reference architectureIntelligent sensor nets Robot control Synchronousproduction

Using Bayesian deep learning approaches for uncertainty-aware building energy surrogate models

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能源与人工智能(英文) 2021年第1期3卷 91-103页

作者： Paul Westermann ralph Evins Energy and Cities Group Department of Civil Engineering University of VictoriaCanada

Fast machine learning-based surrogate models are trained to emulate slow,high-fidelity engineering simulation models to accelerate engineering design *** introduces uncertainty as the surrogate is only an approxi-mation of the original *** methods can quantify that uncertainty,and deep learning models exist that follow the Bayesian *** models,namely Bayesian neural networks and Gaussian process models,enable us to give predic-tions together with an estimate of the model’s *** a result we can derive uncertainty-aware surrogate models that can automatically identify unseen design samples that may cause large emulation *** these samples the high-fidelity model can be queried *** paper outlines how the Bayesian paradigm allows us to hybridize fast but approximate and slow but accurate *** this paper,we train two types of Bayesian models,dropout neural networks and stochastic variational Gaussian Process models,to emulate a complex high dimensional building energy performance simulation *** surrogate model processes 35 building design parameters(inputs)to estimate 12 annual building energy perfor-mance metrics(outputs).We benchmark both approaches,prove their accuracy to be competitive,and show that errors can be reduced by up to 30%when the 10%of samples with the highest uncertainty are transferred to the high-fidelity model.

关键词： Surrogate modelling Metamodel Building performance simulation Uncertainty Bayesian deep learning Gaussian Process Bayesian neural network

Direct Power Control Based on Dead-beat Function and Extended Kalman Filter for PV Systems

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 863-872页

作者： Mostafa Ahmed Ibrahim Harbi ralph Kennel Mohamed Abdelrahem Chair of High-Power Converter Systems(HLU) Technical University of Munich(TUM)80333 MunichGermany Department of Electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71515Egypt Department of Electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Koum 32511Egypt IEEE

In this paper,a new proposal for the implementation of the well-known direct power control(DPC)technique in grid-connected photovoltaic(PV)systems is ***,the DPC is executed using a look-up table procedure based on the error between the actual and reference values of the active and reactive ***,the structure of the DPC is simple and results in a fast transient behavior of the inner current loop(injected currents).Therefore,in the current study,the DPC is reformulated using a dead-beat *** this formulation,the reference voltage vector(RVV)is obtained in theα-βreference ***,the switching states for the inverter can be obtained based on the sign of the components of the *** suggested DPC is compared with the conventional one and other switching tables,which are intended for performance ***,an extended Kalman filter(EKF)is utilized to eliminate all grid-voltage ***,the switching frequency of the proposed technique is minimized without any need for weighting factors or cost function *** overall control technique is validated using a hardware-in-the-loop(HIL)experimental set-up and compared with other schemes under different operating conditions.

关键词： Photovoltaic(PV)system direct power control(DPC) sensorless control switching frequency minimization weighting factor

Effects of Preheating Temperature, Moisture and Sodium Metabisulfite Content on Property of Maize Flour Dough

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Chemical Research in Chinese Universities 2000年第3期16卷 250-258页

作者： TONG Yi Waniska ralph LI Wei College of Life Science Jilin UniversityChangchun130023 Cereal Quality Laboratory Department of Soil&Crop SciencesTexas A&M UniversityCollege StationTexas***

Processing temperature, maze flour particle size, and level of water and sodium metabisulfite were varied during the preparation of maize noodles. Preheated to 90—95 ℃ a mixture of maize flour or meal, water(43%—45% moisture) and salt enabled the preparation of noodles using a pasta extruder. Maize flour with smaller particle size yielded better noodles than did maize meal. The addition of sodium metabisulfite enabled the production of noodles at lower processing temperatures; however, cooking losses increased. Processing maize flour with higher water absorption yielded noodles that required longer cooking time but with decreased losses. The functionalities of starch and protein in raw ingredients and in products were determined. Starch gelatinized and retorgraded during processing maize noodles, as indicated by changes in pasting viscosity curves. Maize proteins contributed to the increased viscosity of dough above 40 ℃. The increased integrity of cooked maize noodles, however, corresponded to the increased amounts of gelatinized and retrograded starch.

关键词： Maize flour Sodium metabisulfite Moisture

New nanostructured sorbents for desulfurization of natural gas

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Frontiers of Chemical Science and Engineering 2014年第1期8卷 8-19页

作者： Lifeng WANG ralph T. YANG Department of Chemical Engineering University of Michigan Ann Arbor M1 48109 USA

Desulfurization of natural gas is achieved commercially by absorption with liquid amine solutions. Adsorption technology could potentially replace the solvent extraction process, particularly for the emerging shale gas wells with production rates that are generally lower than that from the large conventional reservoirs, if a superior adsorbent （sorbent） is developed. In this review, we focus our discussion on three types of sorbents： metal- oxide based sorbents, Cu/Ag-based and other commercial sorbents, and amine-grafted silicas. The advantages and disadvantages of each type are analyzed. Possible approaches for future developments to further improve these sorbents are suggested, particularly for the most promising amine-grafted silicas.

关键词： desulfurization natural gas desulfurization,hydrogen sulfide sorbent amine-silica sorbent

Livestock detection in aerial images using a fully convolutional network

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Computational Visual Media 2019年第2期5卷 221-228页

作者： Liang Han Pin Tao ralph R.Martin Department of Computer Technology and Application Qinghai UniversityXiningChina Department of Computer Science and Technology Tsinghua UniversityBeijingChina School of Computer Science and Informatics Cardiff UniversityCardiffWalesUK

In order to accurately count the number of animals grazing on grassland, we present a livestock detection algorithm using modified versions of U-net and Google Inception-v4 net. This method works well to detect dense and touching instances. We also introduce a dataset for livestock detection in aerial images, consisting of 89 aerial images collected by quadcopter. Each image has resolution of about 3000 ×4000 pixels, and contains livestock with varying shapes,scales, and *** evaluate our method by comparison against Faster RCNN and Yolo-v3 algorithms using our aerial livestock dataset. The average precision of our method is better than Yolo-v3 and is comparable to Faster RCNN.

关键词： livestock detection segmentation classification