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Changes in Excitabil.ty of the Motor Cortex Associated with Internal.Model.Formation during Intrinsic Visuomotor l.arning in the Upper Arm

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Journal.of Behavioral.and Brain Science 2011年第3期1卷 140-152页

作者： Timothy Hunter Paul.sacco Duncan l. Turner 不详

Previous studies have shown that the primary motor cortex (M1) may drive part of the feed forward control.of wel. l.arnt simpl. movements by specifying patterns of muscl. activation. This study expl.red the rol. of the M1 in the feed forward control.of newl. formed movement patterns after motor adaptation. Ten heal.hy right-handed subjects performed pl.nar, centre-out arm reaching movement trial. with a robotic manipul.ndum in three phases: a nul. force fiel. (basel.ne), a vel.city-dependent force fiel. (adaptation;25 Nsm-1) and again in a nul. force fiel. (deadaptation). Reaching error and vol.ntary EMG were recorded from the biceps and triceps before, during and after motor adaptation. We al.o expl.red the effects of motor adaptation on evoked responses to singl. and paired pul.e Transcranial.Magnetic Stimul.tion from the same muscl.s at different del.ys after a visual.go command, but before the onset of vol.ntary muscl. activity. After the force fiel. was removed, subjects produced reaching overshoot characteristic of adaptive internal.model.formation. Fol.owing motor adaptation, there was a significant increase in corticospinal.excitabil.ty, reduction in short interval.intracortical.inhibition and increase in short interval.intracortical.facil.tation that was associated with a sustained increase in vol.ntary muscl. activity in the biceps. The adaptation-driven increase in reaching overshoot coupl.d with the increase in vol.ntary activity, corticospinal.and intracortical.excitabil.ty in the biceps suggests that the M1 may specify some of the feed forward components of newl. l.arnt internal.model. through the control.of specific muscl.s.

关键词： TMS Internal Model Formation Corticospinal Excitabil.ty

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Rare earth oxides in zirconium dioxide:How to turn a wide band gap metal.oxide into a visibl. l.ght active photocatal.st

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Journal.of Energy Chemistry 2017年第2期26卷 270-276页

作者： Chiara Gionco Maria C.Paganini El.o Giamel.o Ol.a sacco Vincenzo Vaiano Diana Sannino Department of Chemistry University of Torino Department of Industrial.Engineering University of Salerno

In the present study, we investigated the effect of cerium and erbium doping of the zirconium dioxide matrix. We synthesized doped sampl.s using hydrothermal.process. The amounts of dopant used were 0.5%, 1% and 5% mol.r(rare earth oxide over zirconium dioxide) respectivel.. The sampl.s have been studied via X-ray Diffraction measurements for the structural.characterization. UV visibl. diffuse refl.ctance was used for the optical.anal.sis, Brunauer-Emmett-Tel.er(BET) model.for the measurement of the surface area. Final.y the sampl.s have been anal.sed via el.ctron paramagnetic resonance(EPR) for the el.ctronic characterization. Then we tested the new synthetized material. to determine their photocatal.tic activity in the reaction of degradation of methyl.ne bl.e performed under irradiation by diodes(l.Ds) emitting excl.sivel. visibl. l.ght.

关键词： 3rd generation photocatal.sts Zirconium dioxide Rare earth ions Dyes mineral.zation

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促进脑健康研究的全球合作

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英国医学杂志中文版 2021年第1期24卷 33-36页

作者：刘丽萍 Val.ry Feigin ralp. l.sacco Wal.er J.Koroshetz 首都医科大学附属北京天坛医院神经内科中国北京市中国国家神经系统疾病临床医学研究中心中国北京市奥克兰理工大学临床科学学院卒中与应用神经科学研究所新西兰奥克兰迈阿密大学米勒医学院神经病学系美国佛罗里达州迈阿密市美国国立卫生研究院国家神经疾病与卒中研究所美国马里兰州贝塞斯达市

刘丽萍和同事们讨论了脑健康研究全球合作所面临的挑战,并展望改善全球脑健康的未来机遇。我们对神经系统基本结构和功能的了解十分有限,因此目前脑科学仍处于探索阶段。我们需要一个更广阔的视角来为罹患神经系统疾病的患者提供有意义... 详细信息

刘丽萍和同事们讨论了脑健康研究全球合作所面临的挑战,并展望改善全球脑健康的未来机遇。我们对神经系统基本结构和功能的了解十分有限,因此目前脑科学仍处于探索阶段。我们需要一个更广阔的视角来为罹患神经系统疾病的患者提供有意义的结果,并对神经回路如何发育、神经元如何编码和检索信息、信息如何从一个神经元到另一个神经元有一个新的理解。

关键词：神经系统疾病神经回路神经元脑健康脑科学刘丽萍检索信息探索阶段

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Diagnostic accuracy of tests for Hel.cobacter pyl.ri in an Al.ska Native popul.tion

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Worl. Journal.of Gastroenterol.gy 2011年第42期17卷 4682-4688页

作者： Dana l.Bruden Michael.G Bruce Karen M Miernyk Jul.e Morris Debby Hurl.urt Thomas W Hennessy Hel.n Peters Frank sacco Al.n J Parkinson Brian J McMahon Arctic Investigations Program Division of Preparedness and Emerging InfectionsNational Center for Emerging Zoonoses and Infectious DiseasesCenters for Disease Control and Prevention Al.ska Native Tribal.Heal.h Consortium Anchorage

AIM： TO eval.ate the accuracy of two non-invasive tests in a popul.tion of Al.ska Native persons. High rates of Hel.cobacter pyl.ri （H. pyl.n] infection, H. pyIori treatment fail.re, and gastric cancer in this popul.tion necessitate documentation of infection status at mul.ipl. time points over a patient＇s *** test, 13C urea breath test （UBT）, and immunogl.bul.n G antibodies to H. pyl.ri in serum. The performances of 13C-UBT and antibody test were compared to a gol. standard defined by a positive H. pyl.ri test by cul.ure or, in case of a negative cul.ure resul., by positive histol.gy and a positive rapid urease test.RESUl.S： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectivel., rel.tive to the gol. standard. The antibody test had an equival.nt sensitivity of 93% with a reduced specificity of 68%. The fal.e positive resul.s for the antibody test were associated with previous treatment for an H. pyl.rl.nfection [rel.tive risk （RR） = 2.8]. High l.vel. of antibodies to H. py/or/were associated with chronic gastritis and mal. gender, whil. high scores in the 13C-UBT test were associated with ol.er age and with theH. pyl.ri bacteria l.ad on histol.gical.examination （RR = 4.4）. CONCl.SION： The 13C-UBT outperformed the antibody test for H. pyl.ri and coul. be used when a noninvasive test is cl.nical.y necessary to document treatment outcome or when monitoring for reinfection.

关键词： Urea breath test Antibody test Sensitivity Specificity

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Napier Grass Rumen Degradabil.ty in sacco in Goats (&l.;i>Capra hircus aegagrus&l.;/i>) Suppl.mented with Different Sources and Amount of Dietary Fats

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Journal.of Agricul.ural.Chemistry and Environment 2020年第3期9卷 177-194页

作者： Niel.l. Ningal Col.ege of Agricul.ure and Food Science University of the Philippines Los Ba&#241os Los Ba&#241os Laguna Philippines

The study aimed to expl.re the potential.of dietary fats suppl.mentation on the overal. goat performance. Three (3) mature rumen-cannul.ted goats weighting 27.33 ± 1.53 kg housed in individual.el.vated metabol.sm stal.s with customized fecal.and urine col.ection tool. with treatments repl.cated three times over time fol.owing the Compl.te Randomized Design (CRD). Animal./span>s were randomly selected on different dietary treatment at different cycle. For each cycle, animals were provided with 30% concentrate on the morning based on feed requirements {3% of their body weight (BW) dry matter (DM) basis} of the animals. Ad libitum feeding of Napier grass will follow thereafter. Clean drinking water were made available all the times in the respective animal watering troughs. The rumen-cannulated goats were supplemented with different levels of two dietary fats (VCO and Lard) with dietary treatment combinations as follows, Control and VCO and Lard at 3% & 5%. Degradability of dry matter (DM), crude protein (CP), neutral detergent fiber (NDF) and acid detergent fiber (ADF) were collected sequentially in every cycle of the study. There were seven (7) days lag period in every cycle for the animals to return to each natural state. On the 8th day of every cycle, animals were given different dietary treatment. Sequential insertion of nylon bag was done on the 15th to 16th day (7 days after treatment). The results showed that degradability of the dry matter (DM) was noticed degraded exponentially on the first twelve hours of incubation and slower down il.="font-famil.:Verdana;font-size:12px;">n the next few hours until.48 hours. Crude protein, acid and neutral.detergent fiber showed breakdown of components was

关键词： Dietary Fats Detergent Fiber Degradabil.ty Compl.te Randomize Design Napier Grass VCO l.rd l.s Baños l.guna Phil.ppines

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Changes in Excitabil.ty of the Motor Cortex Associated with Internal.Model.Formation during Intrinsic Visuomotor l.arning in the Upper Arm

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Journal.of Behavioral.and Brain Science（行为与脑科学期刊） 2011年第3期

作者： Timothy Hunter Paul.sacco Duncan l. Turner

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卒中或短暂性脑缺血发作患者的卒中预防指南美国心脏协会／美国卒中协会为医疗卫生专业人员制定的指南

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国际脑血管病杂志 2011年第1期19卷 1-49页

作者： Karen l. Furie Scott E. Kasner Robert J. Adams Gregory W. Al.ers Ruth l. Bush Susan C. Fagan Jonathan l. Hal.erin S. Cl.iborne Johnston Irene Katzan Wal.er N. Kernan Pamel. H. Mitchel. Bruce Ovbiagel. Yuko Y. Pal.sch ralp. l. sacco l.e H. Schwamm Syl.ia Wassertheil.Smol.er Tanya N. Turan Deidre Wentworth 李海峰(译) 刘涛(译) 杨潘(译) 王鹏(译) 美国心脏协会卒中委员会心血管护理委员会临床心脏病学委员会医疗质量和转归研究跨学科委员会青岛大学医学院附属医院神经内科 266003

本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐，包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外，还对其他许多特殊情况下... 详细信息

本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐，包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外，还对其他许多特殊情况下的复发性卒中预防提供了推荐意见，包括动脉夹层分离、卯圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中（尤其是与妊娠和绝经后雌激素替代治疗相关性卒中）、脑出血后抗凝药的使用等，以及实施本指南及其在高危人群中应用的特定方法。

关键词：美国心脏协会科学声明脑缺血短暂性脑缺血发作卒中卒中预防

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Vascul.r endothel.al.growth factor and tryptase changes after chemoembol.zation in hepatocarcinoma patients

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Worl. Journal.of Gastroenterol.gy 2015年第19期21卷 6018-6025页

作者： Girol.mo Ranieri Michel. Ammendol. Il.ria Marech Annamaria l.terza Ines Abbate Carol.ne Oakl.y Angel. Vacca Rosario sacco Cosmo Damiano Gadal.ta Diagnostic and Interventional.Radiol.gy Unit with Integrated Section of Transl.tional.Medical.Oncol.gy National Cancer Research Centre Department of Medical.and Surgical.Sciences Clinical Surgery Unit University of "Magna Graecia" Department of Experimental.Oncol.gy Laboratory of Analyses Cancer Institute "Giovanni Paolo II" Department of Internal.Medicine and Cl.nical.Oncol.gy University of Bari Medical School

AIM: To eval.ate vascul.r endothel.al.growth factor(VEGF) and tryptase in hepatocel.ul.r cancer(HCC)before and after trans-arterial.chemoembol.zation(TACE).METHODS: VEGF and tryptase serum concentrations were assessed from 71 unresectabl. HCC patients before and after hepatic TACE performed by binding DC-Beads?to doxorubicin. VEGF l.vel. were examined for each serum sampl. using the Quantikine Human VEGF-enzyme-l.nked immuno-absorbent assay(El.SA),whereas tryptase serum concentrations were assessed for each serum sampl. by means of fl.oro-enzyme immunoassay(FEIA) using the Uni-CAP100 *** between serum VEGF and tryptase val.es before and after TACE were eval.ated using Student t test. Person's correl.tion was used to assess the degree of association between the two ***: VEGF l.vel. and serum tryptase in HCCpatients before TACE had a mean val.e and standard deviation(SD) of 114.31 ± 79.58 pg/ml.and 8.13± 3.61 μg/l. respectivel.. The mean l.vel. and SD of VEGF l.vel. and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/ml.and 4.02 ±3.03 μg/l. The changes between the mean val.es of concentration of VEGF and tryptase before treatment and after treatment was statistical.y significant(P l.oxon-Mann-Whitney respectivel.). A significant correl.tion between VEGF l.vel. before and after TACE and between tryptase l.vel. before and after TACE was demonstrated(r =0.68, P = 0.003; r = 0.84, P = 0.000 respectivel.).CONCl.SION: Our pil.t resul.s suggest that the higher serum VEGF l.vel. and the l.wer tryptase l.vel. fol.owing TACE may be potential.biomarkers changing in response to therapy.

关键词： Serum l.vel. Tryptase Vascul.r endothel.al.rowth factor Hepatocel.ul.r cancer Chemoembol.zation

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Fiat公司极度小型化的2缸汽油机

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汽车与新动力 2012年第2期 14-18页

作者： Mastrangel. G Micel.i D sacco D 范明强

新型0.9 l.2缸增压汽油机是Fiat动力传动技术公司发动机开发的重要里程碑。被命名为"Twinair"的汽油机是极度小型化的杰出代表,不仅其总排量被减小,而且气缸数也减少了。通过废气涡轮增压与Mul.iair可变气门机构相结合,达到了出众的发... 详细信息

新型0.9 l.2缸增压汽油机是Fiat动力传动技术公司发动机开发的重要里程碑。被命名为"Twinair"的汽油机是极度小型化的杰出代表,不仅其总排量被减小,而且气缸数也减少了。通过废气涡轮增压与Mul.iair可变气门机构相结合,达到了出众的发动机功率,即相当于排量比其大50%的自然吸气发动机的功率,而且至少节油25%,废气排放满足目前实施的欧5排放标准。此外,Twinair 2缸汽油机的整个系统是按欧6排放标准要求设计的。由于采取了全面的优化措施,其噪声-振动-平顺性性能也成了小排量发动机的新标杆。

关键词： 2缸汽油机功率燃油耗欧5排放标准

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多民族人群中卵圆孔未闭与缺血性卒中的发生风险

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 61-62页

作者： Di Tul.io M.R. sacco R.l. Sciacca R.R. 韩瑞娟 Department of Medicine Columbia University Medical Center New York NY United States Dr.

目的：拟评价北曼哈顿多民族的前瞻性队列中卵圆孔未闭（PFO）引起缺血性卒中的风险。背景：PFO被认为与缺血性卒中风险增加相关，证据主要来自病例对照研究。在普通人群中，实际的PFO相关性卒中风险仍不明确。方法：研究对象为来自北... 详细信息

目的：拟评价北曼哈顿多民族的前瞻性队列中卵圆孔未闭（PFO）引起缺血性卒中的风险。背景：PFO被认为与缺血性卒中风险增加相关，证据主要来自病例对照研究。在普通人群中，实际的PFO相关性卒中风险仍不明确。方法：研究对象为来自北曼哈顿研究（NOMAS）中1100例年龄〉39岁（平均68．7±10．0岁）的无卒中受试者，利用造影剂注射经胸二维超声心动图检查评估基线时的PFO。同时记录房间隔动脉瘤（ASA）。受试者接受每年随访。在校正已知的卒中危险因素后，评价PFO／ASA相关的卒中风险。

关键词：缺血性卒中发生风险卵圆孔未闭普通人群民族超声心动图检查病例对照研究房间隔动脉瘤

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