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A Comprehensive Review on Preclinical Safety and Toxicity of Medicinal Plants

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 95-111页

作者： Madhav Nilakanth Mugale Kapil Dev Bhumika S.More Vaishali Sunil Mishra Kaveri R.Washimkar Kishan Singh rakesh maurya Srikanta Kumar Rath Debprasad Chattopadhyay Naibedya Chattopadhyay Division of Toxicology and Experimental Medicine CSIR-Central Drug Research Institute(CSIR-CDRI)Lucknow 226031India Division of Phytochemistry CSIR-Central Institute of Medicinal and Aromatic Plants(CSIR-CIMAP)Lucknow 226015India Medicinal and Process Chemistry Division CSIR-CDRI Lucknow 226031India Division of Endocrinology CSIR-CDRI Lucknow 226031India Division of Ethnomedicine ICMR-National Institute of Traditional MedicineNehru NagarBelagavi 590010and ICMR-Virus UnitKolkata 700010India Department of Health Research NSHM Knowledge CampusKolkata 700051India

Background:Globally,80%people use plant-derived products for treating or preventing *** prevalent perception about medicinal plants is that they are safe and devoid of adverse ***,approximately 1,50,000 plants contain toxic ***:The present review focuses on medicinal plant extracts/fractions toxicity assessments made in preclin-ical models by oral ***:Detail studies were searched from databases including PubMed and Google Scholar.A manual reference screening of the selected studies was done to identify relevant articles,with no language restriction being imposed at the time of ***:The studies included were performed in rodents,and the test substances were administered *** search revealed 33 widely used plants or products with significant toxicity,and phytochemicals from these plants have been *** a systematic review,we identified a plethora of medicinal plant extracts reporting safety and toxicity ***:In the future,preclinical toxicokinetic studies of herbs and the determination of their no-observed-adverse-effect levels are required for a complete safety ***,the interaction of herbs with com-monly used/over-the-counter drugs in terms of the latter’s metabolic profile should be undertaken.

关键词： Extract Herbal medicine Toxicity Rodent Secondary metabolite

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Modified Sliding Mode Observer-based Direct Torque Control of Six-phase Asymmetric Induction Motor Drive

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Chinese Journal of Electrical Engineering 2023年第3期9卷 111-123页

作者： Krunal Shah Abid Mansuri rakesh maurya Department of Electrical Engineering Sardar Vallabhbhai National Institute of TechnologySurat 395007India

In this study,a six-phase induction asymmetric induction motor(SPAIM)was examined,whose performance surpasses that of its three-phase counterpart,with regard to the torque density,torque pulsation,fault tolerance,power rating per inverter lag,and noise ***-encoder-less direct torque control(DTC)for SPAIM with virtual voltage vectors(VVVs)and a modified sliding mode observer(MSMO)are *** SPAIM model was developed using a stationaryα-βframe for *** conventional DTC of the SPAIM drive is a simple extension of DTC for a 3-Φmotor drive that yields higher distortion in the stator *** mitigate the large amount of distortion in the stator current,VVVs were used to significantly reduce the harmonic content in the stator ***,to overcome the large amount of chattering observed in the case of a traditional sliding mode observer,particularly under low-speed operation,the MSMO was employed to reduce chattering even under low-speed *** performance of the proposed observer was verified under all the operating conditions suitable for the propulsion mode of an electric vehicle using Matlab/Simulink,and the results were experimentally validated.

关键词： Direct torque control multiphase induction motor drive sliding mode observer space vector modulation

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Robust Iteration-dependent Least Mean Square-based Distribution Static Compensator Using Optimized PI Gains

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Chinese Journal of Electrical Engineering 2022年第4期8卷 79-90页

作者： Sabha Raj Arya rakesh maurya Jayadeep Srikakolapu Department of Electrical Engineering Sardar Vallabhbhai National Institute of TechnologySurat 395007India

A robust iteration-dependent least mean square(RIDLMS)algorithm-based fundamental extractor is developed to estimate the fundamental components of the load current for a four-wire DSTATCOM with a nonlinear *** averaging parameter for calculating the variable step size is iteration dependent and uses variable tuning *** than using the current value,the previous learning rate was used in this method to achieve a more adaptive *** additional control factor aids in determining the exact learning rate,resulting in reliable and convergent *** faster convergence rate and the avoidance of local minima make it *** estimation of the PI controller gains is achieved through a self-adaptive multi-population *** adaptive change in the group number will increase exploration and *** self-adaptive nature of the algorithm was used to determine the subpopulation number needed according to the fitness *** main advantage of this self-adaptive nature is the multi-population spread throughout the search space for a better optimal *** estimated gains of the PI controllers are used for the DC bus and AC terminal voltage error *** RIDLMS-based control with PI gains obtained using the proposed optimization algorithm showed better power quality *** considered RIDLMS-supported control was demonstrated experimentally using d-SPACE-1104.

关键词： Least mean square variable learning DSTATCOM local minima Rao algorithm reactive power neutral current

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Designing an On-board Charger to Efficiently Charge Multiple Electric Vehicles

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中国电气工程学报(英文) 2023年第2期9卷 38-56页

作者： Jyoti Gupta rakesh maurya Sabha Raj Arya Department of Electrical Engineering Sardar Vallabhbhai National Institute of TechnologySurat 395007India

An on-board charger for efficiently charging multiple battery-operated electric vehicles(EVs)is *** has evolved as a single-input dual-output(SIDO)integrated boost-single ended primary inductor converter(SEPIC)fly-back converter,offering cost-effectiveness,reliability,and higher efficiency compared to conventional chargers with equivalent *** proposed system includes an additional regulated output terminal,in addition to an existing terminal for charging the EV battery of a 4-wheeler,which can be used to charge another EV battery,preferably a *** the aid of control techniques,unity power factor operations are obtained during constant-voltage(CV)/constant-current(CC)charging for the grid-to-vehicle(G2V)operating *** mathematical modelling analysis,the proposed system is developed in a Matlab/Simulink environment,and the results are validated in a real-time simulator using *** proposed system is employed for charging the batteries of two EVs with capacities of 400 V,40 A·h and 48 V,52 A·h for the 4-wheeler and 2-wheeler,*** performance is investigated under different operating modes and over a wide range of supply voltage variations to ensure safe and reliable operation of the charger.

关键词： Continuous conduction mode(CCM) CV/CC electric vehicles(EVs) power factor correction(PFC) single input dual output(SIDO) state of charge(SOC)

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Assessment of performance,combustion and emissions characteristics of methanol-diesel dual-fuel compression ignition engine:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第5期8卷 638-680页

作者： Mohit Raj Saxena rakesh Kumar maurya Prashant Mishra Department of Mechanical Engineering Indian Institute of Technology RoparRupnagar 140001India

The energy security concern and rapidly diminishing fossil fuel resources demand the development of renewable and economically attractive fuel for reciprocating *** is a promising renewable alternative *** studies have been carried out to explore the various aspects of the utilization of methanol in compression ignition(CI)*** review paper presents a detailed analysis of the effect of methanol on performance,combustion,and emission(NOx,CO,HC,and soot)characteristics of conventional CI-engine along with dual-fuel combustion *** study focuses on methanol utilization in dual-fuel mode,which is an advanced engine combustion ***,methanol production and solubility issues of methanol in diesel are briefly *** study discusses the soot and nano-particle emission from the methanol fueled CI-engine,which is one of the main concerns in the current emission *** was found that the utilization of methanol in CI-engine has the potential to improve the performance and simultaneously with a significant reduction in NOx,CO,soot,and nano-particle emissions in comparison to neat diesel ***,unburnt HC emission reduces for methanol-diesel blended fuel operation whereas HC emissions are higher for methanoldiesel dual-fuel operation.

关键词： Methanol Dual-fuel Combustion Diesel engine Particle emissions Thermal efficiency

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A New Switching Sequences of SVPWM for Six-Phase Induction Motor with Features of Reduced Switching Losses

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CES Transactions on Electrical Machines and Systems 2021年第2期5卷 100-107页

作者： Shaikh Mohammed Suhel rakesh maurya Department of Electrical Engineering R.N.G.Patel Institute of Technology BardoliSuratIndia Department of Electrical Engineering Sardar Vallabhbhai National Institute of TechnologySuratIndia

In this paper,new SVPWM switching sequences for six-phase asymmetrical induction motor drives are derived with the aim to reduce inverter’s switching *** three switching sequences are introduced in this *** sequences are derived such that the phases get continuously clamped when a current of the phases is around its peak magnitude and hence reduced switching losses are *** comparative performances of these modulation techniques are studied with two existing switching ***,analytical and experimental results are *** on these results,it is found that new switching sequences reduce switching losses effectively in dual three phase inverters.

关键词： Six-phase asymmetrical induction motor stator current distortion SVPWM and switching loss

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Adaptive Observer for Dynamic Voltage Restorer with Optimized Proportional Integral Gains

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Chinese Journal of Electrical Engineering 2022年第1期8卷 38-52页

作者： Sabha Raj Arya rakesh maurya Talada Appala Naidu Baladhandautham Chitti Babu Department of Electrical Engineering Sardar Vallabhbhai National Institute of TechnologySurat 395007India Department of Electronics and Communication Engineering IIITDMChennai 600127India

An algorithm based on a sliding-mode adaptive observer is proposed for the effective control of dynamic voltage restorers(DVRs).Three single-phase voltage source converter-based topologies are implemented for the *** this control,frequency adaption is considered for estimating the phase angle,system frequency,and fundamental component of the disturbed input voltage *** estimated fundamental component of the supply voltage is used to generate the DVR reference load *** phase jump in the supply voltage is also considered for DVR compensation studies along with voltage sag,swell,and voltage *** this purpose,the gains of the proportional integral(PI)controllers used in this control algorithm are estimated using a nature-inspired optimization approach for the desired response.A moth flame optimization algorithm is implemented for PI controller gain tuning owing to the advantage of finding the best solution by each moth’s search and updating *** Matlab simulation and hardware testing,the performance of the DVR with an adaptive observer is found to be satisfactory for supply voltage sag,swell,phase jump,and voltage distortions.

关键词： Adaptive observer phase jump power quality frequency estimation DVR triangular wave

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Medicinal Effects, Phytochemistry,Pharmacology of Euphorbia prostrata and Promising MolecularMechanisms

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Chinese Journal of Integrative Medicine 2024年第2期30卷 181-192页

作者： Nirmala Kumari Yadav rakesh Yadav Department of Pharmacy Banasthali VidyapithBanasthali(304022)RajasthanIndia Department of Pharmaceutical Sciences Indira Gandhi UniversityMeerpurRewari(122502)HaryanaIndia National Forensic Sciences University Tripura CampusAgartala(799001)TripuraIndia

Euphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera including Euphorbia prostrata(***).Current research has provided scientific evidence for traditional uses of *** against diverse pathological conditions such as anti-hemorrhoidal,anti-inflammatory,analgesic,wound healing,antioxidant,antibacterial,leishmanicidal,antitumor activity,and so *** phytochemical screening has revealed the presence of glycosides,phytosterols,flavonoids,polyphenols,tannins,and anthraquinones with chemical structures elucidation of their respective *** uniqueness of such multifactorial compounds present in this species endorses it as the potent therapeutic or prophylactic choice for several fatal *** ethnomedical applications served as a significant citation for pharmacology,the molecular mechanism has not been reviewed *** present paper provides a comprehensive review of research outcomes,pharmacology,toxicology,and molecular signaling of phytochemicals of *** species as a reference for relevant *** study of bioactive compounds in crude extracts and fractions,the demonstration of primary mechanisms of pharmacology,along with the addition of toxicity,and clinical trials,should be conceded in *** review underlines the *** species that can be a promising phytomedicine since we are committed to excavating more intensely into their pharmacological role.

关键词： Euphorbia prostrata Euphorbiaceae phytochemicals ethnomedical applications toxicology molecularmechanism

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Multifunctional applications of gadolinium-doped cerium oxide(Ce1-xGdxO2-?) ceramics:A review

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Journal of Rare Earths 2024年第10期42卷 1817-1834页

作者： Subhadip Das rakesh Bhaskar Kannan Badri Narayanan Department of Ceramic Engineering National Institute of Technology Rourkela School of Chemical Engineering Yeungnam University

Cerium oxide（CeO2）,or ceria,and its doped derivatives have been extensively studied for several decades and are well-known oxides valued for their unique structural properties and wide range of *** materials play a crucial role in sustainable development within *** modification through de fect e ngineering of the highly stable cubic fluorite phase enhances the versatility of this doped ceria to a new *** the numerous dopants of the CeO2matrix,ceria doped with gadolinium（Gd）,known as Ce1-xGdxO2-?（CGO）,is gaining popularity due to its *** introduction of defect-induced vacancies in the oxygen sublattice（V_o） and a change in the average valence of cerium(Ce3+/Ce4+) are primarily responsible for the improved performance compared to pristine *** materials are currently undergoing intensive research for potential use as electrolytes in intermediate-temperature solid oxide fuel cells（IT-SOFCs） and dense oxygen-permeable membranes（OPMs）.Additionally,they are being commercially utilized for power generation and oxygen *** materials are also attracting significant attention in various fields such as optics,photocatalysis,electrostriction,spintronics,gas sensing,electrocatalysis,and biomedical *** review paper aims to compile the latest contributions to CGO materials and comprehensively cover their various application *** crystal structure,defect equilibrium in Gd3+-doped CeO2,the origin of multifunctionality,and the prospects of these materials are also exclusively discussed.

关键词： Biomedicine Gadolinium-doped CeO2 Gas sensors Photo/electrocatalysts Rare earths Spintronics

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Surface Modification Aspects for Improving Biomedical Properties in Implants:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 213-241页

作者： J.Sharath Kumar rakesh Kumar Rajeev Verma Industrial and Production Department Dr B R Ambedkar National Institute of Technology JalandharJalandharPunjab144008India

The primary focus during surgery is to ensure successful implantation by achieving long-term and stable fixation of *** surgery is now more focused on the development of novel biomaterials intended to improve implant *** obtain a better understanding of metal implants,this article investigated the causes of material failures in certain cases and analysed a few case *** interaction between the implant and bone tissue was a crucial aspect of successful implantation,and this study explored the factors influencing this interaction as well as ways to improve *** modern approaches used for modifying implant surfaces were systematically illustrated and briefly *** spray coatings were often favoured because of their wide range of coating materials,but other substantial surface modifications(such as friction stir processing and laser surface texturing)were also used for a selection of ***,implant surfaces with desirable features,such as biocompatibility,antibacterial properties,corrosion resistance,and wear resistance,were essential for optimising implant *** systematic review's main aim is to provide exhaustive reference information and a broad overview to advance the production and design of orthopaedic implants.

关键词： Biomaterials Surface treatments Thermal spray coatings Antibacterial Biocompatibility Corrosion resistance Wear resistance

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