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Diagnostic role of fractional exhaled nitric oxide in pediatric eosinophilic esophagitis, relationship with gastric and duodenal eosinophils

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 407-419页

作者： Panamdeep kaur Rachel Chevalier Craig Friesen Jamie Ryan Ashley sherman stephanie Page Department of Pediatric Gastroenterology Connecticut Children’s Medical CenterUniversity of Connecticut School of MedicineHartfordConnecticutCT 06106United States Department of Pediatric Gastroenterology Children's Mercy Kansas CityUniversity of Missouri-Kansas City School of MedicineKansas CityMissouriMO 64108United States Department of Pediatrics University of Kansas School of MedicineKansas CityKansasKS 66160United States Department of Biostatistics Children's Mercy Kansas CityKansas CityMissouriMO 64108United States Department of Pediatric Gastroenterology Midwest Pediatric SpecialistsOverland ParkKansasKS 66215United States

BACKGROUND Eosinophilic esophagitis(EoE)is an eosinophilic-predominant inflammation of the esophagus diagnosed by upper endoscopy and biopsies.A non-invasive and cost-effective alternative for management of EoE is being *** studies assessing utility of fractional exhaled nitric oxide(FeNO)in EoE were low *** investigated the contribution of eosinophilic inflammation of the stomach and duodenum to *** To assess the utility of FeNO as a non-invasive biomarker of esophageal eosinophilic inflammation for monitoring disease *** Patients aged 6-21 years undergoing scheduled upper endoscopy with biopsy for suspected EoE were recruited in our observational *** on steroids and with persistent asthma requiring daily controller medication were *** measurements were obtained in duplicate using a chemiluminescence nitric oxide analyzer(NIOX MINO,Aerocrine,Inc.;stockholm,sweden)prior to *** on the esophageal peak eosinophil count(PEC)/high power field on biopsy,patients were classified as EoE(PEC≥15)or control(PEC≤14).Mean FeNO levels were correlated with presence or absence of EoE,eosinophil counts on esophageal biopsy,and abnormal downstream eosinophilia in the stomach(PEC≥10)and duodenum(PEC≥20).Wilcoxon rank-sum test,spearman correlation,and logistic regression were used for analysis.P values considered *** We recruited a total of 134 patients,of which 45 were diagnosed with EoE by *** median interquartile range FeNO level was 17 parts per billion(11-37,range:7-81)in the EoE group and 12 parts per billion(8-19,range:5-71)in the control *** adjusting for atopic diseases,EoE patients had significantly higher FeNO levels as compared to patients without EoE(Z=3.33,Pstatistically significant positive association was found between the number of esophageal eosinophils and FeNO levels(r=0.30,Psubgroup analysis within the EoE cohort,h

关键词： Nitric oxide Fractional exhaled nitric oxide Eosinophilic esophagitis Esophagus Pediatric Gastroenterology

Impact of diabetes mellitus on risk of cardiovascular disease and all-cause mortality: Evidence on health outcomes and antidiabetic treatment in United states adults

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World Journal of Diabetes 2016年第18期7卷 449-461页

作者： Longjian Liu Barbara simon Jinggaofu shi Arshpreet kaur Mallhi Howard J Eisen Department of Epidemiology and Biostatistics Drexel University Dornsife School of Public Health Division of Endocrinology Drexel University College of Medicine Division of Cardiology Drexel University College of Medicine

AIMTo examine the epidemic of diabetes mellitus (DM) and its impact on mortality from all-cause and cardiovascular disease (CVD), and to test the effect of antidiabetic therapy on the mortality in United states adults. METHODs The analysis included a randomized population sample of 272149 subjects ages ≥ 18 years who participated in the National Health Interview surveys (NHIs) in2000-2009. Chronic conditions (hypertension, DM and CVD) were classified by participants’ self-reports of physician diagnosis. NHIs-Mortality Linked Files, and NHIs-Medical Expenditure Panel survey Linkage Fileson prescribed medicines for patients with DM were used to test the research questions. χ 2, Poisson and Cox’s regression models were applied in data *** Of all participants, 22305 (8.2%) had DM. The prevalence of DM significantly increased from 2000 to 2009 in all age groups (P sD= 3) years of follow-up, male DM patients had 1.56 times higher risk of death from all-cause (HR = 1.56, 95%CI:1.49-1.64), 1.72 times higher from heart disease [1.72 (1.53-1.93)], 1.48 times higher from cerebrovascular disease [1.48 (1.18-1.85)], and 1.67 times higher from CVD [1.67 (1.51-1.86)] than subjects without DM,respectively. similar results were observed in females. In males, 10% of DM patients did not use any antidiabetic medications, 38.1% used antidiabetic monotherapy, and 51.9% used ≥ 2 antidiabetic medications. These corresponding values were 10.3%, 40.4% and 49.4% in females. A significant protective effect of metformin monotherapy or combination therapy (except for insulin) on all-cause mortality and a protective but non-significant effect on CVD mortality were observed. CONCLUsION This is the first study using data from multiple linkage files to confirm a significant increased prevalence of DM in the last decade in the United states. Patients with DM have significantly higher risk of death from all-cause and CVD than those without DM. Antidiabeti

关键词： Epidemic of diabetes mellitus Cardiovascular disease Pharmacoepidemiologic profiles United states

从分生孢子形态,真菌的敏感性及分子谱型对芸苔交链杆菌分离群体多样性证明(英文)

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从分生孢子形态,真菌的敏感性及分子谱型对芸苔交链杆菌分离群体...

sMRT-AgRenseq-d in potato (solanum tuberosum) as a method to identify candidates for the nematode resistance Gpa5

第十二届国际油菜大会

作者： sarbjeet kaur Gurpreet singh s.s.Banga Department of Plant Breeding Genetics and BiotechnologyPunjab Agricultural University Ludhiana 141 004India

在印度,黑斑病(芸苔交链杆菌)是芥菜型油菜的经济毁灭性的疾病。在芸苔类物种中,栽培种植和疾病流行的天气情况下,产量损失可超过50%。在芸苔作物种质中,没有已知的抗黑斑病资源。在缺乏关于生物体病原病变类型资料的情况下,曾经对抗病... 详细信息

在印度,黑斑病(芸苔交链杆菌)是芥菜型油菜的经济毁灭性的疾病。在芸苔类物种中,栽培种植和疾病流行的天气情况下,产量损失可超过50%。在芸苔作物种质中,没有已知的抗黑斑病资源。在缺乏关于生物体病原病变类型资料的情况下,曾经对抗病种质的筛选开展了非常细致的试验,但重复性很差,这可能是由于每年流行病的症状不同造成的。本文展示了我们收集和编目芸苔属交链杆菌病原变异类型的结果。从黑斑病大批滋生的芸苔属叶子上分离出332个群体,这些病叶是从广阔的印度西北地区收集的。分离叶片技术用来测试群体的病原体,有114个被证实的病原体,这些病原种群中,分别从白菜型油菜,甘蓝型油菜,芥菜型油菜和埃塞俄比亚芥中收集到31,24,48和11个病原分离种群。这些病原菌用单孢子培养法进行纯化,然后基于分生孢子的形态,菌斑的直径和孢子形成图案进行分类。分生孢子的长度,宽度和喙长的变异记录范围分别是51.481.2μm,6.96.0μm和16.366.9μm。分生孢子水平、垂直隔片长和喙长的平均数分别是9.7,0.8和3.7。分生孢子群直径和分生孢子数量分别在13.07.5mm和1.0.0×106孢子/ml范围内波动。孢子群有棕色,白色和绿色光滑或有波浪边缘和厚天鹅绒至稀疏生长型。上述形态学数据可以用作多样性分析。七个差异明显的孢子群可以被区分出来,它们表现很广的变异范围。从每个孢子群中取出一个典型的菌落来测定其对六个真菌杀菌剂的敏感性,这六个真菌杀菌剂是二硫代氨基甲酸盐,百菌清,铜氯氧化物,tebuconazole,difenoconazole和propiconazo,分别以五种浓度作毒性培养试验来测定其相应敏感性。七个孢子群对真菌的反应特性与它们的分子孢子形态特征相协调。病原体分离群体的分子多样性数据也将在本文中阐述。

关键词： Oilseed rape Alternaria brassicae genetic diversity conidial morphology fungicidal sensitivity molecular profile

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Horticulture Research 2023年第11期10卷 271-279页

作者： Yuhan Wang Lynn H.Brown Thomas M.Adams Yuk Woon Cheung Jie Li Vanessa Young Drummond T.Todd Miles R.Armstrong Konrad Neugebauer Amanpreet kaur Brian Harrower stan Oome Xiaodan Wang Micha Bayer Ingo Hein Division of Plant sciences at the Hutton The University of DundeeErrol RoadInvergowrieDundeeDD25DAUK The James Hutton Institute Errol RoadInvergowrieDundeeDD25DAUK College of Plant Protection China Agricultural UniversityHaidian DistrictBeijing100083China James Hutton Limited The James Hutton InstituteErrol RoadInvergowrieDundeeDD25DAUK Biomathematics and statistics scotland Errol RoadInvergowrieDundeeDD25DAUK Crop Research Centre TeagascOak ParkCarlow R93 XE12Ireland HZPC Research B.V.HZPC Edisonweg 58501 XG JoureNetherlands

Potato is the thirdmost important food crop in *** pathogens threaten sustainable crop production but can be controlled,in many cases,through the deployment of disease resistance genes belonging to the family of nucleotide-binding,leucine-rich-repeat(NLR)*** identify effective disease resistance genes in established varieties,we have successfully established sMRT-AgRenseq in tetraploid potatoes and have further enhanced the methodology by including dRenseq in an approach that we term *** inclusion of dRenseq enables the filtering of candidates after the association analysis by establishing a presence/absence matrix across resistant and susceptible varieties that is translated into an F1 *** a sMRT-Renseq-based sequence representation of the NLRome from the cultivar Innovator,sMRT-AgRenseq-d analyses reliably identified the late blight resistance benchmark genes Rpi-R1,Rpi-R2-like,Rpi-R3a,and Rpi-R3b in a panel of 117 varieties with variable phenotype *** benchmark genes were identified with an F1 score of 1,which indicates absolute linkage in the *** method also identified nine strong candidates for Gpa5 that controls the potato cyst nematode(PCN)species Globodera pallida(pathotypes Pa2/3).Assuming that NLRs are involved in controlling many types of resistances,sMRT-AgRenseq-d can readily be applied to diverse crops and pathogen systems.

关键词： resistance linkage crops

Roux-en-Y gastric bypass or sleeve gastrectomy for obstructive sleep apnea:A systematic review and meta-analysis

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Laparoscopic, Endoscopic and Robotic surgery 2019年第3期2卷 53-58页

作者： Hussein Al-Rubaye Emma Rose McGlone Borna Farzaneh Livyar Mustafa Mae Johnson Ajit Kayal Caroline-Louise English Vasha kaur Myutan Kalendran Marcus Reddy Omar A.Khan st George's University of LondonLondonSW170REUK Department of Metabolic and Investigative Medicine Hammersmith Hospital CampusImperial College LondonLondonW120HSUK Department of Anaesthetic St George's HospitalLondonSW170QTUK st George's Hospital LondonSW170QTUK Department of Upper Gastrointestinal and Bariatric surgery St George's HospitalLondonSW170QTUK Population Health Research Institute St George'sUniversity of LondonLondonSW170REUK

Objective:Bariatric surgery has been shown to be an effective method of treatment for obstructive sleep apnea(OsA)with long-term benefits,however,the mechanisms of action and the optimum operative procedure remains *** aim of this systemic review was to compare the efficacy of laparoscopic sleeve gastrectomy(LsG)and Roux-en-Y gastric bypass(RYGB)in resolving ***:A comprehensive search of MEDLINE,Pubmed,Embase,and OVID was *** that reported OsA resolution in obese patients with BMI>30 kg/m2 were included in the ***,comparative prospective and matched cohort studies comparing RYGB with LsG were considered for this ***:Five studies(309 participants)were included:4 cohort studies and 1 RCT;all with low risk of *** 12 months follow-up,there was a trend towards improved resolution of OsA with LsG(OR 0.47,95%CI[0.20 to 1.06];p=0.07)when compared to *** contrast,there was a trend to poorer weight loss in the LsG group(sMD 3.83,95%CI[-1.82 to 9.48];p=0.18).similarly,at 36 months follow-up,there was a trend towards better resolution of OsA with LsG(OR 0.52,95%CI[0.16 to 1.71];p=0.28)and a significantly poorer weight loss in LsG when compared to RYGB(sMD 8.25,95%CI[2.91 to 13.58];p=0.002).Conclusion:Despite poorer weight loss following LsG,there is a trend towards increased resolution of sleep apnea *** findings suggest the possibility of weight loss independent factors causing OsA resolution,which should be further ***:PROsPERO:CRD42018090367.

关键词： Obesity Laparoscopic sleeve gastrectomy Laparoscopic Roux-en-Y gastric bypass Obstructive sleep apnea Meta-analysis

同时做皮肤和神经的组织学检查对麻风分型的作用

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中国麻风皮肤病杂志 1994年第2期10卷 136-136页

作者： kaur s 安平

对60例未治疗的麻风同时做皮肤和神经的组织学检查。神经选粗大的纯感觉性皮神经。先做临床分型再做组织分型对照。结果:临床为BT的25例中,病理也诊断为BT的皮肤11例(44％),神经17例(68％);有3例皮肤和神经均诊断为TT,另有3例神经诊断... 详细信息

对60例未治疗的麻风同时做皮肤和神经的组织学检查。神经选粗大的纯感觉性皮神经。先做临床分型再做组织分型对照。结果:临床为BT的25例中,病理也诊断为BT的皮肤11例(44％),神经17例(68％);有3例皮肤和神经均诊断为TT,另有3例神经诊断为BL。皮肤和神经分型一致的14例(56％)。呈非特异性炎症者,发肤11侧远高于神经2例。临床为BL的28例中,病理也诊断为

关键词：麻风皮肤杆菌病皮肤解剖部位分型神经

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印度液体糖生产的概况

广西糖业 2018年第2期38卷 47-48,20页

作者：蓝艳华(编译) r.s.s.kaler imneet jatana mandeep kaur 广东省生物工程研究所(广州甘蔗糖业研究所) 广东广州510316 不详

目前主要有2种标准类型的液体糖，一种是蔗糖型液体糖（固含量为65％。67％的液体糖浆），另一种是转化型液体糖（固含量为77％的液体糖浆）。这2种类型的液体糖都是通过离子交换法精炼而成。液体糖的益处包括：获得稳定的产品质量，节... 详细信息

目前主要有2种标准类型的液体糖，一种是蔗糖型液体糖（固含量为65％。67％的液体糖浆），另一种是转化型液体糖（固含量为77％的液体糖浆）。这2种类型的液体糖都是通过离子交换法精炼而成。液体糖的益处包括：获得稳定的产品质量，节省时间和成本，减少劳力等。它的附加品质包括风味增强，使产品保持湿润和新鲜。

关键词：液体糖精制糖原糖转化糖浆离子交换再生树脂

Ecological and Chemotypic Analysis for Improved Growth and Management of Naturally Occurring Black Cohosh (<i>Actaea racemosa</i>L.) Populations in Western Maryland

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American Journal of Plant sciences 2015年第19期6卷 3272-3281页

作者： Amanda Vickers sunshine L. Brosi James Howell Bhavneet kaur David Puthoff Edward Eisenstein Frostburg state University Frostburg USA Us Botanical safety Lab Candler USA Allegany College of Maryland Cumberland USA Institute for Bioscience and Biotechnology Research Rockville USA sustainable Agricultural systems Laboratory Beltsville Agricultural Research Center USDA-ARSBeltsville USA Fischell Department of Bioengineering University of Maryland Rockville USA

Black cohosh (Actaea racemosa L.) is a perennial herb native to deciduous woodlands in eastern North America with an extensive history of traditional use, most commonly for rheumatoid arthritis and female reproductive issues. Modern clinical research has maintained this herb’s relevance into the 21st century with a majority of authentic black cohosh raw material still harvested from naturally occurring populations in Appalachian woodlands for use in botanical supplements. Increased use and interest in black cohosh have led to increased wild harvesting, reports of adulteration, and stress on this important natural resource. In an effort to study this significant medicinal plant as part of an ecosystem, and to understand factors that would contribute to the more effective growth and maintenance of black cohosh, key chemical, physiological, and ecological aspects of two occurring populations in western Maryland were surveyed. Rhizomes were harvested from six populations of naturally occurring black cohosh in two state forests located in the Allegheny Plateau and Ridge and Valley physiogeographic provinces of Maryland. The concentrations of five medicinal compounds found in black cohosh extracts, actein, 23-epi-26-deoxyactein, cafeic acid, ferulicacid, and N-methylserotonin, were compared with plant reproductive status as well as accompanying overstory and under story species, soil moisture, and soil pH at each site. Compound levels showed a complex dependence on physiography but were independent of reproductive state. The findings provide clues to guide efforts at effective growth and management of wild populations of black cohosh and other threatened medicinal plants.

关键词： Actaea racemosa Rhizome Natural Products Physiographic Province Reproductive state

self-Compassion and Empathy: Impact on Burnout and secondary Traumatic stress in Medical Training

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Open Journal of Epidemiology 2016年第3期6卷 161-166页

作者： David A. Richardson sara Jaber sarah Chan Michelle T. Jesse Hareena kaur Roopina sangha Department of Obstetrics and Gynecology Henry Ford Hospital/Wayne State University Detroit USA Transplant Institute and Behavioral Health services (dual appointments) Henry Ford Health System Detroit USA

Objective: To determine how self-compassion and empathy might influence the degree of burnout, secondary traumatic stress and compassion satisfaction among medical students and residents. Methods: Cross-sectional survey of medical students and select residency programs at Henry Ford Hospital in Detroit, Michigan. Respondents completed the Professional Quality of Life scale (burnout, secondary traumatic stress and compassion satisfaction), Neff’s self-Compassion scale, and the empathic concern and personal distress subscales of the Interpersonal Reactivity Index. Results: The response rate was 28.6%. 23.9% and 27.3% of medical trainees reported high levels of burnout and secondary traumatic stress, respectively. Females reported greater empathy but lower self-compassion than males. Greater concern for others and oneself and lower personal distress predicted greater pleasure derived from professional work. Less concern for others and lower concern for oneself predicted greater burnout. Conclusions: Compassion for oneself and for others within their care appears to ameliorate burnout and can increase professional satisfaction. Initiatives to foster empathy and self-compassion may enhance individual well-being.

关键词： Burnout secondary Traumatic stress Empathy self-Compassion Well-Being