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Analysis of Gene Expression Patterns during seed Coat Development in Arabidopsis

Molecular Plant 2011年第6期4卷 1074-1091页

作者： Gillian Dean YongGuo Cao DaoQuan Xiang Nicholas J. Provart Larissa Ramsay Abdul Ahad Rick White Gopalan selvaraj raju Datla George Haughn Department of Botany University of British Columbia 6270 University Blvd Vancouver BC V6T 1Z4 Canada National Research Council of Canada Plant Biotechnology Institute 110 Gymnasium Place Saskatoon SK S7N owg Canada Department of Cell and systems Biology/Centre for the Analysis of Genome Evolution and Function University of Toronto 25 Willcocks St Toronto ON M5S 3B2 Canada Department of statistics University of British Columbia 6356 Agricultural Road Vancouver BC V6T 1Z2 Canada

The seed coat is important for embryo protection, seed hydration, and dispersal. seed coat composition is also of interest to the agricultural sector, since it impacts the nutritional value for humans and livestock alike. Although some seed coat genes have been identified, the developmental pathways controlling seed coat development are not completely elucidated, and a global genetic program associated with seed coat development has not been reported. This study uses a combination of genetic and genomic approaches in Arabidopsis thaliana to begin to address these knowledge gaps. seed coat development is a complex process whereby the integuments of the ovule differentiate into specialized cell types. In Arabidopsis, the outermost layer of cells secretes mucilage into the apoplast and develops a secondary cell wall known as a columella. The layer beneath the epidermis, the palisade, synthesizes a secondary cell wall on its inner tangential side. The innermost layer （the pigmented layer or endothelium） produces proanthocyanidins that condense into tannins and oxidize, giving a brown color to mature seeds. Genetic separation of these cell layers was achieved using the ap2-7 and tt16-1 mutants, where the epidermis/palisade and the endothelium do not develop respectively. This genetic ablation was exploited to examine the developmental programs of these cell types by isolating and collecting seed coats at key tran- sitions during development and performing global gene expression analysis. The data indicate that the developmental programs of the epidermis and the pigmented layer proceed relatively independently. Global expression datasets that can be used for identification of new gene candidates for seed coat development were generated. These dataset provide a comprehensive expression profile for developing seed coats in Arabidopsis, and should provide a useful resource and reference for other seed systems.

关键词： seed coat microarray APETALA2 TRANsPARENT TEsTA16 mucilage pectin secondary cell wall pigmentedlayer proanthocyanidin.

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Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第18期18卷 2287-2290页

作者： Jamie B sodikoff steven A Keilin sheila J Bharmal Melinda M Lewis Gottumukkala s raju Field F Willingham Division of Digestive Diseases Department of MedicineEmory University School of MedicineAtlantaGA 30322United States Department of Pathology Emory University School of MedicineAtlantaGA 30322United States Department of Gastroenterology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated *** steroid-dependent disease,azathioprine has been used for maintenance of *** mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte *** of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse *** patient was managed without a biliary ***,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per *** the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the *** mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis Mycophenolate mofetil Recurrence

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Exploring emerald global geochemical provenance through fingerprinting and machine learning methods

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Artificial Intelligence in Geosciences 2024年第1期5卷 202-219页

作者： Raquel Alonso-Perez James M.D.Day D.Graham Pearson Yan Luo Manuel A.Palacios raju sudhakar Aaron Palke Earth and Planetary science Department Harvard UniversityCambridgeMA02138USA scripps Institution of Oceanography University of California San DiegoLa JollaCA92037USA University of Alberta EdmontonABT6G 2R3Canada Eigenvector Research Inc.Manson WA98831USA Rockhurst University Kansas CityMO64110USA Gemological Institute of America CarlsbadCA92008USA

Emeralds-the green colored variety of beryl-occur as gem-quality specimens in over fifty deposits *** digital traceability methods for emerald have limitations,sample-based approaches offer robust alterna-tives,particularly for determining the geographic origin of *** factors make emerald suitable for provenance studies and hence for developing models for origin ***,the diverse elemental chemistry of emerald at minor(vels(s ppmw)exhibits unique inter-element fractionations between global ***,minimally destructive techniques,including laser ablation inductively coupled plasma mass spectrometry(LA-ICP-Ms),enable measurement of these diagnostic elemental ***,when applied to extensive datasets,machine learning(ML)techniques enable the creation of predictive models and statistical discrimination with adequate characterization of the *** study em-ploys a carefully selected dataset comprising more than 1000 LA-ICP-Ms analyses of gem-quality emeralds,enriched with new *** dataset represents the largest available for global emerald *** con-ducted unsupervised exploratory analysis using Principal Component Analysis(PCA).For machine learning-based classification,we employed support vector Machine Classification(svM-C),achieving an initial accu-racy rate of 79%.This was enhanced to 96.8%through the use of hierarchical svM-C with PCA filters as our modeling *** ML models were trained using the concentrations of eight statistically significant ele-ments(Li,v,Cr,Fe,sc,Ga,Rb,Cs).By leveraging high-quality LA-ICP-Ms data and ML techniques,accurate identification of the geographical origin of emerald becomes *** models are important for accurate provenance of emerald,and from a geochemical perspective,for understanding the formation environments of beryl-bearing pegmatites and shales.

关键词： Beryl Provenance LA-ICP-Ms Machine learning Multivariate analysis Trace elements

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Brain Tumor Identification Using Data Augmentation and Transfer Learning Approach

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Computer systems science & Engineering 2023年第8期46卷 1845-1861页

作者： K.Kavin Kumar P.M.Dinesh P.Rayavel L.vijayaraja R.Dhanasekar Rupa Kesavan Kannadasan raju Arfat Ahmad Khan Chitapong Wechtaisong Mohd Anul Haq Zamil s.Alzamil Ahmed Alhussen Department of Electronics and Communication Engineering Kongu Engineering College638060Tamil NaduIndia Department of Electronics and Communication Engineering Sona College of Technology636005Tamil NaduIndia Department of Computer science and Engineering Sri Sairam Institute of TechnologyChennai600044Tamil NaduIndia Department of Electrical and Electronics Engineering Sri Sairam Institute of TechnologyChennai600044Tamil NaduIndia Department of Computer science and Engineering Sri Venkateswara College of EngineeringSriperumbudur602117Tamil NaduIndia Department of Electrical and Electronics Engineering Sri Venkateswara College of EngineeringSriperumbudur602117Tamil NaduIndia Department of Computer science College of ComputingKhon Kaen UniversityKhonKaen40002Thailand school of Telecommunication Engineering Suranaree University of TechnologyNakhon Ratchasima30000Thailand Department of Computer science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Engineering College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

A brain tumor is a lethal neurological disease that affects the average performance of the brain and can be *** India,around 15 million cases are diagnosed *** mitigate the seriousness of the tumor it is essential to diagnose at the ***,the manual evaluation process utilizing Magnetic Resonance Imaging(MRI)causes a few worries,remarkably inefficient and inaccurate brain tumor ***,the examination process of brain tumors is intricate as they display high unbalance in nature like shape,size,appearance,and ***,a precise and expeditious prognosis of brain tumors is essential for implementing the of an implicit *** computer models adapted to diagnose the tumor,but the accuracy of the model needs to be *** all the above mentioned things,this work aims to identify the best classification system by considering the prediction accuracy out of Alex-Net,ResNet 50,and Inception *** augmentation is performed on the database and fed into the three convolutions neural network(CNN)models.A comparison line is drawn between the three models based on accuracy and *** accuracy of 96.2%is obtained for AlexNet with augmentation and performed better than ResNet 50 and Inception v3 for the 120th *** the suggested model with higher accuracy,it is highly reliable if brain tumors are diagnosed with available datasets.

关键词： AlexNet brain tumor data augmentation inception v3 ResNet 50

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Neuroimmunomodulation by gut bacteria:Focus on inflammatory bowel diseases

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World Journal of Gastrointestinal Pathophysiology 2021年第3期12卷 25-39页

作者： surbhi Aggarwal raju Ranjha Jaishree Paul Department of Biochemical Engineering and Biotechnology Indian Institute of TechnologyDelhi 110016India school of Life sciences Jawaharlal Nehru UniversityDelhi 110067India Field Unit Raipur ICMR-National Institute of Malaria ResearchRaipur 492015ChhattisgarhIndia

Microbes colonize the gastrointestinal tract are considered as highest complex ecosystem because of having diverse bacterial species and 150 times more genes as compared to the human *** or dysbiosis in gut bacteria can cause dysregulation in gut homeostasis that subsequently activates the immune system,which leads to the development of inflammatory bowel disease(IBD).Neuromediators,including both neurotransmitters and neuropeptides,may contribute to the development of aberrant immune *** are emerging as a regulator of inflammatory processes and play a key role in various autoimmune and inflammatory *** may influence immune cell’s function via the receptors present on these *** cytokines secreted by the immune cells,in turn,regulate the neuronal functions by binding with their receptors present on sensory *** bidirectional communication of the enteric nervous system and the enteric immune system is involved in regulating the magnitude of inflammatory *** in gut bacteria influence the level of neuromediators in the colon,which may affect the gastrointestinal inflammation in a disease *** neuromediators concentration via dysbiosis in gut microbiota is one of the novel approaches to understand the pathogenesis of *** this article,we reviewed the existing knowledge on the role of neuromediators governing the pathogenesis of IBD,focusing on the reciprocal relationship among the gut microbiota,neuromediators,and host *** the neuromediators and host-microbiota interactions would give a better insight in to the disease pathophysiology and help in developing the new therapeutic approaches for the disease.

关键词： Inflammation Gut microbiota Inflammatory bowel disease Enteric nervous system Neuroimmunomodulation Neuromediator

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Diagnostic yield of third eye retroscope on adenoma detection during colonoscopy:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2014年第4期2卷 162-170页

作者： Nirav Thosani Bhavana Rao sachin Batra Babatunde Adeyefa Gottumukkala s raju Robert s Bresalier subhas Banerjee sushovan Guha Division of Gastroenterology Hepa-tology and Nutrition The University of Texas Medical School Houston TX 77030 United States Department of Gastroenterology Hepatology and Nutrition The University of Texas MD Anderson Cancer Center Houston TX 77030 United States Department of Gastroen-terology Stanford University Stanford California CA 94305 United States

AIM： To determine the diagnostic yield of the “third eye retroscope”, on adenoma detection rate during screening ***： The “third eye retroscope” when used with standard colonoscopy provides an additional retro-grade view to visualize lesions on the proximal aspects of folds and fexures. We searched MEDLINE （PubMed and Ovid）, sCOPUs （including MEDLINE and EMBAsE databases）, Cochrane Database of systemic Reviews, Google scholar, and CINAHL Plus databases to identify studies that evaluated diagnostic yield of “third eye retroscope” during screening colonoscopy. Dersimonian Laird random effects model was used to generate the overall effect for each outcome. We evaluated statistical heterogeneity among the studies by using the Cochran Q statistic and quantifed by I2 ***： Four distinct studies with a total of 920 pa-tients, mean age 59.83 （95%CI： 56.77-62.83） years, were included in the review. The additional adenoma detection rate （AADR） defined as the number of ad-ditional adenomas identified due to “third eye retro-scope” device in comparison to standard colonoscopy alone was 19.9% （95%CI： 7.3-43.9）. AADR for right and left colon were 13.9% （95%CI： 9.4-20） and 10.7 （95%CI： 1.9-42）, respectively. AADR for polyps ≥ 6 mm and ≥ 10 mm were 24.6% （95%CI： 16.6-34.9） and 24.2% （95%CI： 12.9-40.8）, respectively. The ad-ditional polyp detection rate defined as the number of additional polyps identifed due to “third eye retro-scope” device in comparison to standard colonoscopyalone was 19.8% （95%CI： 7.9-41.8）. There were no complications reported with use of “third eye retro-scope” ***： The “third eye retroscope” device when used with standard colonoscopy is safe and de-tects 19.9% additional adenomas, compared to stan-dard colonoscopy alone.

关键词： Third Eye Retroscope screening colonoscopy Adenoma detection rate Polyp detection rate Additional adenoma detection rate Additional polyp detection rate

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An external quantum efficiency of>20%from solutionprocessed poly(dendrimer)organic light-emitting diodes

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npj Flexible Electronics 2018年第1期2卷 213-218页

作者： Fatemeh Maasoumi Ross D.Jansen-van vuuren Paul E.shaw Emma v.Puttock Ravi Chandra raju Nagiri Jake A.McEwan Mark Bown Jenny L.O’Connell Christopher J.Dunn Paul L.Burn Ebinazar B.Namdas Centre for Organic Photonics&Electronics(COPE) School of Chemistry&Molecular Biosciences and School of Mathematics&PhysicsUniversity of QueenslandSt.LuciaQLD 4072Australia CsIRO Manufacturing Research WayClaytonVIC 3168Australia

Controlling the orientation of the emissive dipole has led to a renaissance of organic light-emitting diode(OLED)research,with external quantum efficiencies(EQEs)of>30%being reported for phosphorescent *** highly efficient OLEDs are generally manufactured using evaporative methods and are comprised of small-molecule heteroleptic phosphorescent iridium(III)complexes blended with a host and additional layers to balance charge injection and *** area OLEDs for lighting and display applications would benefit from low-cost solution processing,provided that high EQEs could be ***,we show that poly(dendrimer)s consisting of a non-conjugated polymer backbone with iridium(III)complexes forming the cores of firstgeneration dendrimer side chains can be co-deposited with a host by solution processing to give highly efficient *** bilayer devices comprising the emissive layer and an electron transport layer gave an EQE of>20%at luminances of up to≈300 cd/m^(2),showing that polymer engineering can enable alignment of the emissive dipole of solution-processed phosphorescent materials.

关键词： quantum dipole light

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Benign neck masses showing restricted diffusion: Is there a histological basis for discordant behavior?

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World Journal of Radiology 2016年第2期8卷 174-182页

作者： Abanti Das Ashu s Bhalla raju sharma Atin Kumar Meher sharma shivanand Gamanagatti Alok Thakar suresh sharma Department of Radiodiagnosis All India Institute of Medical Sciences Department of Pathology All India Institute of Medical Sciences Department of Otolaryn- gorhinology All India Institute of Medical Sciences

Diffusion weighted imaging(DWI) evolved as a complementary tool to morphologic imaging by offering additional functional information about lesions. Although the technique utilizes movement of water molecules to characterize biological tissues in terms of their cellularity, there are other factors related to the histological constitution of lesions which can have a significant bearing on DWI. Benign lesions with atypical histology including presence of lymphoid stroma, inherently increased cellularity or abundant extracellular collagen can impede movement of water molecules similar to malignant tissues and thereby, show restricted diffusion. Knowledge of these atypical entities while interpreting DWI in clinical practice can avoid potential misdiagnosis. This review aims to present an imaging spectrum of such benign neck masses which, owing to their distinct histology, can show discordant behavior on DWI.

关键词： Diffusion weighted imaging Benign neck masses Restricted diffusion

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New Method of Palladium Metal Trapping through Resins in Antiviral Drug: valacyclovir HCl

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International Journal of Organic Chemistry 2013年第4期3卷 251-255页

作者： Keshava Navin Kumar Reddy Murugulla Adharvana Chari Mayur D. Khunt v. v. N. K. v. Prasada raju Bojja Ramachandra Reddy vurimidi Himabindu Ghanta Mahesh Reddy Department of Chemistry Institute of Science and Technology J. N. T. University Kukatpally Hyderabad India Dr. MACs Bio-Pharma Pvt. Ltd. Western Hills Kukatpally Hyderabad India Research and Development Integrated Product Development Innovation Plaza Dr. Reddy’s Laboratories Ltd. Bachupally Quthubullapur India

This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.

关键词： valacyclovir Hydrochloride Antiviral Drug N-Phthalimide-L-valine Ester Monomethylamine Commercially scalable Process Less Cycle Time

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Does deep sedation with propofol affect adenoma detection rates in average risk screening colonoscopy exams?

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World Journal of Gastrointestinal Endoscopy 2017年第4期9卷 177-182页

作者： selvi Thirumurthi Gottumukkala s raju Mala Pande Joseph Ruiz Richard Carlson Katherine B Hagan Jeffrey H Lee William A Ross Department of Gastroen-terology Hepatology and NutritionUniversity of Texas MD Anderson Cancer Center Department of Anesthesiology and Peri Operative Medicine University of Texas MD Anderson Cancer Center

To determine the effect of sedation with propofol on adenoma detection rate (ADR) and cecal intubation rates (CIR) in average risk screening colonoscopies compared to moderate sedation. METHODsWe conducted a retrospective chart review of 2604 first-time average risk screening colonoscopies performed at MD Anderson Cancer Center from 2010-2013. ADR and CIR were calculated in each sedation group. Multivariable regression analysis was performed to adjust for potential confounders of age and body mass index (BMI). REsULTsOne-third of the exams were done with propofol (n = 874). Overall ADR in the propofol group was significantly higher than moderate sedation (46.3% vs 41.2%, P = 0.01). After adjustment for age and BMI differences, ADR was similar between the groups. CIR was 99% for all exams. The mean cecal insertion time was shorter among propofol patients (6.9 min vs 8.2 min; P sIONDeep sedation with propofol for screening colonoscopy did not significantly improve ADR or CIR in our population of average risk patients. While propofol may allow for safer sedation in certain patients (e.g., with sleep apnea), the overall effect on colonoscopy quality metrics is not significant. Given its increased cost, propofol should be used judiciously and without the implicit expectation of a higher quality screening exam.

关键词： sedation Propofol Adenoma detection rate Cecal intubation rate Colonoscopy Quality metrics

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