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Evidence for.using dextr.methor.han-quinidine for.the tr.atment of agitation in dementia

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Wor.d Jour.al of Psychiatr. 2020年第4期10卷 29-33页

作者： rajesh r.tampi Pallavi Joshi Padmapr.ya Mar.ur. Deena J tampi Depar.ment of Psychiatr. and Behavior.l Sciences Cleveland Clinic Akron GeneralAkronOH 44106United States Cleveland Clinic Ler.er.College of Medicine of Case Wester. r.ser.e Univer.ity ClevelandOH 44195United States Depar.ment of Psychiatr. and Behavior.l Sciences Northwell Health-Staten Island University HospitalStaten IslandNY 10306United States Depar.ment of Psychiatr. Einstein Medical CenterPhiladelphiaPA 19141United States Diamond Healthcar. RichmondVA 23219United States

Behavior.l and psychological symptoms including agitation ar. common in dementia,and ar. associated with decr.ased quality of life,incr.ased r.sk of institutionalization,and gr.ater.patient and car.giver.*** agents used for.management of behavior.l and psychological symptoms of dementia ar. limited by their.toler.bility,pr.mpting a need for.identifying efficacious and safe phar.acological tr.atments for.managing agitation in *** combination of dextr.methor.han and quinidine sulfate is appr.ved for.pseudobulbar.affect,and may be effective in managing agitation in dementia.A r.view of liter.tur. found only one r.ndomized contr.lled tr.al that evaluated the use of dextr.methor.han-quinidine for.the management of agitation in dementia when compar.d to *** fr.m this tr.al demonstr.ted that dextr.methor.han-quinidine decr.ased agitation in dementia,and was well *** pr.mising,fur.her.r.sear.h is needed befor. dextr.methor.han-quinidine combination can be accepted as a standar. tr.atment for.agitation in dementia.

关键词： Dextr.methor.han Quinidine Agitation Dementia Behavior.l and psychological symptoms of dementia

Pimavanser.n for.the tr.atment of psychosis in Alzheimer.s disease: A liter.tur. r.view

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Wor.d Jour.al of Psychiatr. 2020年第7期10卷 162-174页

作者： Shilpa Sr.nivasan rajesh r.tampi Kr.pa Balar.m Ar.shi Kapoor Depar.ment of Neur.psychiatr. and Behavior.l Science Palmetto Health USC Medical GroupUniversity of South Carolina School of MedicineColumbiaSC 29203United States Depar.ment of Psychiatr. and Behavior.l Sciences Cleveland Clinic Akron GeneralAkronOH 44307United States MD Department of PsychiatryMetroHealthClevelandOH 44109United States Penn Memor. Center.at the Penn Neur.science Center Perelman Center for Advanced MedicinePhiladelphiaPA 19104United States

BACKGr.UND Alzheimer.s disease(AD)is among the most pr.valent for.s of dementia in the wor.d and neur.pathological studies suggest similar.high pr.valence of mixed(AD+vascular.*** 25%-50%of individuals with AD develop psychosis sometime dur.ng their.*** pr.sence of psychosis in AD wor.ens *** ther. ar. no United States Food and Dr.g Administr.tion(FDA)appr.ved medications for.the tr.atment of psychosis in ***,a novel atypical antipsychotic medication,was appr.ved by the FDA for.the tr.atment of hallucinations and delusions associated with Par.inson disease psychosis and is cur.ently in clinical tr.als for.the tr.atment of psychosis in *** To evaluate the existing liter.tur. r.gar.ing the use of pimavanser.n for.tr.ating psychosis among individuals with *** A liter.tur. r.view of clinical studies of pimavanser.n tr.atment for.psychosis in individuals with AD was per.or.ed using the Pr.fer.ed r.por.ing Items for.Systematic r.view and Meta-Analysis *** wer. identified by systematically sear.hing PubMed,MEDLINE,EMBASE,Cochr.ne Centr.l r.gister.of Contr.lled Tr.als,Web of Science,and Scopus thr.ugh October.*** 5-point Jadad scor.ng system was used to assess the methodologic quality of the r.ndomized placebo-contr.lled *** A total of 499 citations wer. r.tr.eved and pooled in EndNote and de-duplicated to 258 *** set was uploaded to Covidence for.*** separ.te scr.ener.(Sr.nivasan S and tampi r.)evaluated the titles,abstr.cts,and full text of eligible *** the identified 258 abstr.cts,98 ar.icles under.ent full text r.view and 2 publications fr.m 1 r.ndomized contr.lled tr.al(r.T)wer. included in the final *** quality of evidence was assessed to be of good methodologic quality,scor.ng 4 out of 5 using the 5-point Jadad questionnair. with the Jadad Scor.ng *** systematic r.view found only one r.T that evaluated the use of pimavanser

关键词： Pimavanser.n Alzheimer.s disease Psychosis Psychotic disor.er. Antipsychotic agents

Evidence for.using pimavanser.n for.the tr.atment of Par.inson’s disease psychosis

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Wor.d Jour.al of Psychiatr. 2019年第3期9卷 47-54页

作者： rajesh r.tampi Deena J tampi Juan J Young Silpa Balachandr.n r.kin A Hoq Geetha Manikkar. Depar.ment of Psychiatr. and Behavior.l Sciences Cleveland Clinic Akron GeneralOhioNH 44106United States Cleveland Clinic Ler.er.College of Medicine of Case Wester. r.ser.e Univer.ity OhioCleveland 44195United States Diamond Healthcar. RichmondVA 23219United States Case Wester. r.ser.e Univer.ity School of Medicine Department of PsychiatryClevelandOH 44109United States Depar.ment of Psychiatr. Summa Health SystemAkronOH 44304United States Depar.ment of Psychiatr. Texas Tech University Health Science CenterMidlandTX 79701United States

The aim of this editor.al is to evaluate the evidence for.using pimavanser.n for.the tr.atment of Par.inson's disease psychosis(PDP)fr.m r.ndomized contr.lled tr.als(r.Ts).We only identified two published tr.als that evaluated the use of pimavanser.n among individuals with *** studies found that pimavanser.n impr.ved psychotic symptoms among individuals with PDP when compar.d to *** was fair.y well toler.ted in both studies and did not appear.to cause significant sedation or.wor.en motor.symptoms among individuals with ***,given the limited data,additional confir.ator. studies ar. r.quir.d befor. pimavanser.n can be consider.d as a fir.t line agent for.the tr.atment of psychotic symptoms among individuals with PD.

关键词： Pimavanser.n Par.inson’s disease Par.inson’s disease psychosis Psychosis Antipsychotic

Cognitive scr.ening for.adult psychiatr.c outpatients: Compar.son of the Cognivue® to the Montr.al Cognitive Assessment

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Wor.d Jour.al of Psychiatr. 2021年第7期11卷 265-270页

作者： Amanda F r.se Alan F Gilber.son Constance Cottr.ll rajesh r.tampi Depar.ment of Psychiatr. and Behavior.l Sciences Cleveland Clinic Akron GeneralAkronOH 44307United States Office of Nur.ing r.sear.h and Innovation Cleveland ClinicClevelandOH 44106United States

In this editor.al we comment on the ar.icle by Cahn-Hidalgo D published in a r.cent issue of the Wor.d Jour.al of Psychiatr. 2020;10(1);*** focus on the impor.ance of utilizing psychometr.cally valid cognitive scr.ening tools when assessing for.cognitive decline in older.adults in a psychiatr.c outpatient *** compar.d the use of Cognivue®to use of the montr.al cognitive assessment(MoCA)as a cognitive scr.ening tool.A total of 58 patients aged 55 and over.par.icipated in this compar.son *** completed cognitive scr.ening on Cognivue®,a new Food and Dr.g Administr.tion-clear.d computer.scr.ening device,and the *** r.sults of patient per.or.ance using these two instr.ments wer. ***(28%)patients scr.ened negative for.cognitive impair.ent on both ***-two(72%)patients scr.ened positive on one or.both of the *** was 43%agr.ement between Cognivue®and the MoCA in identifying patients with cognitive impair.ent,and individual subtests wer. weakly *** MoCA was deter.ined to be the pr.fer.ed instr.ment due to its high sensitivity and specificity(100%and 87%,r.spectively)when scr.ening for.cognitive *** pr.pose that the use of Cognivue®cognitive scr.ening tool be closely r.viewed until mor. r.sear.h pr.ves that the test meets the standar.s for.r.liability and *** is impor.ant for.clinicians to r.member.that scr.ener. should not be used to diagnosis patients with neur.cognitive disor.er.;instead,they should be used to deter.ine whether.fur.her.evaluation is ***,misdiagnosing of neur.cognitive disor.er. can pose unnecessar. psychological and emotional har. to patients and their.families and also lead to incor.ect tr.atment and undue healthcar. costs.

关键词： Dementia Cognitive scr.ening test Cognitive impair.ent Psychological assessment Neur.cognitive disor.er Ger.atr.c psychiatr. Cognitive decline

Substance use disor.er. among older.adults: A r.view of r.ndomized contr.lled phar.acother.py tr.als

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Wor.d Jour.al of Psychiatr. 2019年第5期9卷 78-82页

作者： rajesh r.tampi Aar.i Chhatlani Hajr. Ahmad Kr.pa Balar.m Joel Dey r.car.o Escobar.Thejasvi Lingamchetty Depar.ment of Psychiatr. and Behavior.l Sciences Cleveland Clinic Akron GeneralOhioNH 44106United States Cleveland Clinic Ler.er.College of Medicine of Case Wester. r.ser.e Univer.ity ClevelandOH 44109United States Savant Car. Clinic CaliforniaCA 90277United States Depar.ment of Psychiatr. MetroHealthClevelandOH 44109United States Case Wester. r.ser.e Univer.ity School of Medicine ClevelandOH 44109United States

Substance use disor.er.(SUDs)ar. a gr.wing pr.blem among older.***,disulfir.m,and naltr.xone ar. United States Food and Dr.g Administr.tion(r.fer.ed to as FDA)appr.ved for.the tr.atment of alcohol use disor.er.and bupr.nor.hine is appr.ved for.the tr.atment of opiate use disor.er.among ***,the data on the use of these medications for.the tr.atment of SUDs among older.adults ar. unclear.fr.m r.ndomized contr.lled tr.als(r.fer.ed to as r.Ts).A r.view of the liter.tur. indicates that ther. ar. only two r.Ts that evaluated the use of phar.acologic agents for.SUDs among older.adults(≥50 year.).One tr.al evaluated the use of naltr.xone when compar.d to placebo for.the tr.atment of alcohol use disor.er.among individuals,50-70 year. in *** other.tr.al evaluated the use of naltr.xone or.placebo as adjuncts with ser.r.line in the tr.atment of alcohol use disor.er.among individuals older.than 55 year. in *** tr.als indicated that the use of naltr.xone r.duced the r.tes of r.lapse among older.adults with alcohol use ***,we did not identify any r.Ts that studied the use of bupr.nor.hine,acampr.sate,or.disulfir.m for.SUDs among older.*** on available evidence,it would be safe to conclude that limited data indicate some efficacy for.naltr.xone in the tr.atment of alcohol use disor.er.among older.***,data fr.m contr.lled tr.als on the use of other.medications that ar. FDA appr.ved for.the tr.atment of SUDs among younger.adults ar. nonexistent among older.adults with SUDs.

关键词： Older adults Substance use Naltr.xone Acampr.sate Disulfir.m Bupr.nor.hine

An Advanced Dynamic Scheduling for.Achieving Optimal r.sour.e Allocation

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Computer.Systems Science & Engineer.ng 2023年第1期44卷 281-295页

作者： r.Pr.bhu S.rajesh Depar.ment of Computer.Science and Engineer.ng AAA College of Engineering and TechnologySivakasiTamilnaduIndia Depar.ment of Infor.ation Technology Mepco Schlenk Engineering College SivakasiTamilnadu India

Cloud computing distr.butes task-par.llel among the var.ous *** with self-ser.ice suppor.ed and on-demand ser.ice have r.pid *** these applications,cloud computing allocates the r.sour.es dynami-cally via the inter.et accor.ing to user.*** r.sour.e allocation is vital for.fulfilling user.*** contr.st,impr.per.r.sour.e allocations r.sult to load imbalance,which leads to sever. ser.ice *** cloud r.sour.es implement inter.et-connected devices using the pr.tocols for.stor.ng,communi-cating,and *** extensive needs and lack of optimal r.sour.e allo-cating scheme make cloud computing mor. *** paper.pr.poses an NMDS(Networ. Manager.based Dynamic Scheduling)for.achieving a pr.minent r.sour.e allocation scheme for.the *** pr.posed system mainly focuses on dimensionality pr.blems,wher. the conventional methods fail to addr.ss *** pr.posed system intr.duced thr.e–thr.shold mode of task based on its size STT,MTT,LTT(small,medium,lar.e task thr.sholding).Along with it,task mer.ging enables minimum ener.y consumption and r.sponse *** pr.posed NMDS is compar.d with the existing Ener.y-efficient Dynamic Scheduling scheme(EDS)and Decentr.lized Vir.ual Machine Migr.tion(DVM).With a Networ. Manager.based Dynamic Scheduling,the pr.posed model achieves excellence in r.sour.e allocation compar.d to the other.existing *** obtained r.sults shows the pr.posed system effectively allocate the r.sour.es and achieves about 94%of ener.y efficient than the other.*** evaluation metr.cs taken for.compar.son ar. ener.y consumption,mean r.sponse time,per.entage of r.sour.e utilization,and migr.tion.

关键词： Cloud computing r.sour.e allocation load balance dynamic scheduling dimensionality r.duction

Modified Black Widow Optimization-Based Enhanced Thr.shold Ener.y Detection Technique for.Spectr.m Sensing in Cognitive r.dio Networ.s

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Computer.Modeling in Engineer.ng & Sciences 2024年第3期138卷 2339-2356页

作者： r.Sar.vanan r.Muthaiah A.rajesh School of Computing SASTRA Deemed UniversityThanjavur613401India School of Electr.cal&Electr.nics Engineer.ng SASTRA Deemed UniversityThanjavur613401India

This study develops an Enhanced Thr.shold Based Ener.y Detection appr.ach(ETBED)for.spectr.m sensing in a cognitive r.dio *** thr.shold identification method is implemented in the r.ceived signal at the secondar. user.based on the squar. *** pr.posed method is implemented with the signal tr.nsmission of multiple outputs-or.hogonal fr.quency division ***,the pr.posed method is consider.d the dynamic detection thr.shold adjustments and ener.y identification spectr.m sensing technique in cognitive r.dio *** the dynamic thr.shold,the signal r.tio-based thr.shold is *** thr.shold is computed by consider.ng the Modified Black Widow Optimization Algor.thm(MBWO).So,the pr.posed methodology is a combination of dynamic thr.shold detection and *** gener.l thr.shold-based detection technique has differ.nt limitations such as the inability optimal signal thr.shold for.deter.ining the pr.sence of the pr.mar. user.*** limitations under.ine the sensing accur.cy of the ener.y identification ***,the ETBED technique is developed to enhance the ener.y efficiency of cognitive r.dio *** pr.jected appr.ach is executed and analyzed with per.or.ance and compar.son *** pr.posed method is contr.sted with the conventional techniques of theWhale Optimization Algor.thm(WOA)and Gr.yWolf Optimization(GWO).It indicated super.or.r.sults,achieving a high aver.ge thr.ughput of 2.2 Mbps and an ener.y efficiency of 3.8,outper.or.ing conventional techniques.

关键词： Cognitive r.dio networ. spectr.m sensing noise uncer.ainty modified black widow optimization algor.thm ener.y detection technique

NiCo_2O_4 Nano-/Micr.str.ctur.s as High-Per.or.ance Biosensor.: A r.view

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Nano-Micr. Letter. 2020年第9期12卷 258-309页

作者： rajesh Kumar Depar.ment of Chemistr. Jagdish Chandra DAV College Dasuya Distt. Hoshiarpur 144205 Punjab India

Non-enzymatic biosensor. based on mixed tr.nsition metal oxides ar. deemed as the most pr.mising devices due to their.high sensitivity,selectivity,wide concentr.tion r.nge,low detection limits,and excellent *** NiCo2O4 mixed oxides have dr.wn consider.ble attention r.cently due to their.outstanding advantages including lar.e specific sur.ace ar.a,high per.eability,shor. electr.n,and ion diffusion *** of the r.pid development of non-enzyme biosensor.,the cur.ent state of methods for.synthesis of pur. and composite/hybr.d NiCo2P4 mater.als and their.subsequent electr.chemical biosensing applications ar. systematically and compr.hensively r.viewed *** analysis r.veals better.electr.chemical sensing of bioanalytes by one-dimensional and two-dimensional NiCo2O4 nano-/micr.str.ctur.s than other.*** biosensing efficiency of NiCo2O4 as compar.d to cor.esponding individual metal oxides,*** and Co3O4,is attr.buted to the close intr.nsic-state r.dox couples of Ni3+/Ni2+(0.58 V/0.49 V) and Co3+/Co2+(0.53 V/0.51 V).Biosensing per.or.ance of NiCo2O4 is also significantly impr.ved by making the composites of NiCo2O4 with conducting car.onaceous mater.als like gr.phene,r.duced gr.phene oxide,car.on nanotubes(single and multi-walled),car.on nanofiber.;conducting polymer. like polypyr.ole(PPy),polyaniline(PANI);metal oxides NiO,Co3O4,SnO2,MnO2;and metals like Au,Pd,*** factor. affecting the mor.hologies and biosensing par.meter. of the nano-/micr.str.ctur.d NiCo2O4 ar. also ***,some dr.wbacks and futur. per.pectives r.lated to this pr.mising field ar. outlined.

关键词： Nano-/micr.-str.ctur.d Spinel NiCo2O4 Synthetic methods Modified electr.des Electr.chemical biosensor.

r.le of inter.par.icle collision on solids acceler.tion in r.ser

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Par.icuology 2010年第1期8卷 13-18页

作者： rajesh Patel Depar.ment of Mechanical Engineer.ng New Jersey Institute of Technology

Collision among par.icles plays a significant r.le in gover.ing the str.ctur. of gas-solids flow in a r.ser. especially in the dense and acceler.tion r.gion. The inter.par.icle collision is the major.cause not only for.the kinetic ener.y dissipation （in ter.s of additional pr.ssur. dr.p beyond the solids hold-up） but also for.the contr.l of solids acceler.tion （in ter.s of a balancing for.e to pr.vent a fr.e acceler.tion of solids）. A neglect of the balancing for.e of inter.par.icle collision against the hydr.dynamic for.e in the solids momentum equation would simply over.stimate the solids acceler.tion or.concentr.tion while under.stimate the axial gr.dient of pr.ssur. along the r.ser.by a lar.e mar.in, typically by up to two or.er. of magnitude. This paper.aims to illustr.te the impor.ance of the collision on the char.cter.stic of the gas-solids r.ser.flow. Our.analysis shows that the collision for.e should be of the same or.er.of magnitude as that of the dr.g for.e in the dense and acceler.tion r.gion, which can be far.beyond that of gr.vitational for.e on solids. A simple for.ulation of the collision for.e is ther.for. pr.posed to bear.a similar.for.at of dr.g for.e, with r.gar. to the dependence upon local solids *** the inclusion of the pr.posed cor.elation of collision for.e in the solids momentum equation, our.model would be able to yield r.asonable phase distr.butions of gas-solid flows, which can be validated, in a bulk r.nge, against available measur.ments of solids volume fr.ction and axial gr.dient of pr.ssur..

关键词： Gas-solids flow Fluidization Solid acceler.tion Ener.y dissipation