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Genetic association study of P2x7 A1513C(rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1126-1134页

作者： Eyad M.A.Alshammari raju k.mandal Mohd Wahid Sajad A.Dar Arshad Jawed Mohammed Y.Areeshi Saif khan Md.Ekhlaque Ahmed khan Aditya k.Panda Shafiul Haque Department of Clinical Nutrition College of Applied Medical SciencesUniversity of Ha’il Research and Scientific Studies Unit College of Nursing & Allied Health SciencesJazan University The University College of Medical Sciences & GTB Hospital (University of Delhi) Centre for Life Sciences Central University of Jharkhand

Objective:To summarize the precise association between pulmonary tuberculosis(PTB) and P2x7 A1513 C gene ***:PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513 C polymorphism and PTB risk.A meta-analysis was performed for the selected case-control studies and pooled odds ratios(ORs) and 95%confidence intervals(95%CIs) were calculated for all the genetic ***:Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this *** observed overall no significant risk in all the five genetic *** stratified population by the ethnicity,Caucasian population failed to show any risk of PTB in all the genetics *** Asian ethnicity,variant allele(C vs.A:P=0.001;QR=1.375,95%CI=1.159-1.632) and heterozygous genotype(AC ***:P=0.001;OR=1.570,95%CI=1.269-1.944) demonstrated significant increased risk of ***,recessive genetic model(CC+AC ***:P=0.001;OR=1.540,95%CI= 1.255-1.890) also demonstrated increased risk of PTB in ***:Our meta-analysis did not suggest the association of P2x7 A1513 C polymorphism with PTB risk in overall or separately in Caucasian ***,it plays a significant risk factor for predisposing PTB in *** larger sample and expression studies are needed to validate this association.

关键词： Genetic model Meta-analysis Polymorphism P2x7 gene Pulmonary tuberculosis

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Glacier area change (1993-2019) and its relationship to debris cover, proglacial lakes, and morphological parameters in the Chandra-Bhaga Basin, Western Himalaya, India

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Journal of Mountain Science 2024年第4期21卷 1287-1306页

作者： VATSAL Sarvagya AZAM Mohd Farooq BHARDWAJ Anshuman mandal Arindan BAHUGUNA Ishmohan RAMANATHAN Alagappan raju N.Janardhana TOMAR Sangita Singh Department of Civil Engineering Indian Institute of Technology IndoreSimrol 453552India School of Geosciences University of AberdeenKing’s CollegeAberdeen AB243FXUnited Kingdom Interdisciplinary Centre for Water Research Indian Institute of ScienceBengaluru 560012India Space Application Centre Ahmedabad 380015India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography Norwegian University of Science and TechnologyTrondheim No-7491Norway

Glacier inventories serve as critical baseline data for understanding the impacts of climate change on *** present study maps the outlines of glaciers in the Chandra-Bhaga Basin(western Himalaya)for the years 1993,2000,2010,and 2019 using Landsat Thematic Mapper(TM),Enhanced Thematic Mapper(ETM),and Operational Land Imager(OLI)datasets.A total of 251 glaciers,each having an area above 0.5 km^(2),were identified,which include 216 clean-ice and 35 debris-covered *** changes are estimated for three periods:1993-2000,2000-2010,and *** total glacierized area was 996±62 km^(2) in 1993,which decreased to 973±70 km^(2) in *** mean rate of glacier area loss was higher in the recent decade(2010-2019),at 0.036 km^(2),compared to previous decades(0.029 km^(2) in 2000-2010 and 0.025 km^(2) in 1993-2000).Supraglacial debris cover changes are also mapped over the period of 1993 and *** is found that the supraglacial debris cover increased by 14.12±2.54 km^(2)(15.2%)during *** field surveys on Chhota Shigri,Panchi II,Patsio,Hamtah,Mulkila,and Yoche Lungpa glaciers were carried out to validate the glacier outlines and supraglacial debris cover estimated using satellite *** of various morphological parameters on retreat were also *** is observed that small,clean ice,south oriented glaciers,and glaciers with proglacial lakes are losing area at faster rates than other glaciers in the basin.

关键词： Glacier Area change Debris cover Morphology Proglacial lake

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Enhancement of Solar PV Panel Efficiency Using Double Integral Sliding Mode MPPT Control

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Tsinghua Science and Technology 2024年第1期29卷 271-283页

作者： Immadisetty Rahul raju Hariharan Department of Electrical and Electronics Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 602105India

The extraction of maximum power from the solar panels,using the sliding mode control scheme,becomes popular for partial weather atmospheric conditions due to its effective dynamic duty cycle ***,the sliding mode control scheme was sophisticated with single integral and double integral sliding mode control scheme,which offer enhanced maximum power extraction and support enhanced solar panel efficiency in partial weather *** operation of the sliding mode control scheme depends on the selection of a sliding surface selection based on the atmospheric weather condition,which enables the effective sliding duty cycle ratio operation for the DC/DC boost *** duty cycle ratio of the sliding mode control resembles the usual dynamic behavior to achieve enhanced efficiency compared to the various maximum power point tracking(MPPT)*** major limitation of the sliding mode control scheme is to achieve the steady state voltage error of the solar panel in minimum settling time *** single integral sliding mode control scheme achieves the expected steady state voltage error limit but fails to achieve minimum settling time ***,the single integral sliding mode control is extended to a double integral sliding mode control scheme to achieve both steady state voltage error limits within the minimum settling time *** double integral sliding mode control scheme allows us to obtain the higher sliding surface duty cycle ratio which acts as the input signal to the boost *** activates the enhanced stable and reliable system operation,and nullifies the lacuna of maximum solar panel efficiency under partial weather ***,this paper aims to present the design and performance operation of the double integral sliding mode(DISM)MPPT control *** validate the performance analysis of the proposed DISM MPPT control scheme,the MATLAB/Simulink model is designed and ***,the performance analysis of the pr

关键词： maximum power point tracking(MPPT)schemes sliding mode controller(SMC) double integral sliding mode controller(DISMC) pulse width modulation(PWM) photovoltaic(PV)system

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Extended Deep Learning Algorithm for Improved Brain Tumor Diagnosis System

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Intelligent Automation & Soft Computing 2024年第1期39卷 33-55页

作者： M.Adimoolam k.Maithili N.M.Balamurugan R.Rajkumar S.Leelavathy raju kannadasan Mohd Anul Haq Ilyas khan ElSayed M.Tag El Din Arfat Ahmad khan Department of Computer Engineering Government Polytechnic CollegeSevvapetTiruvallurTamil Nadu602025India Department of Computer Science and Engineering KG Reddy College of Engineering and TechnologyHyderabadTelangana500075India Department of Computer Science and Engineering Sri Venkateswara College of EngineeringSriperumbudurChennai602117India Department of Computer Science and Engineering Annamalai UniversityChidambaramTamil Nadu608002India Department of Computer Science and Engineering Aarupadai Veedu Institute of TechnologyVinayaka Mission Research FoundationPaiyanurTamil Nadu603104India Department of Electrical and Electronics Engineering Sri Venkateswara College of EngineeringSriperumbudur602117India Department of Computer Science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia Electrical Engineering Department Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer Science College of ComputingKhon Kaen UniversityKhon Kaen40002Thailand

At present,the prediction of brain tumors is performed using Machine Learning(ML)and Deep Learning(DL)*** various ML and DL algorithms are adapted to predict brain tumors to some range,some concerns still need enhancement,particularly accuracy,sensitivity,false positive and false negative,to improve the brain tumor prediction system ***,this work proposed an Extended Deep Learning Algorithm(EDLA)to measure performance parameters such as accuracy,sensitivity,and false positive and false negative *** addition,these iterated measures were analyzed by comparing the EDLA method with the Convolutional Neural Network(CNN)way further using the SPSS tool,and respective graphical illustrations were *** results were that the mean performance measures for the proposed EDLA algorithm were calculated,and those measured were accuracy(97.665%),sensitivity(97.939%),false positive(3.012%),and false negative(3.182%)for ten *** in the case of the CNN,the algorithm means accuracy gained was 94.287%,mean sensitivity 95.612%,mean false positive 5.328%,and mean false negative 4.756%.These results show that the proposed EDLA method has outperformed existing algorithms,including CNN,and ensures symmetrically improved *** EDLA algorithm introduces novelty concerning its performance and particular activation *** proposed method will be utilized effectively in brain tumor detection in a precise and accurate *** algorithm would apply to brain tumor diagnosis and be involved in various medical diagnoses *** the quantity of dataset records is enormous,then themethod’s computation power has to be updated.

关键词： Brain tumor extended deep learning algorithm convolution neural network tumor detection deep learning

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High Strain-Rate and Shock Response of Carbon SupercompositeTM

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Open Journal of Composite Materials 2024年第3期14卷 132-145页

作者： Suman Babu Ukyam raju P. Mantena Damian L. Stoddard Arunachalam M. Rajendran Department of Mechanical Engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynamic behaviors of carbon SupercompositeTM laminates when subjected to high strain-rates and air blast loads, using a shock tube for testing. The investigation aims to understand the response of these advanced materials under extreme conditions, which is crucial for applications in aerospace, military, and other high-performance industries. SupercompositeTM (CZE) prepreg, made up of a 3k plain weave carbon fabric with milled carbon fibers as interlaminar reinforcements impregnated with epoxy, is used to create SupercompositeTM (CZE) laminates. A woven carbon composite (CBE) laminate was also created using 3k plain weave Carbon/Epoxy (CBE) prepreg. Both types of laminates were designed and fabricated using the autoclave process. The dynamic behaviors of CZE and CBE laminate under transverse compression loads were evaluated using a modified Split Hopkinson Pressure Bar (SHPB). The study found that the 3D reinforcement with milled carbon fibers significantly affected the dynamic behavior of the CZE laminate. Stereo imaging videos, captured using two SHIMADZU high-speed video cameras in shock tube experiments, recorded the time history of back surface deflection. The plate specimens exhibited low deflections without any visible damage. The experimentally observed center point deflections of the CZE plates decayed sooner than those of the CBE laminates, indicating an improvement in damping due to the presence of 3D reinforced milled carbon fibers. This research shows that optimized utilization of milled carbon fibers as 3D reinforcement can withstand high stress in the thickness direction and higher energy absorption when subjected to impact and high strain-rate loading.

关键词： SupercompositeTM GOM Software 3D Reinforcement Milled Carbon Fibers Split Hopkinson Pressure Bar (SHPB) Air-Blast Loads

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Elastic scattering of ^(13)C and ^(14)C isotopes on a ^(208)Pb target at energies of approximately five times the Coulomb barriers

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Chinese Physics C 2024年第3期48卷 65-71页

作者：杨过段芳芳王康杨彦云孙志宇 Valdir Guimarães 庞丹阳陈文棣金磊许世伟马军兵马朋白真汪凌昊刘泉王惠仁吕冰锋郭松 Mukhi kumar raju 王秀华李荣华张玉虎周小红胡正国徐瑚珊 CAS key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100080China Instituto de Física Universidade de São PauloRua do Matão1371São Paulo 05508-090SPBrazil School of Physics and Beijing key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics Science and Engineering Tongji UniversityShanghai 200092China School of physics and Optoelectronic Engineering Anhui UniversityHefei 230601China Department of Physics GITAM School of ScienceGITAM UniversityVisakhapatnam 530045India

The elastic scattering angular distributions of ^(13)C at 340 MeV and ^(14)C at 294 MeV and 342 MeV on a ^(208)Pb target,which correspond to approximately five times the Coulomb barriers,were measured at the Radioactive Ion Beam Line in *** data were analyzed within the optical model and continuum-discretized coupled-channels(CDCC)framework,and the results of both calculations could effectively account for the experimental *** differential cross sections of elastic scattering revealed no particular suppression at the Coulomb nuclear interference peak angles,suggesting that the breakup coupling effects on the elastic scattering angular distributions were negligibly small in this incident energy *** contributions from the couplings with inelastic states to the elastic cross sections were of minor importance within the angular range covered by these experiments.

关键词： elastic scattering radioactive ion beam angular distribution optical model coupling effects

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Assessment of Cross-coupling Effects in PV String-integrated-converters with P&O MPPT Algorithm Under Various Partial Shading Patterns

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CSEE Journal of Power and Energy Systems 2022年第4期8卷 1013-1028页

作者： Suneel raju Pendem Suresh Mikkili the Electrical and Electronics Engineering Department National Institute of Technology GoaPonda 403401India

A signifcant challenge in the progress and development of Building-Integrated-Photovoltaic(B-I-PV)systems is concerned with the extraction of maximum power from PV *** PV system archtecture is an essential feature to extract the maximum *** conventional PV-centralinverter architecture consists of various connections among the PV modules,which are sensitive to shading effects and pro-duces mismatching power loss under partial shading conditions(PSCs),Hence,photovoltaic-distributed-maximum power point tracking(PV-D-MPPT)architecture has been proposed to extract the maximum ***-1 D-MPPT architecture,the output terminals of DC-DC converters are connected either in series or parallel *** main limitation of the series configuration in open-loop MPPT control is the crosscoupling *** of cross-coupling effects,the maximum-power-point(M-P-P)operation of shaded PV modules is lost under *** lost in M-P-P operation of shaded PV module also affects the unshaded modules M-P-P *** crosscoupling ffeets,the DC-DC converters are consuming the power instead of delivering to the *** the research activity,there are hardly any papers presenting a clear,comprehensive and mathematical analysis on the existence of cross-couplings in PV string-integrated-converters(S-1-Cs).This article presents a mathematical analysis and also explains the conditions for the existent of cross-coupling *** experimental results also validate with the mathematically analysed *** article also discusses the modeling of the two-diode model of PV module,design of boost type S-1C,and the Perturb and Observe(P&O)MPPT algorithm implementation.

关键词： Cross-coupling ffects mismatching power loss partial shading conditions(PSCs) PV-central-inverter architecture PV-D-MPPT architecture S-I-Cs series configuration

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Estimating aquifer transmissivity using Dar-Zarrouk parameters to delineate groundwater potential zones in Alluri Seetharama raju District,Andhra Pradesh, India

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Journal of Groundwater Science and Engineering 2023年第2期11卷 116-132页

作者： Bakuru Anandagajapathi raju Palavai Venkateswara Rao Mangalampalli Subrahmanyam Department of Geophysics Colleges of Science&TechnologyAndhra UniversityVisakhapatnam 530003Andhra PradeshIndia

This study aimed to explore groundwater potential zones in the EGMB of Alluri Seetharama raju district, Andhra Pradesh, India, for drinking and agriculture purposes. To achieve this goal, 72 Vertical Electrical Soundings(VES) were conducted using the Schlumberger electrode configuration. The resistivity sounding data were analyzed to determine the aquifer thickness, basement depth, Dar-Zarrouk parameters,and aquifer transmissivity. Spatial distribution maps were generated for these parameters to understand the subsurface formation. The analysis revealed a linear groundwater potential zone(8.46 km~2) in the eastern part of the study area, extending in the NNE-SSW direction for 9.6 km. Six VES locations(P24, P27, P29,P30, P33, and P38) in this zone exhibit good potential(>30 m aquifer thickness), while the three VES locations(OP19, P5, and P46) in the central region are recommended for drilling bore wells. Additionally,moderate aquifer thickness(20–30 m) are identified in other VES locations(OP14, OP20, P4, P10, P12,P13, P15, P17, P18, P31, P46, and P50) along streams in the western and central part of the area, which can yield reasonable quantities of water. This information is useful for groundwater exploration and watershed management to meet the demands of tribal population in the study area.

关键词： Vertical electrical sounding Longitudinal conductance Transverse resistance Coefficient of anisotropy Potential groundwater locations

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Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

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Nano-Micro Letters 2022年第6期14卷 248-281页

作者： Arpana Parihar Ayushi Singhal Neeraj kumar raju khan MohdAkram khan Avanish kSrivastava Industrial Waste Utilization Nano and BiomaterialsCSIR-Advanced Materials and Processes Research Institute(AMPRI)Hoshangabad RoadBhopal 462026MPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India

Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of ***,2 D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of *** high surface area,surface functional groups availability,and excellent electrical conductivity of MXene make it the 2 D material of choice for the fabrication of advanced electrochemical biosensors for disease ***-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of ***,the stability,ease of synthesis,good reproducibility,and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic *** this review,the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been ***,various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been ***,futuristic sensing applications along with challenges will be deliberated herein.

关键词： MXene Electrochemical devices POCT Aptamer Cancer diagnostics

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Computational Fluid Dynamics Study of a Compound Flow Field for Proton Exchange Membrane Fuel Cell(PEMFC) Performance Enhancement

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Journal of Thermal Science 2022年第6期31卷 2374-2384页

作者： Venkateswarlu VELISALA Gandhi PULLAGURA Naveen kumar CHINNAM raju GANTA Automobile Engineering Section Damacharla Anjaneyulu Government PolytechnicOngole 523002Andhra PradeshIndia GITAM Institute of Technology Visakhapatnam 530045Andhra PradeshIndia Vishnu Institute of Technology Bhimavaram 534202Andhra PradeshIndia BVC Engineering College Odalarevu 533210Andhra PradeshIndia

The aim of the present work is to evaluate proton exchange membrane(PEM) fuel cell performance with a modified serpentine flow field with right angle turn by numerical modeling. A 3-D PEM fuel cell model of size 50 cm^(2) active area is developed. A conventional serpentine flow field is modified and the same is considered for the supply of reactants. Computational fluid dynamics(CFD) based simulations were conducted to analyse the pressure drop, distribution of reactants(H_(2) and O_(2)), liquid water activity, current flux density and water content in the membrane. From the simulation results, polarization curve is drawn to validate the literature data of PEMFC with the conventional serpentine flow field. Comparison of simulated polarization curve with literature data revealed that modified serpentine flow field performance is better than conventional serpentine flow field as it offers better water exclusion and uniform sharing of reactants. From this study, it is concluded that model of flow field pattern influences the functioning of fuel cell and utmost care must take while selecting a pattern for flow field of PEM fuel cell.

关键词： PEM fuel cell CFD current density water removal modified serpentine flow field membrane water content

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