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Phytochemicals as therapeutics against COVID-19: An in-silico study

Microenvironment & Microecology Research 2021年第3期3卷 14-19页

作者： Debraj Koiri Ditam Chakraborty Pranotosh Das rajkumar rana Soumyanil Chatterjee Tanmoy Das Paltu Kumar Dhal Department of Life Science and Biotechnology Jadavpur UniversityKolkata-700032West BengalIndia. Department of Life Science and Biotechnology Jadavpur University188 Raja S.C.Mullick RoadKolkata-700032West BengalIndia.

Since December 2019,the worldwide spread of COVID-19 has brought the majority of the world to a standstill,affecting daily lives as well as *** these conditions,it is imperative to develop a cure as soon as *** account of some of the adverse side effects of the existing conventional drugs,researchers all around the world are screening natural antiviral phytochemicals as potential therapeutic agents against *** paper aims to review interactions of some specific phytochemicals with the receptor binding domain(RBD)of the Spike glycoprotein of SARS-CoV-2 and suggest their possible therapeutic *** search was done based on the wide array of in-silico studies conducted using broad spectrum phytochemicals against SARS-CoV-2 and other viruses.26 such phytochemicals specifically targeting the S protein and its interactions with host receptors were shortlisted *** validate the previously published results,molecular docking was performed using the AutoDock Vina application and 6 high potential phytochemicals were identified for therapeutic use based on their binding *** this,availability of these compounds,their mode of action,toxicity data and cost-effectiveness were also taken into *** review specifically identifies 6 phytochemicals that can be used as potential treatments for COVID-19 based on their availability,toxicology results and low costs of ***,all these compounds need to be further validated by wet lab experiments and should be approved for clinical use only after appropriate trials.

关键词： Phytochemicals SARS-CoV-2 S-Protein Molecular docking ACE 2

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