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World Journal of Gastroenterology 2021年第46期27卷 7925-7942页

作者： Koushik Roy Sidra Agarwal rajib banerjee Manash K Paul Prabhat K Purbey Microbiology and Immunology Department of PathologySchool of MedicineUniversity of UtahSalt Lake CityUT 84112United States Department of Gastroenterology Shadan Institute of Medical SciencesPeeramcheru 500086TelanganaIndia Department of Electronics and Communication Engineering Dr.B.C.Roy Engineering CollegeDurgapur 713206West BengalIndia Division of Pulmonary and Critical Care Medicine David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90095United States Department of Microbiology Immunology and Molecular GeneticsUniversity of California Los AngelesLos AngelesCA 90095United States

The disease coronavirus disease 2019(COVID-19)is a severe respiratory illness that has emerged as a devastating health problem *** disease outcome is heterogeneous,and severity is likely dependent on the immunity of infected individuals and *** symptoms of the disease are primarily associated with respiratory problems,additional infection or failure of other vital organs are being *** reports suggest a quite common co-existence of gastrointestinal(GI)tract symptoms in addition to respiratory symptoms in many COVID-19 patients,and some patients show just the GI *** possible cause of the GI symptoms could be due to direct infection of the epithelial cells of the gut,which is supported by the fact that(1)The intestinal epithelium expresses a high level of angiotensin-converting enzyme-2 and transmembrane protease serine 2 protein that are required for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into the cells;(2)About half of the severe COVID-19 patients show viral RNA in their feces and various parts of the GI tract;and(3)SARS-CoV-2 can directly infect gut epithelial cells in vitro(gut epithelial cells and organoids)and in vivo(rhesus monkey).The GI tract seems to be a site of active innate and adaptive immune responses to SARS-CoV-2 as clinically,stool samples of COVID-19 patients possess proinflammatory cytokines(interleukin 8),calprotectin(neutrophils activity),and immunoglobulin A *** addition to direct immune activation by the virus,impairment of GI epithelium integrity can evoke immune response under the influence of systemic cytokines,hypoxia,and changes in gut microbiota(dysbiosis)due to infection of the respiratory system,which is confirmed by the observation that not all of the GI symptomatic patients are viral RNA *** review comprehensively summarizes the possible GI immunomodulation by SARS-CoV-2 that could lead to GI symptoms,their association with disease sev

关键词： COVID-19 Gastrointestinal symptoms Pathogenesis Innate immune response Adaptive immune response Gut microbiota Dysbiosis Therapeutics Probiotic Pre-existing diseases

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Microbial leaching of chromite overburden from Sukinda mines,Orissa,India using Aspergillus niger

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International Journal of Minerals,Metallurgy and Materials 2013年第8期20卷 705-712页

作者： Supratim Biswas Saikat Samanta rajib Dey Siddhartha Mukherjee Pataki C.banerjee Department of Metallurgical and Material Engineering Jadavpur UniversityKolkata-700032India School of Materials Science and Nanotechnology Jadavpur UniversityKolkata-700032India

Leaching of nickel and cobalt from two physical grades （S1, 125-190 μm, coarser and S3, 53-75 μm, finer） of chromite overburden was achieved by treating the overburden （2% pulp density） with 21-d culture filtrate of an Aspergillus niger strain grown in sucrose medium. Metal dissolution increases with ore roasting at 600℃ and decreasing particle size due to the alteration of microstructural properties involving the conversion of goethite to hematite and the increase in surface area and porosity as evident from X-ray diffraction （XRD）, thermogravimetry-differential thermal analysis （DT- TGA）, and field emission scanning electron microscopy （FESEM）. About 65% Ni and 59% Co were recovered from the roasted S3 ore employing bioleaching against 26.87% Ni and 31.3% Co using an equivalent amount of synthetic oxalic acid under identical conditions. The results suggest that other fungal metabolites in the culture filtrate played a positive role in the bioleaching process, making it an efficient green approach in Ni and Co recovery from lateritic chromite overburden.

关键词： nickeliferous laterite bioleaching Aspergillus niger chromite nickel metallurgy cobalt metallurgy

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Extracorporeal blood purification strategies in sepsis and septic shock:An insight into recent advancements

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World Journal of Critical Care Medicine 2023年第2期12卷 71-88页

作者： Yatin Mehta rajib Paul Abdul Samad Ansari Tanmay banerjee Serdar Gunaydin Amir Ahmad Nassiri Federico Pappalardo Vedran Premužić Prachee Sathe Vinod Singh Emilio Rey Vela Institute of Critical Care and Anesthesiology Medanta the MedicityGurugram 12201India Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Internal Medicine&Critical Care Medica Institute of Critical Care MedicineMedica Superspecialty HospitalKolkata 700099India Department of Cardiovascular Surgery University of Health SciencesAnkara City Hospital CampusAnkara 06933Turkey Department of Nephrology Shahid Beheshti University of Medical SciencesTehran 19839-63113Iran Cardiothoracic and Vascular Anesthesia and Intensive Care AO SS Antonio e Biagio e Cesare ArrigoAlessandria 15121Italy Department of Nephrology Clinical Hospital ZagrebClinic for internal diseasesZagreb 10000Croatia Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Institute of critical care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Cardiac Surgery Intensive Care Unit Samaritan University HospitalBogotá11Colombia

BACKGROUND Despite various therapies to treat sepsis,it is one of the leading causes of mortality in the intensive care unit patients *** about the pathophysiology of sepsis has sparked interest in extracorporeal therapies(ECT)which are intended to balance the dysregulation of the immune system by removing excessive levels of inflammatory *** To review recent data on the use of ECT in sepsis and to assess their effects on various inflammatory and clinical *** In this review,an extensive English literature search was conducted from the last two decades to identify the use of ECT in sepsis.A total of 68 articles from peer-reviewed and indexed journals were selected excluding publications with only *** Results showed that ECT techniques such as high-volume hemofiltration,coupled plasma adsorption/filtration,resin or polymer adsorbers,and CytoSorb®are emerging as adjunct therapies to improve hemodynamic stability in ***®has the most published data in regard to the use in the field of septic shock with reports on improved survival rates and lowered sequential organ failure assessment scores,lactate levels,total leucocyte count,platelet count,interleukin-IL-6,IL-10,and TNF *** Clinical acceptance of ECT in sepsis and septic shock is currently still limited due to a lack of large random clinical *** addition to patient-tailored therapies,future research developments with therapies targeting the cellular level of the immune response are expected.

关键词： CytoSorb® Hemadsorbers Inflammatory mediators Extracorporeal therapies Sepsis

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