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Abundance of Carbonic Fluid Inclusions in Hira-Buddini Gold Deposit, Hutti-Maski Greenstone Belt, India: Inferences from Petrography and Volume Ratio Estimation of Fluid Components

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Journal of Earth Science 2020年第3期31卷 492-499页

作者： Rajagopal Krishnamurthi Ajit Kumar Sahoo rajesh Sharma Prabhakar Sangurmath Department of Earth Sciences Indian Institute of TechnologyRoorkeeRoorkee-241661India Department of Geology Banaras Hindu UniversityVaranasi-221005India Wadia Institute of Himalayan Geology Dehradun-24S001India Hutti Gold Mines Company Limited Hutti-584115India

Low saline aqueous carbonic fluids are considered to be the ore forming solutions for orogenic lode gold *** separation/fluid immiscibility of the ore fluid is quite common and is one of the major reasons for deposition of gold in these *** carbonic fluid inclusions have been observed in quartz grains of Hira-Buddnini Gold *** estimation indicates that more volume of H2O compared to CO2 is likely to be trapped in inclusions at different P-T *** loss of H2O from fluid inclusions during ductile deformation of quartz grains have been attributed as the suitable reason for abundance of carbonic fluid inclusions.

关键词： orogenic lode gold deposit carbonic fluid inclusions Redlich-Kwong Equation fluid immiscibility Hira-Buddini Gold Deposit

Efficient discrete firefly algorithm for Ctrie based caching of multiple sequence alignment on optimally scheduled parallel machines

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CAAI Transactions on Intelligence Technology 2019年第2期4卷 92-100页

作者： Soniya Lalwani Harish Sharma Abhay Verma rajesh Kumar Department of Computer Science & Engineering Rajasthan Technical University Kota India Department of Electrical Engineering Malaviya National Institute of Technology Jaipur India

This study introduces a two-level strategy for efficient execution of multiple sequence alignment (MSA) of complex heterogeneous sequences. The two levels of the proposed technique are comprised of: designing the discrete firefly algorithm (DFFA) for the formation and implementation of makespan minimisation on parallel machines, followed by performing Ctrie-based caching for pairwise alignment to reduce the load on the data servers for handling multiple queries. The proposed strategy addresses a multi-client problem that aims to acquire the full advantage of the computational power of parallel connected machines. Further, it is shown that the inclusion of Ctrie as caching mechanism successively improves the performance of the system with accretion in several sequences. Performance of proposed DFFA is also compared with discrete versions of four swarm intelligence based algorithms at the criteria of makespan minimisation and the rate of convergence on two kinds of complex and diverse datasets. The work is unique in this sense: it is the first swarm-intelligence-based implementation for the addressed problem;it is so far the first approach for Ctrie based caching of the MSA on the scheduled parallel machines;hybridisation of DFFA with Ctrie for caching the MSA results is also a novel implementation.

关键词： strategy execution machines

Design and analysis of multi-channel drop filter using dual L defected hexagonal photonic crystal ring resonator

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Digital Communications and Networks 2020年第1期6卷 136-143页

作者： D.Saranya Shoba Mohan A.rajesh school of electronics and engineering vit universityvelloreindia college of science and engineering hamad bin khalifa universitydohaqatar

In this paper,dual L defected hexagonal Photonic Crystal Ring Resonator(PCRR)using Channel Drop Filter(CDF)is designed for Coarse Wavelength Division Multiplexing(CWDM)*** this structure,the external rods of the ring resonator are arranged in a hexagon and the internal rods are removed in L arrangement for introducing *** rods are used to prevent *** using the L defected hexagonal resonator,a multi-channel CDF is designed,which exhibits multiple wavelengths of CWDM(1500 nm–1600 nm)*** addition,the selection of rod size and the position of rods in the proposed multi-channel CDF are validated by varying the radius of coupling and scattering rods,as well as the position of resonators,*** using plane wave expansion and opti Finite Difference Time Domain(FDTD)method,the electromagnetic wave propagation and the photonic band gap are obtained.

关键词： Channel drop filter Photonic crystal ring resonator Coarse wavelength division multiplexing Finite difference time domain

Oxidative Stressand Antioxidant Responses in Young Leaves of Mulberry Plants Grown Under Nitrogen, Phosphorus or Potassium Deficiency

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Journal of Integrative Plant Biology 2007年第3期49卷 313-322页

作者： rajesh Kumar Tewari Praveen Kumar Parma Nand Sharma Department of Botany University of LucknowLucknow226007India

The aim of this study was to associate the generation of reactive oxygen species （ROS） with Induced antloxidant responses and disturbed cellular redox environment in the nitrogen-（N）, phosphorus-（P）, or potassium-（K） deftcient mulberry （Morus alba L. var. Kanva-2） plants. The indicators of oxidative stress and cellular redox environment and antioxldant defense-related parameters were analyzed. Oeficlency of N, P or K suppressed growth, accelerated senescence, and decreased concentrations of chloroplastic pigments and glutathione. Lipid peroxidation and activities of superoxide dismutase, ascorbate peroxidase and glutathione reductase were also increased in these N, P, or K deprived plants. Concentration of hydrogen peroxide Increased in plants deficient in N or P. Oeficlency of N or P particularly altered the cellular redox environment as indicated by changes in the redox couples, namely ascorbic acid/total ascorbate decreased in P-, glutathione sulfydryl/total glutathione decreased in N-, and Increased in P-deficient plants. Activity staining of native gels for superoxide dismutase revealed Increased activity as Indicated by Increased intensity of bands, and induction of few new isoforms in P- and K-deficient plants. Oifferences in the patterns of superoxide dismutase isoforms and redox status （ascorbic acid/total ascorbate and glutathlone sulfydryl/total glutathione） Indicate that N-, P-, or K-deficiency altered antioxidant responses to varying extents in mulberry plants.

关键词： antioxidants potassium-deficiency lipid peroxidation Morus alba mulberry nitrogen-deficiency oxidative stress phosphorus-deficiency reactive oxygen species

Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract

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Journal of Integrative Medicine 2019年第5期17卷 374-382页

作者： Pranay Soni rajesh Choudhary Surendra H.Bodakhe Department of Pharmacology Institute of Pharmaceutical SciencesGuru Ghasidas Vishwavidyalaya

Objective: The present study investigated the anticataract activity of a novel isoflavonoid, isolated from stem bark of Alstonia scholaris, against fructose-induced experimental ***: The bioactivity of fractions extracted from A. scholaris, an isolated isoflavonoid(ASII) was screened using in vitro(goat lens) and in vivo(albino rats) experimental cataract models. For the in vivo evaluation, albino rats(12–15 weeks old) were divided into five groups(n = 6). Group I(normal)received 0.3% carboxymethyl cellulose solution(10 m L/[kgád], p.o.). Group II(control) received 10%(w/v)fructose solution in their drinking water. Groups III–V received ASII at three different doses, 0.1, 1.0 and10 mg/(kgád), concurrently with 10%(w/v) fructose solution. Treatment was given daily for 8 consecutive weeks. During the protocol, systolic blood pressure, diastolic blood pressure, blood glucose level and lenticular opacity were monitored at 2-week intervals. Pathophysiological markers(catalase, superoxide dismutase, glutathione peroxidase, reduced glutathione and malondialdehyde) in eye lenses were examined at the end of the 8-week treatment ***: The results of in vitro study showed that A. scholaris extract and the active fraction(A3) reduced the lenticular opacity as compared to toxic control group. The in vivo study showed that 8-week administration of ASII(0.1, 1.0 and 10 mg/[kgád], p.o.) led to significant reduction in blood pressure and blood glucose level and retarded the initiation and evolution of cataractogenesis, compared to the fructoseinduced cataract model control. Additionally, ASII treatment led to significant improvement in lens antioxidants(catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione) and decreased lens malondialdehyde, compared to the control group(group II).Conclusion: Results revealed that administration of ASII played a crucial role in the reduction of cataract formation in diabetic and hypertensive models.

关键词： Isoflavonoid Oxidative stress Alstonia scholaris Hypertension Diabetes Cataract

Pharmacokinetic aspects and in vitro–in vivo correlation potential for lipid-based formulations

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Acta Pharmaceutica Sinica B 2014年第5期4卷 333-349页

作者： Sivacharan Kollipara rajesh Kumar Gandhi Formulations Department Pharmaceutical&Analytical DevelopmentTechnical R&DNovartis Healthcare Pvt.Ltd.Hyderabad 500078Andhra PradeshIndia

Lipid-based formulations have been an attractive choice among novel drug delivery systems for enhancing the solubility and bioavailability of poorly soluble drugs due to their ability to keep the drug in solubilized state in the gastrointestinal *** formulations offer multiple advantages such as reduction in food effect and inter-individual variability,ease of preparation,and the possibility of manufacturing using common excipients available in the *** these advantages,very few products are available in the present market,perhaps due to limited knowledge in the in vitro tests(for prediction of in vivo fate)and lack of understanding of the mechanisms behind pharmacokinetic and biopharmaceutical aspects of lipid formulations after oral *** current review aims to provide a detailed understanding of the in vivo processing steps involved after oral administration of lipid formulations,their pharmacokinetic aspects and in vitro in vivo correlation(IVIVC)*** pharmacokinetic and biopharmaceutical aspects such as formulation dispersion and lipid digestion,bioavailability enhancement mechanisms,impact of excipients on efflux transporters,and lymphatic transport are discussed with *** addition,various IVIVC approaches towards predicting in vivo data from in vitro dispersion/precipitation,in vitro lipolysis and ex vivo permeation studies are also discussed in detail with help of case studies.

关键词： Pharmacokinetics Lipolysis IVIVC Efflux transporters Lymphatic delivery Food effect

G6PD deficiency shifts polarization of monocytes/macrophages towards a proinflammatory and profibrotic phenotype

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Cellular & Molecular Immunology 2021年第3期18卷 770-772页

作者： rajesh Parsanathan Sushil K.Jain Department of Pediatrics and Center for Cardiovascular Diseases and Sciences Louisiana State University Health Sciences Center-Shreveport1501 Kings HighwayShreveportLA 71130USA

Glucose-6-phosphate dehydrogenase(G6PD)deficiency is the most common inherited trait and affects-7% of the global *** G6PD A^(-)variant(class Ⅲ),which has mild-tomoderate residual enzymatic activity(10-60%),is present in 11-14% of African American(AA)***-analysis and epidemiological studies from different countries have shown that individuals with G6PD deficiency have an increased risk of developing diabetes and cardiovascular disease.

关键词： G6PD population. cardiovascular

Authentication of WSN for Secured Medical Data Transmission Using Diffie Hellman Algorithm

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Computer Systems Science & Engineering 2023年第6期45卷 2363-2376页

作者： A.Jenice Prabhu D.Hevin rajesh Arunachala College of Engineering for Women ManavilaiNagercoil629203India St.Xavier’s Catholic College of Engineering Nagercoil629003India

The applications of wireless sensor network(WSN)exhibits a significant rise in recent days since it is enveloped with various advantageous *** the medical field,the emergence of WSN has created marvelous changes in monitoring the health conditions of the patients and so it is attracted by doctors and *** assists in providing health care services without any delay and so it plays predominant role in saving the life of *** data of different persons,time,places and networks have been linked with certain devices,which are collectively known as Internet of Things(IOT);it is regarded as the essential requirement of people in recent *** the health care monitoring system,IOT plays a magnificent role,which has produced the real time monitoring of patient’s *** the medical data transmission is accomplished quickly with high security by the routing and key *** the data from the digital record system(cloud)is accessed by the patients or doctors,the medical data is transferred quickly through WSN by performing *** Probabilistic Neural Network(PNN)is utilized,which authenticates the shortest path to reach the destination and its performance is identified by comparing it with the Dynamic Source Routing(DSR)protocol and Energy aware and Stable Routing(ESR)*** performing routing,the secured transmission is achieved by key management,for which the Diffie Hellman key exchange is utilized,which performs encryption and decryption to secure the medical *** enables the quick and secured transmission of data from source to destination with improved throughput and delivery ratio.

关键词： Probabilistic neural network(PNN) diffie hellman key exchange internet of things(IOT) wireless sensor network(WSN)

Process Modelling and Experimental Analysis of Optimal Specimen Selection in Organic CMCs

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Computers, Materials & Continua 2022年第2期70卷 2415-2433页

作者： P.V.rajesh Kanak Kalita Xiao-Zhi Gao Faculty of Mechanical Engineering Saranathan College of EngineeringTrichy620012India Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai600062India School of Computing University of Eastern FinlandKuopioFI-70211Finland

Bone grafting is a surgical restructuring procedure of replacing broken bones and reconstructing missing bone pieces so that complex bone fractures can be repaired to avoid any serious health risk as well as permanent bone ***,human bones tend to regenerate and heal completely from *** it needs a small scaffold to provide the necessary space to *** implants allow a broken bone to grow ***,non-corrosive metal alloys are used for fixing broken bones.A metal plate is fastened between two ends of broken bones to join ***,issues like high weight,high cost,low wear resistance,*** to the emergence of ceramics and ceramic-based composites in surgical *** trends indicate the usage of organic ceramics and their associated composites as biomimeticmaterials for prostheses and other biomedical *** research paper deals with the fabrication of one such type of ceramic matrix composite(CMC)specimen with sea sponge and cuttlebone using powder metallurgy process by varying composition of cuttlebone,the particle size of the ceramics and sintering temperature of green *** of thermo-mechanical properties and optimization of process parameters is carried out using the preferential selection index(PSI)*** results obtained from this technique are further validated usingMulti-Level General Factorial Design(MLGFD).

关键词： Grafting implants ceramics composites prostheses powder metallurgy optimization