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Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis,transmission and therapeutic evaluation

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World Journal of Virology 2022年第1期11卷 40-56页

作者： Udhaya Bharathy Saravanan Mayurikaa Namachivayam rajes. jeewon Jian-Dong Huang Siva Sundara Kumar Durairajan Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarur 610005India Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduit 80837Mauritius CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055Guangdong ProvinceChina

There is a critical need to develop animal models to alleviate vaccine and drug development difficulties against zoonotic viral *** coronavirus family,which includes severe acute respiratory syndrome coronavirus 1 and severe acute respiratory syndrome coronavirus 2,crossed the species barrier and infected humans,causing a global outbreak in the 21st *** humans do not have pre-existing immunity against these viral infections and with ethics governing clinical trials,animal models are therefore being used in clinical studies to facilitate drug discovery and testing efficacy of *** ideal animal models should reflect the viral replication,clinical signs,and pathological responses observed in *** animal species should be tested to establish an appropriate animal model to study the disease pathology,transmission and evaluation of novel vaccine and drug candidates to treat coronavirus disease *** this context,the present review summarizes the recent progress in developing animal models for these two pathogenic viruses and highlights the utility of these models in studying SARS-associated coronavirus diseases.

关键词： Animal models SARS-CoV-1 SARS-CoV-2 COVID-19 Mice Hamster Non-human primates Pathogenesis Transmission Therapeutics

Species concepts of Dothideomycetes:classification,phylogenetic inconsistencies and taxonomic standardization

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Fungal Diversity 2021年第4期109卷 283-319页

作者： Dhandevi Pem rajes. jeewon Kandawatte Wedaralalage Thilini Chethana Sinang Hongsanan Mingkwan Doilom Nakarin Suwannarach Kevin David Hyde Innovative Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduitMauritius Faculty of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Guangdong Provincial Key Laboratory for Plant Epigenetics Shenzhen Key Laboratory of Microbial Genetic EngineeringCollege of Life Science and OceanographyShenzhen UniversityShenzhen 518060People’s Republic of China Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand

The species is one of the basic units of biological *** species concepts and recognition are essential topics in taxonomic studies and other biological *** the first part of this review,we briefly discuss the taxonomic history of the class *** the second part of the paper,we review four commonly used species concepts,focusing on morphological,ecological,biological and phylogenetic criteria and their applicability in the taxonomy of *** application and utility of the four criteria is discussed with examples in the genera Ascochyta,Cercospora and *** problems and challenges of studying Dothideomycetes are analyzed and basic guidelines for classifying species under the above criteria are provided.

关键词： Challenges DNA Fungi Morph Phylogeny Species Taxonomy

Investigating species boundaries in Colletotrichum

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Fungal Diversity 2021年第2期107卷 107-127页

作者： Chitrabhanu S.Bhunjun Chayanard Phukhamsakda Ruvishika S.Jayawardena rajes. jeewon Itthayakorn Promputtha Kevin D.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute of Plant Protection College of AgricultureJilin Agricultural UniversityChangchun 130118JilinPeople’s Republic of China Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi Jilin Agricultural UniversityChangchun 130118JilinPeople’s Republic of China Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduitMauritius Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand

Colletotrichum is one of the most important plant pathogenic genera that is responsible for numerous diseases which can have a profound impact on the agricultural *** delineation is difficult due to a lack of distinctive phenotypic ***,in this study three different genomic approaches based on phylogenetic,evolutionary and coalescent-based methods are applied to establish robust species *** reliability of five different DNA barcodes was also assessed to provide further insights into species *** ITS region can resolve the placement of taxa up to the species complex *** GAPDH and TUB2 markers are determined to be the most informative for most ***,no single marker could discriminate between species in all complexes,therefore different molecular approaches based on multi-locus datasets are *** is the first study to provide an estimated divergence time for all species complexes in *** estimated divergence time for species complexes ranged between 4.8 to 32.2 *** on the high level of congruent results obtained from the different molecular approaches,a new species complex,the Colletotrichum agaves complex is *** complex consists of five taxa which are characterised by the presence of straight or slightly curved conidia with obtuse *** study shows that coalescent approaches and multi-locus phylogeny are crucial to establish species boundaries in *** taxonomic placement of three singleton taxa Colletotrichum axonopodi,*** and *** is *** accept 248 species and provide recommendations regarding species boundaries in the graminicola-caudatum complex.

关键词： BEAST General mixed yule coalescent method Glomerellaceae Multi-rate poisson tree process Sordariomycetes Taxonomy

New host and geographic records of five pleosporalean hyphomycetes associated with Musa spp.(Banana)

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Studies in Fungi 2021年第1期6卷 92-115页

作者： Samarakoon BC Phookamsak R Karunarathna SC jeewon R Chomnunti P Xu JC Li YJ The State Phosphorus Resource Development and Utilization Engineering Technology Research Centre Yunnan Phosphate Chemical Group Co.LtdKunming 650201China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanChina Honghe Center for Mountain Futures Kunming Institute of BotanyChinese Academy of SciencesHonghe County 654400YunnanPeople’s Republic of China Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduitMauritius Research Center of Microbial Diversity and Sustainable Utilization Faculty of SciencesChiang Mai UniversityChiang Mai 50200Thailand

A study was undertaken to collect and identify saprobic fungi associated with Musa spp.(banana)from Taiwan(China),and *** were collected during the dry season and their morpho-molecular relationships were *** brown pleosporalean hyphomycetous taxa in Periconiaceae and Torulaceae *** cortaderiae,***,Torula chromolaenae,***,and *** were identified for the first time from Musa spp.(Musaceae).Phylogenetic analyses of a combined SSU,LSU,ITS,RPB2 and TEF DNA sequence dataset further justified the taxonomic placements of these five taxa in the above mentioned *** delonicis is reported for the first time on a monocotyledonous host and *** is the first geographical record from Taiwan(China).

关键词： Dothideomycetes Periconia Pleosporales taxonomy Torula

通过形态学和分子系统学揭示中国核桃上与介壳虫相关的小角壳属两个新种

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通过形态学和分子系统学揭示中国核桃上与介壳虫相关的小角壳属两...

Hypoxia-activatable nano-prodrug for fluorescently tracking drug release in mice

中国菌物学会2023年学术年会

作者：刘枫邓玉王飞虎 rajes. jeewon 曾倩许秀兰刘应高杨春琳四川农业大学林学院长江上游森林资源保育与生态安全国家林业与草原局重点实验室和长江上游林业生态工程重点实验室四川农业大学林学院毛里求斯大学医学与健康科学学院卫生科学系成都农林科学院林业研究所

小角壳属Microcera主要寄生于介壳虫中,但也常在土壤或地衣中发现。我们对中国四川省的昆虫病原真菌多样性进行调查,并对采集的昆虫病原真菌样品进行分离鉴定。通过形态特征观察、系统发育分析和DNA序列数据差异比对,描述了寄生在核桃Ju... 详细信息

小角壳属Microcera主要寄生于介壳虫中,但也常在土壤或地衣中发现。我们对中国四川省的昆虫病原真菌多样性进行调查,并对采集的昆虫病原真菌样品进行分离鉴定。通过形态特征观察、系统发育分析和DNA序列数据差异比对,描述了寄生在核桃Juglans regia上的褐圆盾蚧Chrysomphalus aonidum和桑白蚧Pseudaulacaspis pentagona的小角壳属2个新物种:褐圆盾介壳虫小角壳菌Microcera chrysomphaludis和拟白轮盾介壳虫小角壳菌***。基于最大似然分析(ML)和贝叶斯分析(BI)构建了基于多基因片段ITS、LSU、tef1-α、rpb1、rpb2、acl1、act、tub2、cmd A和his3序列数据的丛赤壳科系统发育树,并获得很好的统计学支持。本研究对这两个新物种进行了详细的形态描述和特征图示,并讨论与近缘种之间的系统关系。

关键词：小角壳属形态学分子系统发育分类学两个新种

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Science China Chemistry 2021年第3期64卷 499-508页

作者： Haidong Li Qichao Yao Zhongji Pu jeewon Chung Haoying Ge Chao Shi Ning Xu Feng Xu Wen Sun Jianjun Du Jiangli Fan Jingyun Wang Juyoung Yoon Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul 03760Korea Ningbo Institute of Dalian University of Technology Ningbo 315016China School of Bioengineering Dalian University of TechnologyDalian 116024China

Chemotherapy is one of the commonly used methods to treat various types of cancers in clinic by virtue of its high efficiency and universality. However, strong side effects and low concentration of conventional drugs at the tumor site have always been important factors that plague the chemotherapy effects of patients, further precluding their practical applications. Thereof, to solve the above dilemma, by integration of anticancer drug(nitrogen mustard, NM) into an NIR fluorophore(a dicyanoisophorone derivative), an intelligent prodrug NIR-NM was developed via molecular engineering strategy. Prodrug NIR-NM stimulated in hypoxia condition exhibits significantly higher toxicity to cancer cells than normal cells, essentially reducing the collateral damage to healthy cells and tissues of nitrogen mustard. More importantly, the nanoparticle prodrug FA-lip@NIR-NM showed the advantages of the high accumulation of drug at tumor site and long-circulation capacity in vivo, which endowed it the ability to track the release of the active chemotherapeutic drug and further treat solid tumors.

关键词： NIR fluorescent probe activatable hypoxia prodrug imaging

A polyphasic approach to delineate species in Bipolaris

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Fungal Diversity 2020年第3期102卷 225-256页

作者： Chitrabhanu S.Bhunjun Yang Dong Ruvishika S.Jayawardena rajes. jeewon Chayanard Phukhamsakda Digvijayini Bundhun Kevin D.Hyde Jun Sheng State Key Laboratory for Conservation and Utilization of Bio‑Resources in Yunnan Yunnan Agricultural UniversityKunming 650201People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Yunnan Research Institute for Local Plateau Agriculture and Industry Kunming 650201People’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50002Thailand Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Centre for Mountain Futures Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China

Bipolaris species are important plant pathogens with a worldwide distribution in tropical and temperate *** recognition in Bipolaris has been problematic due to a lack of molecular data from ex-type cultures,the use of few gene regions for species resolution and overlapping morphological *** this study,we evaluate the efficiency of different DNA barcodes in species delimitation in Bipolaris by phylogenetic analyses,Automatic Barcode Gap Discovery and Objective *** is determined to be the best single marker for the *** approaches are used to clarify the taxonomic placement of all sequences currently named as Bipolaris in GenBank based on ITS and GAPDH gene sequence *** checking various publications,we found that the majority of new host records of fungal species published in the Plant Disease journal from 2010 to 2019 were based on BLAST searches of the ITS sequences and up to 82%of those records could be ***,relying on BLAST searches from GenBank to name species is not *** boards of journals and reviewers of new record papers should be aware of this *** naming Bipolaris species,whether new or known,it is recommended to perform phylogenetic analyses based on GAPDH using the correct taxon sampling for accurate results and the species relationship should have reliable statistical *** least two new species are represented by molecular data in GenBank and we provide an updated taxonomic revision of *** accept 45 species in Bipolaris and notes are provided for all the species including hosts and geographic distribution.

关键词： Classification DNA barcoding Dothideomycetes Integrative taxonomy Pairwise differences Pleosporales

Biphasic taxonomic approaches for generic relatedness and phylogenetic relationships of Teichosporaceae

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Fungal Diversity 2021年第5期110卷 199-241页

作者： Danushka S.Tennakoon rajes. jeewon Kasun M.Thambugala Eleni Gentekaki Dhanushka N.Wanasinghe Itthayakorn Promputtha Kevin D.Hyde Center for Mountain Futures Kunming Institute of BotanyHonghe County 654400YunnanPeople’s Republic of China School of Science Mae Fah Luang University57100Chiang RaiThailand Center of Excellence in Fungal Research Mae Fah Luang University57100Chiang RaiThailand Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduitMauritius Genetics and Molecular Biology Unit Faculty of Applied SciencesUniversity of Sri JayewardenepuraGangodawilaNugegoda 10250Sri Lanka Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Innovative Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhouPeople’s Republic of China

The placement of the dothideomycetous family Teichosporaceae has been *** phylogenetic investigations have used a taxonomic lumping approach with the Floricolaceae and its genera have been synonymized under the earlier fam-ily name,*** relationships were therefore obscure and proper generic delimitation was needed in upcoming *** here taxonomically revised the family Teichosporaceae based on both morphological and phylogenetic *** species have immersed or semi-immersed,erumpent to superficial,ostiolate ascomata,cellular or trabeculate pseudoparaphyses,cylindrical to oblong or sub-clavate asci and ellipsoid to oblong or fusiform,cylindric-fusiform or oblong to elliptical,ovoid to clavate,symmetric or asymmetric,initially hyaline or pale brown to dark brown or yellowish brown,1-3-septate or muriform *** morphs are *** or representative speci-mens of Teichosporaceae were loaned and fresh specimens were collected from China and *** likelihood and Bayesian analyses of a combined ITS,LSU,SSU,tef1-αand rpb2 dataset were performed to clarify the phylogenetic affinities of taxa and examine monophyly of newly proposed *** new species(Floricola festucae),one new host record(Ramusculicola thailandica)and four new combinations(Aurantiascoma nephelii,***,Magnibotryascoma acaciae,***)are *** broad genus concept of Teichospora is dismissed based on morphological dissimilarities and the monophyletic status of the proposed *** accept Asymmetrispora,Aurantiascoma,Floricola,Magnibotryascoma,Misturatosphaeria,Pseudoaurantiascoma,Pseudomisturatosphaeria,Ramusculicola and Teichospora as distinct genera in the *** recognized genera are phenotypically characterized and phylogenetically *** phylogenetic placements of three genera(Chaetomastia,Loculohypoxylon and Sinodidymella),which do not have molecular data

关键词： 1 new species Dothideomycetes Multi-locus phylogeny Pleosporales Sexual morph Taxonomy

Taxonomy and the evolutionary history of Micropeltidaceae

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Fungal Diversity 2019年第4期97卷 393-436页

作者： Xiang-Yu Zeng Hai-Xia Wu Sinang Hongsanan rajes. jeewon Ting-Chi Wen Sajeewa S.N.Maharachchikumbura Putarak Chomnunti Kevin D.Hyde International Fungal Research and Development Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationThe Research Institute of Resource InsectsChinese Academy of ForestryKunming 650224China The Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest Guizhou UniversityGuiyang 550025China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518000China Shenzhen Key Laboratory of Laser Engineering College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518000China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniverstyPO Box 8123 Al KhoudOman School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650201Chin

Micropeltidaceae species are flyspeck fungi which have been subjected to few systematic *** re-examined 27 genera which were accepted in the Micropeltidaceae and re-described them based on herbaria materials and *** on morphology and phylogenetic investigations,we transfer Micropeltidaceae to a new order,Micropeltidales(Lecanoromycetes).Genera with bluish or greenish upper walls(Dictyopeltella,Dictyothyriella,Dictyothyrina,Dictyothyrium,Haplopeltheca,Micropeltis,Scolecopeltidium and Stomiopeltopsis)are accepted in the new taxonomic concept for Micropeltidaceae.A molecular clock approach estimated the divergence time of the Micropeltidaceae crown group at 130(165–104)Mya,which also supports its rank as an order(diverging from 220–100 Mya).The evolutionary histories between Micropeltidaceae species and host plants are interpreted by cophylogenetic analyses calibrated by their divergence *** result indicates that the diversification of Angiospermae(130–80 Mya)fosters the formation of genera of Micropeltidaceae mainly via cospeciation events,and this codivergent period would be an important reference when establishing generic boundaries of epifoliar fungi.

关键词： Codivergence Cophylogeny Dating Lecanoromycetes Micropeltidales