检索结果-南通市图书馆

Surface Modification Aspects for Improving Biomedical Properties in Implants:A Review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 213-241页

作者： J.Sharath kumar rakesh kumar Rajeev Verma Industrial and Production Department Dr B R Ambedkar National Institute of Technology JalandharJalandharPunjab144008India

The primary focus during surgery is to ensure successful implantation by achieving long-term and stable fixation of *** surgery is now more focused on the development of novel biomaterials intended to improve implant *** obtain a better understanding of metal implants,this article investigated the causes of material failures in certain cases and analysed a few case *** interaction between the implant and bone tissue was a crucial aspect of successful implantation,and this study explored the factors influencing this interaction as well as ways to improve *** modern approaches used for modifying implant surfaces were systematically illustrated and briefly *** spray coatings were often favoured because of their wide range of coating materials,but other substantial surface modifications(such as friction stir processing and laser surface texturing)were also used for a selection of ***,implant surfaces with desirable features,such as biocompatibility,antibacterial properties,corrosion resistance,and wear resistance,were essential for optimising implant *** systematic review's main aim is to provide exhaustive reference information and a broad overview to advance the production and design of orthopaedic implants.

关键词： Biomaterials Surface treatments Thermal spray coatings Antibacterial Biocompatibility Corrosion resistance Wear resistance

Role of Pathogen-Related Protein 10 (PR 10) under Abiotic and Biotic Stresses in Plants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2020年第2期89卷 167-182页

作者： rakesh kumar sinha Shiv Shankar Verma Anshu Rastogi Department of Plant Biophysics&Biochemistry Biology Center of the Czech Academy of SciencesInstitute of PlantMolecular BiologyCeskeBudejovice37005Czech Republic School of Medicine Case Western Reserve UniversityCleveland44106USA Department of Ecology and Environmental Protection Laboratory of BioclimatologyPoznan University of Life SciencesPoznan60-649Poland

Members of the Pathogenesis Related(PR)10 protein family have been identified in a variety of plant species and a wide range of functions ranging from defense to growth and development has been attributed to ***10 protein possesses ribonuclease(RNase)activity,interacts with phytohormones,involved in hormone-mediated signalling,afforded protection against various phytopathogenic fungi,bacteria,and viruses particularly in response to biotic and abiotic *** resistance mechanism of PR10 protein may include activation of defense signalling pathways through possible interacting proteins involved in mediating responses to pathogens,degradation of RNA of the invading ***,several morphological changes have been shown to accompany the enhanced abiotic stress *** this review,the possible mechanism of action of PR10 protein against biotic and abiotic stress has been ***,our findings also confirmed that the in vivo Nitric oxide(NO)is essential for most of environmental abiotic stresses and disease resistance against pathogen *** proper level of NO may be necessary and beneficial,not only in plant response to the environmental abiotic stress,but also to biotic *** updated information on this interesting group of proteins will be useful in future research to develop multiple stress tolerance in plants.

关键词： Pathogenesis-related(PR) PR10 abiotic stress biotic stress ribonuclease stress tolerance nitric oxide

Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： Surendra kumar Gautam rakesh kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

Proposed numerical and machine learning models for fiber-reinforced polymer concrete-steel hollow and solid elliptical columns

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第8期18卷 1169-1194页

作者： Tang QIONG Ishan JHA Alireza BAHRAMI Haytham F.ISLEEM rakesh kumar Pijush SAMUI School of Applied Technologies Qujing Normal UniversityQujing 655011China Department of Civil Engineering Indian Institute of Technology-BHUVaranasi 221005India Department of Building Engineering Energy Systems and Sustainability ScienceFaculty of Engineering and Sustainable DevelopmentUniversity of GävleGävle 80176Sweden Department of Civil Engineering National Institute of Technology-PatnaPatna 800005India

This study employs a hybrid approach,integrating finite element method(FEM)simulations with machine learning(ML)techniques to investigate the structural performance of double-skin tubular columns(DSTCs)reinforced with glass fiber-reinforced polymer(GFRP).The investigation involves a comprehensive examination of critical parameters,including aspect ratio,concrete strength,number of GFRP confinement layers,and dimensions of steel tubes used in DSTCs,through comparative analyses and parametric *** ensure the credibility of the findings,the results are rigorously validated against experimental data,establishing the precision and trustworthiness of the *** present research work examines the use of the columns with elliptical cross-sections and contributes valuable insights into the application of FEM and ML in the design and evaluation of structural systems within the field of structural engineering.

关键词： elliptical column fiber-reinforced polymer machine learning finite element method ABAQUS

Detection and analysis of the effects of heat stress on EEG using wavelet transform ——EEG analysis under heat stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2010年第4期3卷 405-414页

作者： Prabhat kumar Upadhyay rakesh kumar sinha Bhuwan Mohan Karan 不详

Continuous wavelet transform (CWT) method has been applied to capture localized time-frequency information of rat electroencephalogram (EEG) in different vigilance states and analyze alterations in transients during awake, slow wave sleep (SWS), and rapid eye movement (REM) sleep stages due to exposure to high environmental heat. Rats were divided in three group (i) acute heat stress-subjected to a single exposure for four hours in the Biological Oxygen Demand (BOD) incubator at 38?C;(ii) chronic heat stress-exposed for 21 days daily for one hour in the incubator at 38?C, and (iii) handling control groups. After two hours long EEG recordings from young healthy rats, EEG data representing three sleep states was visually selected and further subdivided into 2 seconds long epoch. Powers of wavelet spectra corresponding to delta, theta, alpha, and beta bands at all scales and locations were computed and variation in their states investigated. The wavelet analysis of EEG signals following exposure to high environmental heat revealed that powers of subband frequencies vary with time unlike Fourier technique. Changes in higher frequency components (beta) were significant in all sleep-wake states following both acute and chronic heat stress conditions. Percentage power of different components of the four bands was always found to be varying at different intervals of time in the same signal of analysis.

关键词： Electroencephalogram Rat Sleep Wavelet transform

Predicting heat-stressed EEG spectra by self-organising feature map and learning vector quantizers——SOFM and LVQ based stress prediction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2010年第5期3卷 529-537页

作者： Prabhat kumar Upadhyay rakesh kumar sinha Bhuwan Mohan Karan 不详

Self-Organising Feature Map (SOFM) along with learning vector quantizers (LVQ) have been designed to identify the alterations in brain electrical potentials due to exposure to high environmental heat in rats. Three groups of rats were considered—acute heat stressed, chronic heat stressed and control groups. After long EEG recordings following heat exposure, EEG data representing three different vigilance states such as slow wave sleep (SWS), rapid eye movement (REM) sleep and AWAKE were visually selected and further subdivided into 2 seconds long epoch. In order to evaluate the performance of artificial neural network (ANN) in recognizing chronic and acute effects of heat stress with respect to the control subjects, unsupervised learning algorithm was applied on EEG data. Mean performance of SOFM with quadratic taper function was found to be better (chronic-92.6%, acute-93.2%) over the other two tapers. The effect of LVQ after the initial SOFM training seems explicit giving rise to considerable improvements in performance in terms of selectivity and sensitivity. The percentage increase in selectivity with uniform taper function is maximum for chronic and its control group (4.01%) and minimum for acute group (1.29%) whereas, with Gaussian it is almost identical (chronic-2.57%, acute-2.03%, control- 2.33%). Quadratic taper function gives rise to an increase of 2.41% for chronic, 1.96% for acute and 2.91% for control patterns.

关键词： ANN EEG Heat Stress SOFM LVQ

Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第5期32卷 877-897页

作者： KARAN WADHWA PAYAL CHAUHAN SHOBHIT kumar rakesh PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA SHARMA NEHA RAO DEEPAK KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

Endoscopic ultrasound-guided pancreatic fluid collection drainage: Where are we?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 273-281页

作者： Anupam kumar Singh Manish Manrai rakesh Kochhar Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Command HospitalLucknow 226002India Department of Gastroenterology Paras HospitalPanchkula 134109India

Pancreatic fluid collections(PFCs)result from injury to the pancreas from acute or chronic pancreatitis,surgery,or *** of these collections has evolved over the last 2 *** choice of interventions includes percu-taneous,endoscopic,minimally invasive surgery,or a combined *** drainage is the drainage of PFCs by creating an artificial communication between the collection and gastrointestinal lumen that is maintained by placing a stent across the fistulous *** this editorial,we endeavored to update the current status of endoscopic ultrasound-guided drainage of PFCs.

关键词： Pancreatic fluid collections Endoscopic ultrasound-guided drainage Endoscopic necrosectomy Lumen apposing metal stent Review

Extracellular vesicles as tools and targets in therapy for diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra rakesh kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes