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Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India

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World Journal of Gastroenterology 2010年第38期16卷 4800-4808页

作者： Manab Deka Moumita Bose Bharati Baruah Purabi Deka Bose subhash Medhi Sujoy Bose Anjan Saikia Premashish Kar subhash Medhi Sujoy Bose Department of Biotechnology Gauhati University Department of Medicine Maulana Azad Medical College Medical and Gastroenterology Unit Central Hospital N.F.Railway MaligaonGuwahati-781011India

AIM:To investigate hepatitis virus, genetic and environmental factors, and their interactions in predisposing patients to liver diseases in Northeast India. METHODS:A total of 104 jaundice patients and 124 community controls were included. Serological analysis was performed by routine enzyme-linked immunosorbent assay, and nucleic acid testing for hepatitis viruses was done by polymerase chain reaction (PCR), followed by PCR direct sequencing for viral genotyping. Cytochrome P450 2E1 (CYP2E1) polymorphism was studied by PCR-restriction fragment length polymorphism. Nitrite and volatile nitrosamines in indigenous foods consumed routinely by the Northeast Indian ethnic population were estimated by Griess’s reagent and GC-MS, ***: Hepatitis A virus (HAV) infection was predominantly prevalent (36.5%) in our cohort, followed by hepatitis B virus (HBV), hepatitis E virus (HEV) andhepatitis C virus. HBV genotype D and HEV genotype 1 were the most dominant. CYP2E1 c1/c2 genotype frequency was comparatively higher in alcoholic (P<0.0001,OR =30.5) and cryptogenic (P=0.014, OR=8.714) patients, and was associated with significantly higher hepatitis risk (P=0.0.007,OR=6.489). Mutant C allele of Cyp2E1 DraⅠ frequency was comparatively higher in HAV (P=0.006), alcoholic (P =0.003) and cryptogenic (P=0.014) cases, and was associated with overall hepatitis risk (P=0.026, OR=5.083). Indigenous foods, Gundruk, Kharoli, betel leaf and nuts were found to have the highest nitrite content. CONCLUSION: Apart from viral factors, CYP2E1 polymorphism might be associated with increased risk of liver diseases in Northeast India. Indigenous foods that contain nitrite and nitrosamine might be an associated risk factor.

关键词： Viral hepatitis Cytochrome P450 2E1 Gene polymorphism Nitrites Nitrosamines

Hedge fund replication using strategy specific factors

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Financial Innovation 2019年第1期5卷 179-197页

作者： Sujit subhash David Enke Laboratory for Investment and Financial Engineering Department of Engineering Management and Systems EngineeringMissouri University of Science and TechnologyRollaMO 65409-0370USA

Hedge funds have traditionally served wealthy individuals and institutional investors with the promise of delivering protection of capital and uncorrelated positive returns irrespective of market direction,allowing them to better manage portfolio ***,the financial crisis of 2008 has heightened investor sensitivity to the high fees,illiquidity,lack of transparency,and lockup periods typically associated with hedge *** fund replication products,or clones,seek to answer these challenges by providing daily liquidity,transparency,and immediate exposure to a desired hedge fund ***,although lowering cost and adding simplicity by using a common set of factors,traditional replication products might offer lower risk-reward performance compared to hedge *** research explores hedge fund replication further by examining the importance of constructing clones with specific factors relevant to each hedge fund strategy,and then compares the strategy specific clone risk and reward performance against both actual hedge fund performance and hedge fund clones constructed using a more general set of common *** shows that using strategy specific factors to replicate common hedge fund strategies can offer superior risk-reward performance compared to previous general model clones.

关键词： Hedge funds Hedge fund replication Regression Trading strategies Strategy specific factors

Temporal variation of solar flare index during solar cycles 21–24

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Research in Astronomy and Astrophysics 2021年第3期21卷 21-33页

作者： Soumya Roy Amrita Prasad subhash Chandra Panja Sankar Narayan Patra Department of Applied Electronics and Instrumentation Engineering Haldia Institute of TechnologyHaldiaMidnapore(E)-721657West BengalIndia Department of Mechanical Engineering Jadavpur UniversityKolkata-700032West BengalIndia Department of Instrumentation and Electronics Engineering Jadavpur UniversityKolkata-700106West BengalIndia

The present investigation attempts to quantify the temporal variation of Solar Flare Index(SFI)with other activity indices during solar cycles 21-24 by using different techniques such as linear regression,correlation,cross-correlation with phase lag-lead,*** Solar Activity Indices(SAI)considered in this present study are Sunspot Number(SSN),10.7 cm Solar Radio Flux(F10.7),Coronal Index(CI)and MgⅡCore-to-Wing Ratio(MgⅡ).The maximum cycle amplitude of SFI and considered SAI has a decreasing trend from solar cycle 22,and cycle 24 is the weakest solar cycle among all other *** SFI with SSN,F10.7,CI and MgⅡshows hysteresis during all cycles except for solar cycle 22 where both paths for ascending and descending phases are intercepting each other,thereby representing a phase reversal.A positive hysteresis circulation exists between SFI and considered SAI during solar cycles 22 and 23,whereas a negative circulation exists in cycles 21 and *** has a high positive correlation with coefficient values of 0.92,0.94,0.84 and 0.81 for SSN,F10.7,CI and MgⅡ*** to crosscorrelation analysis,SFI has a phase lag with considered SAI during an odd-number solar cycle(solar cycles21 and 23)but no phase lag/lead during an even-numbered solar cycle(solar cycles 22 and 24).However,the entire smoothed monthly average SFI data indicate an in-phase relationship with SSN,F10.7 and MgⅡ,and a one-month phase lag with *** presence of those above characteristics strongly confirms the outcomes of different research work with various solar indices and the highest correlation exists between SFI and SSN as well as F10.7 which establishes that SFI may be considered as one of the prime activity indices to interpret the characteristics of the Sun’s active region as well as for more accurate short-range or long-range forecasting of solar events.

关键词： Methods:data analysis Methods:statistical Sun:activity Sun:flares Sun:general

Decadal trends in precipitable water vapor over the Indus River Basin using ERA5 reanalysis data

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Journal of Mountain Science 2023年第10期20卷 2928-2945页

作者： Seema RANI Jyotsna SINGH subhash SINGH Purushottam TIWARI Suraj MAL Department of Geography Institute of ScienceBanaras Hindu UniversityUttar Pradesh 221005India Department of Geography Shaheed Bhagat Singh CollegeUniversity of DelhiNew Delhi 110017India Center for the Study of Regional Development Jawaharlal Nehru UniversityNew DelhiDelhi 11oo6zIndia

Precipitable Water Vapor(PWV)constitutes a pivotal parameter within the domains of atmospheric science,and remote sensing due to its profound influence on Earth’s climate dynamics and weather *** exerts a significant impact on atmospheric stability absorption and emission of radiation,thus engendering alterations in the Earth’s radiative *** such,precise quantification of PWV holds the potential to enhance weather prognostication and fortify preparedness against severe meteorological *** study aimed to elucidate the spatial and temporal changes in seasonal and annual PWV across the Indus River Basin and its sub-basins using ERA5 reanalysis *** present study used ERA5 PWV(entire atmospheric column),air temperature at 2 m(t2m)and 500 hPa(T_500hPa),evapotranspiration,and total cloud cover data from 1960 to *** Sen slope estimator and Mann-Kendall test were used for trend *** and multiple regression methods were used to understand the association of PWV with other *** findings have unveiled the highest increase in mean PWV during the monsoon(0.40 mm/decade),followed by premonsoon(0.37 mm/decade),post-monsoon(0.27 mm/decade),and winter(0.19 mm/decade)throughout the study ***,the mean PWV exhibited the most pronounced positive trend in the sub-basin Lower Indus(LI),followed by Panjnad(P),Kabul(K),and Upper Indus(UI)across all seasons,except *** PWV has also risen in the Indus basin and its sub-basins over the last six *** exhibits a consistent upward trend up to an elevation of 3500 m within the basin which is most pronounced during the monsoon season,followed by the *** escalating PWV within the basin is reasonably ascribed to increasing air temperatures,augmented evapotranspiration,and heightened cloud *** findings hold potential utility for pertinent authorities engaged in water resource management and planning.

关键词： Himalaya Precipitable Water Vapor Indus River Basin Atmosphere Climate Change ERA5 Reanalysis data

Dealing with detection error in site occupancy surveys: what can we do with a single survey?

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Journal of Plant Ecology 2012年第1期5卷 22-31页

作者： subhash R.Lele Monica Moreno Erin Bayne Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAlbertaCanada T6G 2G1 Department of Biological Sciences University of AlbertaEdmontonAlbertaCanada T6G 2G1

Aim Site occupancy probabilities of target species are commonly used in various ecological studies,*** monitor current status and trends in *** error introduces bias in the estimators of site *** methods for estimating occupancy probability in the presence of detection error use replicate *** methods assume population closure,*** site occupancy status remains constant across surveys,and independence between *** present an approach for estimating site occupancy probability in the presence of detection error that requires only a single survey and does not require assumption of population closure or *** place of the closure assumption,this method requires covariates that affect detection and *** Penalized maximum-likelihood method was used to estimate the *** of the parameters was checked using data *** boostrapping method was used for computing confidence *** Findings The single-survey approach facilitates analysis of historical datasets where replicate surveys are unavailable,situations where replicate surveys are expensive to conduct and when the assumptions of closure or independence are not *** method saves significant amounts of time,energy and money in ecological surveys without sacrificing statistical ***,we show that occupancy and habitat suitability are not synonymous and suggest a method to estimate habitat suitability using single-survey data.

关键词： abundance estimation biodiversity BBS closed population data cloning penalized likelihood species occurrence

An experimental and numerical study of packing, compression, and caking behaviour of detergent powders

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Particuology 2014年第1期12卷 2-12页

作者： subhash C.Thakur Hossein Ahmadian Jin Sun Jin Y.Ooi School of Engineering University of Edinburgh Newcastle Innovation Centre Procter and Gamble Technical Centre Ltd

This paper presents an experimental and numerical study of the packing, compression, and caking behaviour of spray dried detergent （SDD） powders with a two-fold aim： an experimental process of observation and evaluation of the packing, compression and caking behaviour of SDD powders, and a numerical approach based on discrete element modelling （DEM）. The mechanical properties, including the stress-strain response and the corresponding porosity change as a function of consolidation stress in a confined cylinder, the stress-strain response during unconfined shearing and the cake strength as a func- tion of consolidation stress, were evaluated and compared for different SDD powders using an extended uniaxial tester （Edinburgh Powder Tester - EPT）. The experiments using EPT showed excellent repro- ducibility in the measurement of packing, compression and caking behaviour and were therefore very useful for describing the handling characteristics of these powdered products including screening new products and different formulations. It was found that the sample with higher moisture had lower bulk porosity but higher compressibility and cake strength. The porosity, compressibility and cake strength were found to vary across different size fractions of the same sample. The larger sieve-cut samples had higher initial bulk porosity, compressibility and cake strength. It is revealed that moisture plays a sig- nificant role in packing, compression, and shearing behaviour of the powder. Three-dimensional DEM modelling using a recently developed elasto-plastic adhesive-frictional contact model showed that the contact model is able to capture the detergent behaviour reasonably well and can be used to model complex processes involving these powders.

关键词： Discrete element methodPowder flowCohesive materialUniaxial testPlasticityContact model

Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 479-484页

作者： Pinaki Ghosh subhash Laxmanrao Bodhankar Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University

Objective:To determine the association of smoking, alcohol and nonsteroidal anti-inflammatory drugs(NSAIDs) use with presence and virulence of Helicobacter pylori(H. pylori) infection in a representative sample of a random adult population of asymptomatic ***:Non virulent 16S rRNA and virulent cag A and T genes from salivary samples of 854 asymptomatic subjects were determined using polymerase chain reaction. The presence and absence of virulent and non virulent infection was statistically compared with consumption of smoking, alcohol and NSAID ***:The prevalence of infection in male and female subjects was found to be 69.25% and 66.90%, respectively. The prevalence of infection in the population of asymptomaticsubjects with respect to consumption of alcohol was as follows: current(31.22%), former(52.20%) and never(43.58%). The prevalence of infection in the population of asymptomatic subjects withrespect to smoking of cigarettes was as follows: current(88.80%), former(57.14%) and never(33.33%).The prevalence of infection in the subject population consuming NSAIDs and not consuming NSAIDs frequently was found to be 82.75%and 21.16%, respectively. Virulence in male and femalesubjects was found to be 60.00%and 50.00%, respectively. The presence of virulent infection in the population of asymptomatic subjects with respect to consumption of alcohol was as follows:current(28.57%), former(40.15%) and never(50.00%). The prevalence of virulent infection in the population of asymptomatic subjects with respect to smoking of cigarettes was as follows: current(79.32%), former(75.00%) and never(50.00%). The prevalence of virulent infection in the subject population consuming NSAIDs and not consuming NSAIDs frequently was found to be 88.23% and 66.66%, ***:It can be concluded that smoking and NSAIDs consumption are aggravating factors for virulence ofH. pylori and alcohol can inhibitH. pyloriin fection in asymptomatic subjects.

关键词： Smoking Alcohol NSAIDs Helicobacter pylori Cag A Cag T 16S rRNA PCR Agarose gel electrophoresis Virulence Prevalence Infection Asymptomatic

Improved thermoelectric property of cation-substituted CaMnO_3

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Chinese Physics B 2015年第9期24卷 542-547页

作者： Pradeep Kumar subhash C.Kashyap Vijay Kumar Sharma H.C.Gupta Department of Physics Shyam Lal CollegeUniversity of Delhi Department of Physics Indian Institute of Technology Delhi

Single-phase pristine and cation-substituted calcium manganite（Ca1-xBixMn1-yVyO3-δ） polycrystalline samples were synthesized by the solid state reaction technique. Their thermoelectric properties were measured by a set up that was designed and assembled in the laboratory. The Ca1-x BixMn1-yVyO3-δsample with x = y = 0.04 has shown a power factor（S^2σ） of 176 μW/m/K^2 at 423 K, which is nearly two orders of magnitude higher than that of the pristine sample（2.1 μW/m/K2）. The power factor of the substituted oxide remains almost temperature independent as the Seebeck coefficient increases monotonically with temperature, along with the simultaneous decrease in electrical resistivity which is attributed to enhanced electron density due to co-doping of bismuth and vanadium and grain boundary scattering. These cation-substituted calcium manganites can be used as a potential candidate for an n-type leg in a thermoelectric generator（module）.

关键词： thermoelectric materials solid state reaction Seebeck coefficient power factor

Development of Composite Textile Structures for Wound Dressing Applications

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Journal of Donghua University(English Edition) 2013年第5期30卷 447-450页

作者： ANAND subhash UZUN Muhammet SHAH Tahir RAJENDRAN Subbiyan Institute for Materials Research and Innovation The University of Bolton Department of Textile Education Marmara University

The main objective of this research work was the development of novel and responsive nonwoven composite structures containing gelling materials for wound management. The development of novel all inclusive collagen booster(CB) therapeutic nonwoven wound dressings was mainly focused on. It provides essential functional properties such as high absorption,vertical and lateral wicking,and antibacterial and acidic pH properties. The developed composite wound dressing consisted of carboxymethylcellulose(CMC) fibre and also it was reinforced with polylactic acid( PLA) fibre. The produced composite wound dressings were treated with two different CBs at 4% by using the spray method. The details of the CBs have not been disclosed in this paper due to the Intellectual Property Rights( IPR) issues. The important benefit of using CB treatment is that it allows the maintenance of an acidic pH environment at the wound area. It is well known that acidic pH reduces the wound healing time and enhances the wound healing process. Furthermore,one of the CBs not only promotes the proliferation of the epithelial cells in wounds but also can provide antibacterial action. The PLA fibre reinforced CMC composite dressing has enhanced wicking properties which help to minimise the pooling of exudate on the wound bed and as a result maceration is prevented. The CBs treated dressings maintain the wound bed in an acidic pH condition which also improves the wound healing process. In addition to the above-mentioned properties,the CB treatment imparts antimicrobial activity against Gram-positive and Gram-negative bacteria,thus resulting in the reduction in the propensity for wound infection. Ultimately,the research has proved that the 4% CB treatment enhances the antimicrobial activity and the acidic pH characteristics of the developed CMC /PLA composite wound dressings.

关键词： nonwoven composite textile structure wound dressing carboxymethylcellulose(CMC) polylactic acid(PLA)