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Applications of nanotechnology in medical field: a brief review

Global Health Journal 2023年第2期7卷 70-77页

作者： Abid Haleem Mohd Javaid Ravi Pratap Singh Shanay Rab rajiv Suman Department of Mechanical Engineering Jamia Millia IslamiaNew DelhiIndia Department of Mechanical Engineering National Institute of TechnologyKurukshetraHaryanaIndia School of Architecture Technology and EngineeringUniversity of BrightonUnited Kingdom Department of Industrial and Production Engineering G.B.Pant University of Agriculture & TechnologyPantnagarUttarakhandIndia

Nanotechnology has extensive application as nanomedicine in the medical *** nanoparticles have possible applications in novel diagnostic instruments,imagery and methodologies,targeted medicinal products,pharmaceutical products,biomedical implants,and tissue *** treatments of high toxicity can be administered with improved safety using nanotechnology,such as chemotherapeutic cancer ***,wearable gadgets can detect crucial changes in vital signs,cancer cell conditions,and infections that are genuinely happening in the *** anticipate these technologies to provide doctors with considerably much better direct access to critical data on the reasons for changes in the signs of life or illness because of the technological presence at the source of the *** can be utilised for therapies with predictive analytics and artificial *** carrying out this study,relevant papers on Nanotechnology in the medical field from Scopus,Google scholar,ResearchGate,and other research platforms are identified and *** study discusses different types of Nanoparticles used in the medical *** paper discusses nanotechnology applications in the medical *** class,features,and characteristics of Nanotechnology for medicine are also ***,governments,civil society organisations,and the general public will need to collaborate across sectors to assess the significance of nanotechnology and guide its advancement in various *** current research includes several possible Nanotechnology uses in the medical *** a result,the study provides a brief and well-organised report on nanotechnology that should be valuable to researchers,engineers,and scientists for future research projects.

关键词： Nanotechnology Nanomedicine Nanoparticles Medical Treatment

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challenging Youth Employment

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中印对话（英文版） 2022年第3期 48-51页

作者： rajiv Ranjan School of Humonities at K.R.Mangalam University in Gurugram HaryanoIndia

Chinese and Indian youth are struggling to live the life of their dreams and seek a secure future amid all the challenges at home and *** also have extra responsibility to redefine the civilizational journey of their ... 详细信息

关键词： dreams challenging civilization

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Zinc alpha 2 glycoprotein(ZAG):A potential novel pharmacological target in diabetic retinopathy

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BIOCELL 2023年第7期47卷 1473-1482页

作者： UMAPATHY PRAKASH SUBRAMANIAM RAJESH BHARATHIDEVI RAMYA RNADIG rajiv R.AMAN GIRISH SHIV RAO MUNA BHENDE R.S.Mehta Jain Department of Biochemistry and Cell Biology KNBIRVOVision Research FoundationSankara NethralayaChennai600006India Shri Bhagwan Mahavir Vitreoretinal Services Sankara NethralayaChennai600006India

Zinc alpha 2 glycoprotein(ZAG)is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum,saliva,sweat,breast milk,and *** is also found in tissues like the testis,epididymis,kidney,spleen,liver,lungs,heart,and *** is an adipokine with multiple roles,including lipid mobilization,modulating glucose metabolisms,improving insulin sensitivity,inhibiting tumor proliferation through RNAse activity,and suppressing *** levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential biomarkers for diabetic *** zinc has been found to regulate the binding of ZAG to fatty *** on very few reports on the vitreous ZAG and based on its known functions,we speculate that ZAG has a potential role in diabetic *** this article,we discuss the structural component of the protein,its secretion from various tissues,and its distribution in multiple tissues in normal and disease conditions,especially in diabetes and its complications.

关键词： ZAG Lipolysis Inflammation Insulin resistance

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Recalibrating China's Economic Growth

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中印对话（英文版） 2023年第1期 4-6页

作者： rajiv Ranjan Department of Chinese School of Humanities at India's K.R.Mangalam University

The 2022 Central Economic Work Conference was particularly *** goal of policy brainstorming was to benefit China as well as the world.

关键词： policy benefit Economic

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Energy and Bandwidth Based Link Stability Routing Algorithm for IoT

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Computers, Materials & Continua 2022年第2期70卷 3875-3890页

作者： D.Kothandaraman A.Balasundaram R.Dhanalakshmi Arun Kumar Sivaraman S.Ashokkumar rajiv Vincent M.Rajesh School of Computer Science and Artificial Intelligence SR UniversityWarangalTSIndia School of Computer Science and Engineering Center for Cyber Physical SystemsVellore Institute of Technology(VIT)ChennaiIndia Department of Computer Science and Engineering KCG College of TechnologyChennaiIndia School of Computer Science and Engineering Vellore Institute of Technology(VIT)ChennaiIndia Department of Computer Science and Engineering Saveetha School of EngineeringSIMATSChennaiIndia

Internet of Things(IoT)is becoming popular nowadays for collecting and sharing the data from the nodes and among the nodes using internet ***,some of the nodes in IoT are mobile and dynamic in *** maintaining the link among the nodes,efficient bandwidth of the links among the mobile nodes with increased life time is a big challenge in IoT as it integrates mobile nodes with static nodes for data *** such networks,many routing-problems arise due to difficulties in energy and bandwidth based quality of *** to the mobility and finite nature of the nodes,transmission links between intermediary nodes may fail frequently,thus affecting the routing-performance of the network and the accessibility of the *** existing protocols do not focus on the transmission links and energy,bandwidth and link stability of the nodes,but node links are significant factors for enhancing the quality of the *** stability helps us to define whether the node is within or out of a coverage *** paper proposed an Optimal Energy and bandwidth based Link Stability Routing(OEBLS)algorithm,to improve the link stable route with minimized error rate and *** this paper,the optimal route from the source to the sink is determined based on the energy and bandwidth,link stability *** the existing routes,the sink node will choose the optimal route which is having less link stability *** stable link is determined by evaluating link stability value using distance and ***-energy of the node is estimated using the current energy and the consumed *** energy is estimated using transmitted power and the received *** bandwidth in the link is estimated using the idle time and channel capacity with the consideration of probability of collision.

关键词： Link stability internet of things optimal energy optimal bandwidth residual energy

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First Total Synthesis and Biological Potential of a Heptacyclopeptide of Plant Origin

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Chinese Journal of Chemistry 2016年第11期34卷 1158-1164页

作者： rajiv Dahiya Sunil Singh Laboratory of Peptide Research and Development School of Pharmacy Faculty of Medical Sciences The University of the West Indies St. Augustine Trinidad & Tobago West Indies Research Scholar Department of Pharmacy Mewar University Gangrar Chittorgarh Rajasthan India

Synthesis of a natural glycine-rich heptacyclopeptide mahafacyclin A （7） was accomplished by solution-phase technique of peptide synthesis via coupling of tetrapeptide unit Boc-L-Thr-L-Ile-L-Leu-Gly-OH with tripeptide unit L-Val-L-Phe-Gly-OMe followed by cyclization of linear heptapeptide fragment. Structure of the newly synthesized cyclopolypeptide was confirmed by means of chemical, spectroscopic analyses and subjected to antibacterial, antifungal and anthelmintic activity studies. Bioactivity results showed potent antifungal and anthelmintic activities of the synthesized peptide against dermatophytes T. mentagrophytes, M. audouinii and earthworm species M. kon-kanensis, P. corethruses and E. eugeniea.

关键词： Jatropha mahafalensis peptide synthesis cyclopolypeptide natural product pharmacological activity

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Synthesis and Pharmacological Studies on a Cyclooligopeptide from Marine Bacteria

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Chinese Journal of Chemistry 2011年第9期29卷 1911-1916页

作者： rajiv, Dahiya Hemendra, Gautam Department of Pharmaceutical Chemistry Globus College of Pharmacy Bhojpur Road Bhopal-462 045 Madhya Pradesh India Department of Pharmacology Institute of Pharmacy Invertis University Bareilly-243 123 Uttar Pradesh India

A natural proline-rich tetrapeptide cyclo-prolyl-leucyl-prolyl-phenylalanyl was prepared employing solu- tion-phase method of peptide synthesis through coupling of dipeptide fragments Boc-l-Pro-l-Leu-OH and 1-Pro-l-Phe-OMe which utilizes diisopropylcarbodiimide （DIPC） as coupling agent and N-methylmorpholine （NMM） as the base. Deprotection of linear tetrapeptide unit followed by its cyclization provided a cyclopeptide, identical in all aspects to the natural molecule. Pharmacological evaluation showed cytotoxic, antifungal and antihelmintic po- tential of synthesized peptide against Dalton＇s Lymphoma Ascites （DLA） and Ehrlich＇s Ascites Carcinoma （EAC） cell lines, pathogenic dermatophytes and earthworms.

关键词： marine bacteria natural product solution phase synthesis peptides biological activity cytotoxicity

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Synthetic and biological studies on a cyclopolypeptide of plant origin

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第5期9卷 391-400页

作者： rajiv DAHIYA Akhilesh KUMAR Department of Pharmaceutical Chemistry Rajiv Academy for Pharmacy

Objective:A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling of tetrapep-tide units Boc-Leu-Pro-Trp-Leu-OMe and Boc-Ile-Ala-Ala-Gly-OMe after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment. Methods:Solution phase technique was adopted for the synthesis of cyclooctapeptide-sarcodactylamide. Required tetrapeptide units were prepared by coupling of Boc-protected dipeptides viz. Boc-Leu-Pro-OH and Boc-Ile-Ala-OH with respective dipeptide methyl esters Trp-Leu-OMe and Ala-Gly-OMe. Cyclization of linear octapeptide unit was done by p-nitrophenyl ester method. The structure of synthesized cyclopolypeptide was elucidated by FTIR,1H NMR,13C NMR,FABMS spectral data and elemental analysis. The newly synthesized peptide was evaluated for dif-ferent pharmacological activities including antimicrobial,anthelmintic and cytotoxic activities. Results:Synthesis of sarcodac-tylamide was accomplished with >78% yield utilizing dicyclohexylcarbodiimide(DCC) as coupling agent. Newly synthesized peptide possessed potent cytotoxic activity against Dalton's lymphoma ascites(DLA) and Ehrlich's ascites carcinoma(EAC) cell lines,in addition to moderate anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses and Eudrilus sp. Moreover,cyclopolypeptide displayed good antimicrobial activity against pathogenic fungi Candida albicans and Gram-negative bacteria Pseudomonas aeruginosa,in comparison to standard drugs griseofulvin and ciprofloxacin. Conclusion:Solution phase technique employing DCC and triethylamine(TEA) as base proved to be effective for the synthesis of natural cyclooctapeptide. N-methyl morpholine(NMM) was found to be a better base for the cyclization of linear octapeptide unit in comparison to TEA and pyridine.

关键词：循环八肽多肽化合物植物起源生物学

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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5159-5183页

作者： Vivek Panwar Aishwarya Singh Manini Bhatt rajiv K.Tonk Shavkatjon Azizov Agha Saquib Raza Shinjinee Sengupta Deepak Kumar Manoj Garg Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesShoolini UniversitySolanHimachal Pradesh173229India Amity Institute of Molecular Medicine and Stem Cell Research(AIMMSCR) Amity University Uttar PradeshSector-125NoidaUttar Pradesh201313India Department of Biomedical Engineering Indian Institute of TechnologyRoparPunjab140001India Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)New Delhi110017India Laboratory of Biological Active Macromolecular Systems Institute of Bioorganic ChemistryAcademy of Sciences UzbekistanTashkent100125Uzbekistan Faculty of Life Sciences Pharmaceutical Technical University100084TashkentUzbekistan rajive Gandhi Super Speciality Hospital TahirpurNew Delhi110093India

The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular *** mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating *** signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor *** emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human ***,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and ***,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR ***,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug ***,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.

关键词： metabolism homeostasis mTOR

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Optical anisotropy and the direction of polarization of exciton emissions in a semiconductor quantum dot:Effect of heavy-and light-hole mixing

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Chinese Physics B 2017年第8期26卷 400-406页

作者： Ranber Singh rajiv Kumar Vikramjeet Singh Department of Physics Sri Guru Gobind Singh CollegeSector 26Chandigarh 160019India Department of Physics DAV University JalandharPunjab 144012India IKGPTU Campus HoshiarpurPunjab 146001India

The dependence of the directions of polarization of exciton emissions, fine structure splittings （FSS）, and polarization anisotropy on the light- and heavy-hole （LH-HH） mixing in semiconductor quantum dots （QDs） is investigated using a mesoscopic model. In general, all QDs have a four-fold exciton ground state. Two exciton states have directions of polarization in the growth-plane, while the other two are along the growth direction of the QD. The LH-HH mixing does affect the FSS and polarization anisotropy of bright exciton states in the growth-plane in the low symmetry QDs （e.g., C2v, CS, C1 ）, while it has no effect on the FSS and polarization anisotropy in high symmetry QDs （e.g., C3V, D2d）. When the hole ground state is pure HH or LH, the bright exciton states in the growth-plane are normal to each other. The LH-HH mixing affects the relative intensities and directions of bright exciton states in the growth-plane of the QD. The polarization anisotropy of exciton emissions in the growth-plane of the QD is independent of the phase angle of LH-HH mixing but strongly depends on the magnitude of LH-HH mixing in low symmetry QDs.

关键词： light-heavy hole mixing excitons quantum dots

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