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The choline pathway as a strategy to promote central nervous system(CNS) remyelination

Neural Regeneration Research 2015年第9期10卷 1369-1370页

作者： Thomas Skripuletz ralf a.linker Martin Stangel Department of Neurology Hannover Medical School Department of Neurology University Hospital Erlangen Center for Systems Neuroscience

Multiple sclerosis is a chronic companied by demyelination inflammatory disease that is ac- and axonal damage resulting in neurological deficits. Remyelination is the natural endogenous repair mechanism of demyelinated axons and it is supposed to protect axons/neurons from degeneration and thus the patient from progressive disability （Franklin and Ffrench-Constant, 2008）. Current therapeutics for patients with multiple sclerosis are to some extent very effective in inhibiting neuroinflamma- tion and demyelination. However, to date there are no substanc- es available that can enhance remyelination. Remyelination is the result of recruitment/proliferation of new oligodendrocyte precursor cells （OPC） and differentiation into mature myelin producing oligodendrocytes （Franklin and Ffrench-Constant, 2008）. These processes are supported by many factors and signals and failure at any stage might lead to repair failure. Strategies to enhance myelin repair are either the promotion of endogenous repair mechanisms via modulation of OPC prolif- eration and oligodendrocyte differentiation or the transplantion of myelinating cells into lesions. Due to the multiloculated pro- cess in multiple sclerosis and the ethical problems with the cell source, the latter is less favoured. The endogenous promotion of remvelination could be achieved by several approaches such as：

关键词： CDP remyelination The choline pathway as a strategy to promote central nervous system OPC CNS

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CDP-choline to promote remyelination in multiple sclerosis:the need for a clinical trial

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Neural Regeneration Research 2023年第12期18卷 2599-2605页

作者： Viktoria Gudi PawełGrieb ralf Alinker Thomas Skripuletz Department of Neurology Hannover Medical SchoolHannoverGermany Department of Experimental Pharmacology Mossakowski Medical Research InstitutePolish Academy of SciencesWarsawPoland Department of Neurology University Hospital RegensburgRegensburgGermany

Multiple sclerosis is a multifactorial chronic inflammatory disease of the central nervous system that leads to demyelination and neuronal cell death,resulting in functional *** is the natural repair process of demyelination,but it is often incomplete or fails in multiple *** therapies reduce the inflammatory state and prevent clinical ***,therapeutic approaches to increase myelin repair in humans are not yet *** substance cytidine-5′-diphosphocholine,CDP-choline,is ubiquitously present in eukaryotic cells and plays a crucial role in the synthesis of cellular *** properties have been shown in various animal models of diseases of the central nervous *** have already shown that the compound CDPcholine improves myelin regeneration in two animal models of multiple ***,the results from the animal models have not yet been studied in patients with multiple *** this review,we summarise the beneficial effects of CDP-choline on biolipid metabolism and turnover with regard to inflammatory and regenerative *** also explain changes in phospholipid and sphingolipid homeostasis in multiple sclerosis and suggest a possible therapeutic link to CDP-choline.

关键词： astrocytes CDP-choline cuprizone microglia multiple sclerosis oligodendrocytes

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